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BEATING HEART ROBOTIC TECAB:WHEN IS IT A REALISTIC AIM?

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BEATING HEART ROBOTIC TECAB:WHEN IS IT A REALISTIC AIM?

中华医学会第七次全国胸心血管外科学术会议暨2007中华医学会胸心血管外科青年医师论坛

作者： Olivier Jegaden Thomas Sassard Aurélien Scalabre pascale Blanc Fadi Farhat Department of Cardiovascular surgery INSERM U886Claude Bernard UniversityLouis Pradel Hospital28 Avenue du Doyen Lepine69394 LYON-France.

*** closed chest off-pump coronary bypass is the less invasive concept in cardiac *** preliminary experience was analysed to assess the feasibility and efficacy of the technique according to coronary disease. *** a 2-year period,70 patients(61 males,mean age 58 years)underwent robotic coronary bypass grafting using da Vinci Robotic system:51 had one-vessel disease(1VD),16 had double-vessel disease(2VD)

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新书房“佳”具

新材料新装饰（完美居家） 2006年第2期 50-52页

作者：迪卡 pascale

最好的书房家具不会是既单调又乏味的，它一定拥有漂亮的外表、鲜明的风格，好看又好用。

关键词：还都

Pregnancy and Congenital Uterine Anomalies: Case Series

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Open Journal of Obstetrics and Gynecology 2023年第4期13卷 802-813页

作者： Ako Annabel Mangwi Akoh Simon Nji Mpono pascale Mendibi Sandrine Belinga Etienne Noa Ndoua Claude Cyrille Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon ANAKO Mother and Child Medical Center Yaoundé Cameroon Faculty of Health Sciences University of Buea Buea Cameroon Endoscopic Surgery and Human Reproductive Teaching Hospital Yaoundé Cameroon

Background: Congenital Uterine Anomalies are malformations of the Uterus which occur during embryonic life and result from the abnormal formation, fusion or resorption of the Mullerian ducts. Most of them are asymptomatic and diagnosis is done incidentally or during examinations performed for other purposes. We report three cases of women with pregnancies in malformed uteri. Aim: To depict the diagnostic challenges and therapeutic aspects of management of pregnancies in congenitally malformed Uteri. Case Presentation: The first case was a 22-year-old student who came to consult for a second opinion on the management of an ectopic pregnancy. A 2D Ultrasound done prior revealed an ectopic pregnancy but failed to specify its location in a rudimentary uterine horn. Management with a Multi-dose Methotrexate regimen was initiated but progress was not favorable. She came to us for a second opinion on management. Diagnostic laparoscopy was done and revealed an ectopic pregnancy in a rudimentary uterine horn. This was confirmed by histopathology. Management consisted of resection of the rudimentary horn and a right total salpingectomy. The second case was that of a woman who presented with spotting in early pregnancy. An Obstetric 2D ultrasound done revealed a bicornuate Uterus with a Gestational sac in one horn. She was placed on progesterone supplementation for 2 weeks, with regular antenatal contacts. She had an elective cesarean section at 39 weeks. Surgery revealed a complete Bicornuate Uterus. The post-operative period was uneventful with no complications. The third case was that of a woman with a past history of five successive spontaneous abortions, who presented with spotting at about 8 weeks of gestation. An Obstetric Ultrasound done revealed a Bicornuate Uterus and an embryo in one cornus. She was admitted, given her poor obstetric history, for about 14 days and placed on progesterone supplementation till 20 weeks of gestation. Antenatal contacts were regular and

关键词： Congenital Uterine Anomalies Diagnosis Pregnancy Management

Orbital angular momentum based intra- and interparticle entangled states generated via a quantum dot source

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先进光子学(英文) 2023年第4期5卷 74-84页

作者： Alessia Suprano Danilo Zia Mathias Pont Taira Giordani Giovanni Rodari Mauro Valeri Bruno Piccirillo Gonzalo Carvacho Nicolo Spagnolo pascale Senellart Lorenzo Marrucci Fabio Sciarrino Sapienza Universitàdi Roma Dipartimento di FisicaRomaItaly Universite Paris-Saclay UMR 9001Centre for Nanosciences and NanotechnologyCNRSPalaiseauFrance Universitàdi Napoli Federico II Complesso Universitario di Monte Sant’AngeloDipartimento di Fisica“Ettore Pancini”NapoliItaly INFN-Sezione di Napoli NapoliItaly

