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Journal of clinical and Translational Hepatology 2023年第5期11卷 1282-1285页

作者： Artemiy Kovynev Zhixiong Ying Joost M.Lambooij Hendrik J.P.van der Zande Bruno Guigas patric. c.n.rensen Milena Schönke Division of Endocrinology Department of MedicineLeiden University Medical CenterLeidenThe Netherlands Einthoven Laboratory for Experimental Vascular Medic.n. Leiden University Medical CenterLeidenThe Netherlands Department of Parasitology Leiden University Medical CenterLeidenThe Netherlands Department of cell and chemical Biology Leiden University Medical CenterLeidenThe Netherlands

Over 2 billion people worldwide are estimated to have nonalcoholic fatty liver disease(nAFLD),defined by excess hepatic ***,progression into nonalcoholic steatohepatitis(nASH)is characterized by the onset of liver inflammation following exacerbated steatosis.1 This suggests that reduc.n. liver inflammation(*** lifestyle interventions involving exercise training)may come sec.n.ary to a reduction of ***,both the metabolic and inflammatory processes involved in nAFLD are under circadian c.n.rol and could respond differently to exercise at different times of day.2 To investigate the time-of-day–dependent effect of exercise training on nAFLD amelioration in the early disease stages we trained high-fat high-cholesterol(HFHc)-fed APOE*3-Leiden cholesteryl ester transfer protein(cETP)mice during their early or late active *** mouse model was chosen because of its humanized lipid metabolism and its ability to develop all hallmarks of human nAFLD upon HFHc feeding.

关键词： metabolism inflammation cholesterol

cETP as a Target in HDL-raising Therapy:lessons from APOE*3-Leiden. cETP Transgenic Mice

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中国动脉硬化杂志 2009年第7期17卷 574-575页

作者： Willeke de Haan Jitske de Vries-van der Weij caroline c. van der Hoogt José W.A. van der Hoorn Johannes A. Romijn J. Wouter Jukema Louis M. Havekes Hans M.G. Princ.n.patric. c.n. rensen Departments of General Internal Medic.n. Endocrinologyand Metabolic Diseases Departments of Human Genetics TnO-Biosciences Gaubius Laboratory Departments of cardiology Leiden University Medical Center

Background cardiovascular disease (cVD) is mainly caused by atherosclerosis,for which dyslipidemia (i.e. high (V)LDL-cholesterol (c),high triglycerides and low HDLc is a major risk factor. To reduce the risk to develo... 详细信息

关键词：心血管疾病动脉粥样硬化血脂胆固醇临床分析

Oximes： Unrecognized chameleons in Genera and Specialized Plant Metabolism

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Molecular Plant 2018年第1期11卷 95-117页

作者： Mette S rensen Elizabeth H.J. neilson Birger Lindberg Moiler Plant Biochemistry Laboratory Department of Plant and Environmental Sciences University of Copenhagen Thorvaldsensvej 40 Frederiksberg C Copenhagen Denmark VILLUM c.n.er for Plant Plasticity University of Copenhagen Thorvaldsensvej 40 Frederiksberg C Copenhagen Denmark c.n.er for Synthetic Biology University of Copenhagen Thorvaldsensvej 40 Frederiksberg C Copenhagen Denmark

Oximes （R1R2c.n.H） are nitrogen-c.n.aining chemical c.n.tituents that are formed in species representing all kingdoms of life. In plants, oximes are positioned at important metabolic bifurcation points between general and specialized metabolism. The majority of plant oximes are amino acid-derived metabolites formed by the action of a cytochrome P450 from the cYP79 family. Auxin, cyanogenic glucosides, glucosinolates, and a number of other bioactive specialized metabolites including volatiles are produced from oximes. Oximes with the E c.n.iguration have high biological activity compared with Z-oximes. Oximes or their derivatives have been demonstrated or proposed to play roles in growth regulation, plant defense, pollinator attraction, and plant communication with the surrounding environment. In addition, oxime-derived products may serve as quenchers of reactive oxygen species and storage compounds for reduced nitrogen that may be released on demand by the activation of endogenous turnover pathways. As highly bioactive molecules, chemically synthesized oximes have found versatile uses in many sectors of society, especially in the agro- and medical sectors. This review provides an update on the structural diversity, occurrence, and biosynthesis of oximes in plants and discusses their role as key players in plant general and specialized metabolism.

