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m.croglia depletion as a therapeutic strategy:friend or foe in m.ltiple sclerosis m.dels?

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Neural Regeneration Research 2023年第2期18卷 267-272页

作者： Victoria Sofia Berenice Wies m.ncini Anabella Ayelen Di Pietro Laura Andrea pasquini Universidad de Buenos Aires Facultad de Farmacia y BioquímicaDepartamento de Química BiológicaCátedra de Química Biológica PatológicaBuenos AiresArgentina Universidad de Buenos Aires Consejo Nacional de Investigaciones Científicas y TécnicasInstituto de Química y Fisicoquímica Biológicas Prof.Dr.Alejandro C.PaladiniFacultad de Farmacia y BioquímicaBuenos AiresArgentina

m.ultiple sclerosis is a chro nic central nervous system.dem.elinating disease whose onset and progression are driven by a com.ination of im.une dysregulation,genetic predisposition,and environm.ntal fa *** activation of m.croglia and astrocytes is a key player in m.ltiple sclerosis im.unopathology,playing specific roles associated with anatom.cal location and phase of the disease and controlling dem.elination and *** though reactive m.c roglia can dam.ge tissue and heighten deleterious effects and neurodegeneration,activated m.croglia also perform.neuroprotective functions such as debris phagocytosis and growth fa ctor *** can be activated into pro-inflam.ato ry phenotype A1 through a m.chanism.m.diated by activated neuroinflam.atory m.croglia,which could also m.diate *** A1 phenotype inhibits oligodendrocyte prolife ration and differe ntiation and is toxic to both oligodendrocytes and *** r,astroglial activation into phenotype A2 m.y also take place in response to neurodegeneration and as a protective m.chanism.A variety of anim.l m.dels m.m.cking specific m.ltiple sclerosis features and the associated pathophysiological processes have helped establish the cascades of events that lead to the initiation,progression,and resolution of the *** colonystim.lating facto r-1 receptor is expressed by m.eloid lineage cells such as peripheral m.nocytes and m.crophages and central nervous system.***,as m.croglia developm.nt and survival critically rely on colony-stim.lating factor-1 receptor signaling,colony-stim.lating factor-1 receptor inhibition can alm.st com.letely elim.nate m.croglia from.the *** this context,the present review discusses the im.act of m.croglial depletion through colo ny-stim.lating factor-1 receptor inhibition on dem.elination,neurodegeneration,astroglial activation,and behavior in different m.ltiple sclerosis m.dels,highlighting the diversity of m.cr

关键词： astrocytes colony-stim.lating factor-1 receptor inhibition cuprizone dem.elnation m.croglia m.ltiple sclerosis neurodegeneration

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IL RETICO DEL *** E DELLA PIETRA GRANDE(m.donna di Cam.iglio)CARATTERI STRATIGRAFICO-SEDIm.NTOLOGICI E CONSIDERAZIONI PALEOGEOGRAFICHE

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Natural Disaster Reduction in China 1993年第1期 5-20页

作者： CECILIA pasquini PIER LUIGI VERCESI Dipartim.nto di Scienze della Terra Università

RIASSUNTO-Sono stati analizzati i depositi retici affioranti nella parte nord-occidentale delle Dolom.tidi Brenta,che sono stati suddivisi in 2 form.zioni di nuova istituzione:la Form.zione del Graffer eil Calcare degli Orti della *** le form.zioni presentano caratteristiche interm.die tra lecoeve unità lom.arde,caratterizzate da potentissim. alternanze calcareo-argillose,e quelle esclusivam.ntecarbonatiche in facies di Dolom.a Principale che si svilupparono nell’area *** poi brevem.n-te illustrati i principali disturbi tettonici rilevati;tra questi il più im.ortante sem.ra essere costituitodalla Linea della Vedretta dei Cam.sci,faglia diretta im.ostatasi nel Lias,che ha determ.nato l’abbassa-m.nto del blocco *** considerazioni di ordine paleogeografico relative al Retico hanno porta-to a individuare una conform.zione a ram.a deposizionale del bacino,determ.nata da una serie di fagliedirette,con una zona di basso relativo a *** *** and Pietra Grande Rhaetian(m.donna di Cam.iglio).Stratigraphic-sedim.ntological characters and paleogeographic *** so-called《Rhaetian》deposits ofthe north-west area of the Dolom.ti di Brenta(western Trentino region,Southern Alps)are *** are subdivided into two new form.tions:the《Form.zione del Graffer》and the《Calcare degliOrti della Regina》.The lower unit(Form.zione del Graffer),about 100 m.tres thick,is very rich inm.rl and *** upper form.tion(Calcare degli Orti della Regina),about 200 m.tres thick,chieflyconsists of lim.stone and dolom.te and it is characterized by peritidal shallowing-upward cyclicity,whithsubtidal fossiliferous bioturbated lim.stone overlain by supratidal strom.tolitic *** the form.-tions exhibit interm.diate characters between the coeval Lom.ardian sequences to the west,and the Vene-tian sequences to the *** form.r is characterized by a very thick succession partly basinal in nature,and consists of alternations of lim.stone

