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A hypothesis for a novel role of RIN1-the modulation of telomerasefunction by the MAPK signaling pathway

BIOCELL 2020年第4期44卷 525-534页

作者： patric.HAMBLETON MANUEL ALEJANDRO BARBIERI Department of Biological Sciences Florida International UniversityMiami33199USA Biomedical Science Institute Florida International UniversityMiami33199USA Fairchild Tropical Botanic Garden Miami33156USA International Center of Tropical Botany Florida International UniversityMiamiFL33199USA

Cancerous cells display abnormalities in the signal transduction pathways responsible for responding to extracellular growth factors,or *** that alter proteins involved in these types of pathways can lead to inappropriate or unregulated cell growth,and therefore predispose the cell to become *** critical role of the Ras/mitogen-activated protein kinase(MAPK)pathway in transducing growth signals to the interior of the cell and subsequently stimulating cell growth and proliferation is underscored by the fact that roughly one quarter of all human tumors contain mutant forms of Ras proteins.A particular focus on the signaling and membrane trafficking adaptor protein known as Ras interference 1(RIN1)will reveal how this protein can potentially play a significant role in the development of the cancerous phenotype in certain cell *** equal interest is the possible connection between the Ras/MAPK pathway,and subsequent expression and enzymatic activity of telomerase–a key enzyme known to be overexpressed in roughly 85%of all ***1 is a 783 amino acid(84 kDa)cytosolic protein that is involved in key steps of growth factor receptormediated endocytosis and can potentially moderate signaling through the MAPK ***1,with its unique ability to compete directly with Raf for activation by Ras,could potentially influence signaling through more than one of the MAPK *** so,RIN1 may then be able to exert a precise and selective effect on the downstream signal(s)of a MAPK target such as telomerase.

关键词： Cancer Regulation Pathway Telomere

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High-performance imidazole-containing polymers for applications in high temperature polymer electrolyte membrane fuel cells

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Journal of Energy Chemistry 2024年第11期98卷 512-523页

作者： Tong Mu Lele Wang Qian Wang Yang Wu patric.Jannasch Jingshuai Yang Department of Chemistry College of SciencesNortheastern UniversityShenyang 110819LiaoningChina Polymer&Materials Chemistry Department of ChemistryLund UniversitySE-22100 LundSweden College of Chemistry Liaoning UniversityShenyang 10036LiaoningChina

This work focuses on the development of high temperature polymer electrolyte membranes(HT-PEMs)as key materials for HT-PEM fuel cells(HT-PEMFCs).Recognizing the challenges associated with the phosphoric acid(PA) doped polybenzimidazole(PBI) membranes,including the use of carcinogenic monomers and complex synthesis procedures,this study aims to develop more cost-effective,readily synthesized,and high-performance alternatives.A series of superacid-catalyzed polyhydroxyalkylation reactions have been carefully designed between p-terphenyl and aldehydes bearing imidazole moieties,resulting in a new class of *** is found that the chemical structure of aldehyde-substituted N-heterocycles significantly impacts the polymerization ***,the use of 1-methyl-2-imidazole-formaldehyde and 1 H-imidazole-4-formaldehyde monomers leads to the formation of high-viscosity,rigid,and ether-free polymers,denoted as PTIm-a and *** fabricated from these polymers,due to their pendent imidazole groups,exhibit an exceptional capacity for PA ***,PTIm-a,carrying methylimidazole moieties,demonstrates a superior chemical stability by maintaining morphology and structural stability during 350 h of Fenton *** being immersed in 75 wt% PA at 40℃,the PTIm-a membrane reaches a PA content of 152%,maintains a good tensile strength of 13.6 MPa,and exhibits a moderate conductivity of 50.2 mS cm^(-1) at 180℃.Under H_(2)/O_(2) operational conditions,a single cell based on the PTIm-a membrane attains a peak power density of 732 mW cm^(-2) at 180℃ without ***,the membrane demonstrates stable cycle stability over 173 h within 18 days at a current density of 200 mA cm^(-2),indicating its potential for practical application in *** work highlights innovative strategies for the synthesis of advanced HT-PEMs,offering significant improvements in membrane properties and fuel cell performance,thus expanding the horizons of HT-PE

关键词： High temperature polymer electrolyte membrane Imidazole-containing polymer Chemical stability Fuel cell