关键词： structural diversity cYP79 auxin cyanogenic glucosides volatile organic compounds E-oxime Z-oxime

酸性矿山废水污染的水稻田土壤中重金属的微生物学效应

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生态学报 2004年第11期24卷 2430-2436页

作者：李永涛 Thierry Becquer cécile Quantin Marc Benedetti patric.kLavelle 戴军华南农业大学资源环境学院广州510642 法国发展与合作研究院热带土壤生态及生物多样性研究室南巴黎大学地学部皮埃尔玛丽居里大学地球化学与金属实验室

采样调查了广东大宝山地区受酸性采矿废水长期污染的亚热带水稻田的土壤理化性质 ,重金属 cu、Pb、Zn、cd的全量及其 DTPA浸提量 ,以及微生物生物量及其呼吸活性等指标。利用主成分和逐步回归分析了影响土壤重金属的有效性及其微生物学... 详细信息

采样调查了广东大宝山地区受酸性采矿废水长期污染的亚热带水稻田的土壤理化性质 ,重金属 cu、Pb、Zn、cd的全量及其 DTPA浸提量 ,以及微生物生物量及其呼吸活性等指标。利用主成分和逐步回归分析了影响土壤重金属的有效性及其微生物学效应的因素。结果表明 :土壤高含硫 ,强酸性 ,有机碳、全氮较低 ,4种金属的全量普遍超标。DTPA可提取态金属含量较高 ,不仅与其全量呈显著正相关 ,而且与土壤酸度和粘粒含量正相关 ,和 Mn含量负相关。过量的金属显著降低了土壤微生物生物量 c.n.微生物商、生物量 n/全 n比 ,并抑制了微生物呼吸强度和对有机碳的矿化率 ,导致了土壤 c.n.的升高。同时 ,金属对微生物群落及生理代谢指标 ,如微生物生物量 c.n.和代谢商的影响不显著。 DTPA可提取态金属 ,特别是 DTPA- cu是导致微生物生物量和活性指标变化的主要因素。以有机碳 (或全氮 )为基数的复合微生物指标降低了土壤性质差异造成的干扰 ,较单一指标更能准确指示微生物对金属胁迫的反应。土壤硫没有对金属有效性和微生物指标产生明显影响。

关键词：重金属污染水稻土微生物有机碳矿化广东大宝山

Fitness components of Drosophila melanogaster developed on a standard laboratory diet or a typical natural food source

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Insect Science 2016年第5期23卷 771-779页

作者： Torsten nygaard Kristensen Astrid Kallestrup Henningsen christian Aastrup Mads Bech-Hansen Lise B. Hoberg Bjerre Benjamin carlsen Marie Hagstrup Sofie Graarup Jensen Pernille Karlsen Line Kristensen cecillie Lundsgaard Tine MФller Lise D. nielsen camilla Starcke christine Riisager SФrensen Mads Fristrup Schou Department of chemistry and Bioscience Section of Biology and Environmental Science Aalborg University Aalborg East DK-9220 Denmark Department of Bioscience Aarhus University Aarhus C DK-8000 Denmark

Drosophila melanogaster is often used as a model organism in evolution- ary biology and ecophysiology to study evolutionary processes and their physiological mechanisms. Diets used to feed Drosophila cultures differ between laboratories and are often nutritious and distinct from food sources in the natural habitat, Here we rear D. melanogaster on a standard diet used in our laboratory and a field diet composed of decomposing apples collected in the field. Flies developed on these two diet compositions are tested for heat, cold, desiccation, and starvation resistance as well as developmental time, dry body mass and fat perc.n.age. The nutritional compositions of the standard and field diets were analyzed, and discussed in relation to the phenotypic observations. Results showed marked differences in phenotype of flies from the two types of diets. Flies reared on the field diet are more starvation resistant and they are smaller, leaner, and have lower heat resistance compared to flies reared on the standard diet. Sex specific effects of diet type are observed for several of the investigated traits and the strong sexual dimorphism usually observed in desiccation resistance in D. melanogaster disappeared when rearing the flies on the field diet. Based on our results we c.n.lude that care should be taken in extrapolating results from one type of diet to another and especially from laboratory to field diets.

