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Diabetes mellitus:An overview on its pharmacological aspects and reported medicinal plants having antidiabetic activity

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Asian Pacific Journal of Tropical Biomedicine 2012年第5期2卷 411-420页

作者： patel dk Kumar R Laloo D Hemalatha S Pharmacognosy Research Laboratory Department of PharmaceuticsInstitute of TechnologyBanaras Hindu University

Diabetes mellitus is not a single disease but is a group of metabolic disorders affecting a huge numlier of population in the *** is mainly characterized by chronic hyperglycemia,resulting from defects in insulin secretion or insulin *** is predicated that the number of diabetes person in the world could reach upto 366 million by the year *** though the cases of diabetes are increasing day by day,except insulin and oral hypoglycemic drugs no other way of treatment has been successfully developed so ***,the objective of the present review is to provide an insight over the pathophysiological and etiological aspects of diabetes mellitus along with the remedies available for this metabolic *** review also contains brief idea about diabetes mellitus and the experimental screening model with their relevant mechanism and significance mainly used *** and streptozotocin are mainly used for evaluating the antidiabetic activity of a particular *** review contain list of medicinal plants which have been tested for their antidiabetic activity in the alloxan induced diabetic rat *** the available data in the literature,it was found that plant having antidiabetic activity is mainly due to the presence of the secondary ***,the information provided in this review will help the researchers for the development of an alternative methods rather than insidin and oral hypoglycemic agents for the treatment of diabetes niellitus,which will minimize the complication associated with the diabetes and related disorder.

关键词： Aldose reductase Alloxan Antioxidant Diabetes mellitus Insulin Phytoconstituents Streptozotocin Oral hypoglycemic agents

An overview on antidiabetic medicinal plants having insulin mimetic property

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Asian Pacific Journal of Tropical Biomedicine 2012年第4期2卷 320-330页

作者： patel dk Prasad SK Kumar R Hemalatha S Pharmacognosy Research Laboratory Department of PharmaceuticsInstitute of TechnologyBanaras Hindu University

Diabetes mellitus is one of the common metabolic disorders acquiring around 2.8%of the world's population and is anticipated to cross 5.4%by the year *** long back herbal medicines have been the highly esteemed source of medicine therefore,they have become a growing part of modern,high-tech *** view of the above aspects the present review provides profiles of plants(65 species) with hypoglycaemic properties,available through literature source from various database with proper categorization according to the parts used,mode of reduction in blood glucose(insulinomimetic or insulin secretagugues activity) and active phyloconsliluents having insulin mimetics *** the review it was suggested that,plant showing hypoglycemic potential mainly belongs to the family Leguminoseae,Lamiaceae,Liliaceae,Cucurbitaceae, Asteraceae,Moraceae,Rosaceae and *** most active plants are Allium sativum. Gymnema sylvestre,Citrullus colocynthis,Trigonella foenum greacum,Momordica charantia and Ficuts *** review describes some new bioactive drugs and isolated compounds from plants such as roseoside,epigallocatechin gallate,beta-pyrazol-1-ylalanine,cinchonain Ib,leucocyandin 3-O-beta-d-galactosyl cellobioside,leucopelargonidin-3- O-alpha-L rhamuoside,glycyrrhetinic acid,dehydrotrametenolic acid,strictinin,isostrictinin,pedunculagin, epicatechin and christinin-A showing significant insulinomimetic and antidiabetic activity with more efficacy than conventional hypoglycaemic ***,from the review majorly,the antidiabetic activity of medicinal plants is attributed to the presence of polyphenols,flavonoida, terpenoids,coumarins and other constituents which show reduction in blood glucose *** review also discusses the management aspect of diabetes mellitus using these plants and their active principles.

关键词： Diabetes Insulin secretagogues Insulin mimetics Phytoconstituents Pancrease Blood glucose Insulin Beta cell Antidiabetic activity Medicinal plant Metabolic disorder Herbal medicine Diabetes mellitus Hypoglycaemic activity

Pedalium murex Linn(Pedaliaceae) fruits:a comparative antioxidant activity of its different fractions

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Asian Pacific Journal of Tropical Biomedicine 2011年第5期1卷 395-400页

作者： dk patel R Kumar SK Prasad S Hemalatha Pharmacognosy Research Laboratory Department of PharmaceuticsInstitute of TechnologyBanaras Hindu University

Objective:To examine the antioxidant activity and total phenolic content of different solvent fractions of Pedulium murex(***)Linn fruits(Family:Pedaliaceae)as well as the correlation between the total antioxidant capacity and total phenolic ***:In the present study,the antioxidant activities of *** were evaluated using six in-vitro assays,namely total antioxidant assay,DPPH assay,reducing power,nitric oxide scavenging,hydrogen peroxide scavenging and deoxyribose scavenging assays,and total phenol contents were also ***:The ethyl acetate(EA)fraction was found to have high levels of phenolic content(298.72±2.09 mg GAE/g).The EA fraction exhibit higher total antioxidant capacity,higher percentage of DPPH radical scavenging activity(135.11±2.95μg/mL),nitric oxide(200.57±4.5lμg/mL),hydrogen peroxide(2I7.91±6.12μg/mL),deoxyribose(250.01±4.68μg/mL)and higher reducing *** coefficient(r^2=0.914)was found to be significant between total phenolic content and total antioxidant ***:In general,the results indicate that the EA fractions are rich in phenolic antioxidants with potent free radical scavenging activity implying their importance to human health.

