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Considerations for determining optimal mouse caging density

中国比较医学杂志 2008年第1期18卷 26-26页

作者： Charmaine Foltz Larry Carbone David DeLong Bernard E. Rollin pascalle van loo Julia Whitaker Axel Wolff Division of Veterinary Resources National Institutes of Health Bethesda MD. University of California San Francisco San Francisco CA. Veterinary Medical Unit VA Medical Center Minneapolis MN. Colorado State University Fort Collins CO. Utrecht University The Netherlands. Department of Pathology and Laboratory Medicine Division of Laboratory Animal Medicine University of North Carolina Chapel Hill NC. Division of Compliance Oversight OLAW National Institutes of Health Bethesda MD. Correspondence should be addressed to Charmaine Foltz DVM

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Challenges and prospects for consumer acceptance of cultured meat

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Journal of Integrative Agriculture 2015年第2期14卷 285-294页

作者： Wim Verbeke Pierre Sans Ellen J van loo Department of Agricultural Economics Ghent UniversityGent B-9000 Belgium INP-ENV Toulouse Toulouse 31076 France UR1303 ALISS INRA Ivry-sur-Seine 94205 France

Consumer acceptance of cultured meat is expected to depend on a wide diversity of determinants ranging from technologyrelated perceptions to product-specific expectations, and including wider contextual factors like media coverage, public involvement, and trust in science, policy and society. This paper discusses the case of cultured meat against this multitude of possible determinants shaping future consumer acceptance or rejection. The paper also presents insights from a primary exploratory study performed in April 2013 with consumers from Flanders（Belgium）（n=180）. The concept of cultured meat was only known（unaided） by 13% of the study participants. After receiving basic information about what cultured meat is, participants expressed favorable expectations about the concept. Only 9% rejected the idea of trying cultured meat, while two thirds hesitated and about quarter indicated to be willing to try it. The provision of additional information about the environmental benefits of cultured meat compared to traditional meat resulted in 43% of the participants indicating to be willing to try this novel food, while another 51% indicated to be ‘maybe＇ willing to do so. Price and sensory expectations emerged as major obstacles. Consumers eating mostly vegetarian meals were less convinced that cultured meat might be healthy, suggesting that vegetarians may not be the ideal primary target group for this novel meat substitute. Although exploratory rather than conclusive, the findings generally underscore doubts among consumers about trying this product when it would become available, and therefore also the challenge for cultured meat to mimic traditional meat in terms of sensory quality at an affordable price in order to become acceptable for future consumers.

关键词： acceptance artificial attitude consumer cultured in vitro meat synthetic

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Nitridation of Ni-based alloys:thermodynamics,kinetics,and deformation phenomena accompanying internal precipitation

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Rare Metals 2006年第5期25卷 501-511页

作者： Alexander A.Kodentsov Jorma K.Kivilahti Frans J.J.van loo Laboratory of Materials and Interface Chemistry Eindhoven University of TechnologyP.O.Box 5135600 MBEindhovenThe Netherlands Laboratory of Electronics Production Technology Helsinki University of TechnologyFIN-02150 EspooFinland

When a moderately stable phase is precipitated out during an intemal reaction, the behaviour of the penetrating atoms within the diffusion zone can be interpreted based on thermodynamic considerations. Evidence for “up-hill” diffusion of the penetrating species through the matrix towards the precipitation front during the intemal nitridation of Ni-Cr alloys at 1125℃ and 6000 bar of N2-pressure was predicted. Such behaviour of nitrogen is opposite to the boundary conditions in Wagner＇s description of internal reactions. A volume change associated with the precipitation reaction resulted in a stress gradient between the alloys surface and the intemal nitridation front. Stress relief occurred mainly by transport of nickel to the gas/metal interface. Pipe diffusion-controlled creep is the dominant stress accommodation mechanism during nitriding of dilute Ni-Cr alloys at 700℃ under a flowing NH3 ＋ H2 gas mixture.

