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Long-term results of subtotal colectomy with cecorectal anastomosis for isolated colonic inertia

World Journal of Gastroenterology 2007年第18期13卷 2590-2595页

作者： Antonio Iannelli Thierry Piche Raffaella Dainese pascal Fabiani Albert Tran Jean Mouiel Jean Gugenheim Service de Chirurgie Digestive-Université de Nice-Sophia-Antipolis Faculté de Médecine Nice F-06107 France & Centre Hospitalier Universitaire de Nice Ple Digestif Nice F-06107 France Service de Gastroentérologie-Université de Nice-Sophia-Antipolis Faculté de Médecine Nice F-06107 France & Centre Hospitalier Universitaire de Nice Ple Digestif Nice F-06107 France Inserm U526 Nice F-06107 France Service de Gastroentérologie-Université de Nice-Sophia-Antipolis Faculté de Médecine Nice F-06107 France & Centre Hospitalier Universitaire de Nice Ple Digestif Nice F-06107 France

AIM： To evaluate the results of sub total colectomy withI cecorectal anastomosis （STC-CRA） for isolated colonicinertia （CI）. METHODS： Fourteen patients （mean age 57.5±16.5 year） underwent surgery for isolated CI between January 1986 and December 2002. The mean frequency of bowel motions with the aid of laxatives was 1.2±0.6 per week. All subjects underwent colonoscopy, anorectal manometry, cinedefaecography and colonic transit time （CTF）. CI was defined as diffuse markers delay on CTF without evidence of pelvic floor dysfunction. All patients underwent STC-CRA. Long-term follow-up was obtained prospectively by clinical visits between October 2005 and February 2006 at a mean of 10.5 ＋ 3.6 years （range 5-16 years） during which we considered the number of stool emissions, the presence of abdominal pain or digitations, the use of pain killers, laxatives and/or fibers. Patients were also asked if they were satisfied with the surgery. RESULTS： There was no postoperative mortality Postoperative complications occurred in 21.4% （3/14）. At the end of follow-up, bowel frequency was significantly （P〈0.05）increased to a mean of 4.8±7.5 per day （range 1-30）. One patient reported disabling diarrhea. Two patients used laxatives less than three times per month without complaining of what they called constipation Overall, 78.5% of patients would have chosen surgery again if necessary. CONCLUSION： STC-CRA is feasible and safe in patients with CI achieving 79% of success at a mean follow-up of 10.5 years. A prospective controlled evaluation is warranted to verify the advantages of this surgical approach in patients with CI.

关键词： Constipation Colonic inertia Surgery Subtotal colectomy Cecorectal anastomosis

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X-ray-induced radiophotodynamic therapy （RPDT） using lanthanide micelles： Beyond depth limitations

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Nano Research 2015年第7期8卷 2373-2379页

作者： Slavka Kascakova Alexandre Giuliani Sara Lacerda Agnes Pallier pascal Mercere eva Toth Matthieu Refregiers Synchrotron SOLEIL L'Orme des Merisiers 91190 Gif-sur-Yvette France Universite Paris-Sud XI UMR-S I 193 94800 Villejuif France INRA UAR 1008 Caracterisation et elaboration des Produits Issus de I'Agriculture 44316 Nantes France Centre de Biophysique Moleculaire CNRS Rue Charles Sadron 45071 Orleans Cedex 2 France

We report lanthanide-based micelles integrating hypericin （Hyp） for X-ray- triggered photodynamic therapy （PDT）. The lanthanide luminescence induced by X-ray irradiation excites the photosensitizer, which leads to the generation of singlet oxygen. This versatile approach can be extended to other photosensitizers or other types of liponanoparticles and can allow for magnetic resonance imaging （MRI） guidance.

关键词： photodynamic therapy liponanoparticles,x-ray deep tumour photosensitizer

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Nonlinear profile order for three-dimensional hybrid radial acquisition applied to self-gated free-breathing cardiac cine MRI

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Chinese Physics B 2017年第1期26卷 568-573页

作者： Yanchun Zhu pascal Spincemaille Jing Liu Shuo Li Thanh D Nguyen Martin R Prince Yaoqin Xie Yi Wang Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China Department of Radiology Weill Cornell Medical College New York 10021 United States

This paper presents a nonlinear profile order scheme for three-dimensional（3D） hybrid radial acquisition applied to self-gated, free-breathing cardiac cine magnetic resonance imaging（MRI）. In self-gated, free-breathing cardiac cine MRI,respiratory and cardiac motions are unpredictable during acquisition, especially for retrospective reconstruction. Therefore,the non-uniformity of the k-space distribution is an issue of great concern during retrospective self-gated reconstruction. A nonlinear profile order with varying azimuthal increments was provided and compared with the existing golden ratio-based profile order. Optimal parameter values for the nonlinear formula were chosen based on simulations. The two profile orders were compared in terms of the k-space distribution and phantom and human image results. An approximately uniform distribution was obtained based on the nonlinear profile order for persons with various heart rates and breathing *** nonlinear profile order provides more stable profile distributions and fewer streaking artifacts in phantom images. In a comparison of human cardiac cine images, the nonlinear profile order provided results comparable to those provided by the golden ratio-based profile order, and the images were suitable for diagnosis. In conclusion, the nonlinear profile order scheme was demonstrated to be insensitive to various motion patterns and more useful for retrospective reconstruction.