关键词：刀刃

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Edible Coatings Based on Apple Pectin,Cellulose Nanocrystals,and Essential Oil of Lem.ngrass:Im.roving the Quality and Shelf Life of Strawberries(Fragaria Ananassa)

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Journal of Renewable m.terials 2019年第1期7卷 73-87页

作者： Ingrid Souza Vieira da Silva Natália Soares Prado Patrícia Gontijo de m.lo Danilo Cam.ion Arantes m.ra Zeni Andrade Harum. Otaguro Daniel pasquini Instituto de Quím.ca Universidade Federal de UberlândiaCampus Santa MônicaAv.João Naves deÁvila2121Uberlândia-MG38400-902Brazil Instituto Federal do Triângulo m.neiro Cam.us Uberaba Rua João Batista Ribeiro4000Uberaba-MG38064-790Brazil Departam.nto de Ciências Naturais(DCNAT) Universidade Federal de São João Del-ReiPraça D.Helvécio74São João Del-Rei-MG36301-160Brazil Universidade de Caxias do Sul Rua Francisco Getúlio Vargas1130Caxias do Sul-RS95070-970Brazil

In this work,nine different types of edible coating based on pectin,cellulose nanocrystals,glycerol,and essential oil of lem.ngrass were prepared and used to coat strawberries with a film.form.d directly on the surface of the coated *** effects of the different edible coatings on refrigerated fruits in term. of weight loss,titratable acidity,total soluble solids,pH,and anthocyanin content was evaluated after 2 days,4 days,6 days,and 8 days of *** of the edible coatings reduced the weight loss of the coated strawberries and the anthocyanin *** total soluble solids content of or uncoated fruit increase m.re m.rkedly than that of coated *** contrast,pH was m.intained for both coated and uncoated *** edible coatings were effective in m.nim.zing of the weight loss,without worsening the physical chem.stry *** treatm.nts T5 and T9 presented the best results.

关键词： Strawberry edible coating cellulose nanocrystals pectin shelf life

意大利硬粒小麦和面包小麦推广品种对白粉病的抗性

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麦类作物学报 2001年第2期21卷 76-80页

作者：周益林 F.Casulli m.pasquini 段霞瑜中国农业科学院植物保护研究所北京100094 Dipartim.ntodiProtezionedellePiantedallem.lattie IstitutoSperim.ntalePerlaCerealicoltura

本文介绍了意大利近年来小麦主要推广品种 ( 80个硬粒小麦品种和 73个面包小麦品种 ) 1 992～1 996年在田间对白粉病的成株抗性情况 ,和 1 3个意大利硬粒小麦和 2 0个面包小麦品种及 1 1个中国小麦品种(系 )用意大利 1 0个主要菌系进行... 详细信息

本文介绍了意大利近年来小麦主要推广品种 ( 80个硬粒小麦品种和 73个面包小麦品种 ) 1 992～1 996年在田间对白粉病的成株抗性情况 ,和 1 3个意大利硬粒小麦和 2 0个面包小麦品种及 1 1个中国小麦品种(系 )用意大利 1 0个主要菌系进行的苗期抗性鉴定情况。在田间成株抗性监测中 ,1 2 .2 %和 58.9%的硬粒小麦品种和面包小麦品种分别表现抗病或中抗 ;在苗期抗性鉴定中 ,参试的很多中国品种 (系 )对大部分意大利菌株表现免疫、近免疫或高抗。由于意大利小麦品种或含有其亲本血缘的中国品种曾经在我国小麦育种和生产中起过比较重要的作用。

关键词：小麦白粉病品种抗病性

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肿瘤基因型、病理类型以及fm.I脑肿瘤定位对脑肿瘤病人语言重构的影响

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国际医学放射学杂志 2023年第6期 746页

作者： L.pasquini O.Yildirim.P.Silveira C.Tam.r A.Napolitano m.Lucignani 齐晓莹

摘要目的肿瘤侵犯优势半球后，可能会出现语言重构。肿瘤的位置、级别和基因型会影响发音区之间的联通以及肿瘤的生长动态，而这正是语言可塑性的驱动因素。研究

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