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Prevalence of pulmonary hypertension among children with Down syndrome:A systematic review and meta-analysis

World Journal of Clinical Pediatrics 2021年第6期10卷 177-191页

作者： Amar Taksande Divya Pujari patel zeeshan jameel Bharati Taksande Revat Meshram Department of Pediatrics Jawaharlal Nehru Medical CollegeWardha 442004MaharashtraIndia Department of Medicine Mahatma Gandhi Institute of Medical SciencesWardha 442102MaharashtraIndia

BACKGROUND Pulmonary hypertension(PH)has serious short-and long-term *** is gaining increasing importance in high risk groups such as Down syndrome(DS)as it influences their overall survival and ***,there is a dire need to collate the prevalence rates of PH in order to undertake definitive measures for early diagnosis and *** To determine the prevalence of PH in children with *** The authors individually conducted a search of electronic databases manually(Cochrane library,PubMed,EMBASE,Scopus,Web of Science).Data extraction and quality control were independently performed by two reviewers and a third reviewer resolved any conflicts of *** words used in the literature search were“pulmonary hypertension”and“pulmonary arterial hypertension”;“Down syndrome”and“trisomy 21”and“prevalence”.The data were analyzed by Comprehensive Meta-Analysis Software Version *** of bias assessment and STROBE checklist were used for quality *** Of 1578 articles identified,17 were selected for final *** pooled prevalence of PH in these studies was 25.5%.Subgroup analysis was carried out for age,gender,region,year of publication,risk of bias and etiology of *** This review highlights the increasing prevalence of PH in children with *** is crucial for pediatricians to be aware of this morbid disease and channel their efforts towards earlier diagnosis and successful ***-based studies with a larger sample size of children with DS should be carried out to better characterize the epidemiology and underlying etiology of PH in DS.

关键词： Down syndrome Pulmonary hypertension Prevalence Trisomy 21 Persistent pulmonary hypertension Congenital heart disease

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