关键词： Pedalium murex Antioxidant activity Total phenolics Different solvent fraction In vitro assay Scavenging activity

Antidiabetic and in vitro antioxidant potential of Hybanthus enneaspermus(Linn) *** in streptozotocin—induced diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2011年第4期1卷 316-322页

作者： patel dk Kumar R Prasad SK Sairam K Hemalatha S Pharmacognosy Research Laboratory Department of PharmaceuticsInstitute of TechnologyBanaras Hindu University

Objective:To evaluate antidiabetic and antioxidant potential of Hybanthus enneaspermus in different ***:The oral glucose tolerance test(OGTT) and normoglycemic effect of alcoholic extract of Hybanthus enneaspermus(AHE) were evaluated at a dose of 125,250 and 500mg/kg *** hypoglycemic activity and effect on body weight were tested at 250 and 500 mg/kg *** day for 21 days in Streptozotocin(STZ) induced diabetic ***,glucose uptake by hemidiaphram was also *** total polyphenolic and flavonoid were determined and their correlation with various antioxidant assays was also ***:The results showed high level of phenolic content in *** also exhibited higher total antioxidant capacity,good reducing power and a significant scavenger of reactive oxygen species like DPPH radical,nitric oxide,hydrogen peroxide and *** there was a significant increase in the body weight and decrease in the blood glucose level on treatment with the *** increased glucose uptake on isolated rat hemi-diaphragm compared to control ***:AHE reduce blood glucose level in STZ-induced diabetic *** does not show significant effect in normoglycemic study but showes significant effect in *** has significant antioxidant activity,which may be attributed to high phenolic content.

关键词： Hybanthus enneaspermus Diabetic Antioxidant Total phenol Flavonoid Flavonol Glucose uptake

Evaluation of in vitro aldose reductase inhibitory potential of different fraction of Hybanthus enneaspermus Linn ***

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Asian Pacific Journal of Tropical Biomedicine 2012年第2期2卷 134-139页

作者： patel dk Kumar R Kumar M Sairarn K Hemalatha S Pharmacognosy Research Laboratory Department of PharmaceuticsInstitute of TechnologyBanaras Hindu University

Objective:To evaluate the aldose reductase inhibitory(ARI)activity of different fractions of Hybanthus enneaspermus for potential use in diabetic ***:Total phenol and flavonoid content of different fractions was *** activity of different fractions in rat lens was investigated in ***:The results showed significant level of phenolic and flavonoid content in ethyl acetate fraction[total phenol(212.15±0.79 mg/g),total flavonoid(39.11±2.27mg/g)]and aqueous fraction[total phenol(140.62±0.57mg/g),total flavonoid(26.07±1.49 mg/g)]as compared with the chloroform fraction[total phenol(68.56±0.51mg/g),total flavonoid(13.41±0.82mg/g)]and petrolium ether fraction[total phenol(36.68±0.43mg/g),total flavonoid(11.55±1.06mg/g)].There was a significant difference in the ARI activity of each fraction,and it was found to be the highest in ethyl acetate fraction[IC_(50)(49.26±1.76μg/mL)]followed by aqueous extract[IC_(50)(70.83±2.82μg/mL)]and it was least in the petroleum ether fraction[IC_(50)(118.89±0.71μg/mL)].Chloroform fraction showed moderate activity[IC_(50)(98.52±1.80μg/mL)].Conclusions:Different fractions showed significanct amount of ARI activity,where in ethyl acetate fraction it was found to be maximum which may be due to its high phenolic and flavonoid *** extract after further evaluation may be used in the treatment of diabetic cataract.

关键词： Hybanthus enneaspermus Total phenol Total flavonoid Rat lens Aldose reductase Diabetic cataract Different fractions

Analytical study of atmospheric internal waves model with fractional approach

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Journal of Ocean Engineering and Science 2024年第4期9卷 326-337页

作者： Trushit patel Hardik patel Ramakanta Meher Computer Science University of the PeoplePasadenaCA 91101United States Department of Mathematics Uka Tarsadia UniversityBardoliGujaratIndia Mathematics and Humanities Department Sardar Vallabhbhai National Institute of TechnologySuratGujaratIndia

This study looks at the mathematical model of internal atmospheric waves,often known as gravity waves,occurring inside a fluid rather than on the *** the shallow-fluid assumption,internal atmospheric waves may be described by a nonlinear partial differential equation *** shallow flow model’s primary concept is that the waves are spread out across a large horizontal area before rising *** Fractional Reduced Differential Transform Method(FRDTM)is applied to provide approximate solutions for any given *** aids in the modelling of the global atmosphere,which has applications in weather and climate *** the integer-order value(α=1),the FRDTM solution is compared to the precise solution,EADM,and HAM to assess the correctness and efficacy of the proposed technique.