关键词： nonlinear profile order hybrid radial self-gating cardiac cine MRI

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Computational neuroanatomy and co-expression of genes in the adult mouse brain, analysis tools for the Allen Brain Atlas

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Frontiers of Electrical and Electronic Engineering in China 2013年第1期8卷 91-100页

作者： pascal Grange Michael Hawrylycz Partha P. Mitra Cold Spring Harbor Laboratory Cold Spring Harbor New York NY 11724 USA Allen Institute for Brain Science Washington WA 98103 USA

We review quantitative methods and software developed to analyze genome-scale, brain-wide spatiallymapped gene-expression data. We expose new methods based on the underlying high-dimensional geometry of voxel space and gene space, and on simulations of the distribution of co-expression networks of a given size. We apply them to the Allen Atlas of the adult mouse brain, and to the co- expression network of a set of genes related to nicotine addiction retrieved from the NicSNP database. The computational methods are implemented in BrainGeneExpressionAnalysis （BGEA）, a Matlab toolbox available for download.

关键词： Adult Mouse Brain Allen Brain Allen Brain Atlas Expression Energy Voxel Space

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Effect of crosslinking by microbial transglutaminase of gelatin films on lysozyme kinetics of release in food simulants

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Food Bioscience 2022年第4期48卷 541-550页

作者： Moslem Sabaghi Catherine Joly Isabelle Adt Keziban Ozturk Amandine Cottaz pascal Degraeve Department of Food Science and Technology Gorgan University of Agricultural and Natural ResourcesGorganIran Univ Lyon Universit´e Claude Bernard Lyon 1ISARA LyonBioDyMIA Research UnitTechnopole Alimentec155 rue Henri de BoissieuF-01000Bourg en BresseFrance

The effect of enzymatic crosslinking by microbial transglutaminase on the physico-chemical properties of gelatin-based films incorporated with lysozyme were *** in the crosslinking degree of gelatin with microbial transglutaminase concentration in film-forming suspensions was correlated with a decrease of films ***,the enhancement in crosslinking resulted in a decrease of the solubility in water,as well as of the extent of swelling degree,and of the water vapor permeability of films and in an increase of films tensile *** kinetics of release at 4◦C of lysozyme from control non-reticulated films and reticulated films to either sodium acetate buffer,or 2%(w/v)agar gels in direct contact were ***,the kinetics of release of lysozyme were always slower from crosslinked films than from control *** difference was higher for lysozyme release to agar gels,which was dominated by Fickian *** crosslinking by microbial transglutaminase of gelatin-based films incorporated with lysozyme can thus effectively control the release of this food preservative.

关键词： Gelatin-based films Enzymatic crosslinking Microbial transglutaminase Lysozyme Controlled release

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Melt pool monitoring in laser beam melting with two-wavelength holographic imaging

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Light(Advanced Manufacturing) 2022年第1期3卷 154-165页

作者： Matthieu Piniard Beatrice Sorrente Gilles Hug pascal Picart DOTA ONERAUniversitéParis Saclay91123 PalaiseauFrance Laboratoire d’Étude des Microstructures ONERA-CNRSUMR 10429 Avenue de la Division Leclerc92320 ChâtillonFrance Laboratoire d’Acoustique de l’Universitédu Mans CNRS 6613Institut d’Acoustique-Graduate School(IAGS)Le Mans UniversitéAvenue Olivier Messiaen72085 Le MansFrance

Over the past two decades, laser beam melting has emerged as the leading metal additive manufacturing process for producing small- and medium-size structures. However, a key obstacle for the application of this technique in industry is the lack of reliability and qualification mainly because of melt pool instabilities during the laser-powder interaction, which degrade the quality of the manufactured components. In this paper, we propose multi- wavelength digital holography as a proof of concept for in situ real-time investigation of the melt pool morphology. A two-wavelength digital holographic setup was co-axially implemented in a laser beam melting facility. The solidified aluminum tracks and melt pools during the manufacturing of 316L were obtained with full- field one-shot acquisitions at short exposure times and various scanning velocities. The evaluation of the complex coherence factor of digital holograms allowed the quality assessment of the phase reconstruction. The motion blur was analyzed by scanning the dynamic melt pool.

