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Immune precision medicine for cancer:a novel insight based on the efficiency of immune effector cells

cancer communications 2019年第1期39卷 318-333页

作者： Jean-François Rossi patrice céballos Zhao-Yang Lu Institut Sainte catherine 84918 AvignonFrance UniversitéMontpellier 1 UFR Médecine34396 MontpellierFrance Département d’Hématologie CHU de Montpellier34295 MontpellierFrance Unitéde Thérapie cellulaire CHU Saint-Eloi34295 MontpellierFrance

cancer cell growth is associated with immune surveillance ***,restoring the desired immune response against cancer cells remains a major therapeutic *** to the recent advances in biological knowledge,efficient therapeutic tools have been developed to support the best bio-clinical approaches for immune precision *** of the most important successes in immune therapy is represented by the applicational use of monoclonal antibodies,particularly the use of rituximab for B-cell lymphoproliferative *** recently,other monoclonal antibodies have been developed,to inhibit immune checkpoints within the tumor microenvironment that limit immune suppression,or to enhance some immune functions with immune adjuvants through different targets such as Toll-receptor *** aim is to inhibit cancer proliferation by the diminishing/elimination of cancer residual cells and clinically improving the response duration with no or few adverse *** effect is supported by enhancing the number,functions,and activity of the immune effector cells,including the natural killer(NK)lymphocytes,NKT-lymphocytes,γδT-lymphocytes,cytotoxic T-lymphocytes,directly or indirectly through vaccines particularly with neoantigens,and by lowering the functions of the immune suppressive *** these new therapeutics and their personalized usage,new considerations have to be taken into account,such as epigenetic regulation particularly from microbiota,evaluation of transversal functions,particularly cellular metabolism,and consideration to the clinical consequences at the body *** aim of this review is to discuss some practical aspects of immune therapy,giving to clinicians the concept of immune effector cells balancing between control and *** precision medicine is a combination of modern biological knowledge and clinical therapeutic decisions in a global vision of the patient.

关键词： Precision therapy Immunotherapy NK lymphocytes T-lymphocytes Dendritic cells Vaccination cancer

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FLAG方案治疗高危骨髓异常增生综合征、急性髓细胞性白血病的临床研究

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江苏医药 2004年第4期30卷 298-299页

作者：孙爱宁 Nathalie F carole E patrice c 苏州大学附属第一医院血液科 215006 Department of Hematology CHU Hospital Lapeyronie

目的　了解FLAG方案 (Fludarabine、cytarabine、G cSF)诱导治疗高危骨髓异常增生综合征 (MDS)和急性髓细胞性白血病 (AML)的疗效及其耐受性。方法　对 4 3例高危MDS和AML进行FLAG诱导治疗 ,观察疗效及其不良反应。结果　 4 3例患者中... 详细信息

目的　了解FLAG方案 (Fludarabine、cytarabine、G cSF)诱导治疗高危骨髓异常增生综合征 (MDS)和急性髓细胞性白血病 (AML)的疗效及其耐受性。方法　对 4 3例高危MDS和AML进行FLAG诱导治疗 ,观察疗效及其不良反应。结果　 4 3例患者中获得完全缓解 (cR) 2 2例 (5 1% ) ,部分缓解 (PR) 9例 (2 1% ) ,有效率达 72 %。 1个疗程cR率为 6 8%。其中年龄 cR率均较高。FLAG方案的血液系统不良反应较重。中性粒细胞数恢复至 >0 5× 10 9/L的中位时间为 17(13～ 39)d ,血小板数恢复至 >2 0× 10 9/L的中位时间为 2 0(12～ 4 1)d。因粒缺发热的中位时间是 5 (0～ 31)d。红细胞输注支持的中位数为 7(0～ 70 )U ,血小板输注支持的中位数为 12 (3～ 2 6 )U。非血液系统不良反应非常轻。结论　FLAG方案作为高危MDS/AML的诱导治疗 ,是可耐受的。

关键词：高危骨髓异常增生综合征急性髓细胞性白血病 FLAG方案联合化疗不良反应骨髓抑制

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癌症的免疫精准医学:一种基于免疫效应细胞作用的新策略

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癌症 2020年第2期39卷 51-70页

作者： Jean‑François Rossi patrice céballos Zhao‑Yang Lu Institut Sainte catherine 84918 AvignonFrance UniversitéMontpellier 1 UFR Médecine34396 MontpellierFrance Département d’Hématologie CHU de Montpellier34295 MontpellierFrance Unitéde Thérapie cellulaire CHU Saint-Eloi34295 MontpellierFrance.

