检索结果-南通市图书馆

A hypothesis for a novel role of RIn1-the modulation of telomerasefunction by the MAPK signaling pathway

BIOcELL 2020年第4期44卷 525-534页

作者： patric HAMBLETOn MAnUEL ALEJAnDRO BARBIERI Department of Biological Sciences Florida International UniversityMiami33199USA Biomedical Science Institute Florida International UniversityMiami33199USA Fairchild Tropical Botanic Garden Miami33156USA International center of Tropical Botany Florida International UniversityMiamiFL33199USA

cancerous cells display abnormalities in the signal transduction pathways responsible for responding to extracellular growth factors,or *** that alter proteins involved in these types of pathways can lead to inappropriate or unregulated cell growth,and therefore predispose the cell to become *** critical role of the Ras/mitogen-activated protein kinase(MAPK)pathway in transducing growth signals to the interior of the cell and subsequently stimulating cell growth and proliferation is underscored by the fact that roughly one quarter of all human tumors contain mutant forms of Ras proteins.A particular focus on the signaling and membrane trafficking adaptor protein known as Ras interference 1(RIn1)will reveal how this protein can potentially play a significant role in the development of the cancerous phenotype in certain cell *** equal interest is the possible connection between the Ras/MAPK pathway,and subsequent expression and enzymatic activity of telomerase–a key enzyme known to be overexpressed in roughly 85%of all ***1 is a 783 amino acid(84 kDa)cytosolic protein that is involved in key steps of growth factor receptormediated endocytosis and can potentially moderate signaling through the MAPK ***1,with its unique ability to compete directly with Raf for activation by Ras,could potentially influence signaling through more than one of the MAPK *** so,RIn1 may then be able to exert a precise and selective effect on the downstream signal(s)of a MAPK target such as telomerase.

关键词： cancer Regulation Pathway Telomere

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phytochemical and anti-bacterial activity of epidermal glands extract of christella parasitica (L.) H. Lev.

引用

Asian Pacific Journal of Tropical Biomedicine 2011年第1期1卷 8-11页

作者： Paul Raj K Irudayaraj V Johnson M patric Raja D Dartment of Plant Biology and Plant Biotechnology St.Xavier's College(Autonomous)

Objective:To study the morphology,biochemistry and bioactivity of the epidermal glands of the glandular morphotype of christella parasitica(***)(L.) ***: Morphological studies on epidermal glands were earned out by using light microscope and scanning electron *** prepare the extract,the shade-dried fronds of glandular morphotype were soaked in *** antibacterial studies paper disc method was followed by using various pathogenic ***:Detailed micromorphological,phytochemical and bioactivity studies on a medicinal fern ***(L.) *** its inlraspecific variation in antibacterial *** presence or absence of the epidermal glands was the key factor for antibacterial activity in the morphovariants of this *** epidermal glands were orange-coloured,stalked and elongated ones of about 84.2μm×45μm,and distributed on the undersurface of cosla,coslules and veins in croziers,young and mature *** of glands varied from 15/cm on costa in mature leaves to 140/cm on costules in *** acetone extract of the glands showed antibacterial activities and also toxic effect against mosquito larvae and tadpoles of *** phytochemical analysis and HPLc studies of the gland extract showed the presence of various kinds of terpenoids,alkaloids,tannins,saponins and flavonoids in ***:The present study shows that epidermal glands of the glandular morphotype of c. parasitica(L.) *** several bioactive compounds and such rare moiphovariant should be conserved in *** next step is to isolate the pure compounds and to screen the bioactivity of individual compounds of the epidermal glands.

关键词： Epidermal glands christella parasitica Bioactivity Phytochemical activity Anti-bacterial activity Morphology Biochemistry Glandular morphotype Light microscope Shade-dried frond Bioactive compound Morphovariant Preliminary phytochemical analysis Gland extract Flavonoid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Small bowel volvulus as a complication of von Recklinghausen's disease:A case report

引用

World Journal of Gastroenterology 2014年第24期20卷 7979-7983页

作者： Thomas Artur Werner Feride Krpil Martin Olaf Schoppe patric Krpil Wolfram Trudo Knoefel Andreas Krieg Department of Surgery (A) HeinrichHeine-University and University Hospital Duesseldorf40225 DuesseldorfGermany Institute of Pathology Heinrich-Heine-University and University Hospital Duesseldorf40225 DuesseldorfGermany Institute of Diagnostic and Interventional Radiology Heinrich-Heine-University and University Hospital Duesseldorf40225 DuesseldorfGermany