关键词： Shallow-fluid equations Atmospheric internal waves Time-fractional partial differential equations Fractional reduced differential transform method(FRDTM) Climate prediction

FPGA Accelerators for Computing Interatomic Potential-Based Molecular Dynamics Simulation for Gold Nanoparticles:Exploring Different Communication Protocols

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Computers, Materials & Continua 2024年第9期80卷 3803-3818页

作者： Ankitkumar patel Srivathsan Vasudevan Satya Bulusu Department of Electrical Engineering Indian Institute of Technology IndoreIndore453552India Department of Chemistry Indian Institute of Technology IndoreIndore453552India

Molecular Dynamics(MD)simulation for computing Interatomic Potential(IAP)is a very important High-Performance Computing(HPC)*** simulation on particles of experimental relevance takes huge computation time,despite using an expensive high-end *** computing,a combination of the Field Programmable Gate Array(FPGA)and a computer,is proposed as a solution to compute MD simulation *** such heterogeneous computation,communication between FPGA and Computer is *** such MD simulation,explained in the paper,is the(Artificial Neural Network)ANN-based IAP computation of gold(Au_(147)&Au_(309))*** simulation calculates the forces between atoms and the total energy of the chemical *** work proposes the novel design and implementation of an ANN IAP-based MD simulation for Au_(147)&Au_(309) using communication protocols,such as Universal Asynchronous Receiver-Transmitter(UART)and Ethernet,for communication between the FPGA and the host *** improve the latency of MD simulation through heterogeneous computing,Universal Asynchronous Receiver-Transmitter(UART)and Ethernet communication protocols were explored to conduct MD simulation of 50,000 *** this study,computation times of 17.54 and 18.70 h were achieved with UART and Ethernet,respectively,compared to the conventional server time of 29 h for Au_(147) *** results pave the way for the development of a Lab-on-a-chip application.

关键词： Ethernet hardware accelerator heterogeneous computing interatomic potential(IAP) MDsimulation peripheral component interconnect express(PCIe) UART

Optimization of gas lift system for well performance improvement in Asmari formation:A techno-economic perspective

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Petroleum Research 2024年第1期9卷 115-124页

作者： Hari Sreenivasan Jash patel Dev Jain Setu patel Isaac Wilson Shanker Krishna Drilling Cementing&Stimulation(DCS)Research CentreDepartment of Petroleum EngineeringSchool of Energy Technology(SoET)Pandit Deendayal Energy University(PDEU)Knowledge CorridorRaysanGandhinagarGujarat382426India

Well productivity in the Asmari carbonate formation of southwest Iran has decreased in recent years as a result of production *** production rate must be maintained below 1500 STB/day to prevent water *** this study,a gas lift well is modeled using data from one of the producing wells of this *** analysis is performed using lift-gas injection rates and wellhead pressures at different reservoir pressures and water cut conditions to optimize *** aspects are considered to optimize the artificial gas injection rates at different tubing head pressures and water cut *** the lift-gas injection rate from 0.4 MMscf/day to 1 MMscf/day enhances the oil production rate by 37.71%and 43.89%for 10%and 30%water cut conditions,*** injection rates of 5.2 MMscf/day and 5.4 MMscf/day are determined to be economically optimal for 30%water cut with tubing head pressures of 260 psig and 270 psig,respectively.

关键词： Production enhancement Artificial lift Gas lift Asmari carbonate formation Techno-economic analysis Well productivity

Magnetohydrodynamics bio-convection flow at Casson fluid stagnation point in porous medium:Cross-diffusion effect and heat production

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Propulsion and Power Research 2024年第3期13卷 445-457页

作者： Snehal patel Harshad R.patel Gujarat Technological University AhmedabadGujaratIndia Department of Mathematics U V Patel College of EngineeringGanpat UniversityMahesanaIndia

This study examines the effect of heat production and radiation absorption on the magnetohydrodynamic Cassonfluidflow at the stagnation point in a porous *** convert the group offluidflow equations,which are non-linear partial differential equations with suitable boundary constraints,into a set of non-linear ordinary differential equations using similarity *** homotopy analysis method(HAM)solves the converted system of ordinary differential *** draw graphs for numerous values of non-dimensional pa-rameters and tables of surface drag force,rates of heat transfer,and mass transfer to analyze the relationship between velocityfield,temperaturefield,concentrationfield,and other essential parameters involved in the *** have proven that the Dufour number,radiation parameter,and heat generation parameter elevate thefluid temperature,whereas the magnetic parameter lowers *** Cassonfluid parameter,buoyancy force parameter,and mixed convection param-eter all promotefluid movement throughout *** presented tabular data allows us to see the trend of heat and mass transfer rates,as well as drag force rates,against important parameters,enhancing our understanding of these rates.

关键词： Cassonfluid Magnetohydrodynamics(MHD) Stagnation pointflow Thermal radiation Heat source/sink Soret effect