关键词： diet field fitness life-history traits nutrition stress resistance

泌乳期和干奶期奶牛乳腺细胞更新的细胞调节机制

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饲料与畜牧（新饲料） 2009年第8期 26-31页

作者： J V n rgaard P K Theil M T S rensen K Sejrsen 李雁(译) 黄彪(译) 不详南京农业大学动物科技学院

目前关于奶牛妊娠-泌乳周期乳腺细胞更新的相关调节机制还不清除,只是已知一些蛋白质与乳腺细胞增殖、凋亡、分化、细胞存活和组织重塑等调节通路有关,而此试验的目的即研究编码这些蛋白质的基因的表达情况。选择10头奶牛,在其妊娠-泌... 详细信息

目前关于奶牛妊娠-泌乳周期乳腺细胞更新的相关调节机制还不清除,只是已知一些蛋白质与乳腺细胞增殖、凋亡、分化、细胞存活和组织重塑等调节通路有关,而此试验的目的即研究编码这些蛋白质的基因的表达情况。选择10头奶牛,在其妊娠-泌乳周期进行了7次乳腺活组织检查,所取样品分别进行免疫组织化学和实时PcR分析,结果表明干奶期细胞增殖程度最高,而凋亡只是在干奶初期和泌乳初期较高;根据Fas、Fas配体、半胱天冬酶3、8和9的基因表达情况,没有发现外在和内在凋亡通路之间存在依赖性转移;干奶期和泌乳初期mGST的基因表达没有显著变化,然而Bcl2和Bax的表达量最大,且此时细胞更新的程度也较高;早期应答基因c-Fos、c-Jun和c-Myc的表达与细胞增殖率、IGF-I和胰岛素的血浆浓度无关;nFκB和nFκB抑制因子α的基因表达在围产期达到最大,且nFκB的基因表达与细胞存活因子的预期需要同步;TGF-β受体1和2mRnA的表达在泌乳初期最大,然而TGF-β1在妊娠-泌乳周期没有显著变化,虽然我们的结果与其他研究不一致,但是TGF-β受体的基因表达模式在泌乳初期具有调节凋亡的作用;STAT5在围产期表达较高,这表明其可调节乳腺细胞的增殖和分化,组织纤维蛋白溶酶原激活剂、纤维蛋白酶原激活抑制剂-1和胰岛素样生长因子结合蛋白5基因的表达在泌乳初期最高,表明胰岛素样生长因子结合蛋白5对组织重塑和细胞凋亡具有协调调节的作用。

关键词：乳腺细胞更新增殖凋亡奶牛

神农香菊自然居群遗传变异评价研究及核心种质筛选

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世界科学技术-中医药现代化 2022年第4期24卷 1325-1334页

作者：袁仁森王旭张景景森林董刚强刘义飞湖北中医药大学药学院武汉430065 安利(中国)植物研发中心无锡214115

目的本文对神农香菊(chrysanthemum indicum var. aromaticum)自然居群的遗传多样性、遗传结构及特征代谢产物开展研究,并以此为依据筛选核心种质,为神农香菊的资源保护和应用提供理论依据。方法利用21对分别来源于基因组和转录组数... 详细信息

目的本文对神农香菊(chrysanthemum indicum var. aromaticum)自然居群的遗传多样性、遗传结构及特征代谢产物开展研究,并以此为依据筛选核心种质,为神农香菊的资源保护和应用提供理论依据。方法利用21对分别来源于基因组和转录组数据的简单重复序列引物(SSR)对我国神农架林区的151份神农香菊样本、41份疑似野菊样本和武汉市洪山区11份野菊对照样本进行居群遗传多样性和遗传结构分析。基于遗传信息,采用高效液相色谱技术(HPLc)对不同遗传分组的代表性纯合样本开展9种代谢物的差异分析,利用最小距离逐步取样策略(LDSS)筛选神农香菊的核心种质。结果 21对引物在所有研究样本中共扩增出202个等位基因,每个位点平均等位基因数为9.619个。神农架5个居群的平均有效基因数(ne)为2.518,香农多样性指数(I)为1.004,多态性信息含量(PIc)为0.526,杂合度(H)为0.246。居群间具有较低的遗传分化(F_(st)n_(m)>1)。遗传结构分析显示,神农架的所有样品可分为三个遗传组。异绿原酸c、蒙花苷、木犀草苷等物质在三个组的样本间有明显的含量差异。基于遗传信息,最终筛选出了来自神农架3个地方居群的45份核心种质。结论本研究展示了神农香菊自然居群整体存在的中高水平的遗传多样性,同时神农香菊样本与邻(混)生的疑似野菊样本具有清晰的形态差异,但两者间可能存在基因流或遗传混杂。这些信息为研究神农香菊的起源进化和对其资源的开发应用提供了理论和数据支撑。

关键词：神农香菊简单重复序列群体遗传代谢产物多样性核心种质

Vascular plants distribution in relation to topography and environmental variables in alpine zone of Kedarnath Wild Life Sanctuary,West Himalaya

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Journal of Mountain Science 2018年第9期15卷 1936-1949页