关键词： nitridation nickel alloys thermodynamics diffusion internal precipitation

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Scalable fabrication,compartmentalization and applications of living microtissues

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Bioactive Materials 2023年第1期19卷 392-405页

作者： Maik Schot Nuno Araújo-Gomes Bas van loo Tom Kamperman Jeroen Leijten Department of Developmental Bioengineering Faculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522NBEnschedethe Netherlands

Living microtissues are used in a multitude of applications as they more closely resemble native tissue physiology,as compared to 2D *** are typically composed of a combination of cells and materials in varying combinations,which are dictated by the applications’design *** applications range wide,from fundamental biological research such as differentiation studies to industrial applications such as cruelty-free meat ***,their translation to industrial and clinical settings has been hindered due to the lack of scalability of microtissue production *** microfluidic processes provide an opportunity to overcome this limitation as they offer higher throughput production rates as compared to traditional batch techniques,while maintaining reproducible control over microtissue composition and *** this review,we provide a comprehensive overview of the current approaches to engineer microtissues with a focus on the advantages of,and need for,the use of continuous processes to produce microtissues in large ***,an outlook is provided that outlines the required developments to enable large-scale microtissue fabrication using continuous processes.

关键词： Tissue engineering Micromaterials Microfluidics Upscaling Clinical translation Industrial translation

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Comparative Analysis of Internal and External-Hex Crown Connection Systems - A Finite Element Study

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Journal of Biomedical Science and Engineering 2008年第1期1卷 10-14页

作者： RUDI C. van STADEN HONG GUAN YEW-CHAYE loo NEWELL W. JOHNSON Griffith School of Engineering/Dentistry and Oral Health Griffith University Gold Coast Campus Queensland 4222 Australia

The abutment connection with the crown is fundamental to the structural stability of the implant system and to the prevention of mechanical exertion that can compromise the success of the implant treatment. The aim of this study is to clarify the difference in the stress distribution patterns between implants with internal and external-hex connections with the crown using the Finite Element Method (FEM). Material and Methods: The internal and external-hex connections of the Neoss and 3i implant systems respectively, are considered. The geometrical properties of the implant systems are modeled using three-dimensional (3D) brick elements. Loading conditions include a masticatory force of 200, 500 and 1000N applied to the occlusal surface of the crown along with an abutment screw torque of 110, 320 and 550Nmm. The von Mises stress distributions in the crown are examined for all loading conditions. Assumptions made in the modeling include: 1. half of the implant system is modeled and symmetrical boundary conditions applied;2. temperature sensitive elements are used to replicate the torque within the abutment screw. Results: The connection type strongly influences the resulting stress characteristics within the crown. The magnitude of stress produced by the internal-hex implant system is generally lower than that of the external-hex system. The internal-hex system held an advantage by including the use of an abutment between the abutment screw and the crown. Conclusions: The geometrical design of the external-hex system tends to induce stress concentrations in the crown at a distance of 2.89mm from the apex. At this location the torque applied to the abutment screw also affects the stresses, so that the compressive stresses on the right hand side of the crown are increased. The internal-hex system has reduced stress concentrations in the crown. However, because the torque is transferred through the abutment screw to the abutment contact, changing the torque has greater e

关键词： component biomedical modelling dental implant finite element technique

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Correlation, Regression and Path Analyses of Seed Yield Components in <i>Crambe abyssinica</i>, a Promising Industrial Oil Crop

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American Journal of Plant Sciences 2013年第1期4卷 42-47页

作者： Banglian Huang Yiming Yang Tingting Luo Shu Wu Xuezhu Du Detian Cai Eibertus N. van loo Bangquan Huang College of Life Science Hubei University Wuhan China Plant Research International Wageningen the Netherlands