Engineering single-photon states endowed with orbital angular momentum (OAM) is a powerful toolfor quantum information photonic implementations. Indeed, due to its unbounded nature, OAM is suitable forencoding qudits, allowing a single carrier to transport a large amount of information. Most of the experimentalplatforms employ spontaneous parametric down-conversion processes to generate single photons, evenif this approach is intrinsically probabilistic, leading to scalability issues for an increasing number of *** quantum dots (QDs) have been used to get over these limitations by producing on-demand pure and indistinguishable single-photon states, although only recently they have been exploitedto create OAM modes. Our work employs a bright QD single-photon source to generate a complete set ofquantum states for information processing with OAM-endowed photons. We first study hybrid intraparticleentanglement between OAM and polarization degrees of freedom of a single photon whose preparationwas certified by means of Hong–Ou–Mandel visibility. Then, we investigate hybrid interparticle OAM-based entanglement by exploiting a probabilistic entangling gate. The performance of our approach isassessed by performing quantum state tomography and violating Bell inequalities. Our results pave theway for the use of deterministic sources for the on-demand generation of photonic high-dimensionalquantum states.

关键词： orbital angular momentum quantum dot intraparticle entanglement interparticle entanglement Bell violation

Predictive Factors of Intracranial Response of Immune Checkpoint Inhibitors in Patients with Brain Metastasis from Non-Small Cell Lung Cancer

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Journal of Cancer Therapy 2019年第8期10卷 692-707页

作者： Julien Bermudez Celine Mascaux Youssef Trigui Julie Biemar Mohamed Boucekine Laurent Greillier Fabrice Barlesi pascale Tomasini Assistance Publique Hopitaux de Marseille Department of Multidisciplinary Oncology and Therapeutic Innovations Aix Marseille University Marseille France Assistance Publique Hopitaux de Marseille Department of Multidisciplinary Oncology and Therapeutic Innovations Aix Mar-seille University Marseille France Centre de Recherche en Cancérologie de Marseille (CRCM) Marseille France Public Health Chronic Diseases and Quality of Life: Research Unit Aix Marseille University Marseille France

Background: Immune checkpoint inhibitors (ICI)s were recently approved for the treatment of advanced non-small cell lung cancer (NSCLC). Whereas brain metastases (BM) are frequent in NSCLC patients, data are missing regarding ICIs intracranial efficacy and tolerance in patients with BM from NSCLC. Methods: This retrospective study was performed in the Multidisciplinary Oncology and Therapeutic Innovation department, Marseille, France between April 2013 and February 2016. Data from patients with NSCLC with at least one BM, and treated with ICIs (anti-PD1, anti-PDL1 or anti-CTL4) were analyzed. Clinical, biological data and outcomes were retrieved from electronic patients’ records. We assessed ICIs intracranial efficacy and tolerance. Results: Data from 55 patients were analyzed. Objective Response Rate (ORR) and Disease Control Rate (DCR) were respectively of 1.8 and 36.4%. Median overall survival was 17.2 months and median progression free survival was 2.9 months. Intracranial ORR (icORR) and intracranial DCR (icDCR) were respectively 16.4% and 45.5%. Both were independent of smoking status, intracranial treatment, performance status, pathology, molecular profile and the presence or number of BM at diagnosis. However, there was a trend towards an association between icORR and ECOG PS (p = 0.05), tobacco status (p = 0.057) and intracranial treatment. Adverse events were seen in 38.2% patients without identified predictive factor. Neurological symptoms appeared in 5.5% patients during immunotherapy and improved in 3.63% patients. Conclusions: ICIs can be used safely on patients with BM from NSCLC. However, intracranial response is heterogeneous in such patients and we showed ECOG PS, tobacco smoking and intracranial treatment to be associated with an improved icORR. This is the first study looking for predictive factors of intracranial response of ICIs in patients with BM from NSCLC.

