检索结果-南通市图书馆

Iron dysregulation in beta-thalassemia

Asian Pacific Journal of Tropical Medicine 2016年第11期9卷 1013-1021页

作者： Kamonlak Leecharoenkiat pathrapol lithanatudom Wannapa Sornjai Duncan R.Smith Department of Clinical Microscopy Faculty of Allied Health SciencesChulalongkorn University Department of Biology Faculty of ScienceChiang Mai University Molecular Pathology Laboratory.Institute of Molecular Biosciences Mahidol University

Iron deficiency anemia and iron overload conditions affect more than one billion people *** homeostasis involves the regulation of cells that export iron into the plasma and cells that utilize or store *** cellular iron balance in humans is primarily mediated by the hepcidin-ferroportin *** is the sole cellular iron export protein,and its expression is regulated transcriptionally,post-transcriptionally and ***,a hormone produced by liver cells,post-translationally regulates ferroportin expression on iron exporting cells by binding with ferroportin and promoting its internalization by endocytosis and subsequent degradation by *** of iron homeostasis leading to iron deposition in vital organs is the main cause of death in betathalassemia ***-thalassemia patients show marked hepcidin suppression,ineffective eiythropoiesis,anemia and iron ***-thalassemia is common in the Mediterranean region,Southeast Asia and the Indian subcontinent,and the focus of this review is to provide an update on the factors mediating hepcidin related iron dysregulation in beta-thalassemia *** this process may pave the way for new treatments to ameliorate iron overloading and improve the long term prognosis of these patients.

关键词： Beta-thalassemia Hepcidin Iron overload Ferroportin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Endogamous marriage and the prevalence of hemoglobin E in ethnic groups of northern Thailand

引用

Asian Pacific Journal of Tropical Medicine 2017年第4期10卷 392-395页

作者： Praphat Ruengthanoo pathrapol lithanatudom Pitsinee Inthi Janjira Termphiriyakit Phaivit Laphyai Daoroong Kangwanpong Duncan R.Smith Jatupol Kampuansai Department of Biology Faculty of ScienceChiang Mai University Molecular Pathology Laboratory Institute of Molecular BiosciencesMahidol University

Objective:To investigate the impact of the endogamous marriage culture on the prevalence of the hemoglobin E(HbE) recessive ***:The prevalence of the hemoglobin E(HbE)recessive variant was determined by dot-blot hybridization in 4 endogamous villages(1 Mlabri and 3 Htin ethnic groups) in comparison with 9 other nearby non-endogamous ***:Although the overall HbE prevalence in the population studied(8.44%,33/391)was not significantly different from that of the general southeast Asian population,a high prevalence and individuals with homozygous HbE were observed in two villages,the Mlabri from Wiang Sa district and the Htin from Thung Chang district of Nan province(26.3%and26.9%,respectively).The low HbE allelic frequency noticed in some endogamous populations suggests that not only endogamy but also other evolutionary forces,such as founder effect and HbE/β-thalassemia negative selection may have an effect on the distribution of the HbE ***:Our study strongly documents that cultural impact has to be considered in the extensive prevalence studies for genetic disorders in the ethnic groups of northern Thailand.

关键词： Endogamous marriage Hemoglobin E Ethnic group Northern Thailand

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：