关键词： Laser beam melting Optical diagnostic Digital holography Multi-wavelength holography

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Post-orogenic transients and relict landforms of the Bafoussam–Mamfe region(West-Cameroon Highland margin)

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Journal of Mountain Science 2022年第8期19卷 2180-2201页

作者： pascal Landry WABO DEFO Sébastien OWONA Moussa NSANGOU NGAPNA Christian BALLA ATEBA Christian MWABANUA MUTABI The University of Douala Faculty of ScienceDepartment of Earth SciencesDouala 24157Cameroon The University of Lubumbashi Faculty of ScienceDepartment of GeologyLubumbashi 1825Democratic Republic of Congo

The Bafoussam-Mamfe Region(BMR)belongs to the Western Cameroon Highland margin,an amalgam of transient landscape that evolved from the interactions between tectonics,lithology and climate *** area is tectonically active and shows differential tectonic uplift,contrasting relief,variations in erosion rates,in river incision,and in channel *** order to appraise the BMR tectono-geomorphic evolution,it is essential to understand relationships between internal and external processes and their geomorphic expression at a river basin *** this purpose,we use drainage texture(Dt),stream frequency(Fs),drainage density(Dd),asymmetry factor(AF),the transverse topographic symmetry factor(TTSF),the mean of mountain front sinuosity per unit(Smf),concavity factor(Cf),hypsometry integral(HI)and streamlength gradient index(SL-index)based on 30 m Digital Elevation Models(DEM)and field *** results reveal considerable variations in geology,relief,topography and geomorphic indices values differentiated into three geomorphic units;the Mamfe unit developed on the Mamfe Cretaceous basin,the Nguti and Bafoussam high plateau units build up on the Precambrian granito-gneissic basement overlaid by a volcanic *** stepped(longitudinal and normalized)river profiles and complex hypsometric curves show the lithostructural control of the hydrographic ***(from~1.21 to~4.59),Fs(from~0.26 to~1.91),Dd(from~0.66 to~1.71)geomorphic indice values indicate a part of lithologic control on this morphology while the AF(from~1.16to~24.91),TTSF(from~0.20 to~0.71),Smf(U2=1.11 and U3=1.19),Cf(from~-20.91 to~78.93),HI(from~0.12 to~0.52)and SL-index designate the active tectonics as the main factor that had controlled the morphology of this same *** results pinpoint the combined post-Pan-African to Recent tectonic features,lithologic heterogeneities and the differential erosion processes as main factors that have controlled the BMR *** results highlight how

关键词： Geomorphic indices Tectonic,Lithology Differential erosion Bafoussam-Mamfe Cameroon

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Identification of adrafinil and its main metabolite modafinil in human ***-administration study and interpretation of an authentic case

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Forensic Sciences Research 2020年第4期5卷 322-326页

作者： Alice Ameline Laurie Gheddar Jean-Sébastien Raul pascal Kintz Institut de Médecine Légale Laboratoire de toxicologieStrasbourgFrance X-Pertise Consulting Département de toxicologieMittelhausbergenFrance

For several years,the misuse of stimulant substances is increasingly observed both in the field of sport,to improve the functions of the body and therefore to be more performant,and also by non-athletes to make life more tolerable on a daily ***,2-((diphenylmethyl)sulfinyl)-N-hydroxyacetamide,is a drug designed for the treatment of narcolepsy by promoting an awakened state,and to treat alertness and neurological symptoms in the *** is primarily metabolized in vivo to an active form,***,2-((diphenylmethyl)sulfinyl)*** World Anti-Doping Agency(WADA)banned these two drugs in sports in *** authors report an authentic case involving adrafinil and *** laboratory was requested to test for adrafinil in a hair strand collected from a woman found in posses-sion of vials of adrafinil and suspected of trafficking.A specific method was developed by liquid chromatography tandem mass spectrometry(LC-MS/MS).Unlike modafinil(varying from 6.8 to 13.9ng/mg),adrafinil was not identified in the *** interpretation of the results was difficult because this is the first case describing human hair *** order to be able to interpret the results,a self-administration study was conducted after an oral administration to a volunteer(200 mg)whose beard hair was collected 10days after *** analysis of this specimen highlighted the presence of adrafinil at 0.8ng/mg and modafinil at 0.5 ng/*** results demonstrate the dual identification of both compounds after a single consumption,even after administration of a low *** to these results,the analysis of the hair strand from the authentic case does not match with a con-sumption of adrafinil,in accordance with abuse of modafinil *** considered that this was a trafficking case of adrafinil,with no self-consumption.