We report the case of a 25-year-old male with neurofibromatosis type I (nF-1), who presented at the time of admission with clinical findings of an acute abdomen caused by a mechanical obstruction. computerized tomography showed a volvulus of the terminal ileum with mesenteric swirling as the cause of the patient’s symptoms. consecutive exploratory laparotomy confirmed the diagnosis and 70 cm of the small intestine was resected due to an affection of the mesentery by multiple neurofibromas. The gastrointestinal tract is affected in approximately 10% of patients with nF-1, however the mesentery is almost always spared. Here we describe the unique case of a patient with a volvulus caused by mesenteric manifestation of von Recklinghausen’s disease, emphasizing the role of surgery in a team of multidisciplinary specialists to treat this multiorganic disease.

关键词： Volvulus Obstruction Von Recklinghausen´ s disease neurofibromatosis type I Mesenteric neurofibromas

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Twiddler’s Syndrome in a Patient with Dystonic Tremor Treated with DBS

引用

Open Journal of Modern neurosurgery 2014年第4期4卷 193-195页

作者： Jennifer Samuelsson patric Blomstedt Department of neurosurgery Umea University Hospital Umea Sweden Department of neurosurgery Umea University Umea Sweden

Background and Importance: Twiddler’s syndrome is a rare complication of DBS. This condition occurs when the IPG is consciously or inadvertently rotated in its pocket, resulting in torsion and possible dislodgement of implanted electrodes, with subsequent loss of function. Methods: Here we present a patient diagnosed with Twiddler’s syndrome. The patient presented with straining cables at the neck five months after bilateral Gpi DBS and an x-ray demonstrated Twiddler’s syndrome. Initial revision with preventive measures proved futile. After some time the condition recurred, now with dislocation of one of the intracerebral electrodes. In a second revision the IPG was placed under the pectoralis muscle, which has so far prevented further rotation. Results and conclusion: While Twiddler’s syndrome is fairly uncommon, it remains to be a risk associated with DBS, recognizing the potential risks and signs might allow for preventive measures avoiding dislocation of the intracerebral electrodes.

关键词： Twiddler’s Syndrome IPG DBS complications

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acute effects of partial-body vibration in sitting position

引用

World Journal of Orthopedics 2018年第9期9卷 156-164页

作者： Yannik Faes nora Banz nathalie Buscher Angela Blasimann Lorenz Radlinger patric Eichelberger Achim Elfering Department of Work and Organizational Psychology University of Bern Department of Health Professions Bern University of Applied Sciences

AIM To investigate the acute effects of sinusoidal and stochastic resonance partial-body vibration in sitting position, including muscle activity, heart rate variability, balance and *** Fifty healthy participants were assigned randomly to two training conditions: A sinusoidal partial-body vibration(SIn, 8 Hz) or a stochastic resonance partial-body vibration(STOcH, 8 ± 2 Hz). For baseline assessment participants sat on the vibration platform without vibration. Both training conditions consisted of five series of a one-minute vibration training and a one-minutebreak between them. In this experimental study surface electromyography(EMG) of the erector spinae(ES), one of the back muscles, and heart rate variability(HRV) was measured at baseline and during training. Balance and flexibility were assessed at baseline and immediately after training. Balance was measured with the modified star excursion balance test(mS EBT) and flexibility was assessed through the modified fingertip-to-floor method(mF TF).RESULTS Paired sample t-test showed a significant increase in balance that was restricted to STOcH(t =-2.22, P = 0.018; SIn: t =-0.09, P = 0.466). An increase in flexibility was also restricted to STOcH(t = 2.65, P = 0.007; SIn: t = 1.41, P = 0.086). There was no significant change of muscle activity in the ES-EMG in STOcH or SIn conditions. In both training conditions, HRV decreased significantly, but remained in a low-load range(STOcH: t = 2.89, P = 0.004; SIn: t = 2.55, P = 0.009).cOncLUSIOn In sitting position, stochastic resonance partial-body vibration can improve balance and flexibility while cardiovascular load is low. STOcH can be a valuable training option to people who are unable to stand(e.g., people, who are temporarily wheelchair-bound).