癌细胞生长与免疫监视逃逸相关。目前,恢复对癌细胞的免疫应答仍是一种主要的治疗策略。得益于生物学领域的最新研究成果,人们已经开发出了可支持免疫精准治疗相关的最佳生物临床途径的有效治疗工具。免疫治疗中最重要的、有效的成果之... 详细信息

癌细胞生长与免疫监视逃逸相关。目前,恢复对癌细胞的免疫应答仍是一种主要的治疗策略。得益于生物学领域的最新研究成果,人们已经开发出了可支持免疫精准治疗相关的最佳生物临床途径的有效治疗工具。免疫治疗中最重要的、有效的成果之一是单克隆抗体的应用,特别是利妥昔单抗在B细胞淋巴增生性疾病中的应用。最近,也开发出一些其他的单克隆抗体,通过抑制限制免疫抑制的肿瘤微环境中的免疫检查点,或者通过联合如Toll受体激动剂等免疫佐剂针对不同靶点来增强免疫功能。其目的是通过减少/消除癌症残留细胞来抑制癌症增殖,在临床上改善反应持续时间而无副作用或副作用较小。该效应是依靠直接或间接通过疫苗特别是新抗原来增强免疫效应细胞[包括自然杀伤(natural killer,NK)淋巴细胞、NKT-淋巴细胞、γδT-淋巴细胞、细胞毒性T-淋巴细胞]的数量、功能和活性,以及依靠降低免疫抑制细胞的功能而产生的。除了这些新疗法及其个体化治疗外,还必须考虑新的因素,例如表观遗传调控(特别是来自微生物菌群)、横向功能的评估(特别是细胞代谢),以及对身体整体的临床疗效。本综述旨在探讨免疫治疗的一些实践,向临床医生介绍如何在免疫效应细胞的控制和耐受之间取得平衡。免疫精准医学是现代生物学知识和着眼于患者全局的临床治疗决策的结合。

关键词：精准治疗免疫治疗 NK淋巴细胞 T-淋巴细胞树突状细胞疫苗接种癌症

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computational Insights into charge Storage Mechanisms of Supercapacitors

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Energy & Environmental Materials 2020年第3期3卷 235-246页

作者： Kui Xu Hui Shao Zifeng Lin céline Merlet Guang Feng Jixin Zhu patrice Simon Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing Tech University(NanjingTech)30 South Puzhu RoadNanjing 211816China cIRIMAT Universite de ToulouseCNRSUniversite Toulouse 3-Paul Sabatier118 Route de NarbonneToulouse cedex 931062France Reseausurle Stockage Electrochimique de l’Energie(RS2E) Federation de Recherche CNRS 3459HUB de l’EnergieRue BaudelocqueAmiens 80039France college of Materials Science and Engineering Sichuan UniversityNo.24 South Section 1Yihuan RoadChengdu 610065China State Key Laboratory of coal combustion School of Energy and Power EngineeringHuazhong University of Science and Technology(HUST)Wuhan 430074China Nano Interface centre for Energy School of Energy and Power EngineeringHuazhong University of Science and TechnologyWuhan 430074China

computational modeling methods,including molecular dynamics(MD)and Monte carlo(Mc)simulations,and density functional theory(DFT),are receiving booming interests for exploring charge storage mechanisms of electrochemical energy storage *** methods can effectively be used to obtain molecular scale local information or provide clear explanations for novel experimental findings that cannot be directly interpreted through experimental *** short review is dedicated to emphasizing recent advances in computational simulation methods for exploring the charge storage mechanisms in typical nanoscale materials,such as nanoporous carbon materials,2 D MXene materials,and metal-organic framework *** a better understanding of charge storage mechanisms and experimental observations,fast and accurate enough models would be helpful to provide theoretical guidance and experimental basis for the design of new high-performance electrochemical energy storage devices.

关键词： 2D material charge storage mechanism molecular simulations porous electrode supercapacitor

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Diabetes mellitus, insulin resistance and hepatitis c virus infection: A contemporary review

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World Journal of Gastroenterology 2017年第9期23卷 1697-1711页

作者： Anne-claire Desbois patrice cacoub Inflammation-Immunopathology-Biotherapy Department Sorbonne Universités UMR_S 959 French National Institute of Health and Medical Research FRE3632 The French National Center for Scientific Research Department of Internal Medicine and clinical Immunology Groupe Hospitalier Pitié-Salpêtrière AP-HP