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Urological and genital surgery in ancient Egypt

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History & Philosophy of Medicine 2023年第1期5卷 16-23页

作者： patric.Blomstedt Department of Clinical Neuroscience UmeåUniversityUmeåSE-90185Sweden

Background:Ancient Egypt might be considered the cradle of *** modern literature is somewhat too enthusiastic regarding the procedures given an Egyptian *** aim of the current paper is to briefly analyze the claims regarding urological and genital surgery in Egypt,in order to decide what the Egyptian actually do,and what has incorrectly been ascribed to ***:The original sources as well as the modern literature was reviewed regarding surgery in ancient ***:There is only one source indicating a urological procedure for medical indications in the Egyptian *** Ebers papyrus can be interpreted as describing a surgical treatment for *** sources are more abundant regarding male circumcision,while female circumcision is mainly documented from a later *** suggestions that castration and lithotomy were performed are based on a lack of understanding of the ***:The ancient Egyptians did possibly treat hydrocele with a minor surgical procedure,but there are no indications in the sources that other urological procedures were *** were common,but were not performed on a medical *** findings are in line with the general level of Egyptian surgery.

关键词： Egypt urology circumcision castration history

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Anatomy and its importance for surgery in ancient Egypt

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History & Philosophy of Medicine 2020年第3期2卷 58-67页

作者： patric.Blomstedt Department of Pharmacology and Clinical Neuroscience UmeåUniversitySweden

Ancient Egypt might be considered the cradle of medicine,but the modern literature is often too enthusiastic regarding the ancient Egyptians *** often meet the statement that their surgical skills were to a large extent based on their considerable anatomical *** anatomical knowledge is supposedly demonstrated by their anatomical vocabulary,preserved and lost literary works related to anatomy,the existence of human dissections and knowledge achieved from the ***,an analysis of the original sources as well as the modern literature provides a rather different picture of the status of anatomy in Ancient *** medical papyruses demonstrates a rather confused understanding of anatomy and *** though a considerable number of anatomical terms are known,it is of interest to note that that those dealing with internal anatomy seem to be dependent on animal *** existence of anatomical books is only mentioned in late works separated by millennia from the period they are describing,and can thus not be *** texts used as support for the existence of human dissections are either incorrectly translated,or are referring to Hellenistic ***,it seems likely that lessons from the graves,traumatic injuries and animal slaughter are more important sources of anatomical knowledge than the mummifications,which have little in common with the human dissections performed in Alexandria during the Hellenistic *** anatomical knowledge of the ancient Egyptians was thus quite ***,a very basic anatomical understanding would have been more than sufficient for the simple surgical procedures such as the stitching of wounds,repositioning of fractures and removal of superficial tumors performed in Ancient Egypt.

关键词： Egypt Anatomy Surgery History

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Phytochemical and anti-bacterial activity of epidermal glands extract of Christella parasitica (L.) H. Lev.

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Asian Pacific Journal of Tropical Biomedicine 2011年第1期1卷 8-11页

作者： Paul Raj K Irudayaraj V Johnson M patric.Raja D Dartment of Plant Biology and Plant Biotechnology St.Xavier's College(Autonomous)

Objective:To study the morphology,biochemistry and bioactivity of the epidermal glands of the glandular morphotype of Christella parasitica(***)(L.) ***: Morphological studies on epidermal glands were earned out by using light microscope and scanning electron *** prepare the extract,the shade-dried fronds of glandular morphotype were soaked in *** antibacterial studies paper disc method was followed by using various pathogenic ***:Detailed micromorphological,phytochemical and bioactivity studies on a medicinal fern ***(L.) *** its inlraspecific variation in antibacterial *** presence or absence of the epidermal glands was the key factor for antibacterial activity in the morphovariants of this *** epidermal glands were orange-coloured,stalked and elongated ones of about 84.2μm×45μm,and distributed on the undersurface of cosla,coslules and veins in croziers,young and mature *** of glands varied from 15/cm on costa in mature leaves to 140/cm on costules in *** acetone extract of the glands showed antibacterial activities and also toxic effect against mosquito larvae and tadpoles of *** phytochemical analysis and HPLC studies of the gland extract showed the presence of various kinds of terpenoids,alkaloids,tannins,saponins and flavonoids in ***:The present study shows that epidermal glands of the glandular morphotype of C. parasitica(L.) *** several bioactive compounds and such rare moiphovariant should be conserved in *** next step is to isolate the pure compounds and to screen the bioactivity of individual compounds of the epidermal glands.