关键词： Partial-body vibration Balance Flexibility Sinusoidal Stochastic resonance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

经皮加压钢板内固定治疗股骨转子间骨折初步报告

引用

中国矫形外科杂志 2007年第4期15卷 296-298页

作者：凌尚准 Hockman patric 百色市人民医院骨科广西百色市533000 比利时-尼日尔医疗技术合作中心

[目的]探讨应用微创手术治疗股骨转子间骨折的方法和疗效，及就手术的侵袭性、手术时间、受辐射的时间、失血量等指标进行评估和比较。[方法]自2003年以来，应用经皮加压钢板（percutaneous compressionplating，PccP），在c型臂X线机... 详细信息

[目的]探讨应用微创手术治疗股骨转子间骨折的方法和疗效，及就手术的侵袭性、手术时间、受辐射的时间、失血量等指标进行评估和比较。[方法]自2003年以来，应用经皮加压钢板（percutaneous compressionplating，PccP），在c型臂X线机监视下，经皮小切口置入加压钢板行内固定治疗股骨转子间骨折19例，选择稳定性骨折或者轻度移位而容易复位的骨折为适应证。其中女11例，男8例，年龄54—85岁，平均68岁。随访6—28个月，平均16．8个月。[结果]手术时间30-55min，平均45min；应用c型臂X线机时间45—85s，平均58s；术中失血40-120ml，平均80ml。所有病例X线片骨折愈合时间为3个月。[结论]应用PccP钢板经皮内固定手术治疗股骨转子间骨折，比照传统的DHS、Gamma钉和PFn具有手术创伤小，操作简单，手术时间短，出血少，减少术中X线片的曝光时间等特点，疗效满意，并发症少。

关键词：股骨骨折加压钢板骨折固定术经皮

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Target-oriented robust optimization of a microgrid system investment model

引用

Frontiers in Energy 2018年第3期12卷 440-455页

作者： Lanz UY patric UY Jhoenson SIY Anthony Shun Fung cHIU charlle SY Department of Industrial Engineering De La Salle University Manila1004 the Philippines

An emerging alternative solution to address energy shortage is the construction of a microgrid system. This paper develops a mixed-integer linear programming microgrid investment model considering multi-period and multi-objective investment setups. It further investigates the effects of uncertain demand by using a target-oriented robust optimization （TORO） approach. The model was validated and analyzed by subjecting it in different scenarios. As a result, it is seen that there are four factors that affect the decision of the model： cost, budget, carbon emissions, and useful life. Since the objective of the model is to maximize the net present value （nPV） of the system, the model would choose to prioritize the least cost among the different distribution energy resources （DER）. The effects of load uncertainty was observed through the use of Monte carlo simulation. As a result, the deterministic model shows a solution that might be too optimistic and might not be achievable in real life situations. Through the application of TORO, a profile of solutions is generated to serve as a guide to the investors in their decisions considering uncertain demand. The results show that pessimistic investors would have lower nPV targets since they would invest more in storage facilities, incurring more electricity stock out costs. On the contrary, an optimistic investor would tend to be aggressive in buying electricity generating equipment to meet most of the demand, however risking more storage stock out costs.

关键词： microgrid renewable resources robust optimization target-oriented robust optimization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

酸性矿山废水污染的水稻田土壤中重金属的微生物学效应

引用

生态学报 2004年第11期24卷 2430-2436页

作者：李永涛 Thierry Becquer cécile Quantin Marc Benedetti patric kLavelle 戴军华南农业大学资源环境学院广州510642 法国发展与合作研究院热带土壤生态及生物多样性研究室南巴黎大学地学部皮埃尔玛丽居里大学地球化学与金属实验室

采样调查了广东大宝山地区受酸性采矿废水长期污染的亚热带水稻田的土壤理化性质 ,重金属 cu、Pb、Zn、cd的全量及其 DTPA浸提量 ,以及微生物生物量及其呼吸活性等指标。利用主成分和逐步回归分析了影响土壤重金属的有效性及其微生物学... 详细信息