To summarise the literature data on hepatitis c virus (HcV)-infected patients concerning the prevalence of glucose abnormalities and associated *** conducted a PubMed search and selected all studies found with the key words 'HcV' or 'hepatitis c virus' and 'diabetes' or 'insulin resistance'. We included only comparative studies written in English or in French, published from January 2000 to April 2015. We collected the literature data on HcV-infected patients concerning the prevalence of glucose abnormalities [diabetes mellitus (DM) and insulin resistance (IR)] and associated risk [i.e., severe liver fibrosis, response to antivirals, and the occurrence of hepatocellular carcinoma (Hcc)].RESULTSHcV infection is significantly associated with DM/IR compared with healthy volunteers and patients with hepatitis B virus infection. Glucose abnormalities were associated with advanced liver fibrosis, lack of sustained virologic response to interferon alfa-based treatment and with a higher risk of Hcc development. As new antiviral therapies may offer a cure for HcV infection, such data should be taken into account, from a therapeutic and preventive point of view, for liver and non-liver consequences of HcV disease. The efficacy of antidiabetic treatment in improving the response to antiviral treatment and in decreasing the risk of Hcc has been reported by some studies but not by others. Thus, the effects of glucose abnormalities correction in reducing liver events need further *** abnormalities are strongly associated with HcV infection and show a negative impact on the main liver related outcomes.

关键词： Hepatitis c virus Diabetes mellitus Insulin resistance Liver fibrosis Treatment

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Global latitudinal patterns in leaf herbivory are related to variation in climate, rather than phytochemicals or mycorrhizal types

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National Science Review 2023年第12期10卷 66-69页

作者： Hui Tang Xianhui Zhu Yonglin Zhong Yuanzhi Li Wenqi Luo Hanlun Liu patrice Descombes Alan c.Gange chengjin chu State Key Laboratory of Biocontrol School of Ecology/School of Life Sciences Sun Yat-sen University Guangdong Provincial Key Laboratory of Silviculture Protection and Utilization Guangdong Academy of Forestry Musée et Jardins botaniques cantonaux Department of Ecology and Evolution University of Lausanne Department of Biological Sciences Royal Holloway University of London

Plant-herbivore interactions are among the most important factors shaping plant community dynamics and ecosystem functioning. The latitudinal herbivory hypothesis proposed that insect herbivory rates decline with increasing latitudes owing to benign environmental conditions in the tropics, but studies have produced contradictory conclusions[1–3].

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Development and validation of a thermally regulated atmospheric simulation chamber(THALAMOS): A versatile tool to simulate atmospheric processes

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Journal of Environmental Sciences 2020年第9期32卷 141-154页

作者： Noureddin Osseiran Manolis N.Romanias Vincent Gaudion Maria E.Angelaki Vassileios c.Papadimitriou Alexandre Tomas patrice coddeville Frederic Thevenet IMT Lille Douai Univ.LilleSAGELille F-59000France Laboratory of photochemistry and chemical kinetics(LAPKIN) University of CreteHeraklion 71003CreteGreece

Atmospheric simulation chambers,are unique tools for investigating atmospheric processes in the gas and heterogeneous *** can provide a controlled yet realistic environment that simulates atmospheric *** the current study,a Teflon atmospheric simulation chamber of 600 L,named THALAMOS(thermally regulated atmospheric simulation chamber) has been developed and *** can be operated over the temperature range 233 to 373 K under both static and flow *** is equipped with state of the art instrumentation(selective ion flow tube mass spectrometry(SIFT-MS),long path Fourier transform infrared spectroscopy(FTIR),gas chromatography-mass spectrometry(Gc-MS),various analyzers) for the in-line monitoring of both reactants and *** was validated by measuring the rate coefficients of well documented reactions,*** reaction of ethanol with OH radicals and the reaction of dichloromethane with cl atoms,in a wide temperature *** different detection techniques were used in parallel,FTIR and SIFT-MS,to internally cross-validate the obtained *** measured rate coefficients are in excellent agreement,both between each other and with the literature recommended ***,the gas phase oxidation of toluene by cl atoms(kinetics and product yields) was studied in the temperature range of 253 to 333 *** the best of our knowledge,THALAMOS is a unique facility on national level and among a few smog chambers internationally that can be operated in such a wide temperature range providing the scientific community with a versatile tool to simulate both outdoor and indoor physicochemical processes.

关键词： versatile equipped kinetics

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Interaction between a diesel-fuel spray and entrained air with single- and double-injection strategies using large eddy simulations

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Propulsion and Power Research 2020年第1期9卷 37-50页

作者： Jonathan Brulatout François Garnier patrice Seers Mechanical Engineering Department École de Technologie Supérieure1100 Notre-Dame Street WestMontrealH3C 1K3Canada

Interaction between fuel and air in a combustion chamber is one of the main drivers of the mixing ***,flow visualizations are limited by high droplet density in the ***,the ability of large eddy simulations(LES)to resolve large scales of flow offers good perspectives on capturing flow structures issued from the interaction between the Lagrangian(fuel droplets)and Eulerian(ambient gas)*** study examined these interactions first during a single injection using 3D and 2D criteria for both *** for the 3D criteria,the spray shape was analyzed in parallel to the Q-criteria applied to the Eulerian phase,making it possible to relate the spray deformations to some specific Eulerian ***,2D criteria were the fuel mass-fraction field and Eulerian streamlines,both taken in the mid-plane of the *** last analysis allows for identifying certain mechanisms involved in the Eulerian phase’s structure generation and relates it to high fuel-concentration areas in the fuel mass-fraction visualizations.