关键词： Forensic sciences forensic toxicology adrafinil modafinil human hair UPLC-MS/MS stimulants

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Epidemiology of the outbreak,vectors and reservoirs of cutaneous leishmaniasis in Mali:A systematic review and meta-analysis

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Asian Pacific Journal of Tropical Medicine 2016年第10期9卷 963-968页

作者： Abdoulaye Kassoum Kone Doumbo Safiatou Niare Mahamadou Ali Thera Kassoum Kayentao Abdoulaye Djimde pascal Delaunay Bourema Kouriba pascal del Giudice Arezki Izri Pierre Marty Ogobara K Doumbo Malaria Research and Training Center Department of Epidemiology of Parasitic Diseases/Faculty of Medicineand Dentistry/ UMI-3189/University of ScienceTechnique and Technology of BamakoBP 1805BamakoMali Inserm U1065 Centre Mediterraneen de Medecine MoleculaireC3MUniversite de Nice-Sophia Antipolis151route St Antoine de GinestiereBP2319406204 Nice CedexFrance AND Parasitologie-MycologieHopital de l'ArchetCentre Hospitalier Universitaier de NiceFrance Unit of Infectious et Tropical Diseases Hospital Bonnet 83700 FrejusFrance Parasitology-Mycology Hospital AvicenneParis 13 UniversityUMR 190Aix-Marseille UniversityFrance

Objective: To compile available data and to estimate the burden, characteristics and risks factors of cutaneous leishmaniasis(CL) in Mali. Methods: Articles in English and French were searched in Hinari, Google scholar and PubM ed. Unpublished studies were identified by searching in ***. Terms used were Cutaneous leishmaniasis Mali; Leishmaniasis Mali, Leishmania major Mali; or Phlebotomus Mali or Sergentomyia Mali. We select descriptive studies on CL and sandflies in Mali. Data were extracted and checked by the author, then analyzed by region, by study population and type of biological tests, meta-analysis approach with STATA software was used. Results: Nineteen published(n=19) and three unpublished were included. CL epidemiology was characterized by occurrence of clinical cases in different areas of Mali, outbreaks restricted to known areas of transmission and isolated cases diagnosed in travelers. In endemic areas, population at risk are young age persons, farmers, ranchers, housewives, teachers and military personnel. The annual incidence ranged from 290 to 580 cases of CL. Leishmania major is the main species encountered throughout the country(North Savanna, Sahel and Sub-Saharan areas), and Phlebotomus duboscqi has been identified as the vector and Sergentomyia(Spelaeomyia)darlingi as possible vector. The overall estimated prevalence of positive LST(Leishmanin Skin Test) was 22.1%. The overall frequency of CL disease among suspected cases was 40.3%. Conclusions: Although descriptive, hospital-based and cross-sectional studies are robust enough to determine the extent of CL in Mali; future well-designed eco-epidemiological studies at a nationwide scale are needed to fully characterize CL epidemiology and risk factors in Mali.

关键词： Epidemiology Leishmaniasis Cutaneous Risk Factors Vectors Reservoirs Mali

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Fast, green microwave-assisted synthesis of single crystalline Sb_2Se_3 nanowires towards promising lithium storage

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Journal of Energy Chemistry 2019年第3期28卷 27-33页

作者： Wen Luo Jean-Jacques Gaumet Pierre Magri Sébastien Diliberto Feng Li pascal Franchetti Jaafar Ghanbaja Liqiang Mai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Laboratoire de Chimie et Physique: Approche Multi-échelles des Milieux Complexes Institut Jean Barriol Université de Lorraine Institut Jean Lamour UMR CNRS 7198 Université de Lorraine Campus Artem

In this work, a fast(0.5 h), green microwave-assisted synthesis of single crystalline Sb_2Se_3 nanowires was developed. For the first time we demonstrated a facile solvent-mediated process, whereby intriguing nanostructures including antimony selenide(Sb_2Se_3) nanowires and selenium(Se) microrods can be achieved by merely varying the volume ratio of ethylene glycol(EG) and H_2O free from expensive chemical and additional surfactant. The achieved uniform Sb_2Se_3 nanowire is single crystalline along [001]growth direction with a diameter of 100 nm and a length up to tens of micrometers. When evaluated as an anode of lithium-ion battery, Sb_2Se_3 nanowire can deliver a high reversible capacity of 650.2 m Ah g^(-1) at 100 mA g^(-1) and a capacity retention of 63.8% after long-term 1000 cycles at 1000 mA g^(-1), as well as superior rate capability(389.5 m Ah g^(-1) at 2000 mA g^(-1)). This easy solvent-mediated microwave synthesis approach exhibits its great universe and importance towards the fabrication of high-performance metal chalcogenide electrode materials for future low-cost, large-scale energy storage systems.

关键词： Microwave synthesis Sb2Se3 nanowires Solvent-mediated process Lithium-ion battery High-performance anode

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