关键词： Epidermal glands Christella parasitica Bioactivity Phytochemical activity Anti-bacterial activity Morphology Biochemistry Glandular morphotype Light microscope Shade-dried frond Bioactive compound Morphovariant Preliminary phytochemical analysis Gland extract Flavonoid

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Small bowel volvulus as a complication of von Recklinghausen's disease:A case report

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World Journal of Gastroenterology 2014年第24期20卷 7979-7983页

作者： Thomas Artur Werner Feride Krpil Martin Olaf Schoppe patric.Krpil Wolfram Trudo Knoefel Andreas Krieg Department of Surgery (A) HeinrichHeine-University and University Hospital Duesseldorf40225 DuesseldorfGermany Institute of Pathology Heinrich-Heine-University and University Hospital Duesseldorf40225 DuesseldorfGermany Institute of Diagnostic and Interventional Radiology Heinrich-Heine-University and University Hospital Duesseldorf40225 DuesseldorfGermany

We report the case of a 25-year-old male with Neurofibromatosis type I (NF-1), who presented at the time of admission with clinical findings of an acute abdomen caused by a mechanical obstruction. Computerized tomography showed a volvulus of the terminal ileum with mesenteric swirling as the cause of the patient’s symptoms. Consecutive exploratory laparotomy confirmed the diagnosis and 70 cm of the small intestine was resected due to an affection of the mesentery by multiple neurofibromas. The gastrointestinal tract is affected in approximately 10% of patients with NF-1, however the mesentery is almost always spared. Here we describe the unique case of a patient with a volvulus caused by mesenteric manifestation of von Recklinghausen’s disease, emphasizing the role of surgery in a team of multidisciplinary specialists to treat this multiorganic disease.

关键词： Volvulus Obstruction Von Recklinghausen´ s disease Neurofibromatosis type I Mesenteric neurofibromas

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Twiddler’s Syndrome in a Patient with Dystonic Tremor Treated with DBS

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Open Journal of Modern Neurosurgery 2014年第4期4卷 193-195页

作者： Jennifer Samuelsson patric.Blomstedt Department of Neurosurgery Umea University Hospital Umea Sweden Department of Neurosurgery Umea University Umea Sweden

Background and Importance: Twiddler’s syndrome is a rare complication of DBS. This condition occurs when the IPG is consciously or inadvertently rotated in its pocket, resulting in torsion and possible dislodgement of implanted electrodes, with subsequent loss of function. Methods: Here we present a patient diagnosed with Twiddler’s syndrome. The patient presented with straining cables at the neck five months after bilateral Gpi DBS and an x-ray demonstrated Twiddler’s syndrome. Initial revision with preventive measures proved futile. After some time the condition recurred, now with dislocation of one of the intracerebral electrodes. In a second revision the IPG was placed under the pectoralis muscle, which has so far prevented further rotation. Results and Conclusion: While Twiddler’s syndrome is fairly uncommon, it remains to be a risk associated with DBS, recognizing the potential risks and signs might allow for preventive measures avoiding dislocation of the intracerebral electrodes.

关键词： Twiddler’s Syndrome IPG DBS Complications

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Acute effects of partial-body vibration in sitting position

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World Journal of Orthopedics 2018年第9期9卷 156-164页

作者： Yannik Faes Nora Banz Nathalie Buscher Angela Blasimann Lorenz Radlinger patric.Eichelberger Achim Elfering Department of Work and Organizational Psychology University of Bern Department of Health Professions Bern University of Applied Sciences