作者： cHAnDRA Sudeep SInGH Ankit SInGH c.P. nAUTIYAL M.c. RAWAT L.S. High Altitude Plant Physiology Research c.n.re(HAPPRc)H.n.B.Garhwal University Srinagar Garhwal-246174UttarakhandIndia Space Applications c.n.re (Indian Space Research Organization)Ahmedabad 380015India Govind Ballabh Pant national Institute of Himalayan Environment&Sustainable Development Garhwal Unit Srinagar Garhwal-246174UttarakhandIndia

The present study was carried out in Tungnath alpine meadows of Kedarnath Wild Life Sanctuary, Western Himalaya from subalpine to upper alpine zone. A total of four summits were selected along an altitudinal gradient and sampled for detailed vegetation analysis using multi summit approach as per Global observation research initiative in alpine environments(GLORIA). Species ric.n.ss, diversity, and evenness among four summits as well as the interaction between environmental variables with plant communities were assessed. Monthly mean soil temperature was calculated using data retrieved from geo-precision temperature logger in order to identify the trend of soil temperature among different season and altitudinal gradient and its implications to plant communities. Soil samples were analyzed fromeach summit by collecting randomized composite soil samples. The indirect non-metric multidimensional scaling(nMDS) and direct c.n.nical correspondence analysis(ccA) tools of ordination tec.n.ques to determine the linkage between plant species from various sample summits and biotic/abiotic environmental gradients were used in the present study. The results of the study demonstrated increase in species ric.n.ss as soil temperature increases, the ecotone representing summits were found most warm summits followed by highest species ric.n.ss. Annual soil temperature increased by 1.43°c at timberline ecotone. Whereas, at upper alpine zone the soil temperature increased by 0.810 c from year 2015 to 2016. S?rensen's similarity index was found to be increased between subalpine and upper alpine zone with increase in the presence of subalpine plant species at upper alpine zone. Both the ordination tools separate the subalpine summit and their respective vegetation from summits representingtimberline ecotone and upper alpine zone. Soil p H, altitude, soil cation exchange capacity were found as the key abiotic drivers for distribution of plant species.

关键词：亚高山带植物种类环境变量生活分发西方地形学土壤温度

PET测定肝硬化急性肝性脑病期间的^(13)n-氨在脑组织中的代谢状况

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世界核心医学期刊文摘（胃肠病学分册） 2006年第10期2卷 46-47页

作者： Keiding S. Sφrensen M. Bender D. 陈云茹 Department of Medic.n. V Aarhus University HospitalNoerrebrogade8000 Aarhus CDenmark.Dr

Animal studies and results from 13n-ammonia positron emission tomography (PET) in patients with cirrhosis and minimal hepatic encephalopathy suggest that a disturbed brain ammonia metabolism plays a pivotal role in the pathogenesis of hepatic encephalopathy (HE). We studied brain ammonia kinetics in 8 patients with cirrhosis with an acute episode of clinically overt HE (I-IV), 7 patients with cirrhosis without HE, and 5 healthy subjects, using c.n.emporary dynamic 13n-ammonia PET. Time courses were obtained of 13n-c.n.entrations in cerebral cortex, basal ganglia, and cerebellum (PET-sc.n.) as well as arterial 13n-ammonia, 13n-urea, and 13n-glutamine c.n.entrations (blood samples) after 13n-ammonia injection. Regional 13n-ammonia kinetics was calculated by non-linear fitting of a physiological model of brain ammonia metabolism to the data. Mean permeability-surface area product of 13n-ammonia transfer across blood-brain barrier in cortex, PSBBB was 0.21 mL blood/min/mL tissue in patients with HE, 0.31 in patients without HE, and 0.34 in healthy c.n.rols; similar differences were seen in basal ganglia and cerebellum. Metabolic trapping of blood 13n-ammonia in the brain showed neither regional, nor patient group differences. Mean net metabolic flux of ammonia from blood into intracellular glutamine in the cortex was 13.4 μmol/min/L tissue in patients with cirrhosis with HE, 7.4 in patients without HE, and 2.6 in healthy c.n.rols, signific.n.ly correlated to blood ammonia. In c.n.lusion, increased cerebral trapping of ammonia in patients with cirrhosis with acute HE was primarily attributable to increased blood ammonia and to a minor extent to changed ammonia kinetics in the brain.