In the present study correlation, regression and path analyses were carried out to decide correlations among the agro- nomic traits and their contributions to seed yield per plant in Crambe abyssinica. Partial correlation analysis indicated that plant height (X1) was significantly correlated with branching height and the number of first branches (P 2) was significantly correlated with pod number of primary inflorescence (P 3) was significantly correlated with number of secondary branches (P -grain weight (P 4) was significantly correlated with seed yield per plant (P 7) was significantly correlated with seed yield per plant (P -grain weight (P -grain weight (X8) was significantly correlated with seed yield per plant (P -grain weight contributed significantly to seed yield per plant at P 7) and 1000-grain weight (X8) to seed yield per plant (Y) is Y = 0.006 X7 + 1.222 X8 - 7.191. The path coefficient of pod number per plant to seed yield per plant was 0.967 and that of 1000-grain weight was 0.194. The determination coefficient of pod number per plant and 1000-grain weight to seed yield per plant was 0.983 and the determination coefficient of other agronomic traits was 0.130. Coefficient of variance indicated that the length of primary inflorescence showed the greatest variation, followed by seed yield per plant, pod number per plant, number of secondary branches, branching height, pod number of primary inflorescence, number of first branches, seed yield per plot, 1000-grain weight and plant height. It was suggested that seed yield per plant in Crambe might be improved by increasing the pod number per plant through selection or cultivation, but the negative correlation between pod number per plant and 1000-grain weight also needs to be considered.

关键词： Correlation Crambe abyssinica Path Analysis Regression Seed Yield Components

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危机之下董事会如何作为?

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董事会 2020年第4期 72-73页

作者： Jaap Winter Erik van de loo 不详

如果公司要在COVID-19大流行中生存下来,董事会以及非执行董事需要发挥协作作用、积极主动参与决策领导与高管情感支持COVID-19大流行正在以一种前所未有的规模对人类生产生活造成严重破坏。各国政府为了"拉平病例增长曲线"而采取的严... 详细信息

如果公司要在COVID-19大流行中生存下来,董事会以及非执行董事需要发挥协作作用、积极主动参与决策领导与高管情感支持COVID-19大流行正在以一种前所未有的规模对人类生产生活造成严重破坏。各国政府为了"拉平病例增长曲线"而采取的严厉措施引发了一场迅速而大规模的经济危机。公司必须不断适应快速变化的形势,做出相应计划安排,在大浪中求生。危机管理的大部分工作主要由高管来完成,但由于许多决定关系到公司的存亡,因此,董事会也应作为一个整体迅速深入相关讨论与决策。

关键词：非执行董事利益相关者情感支持

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Implementation of two high through-put techniques in a novel application:detecting point mutations in large EMS mutated plant populations

Implementation of two high through-put techniques in a novel...

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中国的遗传学研究——遗传学进步推动中国西部经济与社会发展——2011年中国遗传学会大会

作者： Antoine LF Gady Freddy WK Hermans Marion HBJ van de Wal Eibertus N van loo Richard GF Visser Christian WB Bachem Wageningen UR Plant BreedingWageningen University and Research CenterPO box 3866700 AJ Wageningen The Netherlands

Background:The establishment of mutant populations together with the strategies for targeted mutation detection has been applied successfully to a large number of organisms including many species in the plant *** efforts have been invested into research on tomato as a model for berry-fruit *** the progress of the tomato sequencing project,reverse genetics becomes an obvious and achievable goal.

关键词： EMS mutated plant mutation detection HRM CSCE

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结合MRI表型与肿瘤基因表达的乳腺癌放射基因组学分析

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国际医学放射学杂志 2020年第5期 613-614页

作者： T.Bismeijer B.H.M.van der Velden S.Canisius E.H.Lips C.E.loo M.A.Viergever 张一玮 Division of Molecular Carcinogenesis Oncode Institutethe Netherlands Cancer Institute

摘要更好地了解与MRI表型相关的分子生物学可能有助于乳腺癌的诊断和治疗。目的从基因表达数据中发现乳腺癌MRI表型与其潜在分子生物学之间的关系。材料与

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新辅助内分泌治疗前及治疗期间对侧乳腺MRI增强与术前内分泌预后指数的关系

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国际医学放射学杂志 2021年第1期44卷 123-123页

作者： M.A.A.Ragusi C.E.loo B.H.M.van der Velden J.Wesseling S.C.Linn R.G.Beets-Tan 陈丽华

摘要目的探讨ER+/HER2-乳腺癌病人新辅助内分泌治疗(NET)时MRI上对侧乳腺实质强化(CPE)与术前内分泌预后指数(PEPI)是否相关。方法这项回顾性观察性队列

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