AIM To investigate the acute effects of sinusoidal and stochastic resonance partial-body vibration in sitting position, including muscle activity, heart rate variability, balance and *** Fifty healthy participants were assigned randomly to two training conditions: A sinusoidal partial-body vibration(SIN, 8 Hz) or a stochastic resonance partial-body vibration(STOCH, 8 ± 2 Hz). For baseline assessment participants sat on the vibration platform without vibration. Both training conditions consisted of five series of a one-minute vibration training and a one-minutebreak between them. In this experimental study surface electromyography(EMG) of the erector spinae(ES), one of the back muscles, and heart rate variability(HRV) was measured at baseline and during training. Balance and flexibility were assessed at baseline and immediately after training. Balance was measured with the modified star excursion balance test(mS EBT) and flexibility was assessed through the modified fingertip-to-floor method(mF TF).RESULTS Paired sample t-test showed a significant increase in balance that was restricted to STOCH(t =-2.22, P = 0.018; SIN: t =-0.09, P = 0.466). An increase in flexibility was also restricted to STOCH(t = 2.65, P = 0.007; SIN: t = 1.41, P = 0.086). There was no significant change of muscle activity in the ES-EMG in STOCH or SIN conditions. In both training conditions, HRV decreased significantly, but remained in a low-load range(STOCH: t = 2.89, P = 0.004; SIN: t = 2.55, P = 0.009).CONCLUSION In sitting position, stochastic resonance partial-body vibration can improve balance and flexibility while cardiovascular load is low. STOCH can be a valuable training option to people who are unable to stand(e.g., people, who are temporarily wheelchair-bound).

关键词： Partial-body vibration Balance Flexibility Sinusoidal Stochastic resonance

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经皮加压钢板内固定治疗股骨转子间骨折初步报告

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中国矫形外科杂志 2007年第4期15卷 296-298页

作者：凌尚准 Hockman patric 百色市人民医院骨科广西百色市533000 比利时-尼日尔医疗技术合作中心

[目的]探讨应用微创手术治疗股骨转子间骨折的方法和疗效，及就手术的侵袭性、手术时间、受辐射的时间、失血量等指标进行评估和比较。[方法]自2003年以来，应用经皮加压钢板（percutaneous compressionplating，PCCP），在C型臂X线机... 详细信息

[目的]探讨应用微创手术治疗股骨转子间骨折的方法和疗效，及就手术的侵袭性、手术时间、受辐射的时间、失血量等指标进行评估和比较。[方法]自2003年以来，应用经皮加压钢板（percutaneous compressionplating，PCCP），在C型臂X线机监视下，经皮小切口置入加压钢板行内固定治疗股骨转子间骨折19例，选择稳定性骨折或者轻度移位而容易复位的骨折为适应证。其中女11例，男8例，年龄54—85岁，平均68岁。随访6—28个月，平均16．8个月。[结果]手术时间30-55min，平均45min；应用C型臂X线机时间45—85s，平均58s；术中失血40-120ml，平均80ml。所有病例X线片骨折愈合时间为3个月。[结论]应用PCCP钢板经皮内固定手术治疗股骨转子间骨折，比照传统的DHS、Gamma钉和PFN具有手术创伤小，操作简单，手术时间短，出血少，减少术中X线片的曝光时间等特点，疗效满意，并发症少。

关键词：股骨骨折加压钢板骨折固定术经皮

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Target-oriented robust optimization of a microgrid system investment model

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Frontiers in Energy 2018年第3期12卷 440-455页

作者： Lanz UY patric.UY Jhoenson SIY Anthony Shun Fung CHIU Charlle SY Department of Industrial Engineering De La Salle University Manila1004 the Philippines

An emerging alternative solution to address energy shortage is the construction of a microgrid system. This paper develops a mixed-integer linear programming microgrid investment model considering multi-period and multi-objective investment setups. It further investigates the effects of uncertain demand by using a target-oriented robust optimization （TORO） approach. The model was validated and analyzed by subjecting it in different scenarios. As a result, it is seen that there are four factors that affect the decision of the model： cost, budget, carbon emissions, and useful life. Since the objective of the model is to maximize the net present value （NPV） of the system, the model would choose to prioritize the least cost among the different distribution energy resources （DER）. The effects of load uncertainty was observed through the use of Monte Carlo simulation. As a result, the deterministic model shows a solution that might be too optimistic and might not be achievable in real life situations. Through the application of TORO, a profile of solutions is generated to serve as a guide to the investors in their decisions considering uncertain demand. The results show that pessimistic investors would have lower NPV targets since they would invest more in storage facilities, incurring more electricity stock out costs. On the contrary, an optimistic investor would tend to be aggressive in buying electricity generating equipment to meet most of the demand, however risking more storage stock out costs.

关键词： microgrid renewable resources robust optimization target-oriented robust optimization

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