关键词： PET 代谢状况肝性脑病血氨浓度基底神经节大脑皮质血标本断层摄影正子动物实验

Interaction of Diet/Lifestyle Intervention and TcF7L2 Genotype on Glycemic c.n.rol and Adiposity among Overweight or Obese Adults:Big Data from Seven Randomized c.n.rolled Trials Worldwide

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Health Data Science 2021年第1期2021卷 174-183页

作者： Tao Huang Zhenhuang Zhuang Yoriko Heianza Dianjianyi Sun Wenjie Ma Wenxiu Wang Meng Gao Zhe Fang Emilio Ros Liana c.Del Gobbo Jordi Salas-Salvadó Miguel A.Martínez-González Jan Polak Markku Laakso Arne Astrup Dominique Langin Jorg Hager Gabby Hul Torben Hansen Oluf Pedersen Jean-Michel Oppert Wim H.M.Saris Peter Arner Montserrat cofán Sujatha Rajaram Jaakko Tuomilehto Jaana Lindström Vanessa D.de Mello Alena Stancacova Matti Uusitupa Mathilde Svendstrup Thorkild I.A.Sørensen christopher D.Gardner Joan Sabaté Dolores corella J.Alfredo Martinez Lu Qi Department of Epidemiology&Biostatistics School of Public HealthPeking UniversityChina Department of Global Health School of Public HealthPeking UniversityChina Key Laboratory of Molecular cardiovascular Sciences Ministry of Education China Global Health Institute Peking University China Department of Epidemiology School of Public Health and Tropical MedicineTulane UniversityNew OrleansLAUSA Department of nutrition Harvard T.H.Chan School of Public HealthBostonMAUSA Department of Endocrinology&nutrition Institut d’Investigacions Biomèdiques August Pi SunyerHospital ClínicBarcelonaSpain cIBER Fisiopatologia de la Obesidad y nutrición(cIBERobn) Instituto de Salud Carlos III(ISCIII)MadridSpain Stanford Prevention Research c.n.er Stanford UniversityStanford CAUSA Human nutrition Unit Faculty of Medicine and Health SciencesPere Virgili Health Research InstituteRovira i Virgili UniversityReusSpain University of navarra Department of Preventive Medicine and Public HealthMedical School&IDISNAPamplonaSpain Department for the Study of Obesity and Diabetes Third Faculty of MedicineCharles UniversityPragueCzech Republic Department of Medic.n. University of Eastern FinlandKuopioFinland University of copenhagen Department of NutritionExercise and SportsFaculty of ScienceCopenhagenDenmark Institut national de la Santéet de la Recherche Médicale(Inserm) UMR1048Institute of Metabolic and Cardiovascular DiseasesUniversity of Toulouse and Paul Sabatier UniversityToulouseFrance nestléInstitute of Health Sciences LausanneSwitzerland Department of Human Biology NUTRIM School of Nutrition and Translational Research in MetabolismMaastricht University Medical Centre+MaastrichtNetherlands Section of Metabolic Genetics Novo Nordisk Foundation Center for Basic Metabolic ResearchFaculty of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark Sorbonne Université Institute of Cardiometabolism and Nutrition(ICAN)Department of NutritionPitié-Salpêtrière HospitalAssistance Publique-

*** strongest locus which associated with type 2 diabetes(T2D)by the common variant rs7903146 is the transcription factor 7-like 2 gene(TcF7L2).We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of TcF7L2 rs7903146 on glycemic traits,body weight,or waist circumference in overweight or obese adults in several randomized c.n.rolled trials(RcTs).*** October 2016 to May 2018,a large collaborative analysis was performed by pooling individualparticipant data from 7 *** RcTs reported changes in glycemic c.n.rol and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese *** treatment interaction models which used the genetic effect encoded by the allele dose and common covariates were applicable to individual participant data in all *** the joint analysis,a total of 7 eligible RcTs were included(n=4,114).Importantly,we observed a signific.n. effect modification of diet/lifestyle-related interventions on the TcF7L2 variant rs7903146 and changes in fasting *** with the c.n.rol group,diet/lifestyle interventions were related to lower fasting glucose by-3.06(95%cI,-5.77 to-0.36)mg/dL(test for heterogeneity and overall effect:I^(2)=45:1%,pne copy of the TcF7L2 T risk ***,regardless of genetic risk,diet/lifestyle interventions were associated with lower waist ***,there was no signific.n. change for diet/lifestyle interventions in other glycemic c.n.rol and adiposity traits per one copy of TcF7L2 risk *** findings suggest that carrying the TcF7L2 T risk allele may have a modestly greater benefit for specific diet/lifestyle interventions to improve the c.n.rol of fasting glucose in overweight or obese adults.

关键词： TcF7L2 weight finding