采样调查了广东大宝山地区受酸性采矿废水长期污染的亚热带水稻田的土壤理化性质 ,重金属 cu、Pb、Zn、cd的全量及其 DTPA浸提量 ,以及微生物生物量及其呼吸活性等指标。利用主成分和逐步回归分析了影响土壤重金属的有效性及其微生物学效应的因素。结果表明 :土壤高含硫 ,强酸性 ,有机碳、全氮较低 ,4种金属的全量普遍超标。DTPA可提取态金属含量较高 ,不仅与其全量呈显著正相关 ,而且与土壤酸度和粘粒含量正相关 ,和 Mn含量负相关。过量的金属显著降低了土壤微生物生物量 c、n、微生物商、生物量 n/全 n比 ,并抑制了微生物呼吸强度和对有机碳的矿化率 ,导致了土壤 c/n比的升高。同时 ,金属对微生物群落及生理代谢指标 ,如微生物生物量 c/n比和代谢商的影响不显著。 DTPA可提取态金属 ,特别是 DTPA- cu是导致微生物生物量和活性指标变化的主要因素。以有机碳 (或全氮 )为基数的复合微生物指标降低了土壤性质差异造成的干扰 ,较单一指标更能准确指示微生物对金属胁迫的反应。土壤硫没有对金属有效性和微生物指标产生明显影响。

关键词：重金属污染水稻土微生物有机碳矿化广东大宝山

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Estimation of Treatment Benefit in Patients with cerebral Arteriovenous Malformations

引用

Open Journal of Modern neurosurgery 2012年第3期2卷 29-35页

作者： Peter Lindvall patric Blomstedt A.Tommy Bergenheim Department of neurosurgery Umea University HospitalUmeaSweden

Background: cerebral arteriovenous malformations (AVMs) are vascular lesions that may be associated with a significant morbidity and mortality. There is still today no consensus regarding treatment of unruptured AVMs. Using known data from the literature, and data from our own institution concerning stereotactic radiotherapy, our aim was to construct an equation that may be used to evaluate the benefit of intervention vs. conservative treatment in unruptured AVMs. Methods: Assuming an annual bleeding risk of 4% and previously reported mortality (29%) and morbidity (16%) rates after a bleeding from an AVM, an equation was constructed. This equation would estimate the time until the combined mortality and morbidity associated with conservative treatment would equal the mortality and morbidity of stereotactic radiotherapy. Results: Using stereotactic radiotherapy this treatment would benefit over conservative treatment in excess of 8.12 years. The risk of bleeding was the most important factor influencing the benefit of intervention vs. conservative treatment. conclusions: We argue that that it may be possible to estimate the benefit of intervention vs. conservative treatment in an unruptured AVM. This may be achieved using our proposed equation and data specific to each center performing treatment for AVMs.

关键词： Arteriovenous Malformation cerebrovascular Disease Strokes Treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

characterisation of Real-World Bus Acceleration and Deceleration Signals

引用

Journal of Signal and Information Processing 2014年第1期5卷 8-13页

作者： Marietta Kirchner patric Schubert christian T. Haas Faculty of Health and Social Sciences Institute of Complex Health Research Fresenius University of Applied Sciences Idstein Germany

Public transportation by bus is an essential part of mobility. Braking and starting, e.g., approaching a bus stop, are documented as the main reason for non-collision incidents. These situations are evoked by the acceleration forces leading to perturbations of the passenger’s base of support. In laboratory studies perturbations are applied to getting insight into the postural control system and neuromuscular responses. However, bus perturbations diverge from laboratory ones with respect to duration, maximum and shape, and it was shown recently that these characteristics influence the postural response. Thus, results from posturographic studies cannot be generalised and transferred to bus perturbations. In this study, acceleration (Acc) and deceleration (DEc) signals of real traffic situations were examined. A mathematical approach is proposed in order to identify characteristics of these signals and to quantify their similarity and complexity. Typical characteristics (duration, maximum, and shape) of real-world driving manoeuvres concerning start and stop situations could be identified. A mean duration of 13.6 s for Acc and 9.8 s for DEc signals was found which is clearly longer than laboratory perturbations. Acc and DEc signals are more complex than the used signals for platform displacements in the laboratory. The proposed method enables the reconstruction of bus Acc and DEc signals. The data can be used as input for studies on postural control with high ecological validity.

关键词： Bus Acceleration Signal complexity Index Similarity Legendre Polynomials Postural control Perturbation Ecological Validity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：