关键词： Lung Cancer Brain Metastasis Immunotherapy Efficacy Tolerance

High Plasma Concentrations of Sclerostin, an Inhibitor of the Wnt Signaling Pathway, in Young Horses Affected by Osteochondrosis

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Open Journal of Orthopedics 2014年第12期4卷 335-342页

作者： Didier Serteyn Luis Mendoza Charlotte Sandersen Isabelle Caudron David Piquemal pascale Chavatte-Palmer Jean-Philippe Lejeune Equine Clinic University of Liege Liege Belgium Equine Research and Development Center Mont-le-Soie Belgium Center of Oxygen Research and Development University of Liege Liege Belgium Computational Biology Institut (IBC) Montpellier France Acobiom Montpellier France INRA URM1198 Biologie du Développement et Reproduction F-78350 Jouy en Josas Paris France

Osteochondrosis (OC) is a developmental disease in horses with a significant impact on the horse’s welfare and performance. The early disturbance of enchondral ossification progresses to inflammatory and healing process in older horses. Metabolic pathway analysis showed an obvious dysregulation of several signaling pathways related to cartilage formation and cartilage repair such as Wnt/β-catenin, Indian hedgehog and TGF-β signaling pathways. Other regulated genes appeared to be involved in high carbohydrate diet, abnormal insulin metabolism or inflammation. Sclerostin is an osteocyte-secreted soluble antagonist of the Wnt/β-catenin signaling pathway. It is crucial for osteoblast development and activity and is increased in naturally occurring lesions of equine osteochondrosis. The aim of this study is to compare the circulating sclerostin levels between OC-affected (n = 20) and healthy horses (n = 19). A significant linear regression between plasma sclerostin and age is observed especially in the healthy young horses. The mean plasma sclerostin concentration is significantly higher in young horses suffering from osteochondrosis compared to the control horses. These results reinforce the possible role of the Wnt/β-catenin signaling pathway in the OC pathogeny. The inhibition of this essential pathway could disturb the osteo-chondral differentiation. More studies are currently needed to define the eventual clinic interest of plasma sclerostin as future biomarker in bone and cartilage diseases.

关键词： Sclerostin Osteochondrosis Wnt/β-Catenin Pathway Horse Equine Osteochondrosis

Conformational States of AChBP revealed by X-ray crystal Structures of bound nAChR Agonists. Antagonists and Non- competitive ligands.

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Conformational States of AChBP revealed by X-ray crystal Str...

第十五届国际药理学大会

作者： Hansen Scott Sulzenbacher Gerlind Huxford Tom Marchot pascale Bourne Yves Taylor Palmer Dept of Pharmacology UCSD CNRS Marseille Dept of Chemistry and Biochemistry UCSD CNRS Marseille CNRS Marseille Dept of Pharmacology UCSD

＜正＞ We use the acetylcholine binding protein （AChBP） from mollusks as a soluble surrogate for the extracellular ligand binding domain of nicotinic acetylcholine receptors （ nAChR）. Ligand binding in the nAChR extracellular domain induces conformational states that allosterically open an ion channel. nAChR states have not been studied at atomic resolution. We have solved X- ray crystal structures of receptor agonists, antagonists and non- competitive ligand bound to AChBP. These structures reveal large conformation changes in the ligand binding pocket and distinct interface binding surfaces. Conformational changes in loop C reveal a general mechanism for agonism and partial agonism. X- ray structures of noncompetitivereceptor ligands galanthamine. cocaine, and thienyl - cylohexylpiperidine（TCP） in complex with AChBP reveal valuable information for accurately describing non- competitive receptor modulation. A crystal structure of apo AChBP is presented and compared to that of bound agonists, lobeline and epibatidine. and antagonists, alpha-conotoxin Iml and methyllycaconitine.

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细菌中的独行侠

生物技术世界 2010年第2期7卷 55-57页

作者： pascale Cossart（编译）洪浩舟

它在细胞质中穿棱留下一条长长的聚合肌动蛋白尾巴，变化一下RNA结构便能激活大量的毒力因子？并将RNA转录物的密码子隐藏在错误的DNA链上，利斯塔氏菌谱写着自己的生存法则。

关键词：细菌肌动蛋白毒力因子 DNA链 RNA 细胞质密码子转录物

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药物的分配技术：设计、使用与安全

气雾剂通讯 2012年第4期 17-20页

作者： pascale Gauthier 金安琪(译)

概述现如今，设计在我们的日常生活中几乎无所不在。合理的设计能让药物更准确地为患者使用。兼备技术与效率的药物分配技术将令药物的使用更为安全：保证药物分析实验的准确性和可重复性．提高配方的存储安全性。本文将提到各种药品规... 详细信息

概述现如今，设计在我们的日常生活中几乎无所不在。合理的设计能让药物更准确地为患者使用。兼备技术与效率的药物分配技术将令药物的使用更为安全：保证药物分析实验的准确性和可重复性．提高配方的存储安全性。本文将提到各种药品规格的演化，并对新配方的未来前景做出展望。

关键词：安全性药物设计技术分配可重复性分析实验新配方