关键词： Diesel fuel spray Large eddy simulation Multiple injection coherent structures Lagrangian-Eulerian interaction Air-spray interactions

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Experimental characterization of the removal efficiency and energy effectiveness of central air cleaners

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Energy and Built Environment 2021年第1期2卷 1-12页

作者： patrice Blondeau Marc Olivier Abadie Alexandra Durand Pascal Kaluzny Sylvie Parat Alain Ginestet Dominique Pugnet céline Tourreilles Thierry Duforestel LaSIE/La Rochelle University UMR CNRS 7356Avenue Michel Crépeau17042 La Rochelle cedex 1France Tera Environnement 628 rue Charles de Gaulle38920 CrollesFrance Air&Bio 13 rue Jules Ferry73000 ChambéryFrance cETIAT 25 avenue des artsBP 5204269603 VilleurbanneFrance EDF R&D Avenue des Renardières77818 Moret-sur-Loing cedexFrance.

This study assessed six commercially available in-duct air cleaning devices which are designed to be mounted in the central ventilation system of offices or commercial *** selected devices use different air cleaning technologies:mechanical filtration,electrostatic precipitation,gas filtration,ionization/cold plasma,photocatalytic oxidation(PcO)and catalysis under UV *** were tested against particles,a mixture of volatile organic compounds containing acetone,acetaldehyde,toluene,heptane and formaldehyde,and two bio-contaminants:Aspergillus brasiliensis(fungus)and Staphylococcus epidermidis(bacteria).Two different test rigs were *** single pass efficiency of each device was determined for three airflow rates,corresponding to face velocities ranging from 0.9 to 2.7 m/s,and two sets of temperature and humidity that are representative of indoor air conditions in wintertime and *** concentration of the chal-lenge volatile organic compounds was also varied in the 30 to 100μg/m^(3)range as a way to characterize their influence on efficiency at realistic concentration levels for non-industrial *** of ozone and formaldehyde concentration downstream of the air cleaners were carried out to determine the emission rate of by-products into the air ***,the energy issue was addressed by measuring the electric power drawn and pressure loss of the *** results showed that two devices,namely a radiant catalytic ionizer and a plasma ionizer,had a very low single pass efficiency against all the challenge *** association of the plasma ionizer and the electrostatic precipitator did not produce a synergetic effect between the two technologies either,contrary to what their manufacturer ***,three of the six devices tested were effective in terms of pollutant removal,but only two had an acceptable energy effectiveness in view of their use in low or zero energy *** energy effectiveness ranged

关键词： central air cleaners Efficiency clean air delivery rate Energy effectiveness By-products Ozone

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Ultrafast Synthesis of calcium Vanadate for Superior Aqueous calcium-Ion Battery

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Research 2019年第1期2019卷 85-95页

作者： Liyuan Liu Yih-chyng Wu Patrick Rozier Pierre-Louis Taberna patrice Simon cIRIMAT UMR CNRS 5085UniversitéPaul Sabatier Toulouse III118 route de Narbonne31062 ToulouseFrance RS2E Réseau Français sur le Stockage Electrochimique de l’EnergieFR CNRS 345980039 Amiens CEDEXFrance

Recently,multivalent aqueous calcium-ion batteries(cIBs)have attracted considerable attention as a possible alternative to Li-ion ***,traditional ca-ion storage materials show either limited rate capabilities and poor cycle life or insufficient specific ***,we tackle these limitations by exploring materials having a large interlayer distance to achieve decent specific capacities and one-dimensional architecture with adequate ca-ion passages that enable rapid reversible(de)intercalation *** this work,we report the high-yield,rapid,and low-cost synthesis of 1D metal oxides MV_(3)O_(8)(M=Li,K),caV_(2)O_(6),and caV_(6)O_(16)·7H_(2)O(cVO)via a molten salt ***,using 1D cVO as electrode materials,we show high capacity 205 mA h g^(-1),long cycle life(>97%capacity retention after 200 cycles at 3.0 c),and high-rate performance(117 mA h g^(-1) at 12 c)for ca-ion(de)*** work represents a step forward for the development of the molten salt method to synthesize nanomaterials and to help pave the way for the future growth of ca-ion batteries.

关键词： method. retention reversible

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