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Frontiers of Optoelectronics 2016年第3期9卷 341-345页

作者： Michael J. CONNELLY Lukasz KRZCZANOWICZ pascal morel Ammar SHARAIHA Francois LELARGE Romain BRENOT Siddharth JOSHI Sophie BARBET Optical Communications Research Group Department of Electronic and Computer Engineering University of Limerick Limerick Ireland Lab-STICC UMR CNRS 6285 Ecole Nationale d'Ingenieurs de Brest CS 73862 29238 Brest Cedex 3 France Alcatel Thales III-V Laboratory Route Departementale 128 91767 Palaiseau France

Differential quadrature phase shift keying （DQPSK） modulation is attractive in high-speed optical communications because of its resistance to fiber non-linearities and more efficient use of fiber bandwidth compared to conventional intensity modulation schemes. Because of its wavelength conversion ability and phase preservation, semiconductor optical amplifier （SOA） four- wave mixing （FWM） has attracted much attention. We experimentally study wavelength conversion of 40 Gbit/s （20 Gbaud） non-return-to-zero （NRZ）-DQPSK data using FWM in a quantum dash SOA with 20 dB gain and 5 dBm output saturation power. Q factor improvement and eye diagram reshaping is shown for up to 3 nm pump-probe detuning and is superior to that reported for a higher gain bulk SOA.

关键词： differential quadrature phase shift keying (DQPSK) phase modulation quantum-dash semiconductor optical amplifier (SOA) four-wave mixing (FWM) wavelength conversion

Segmental duodenectomy for gastrointestinal stromal tumor of the duodenum

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World Journal of Gastroenterology 2010年第22期16卷 2788-2792页

作者： Nicolas Christian Buchs pascal Bucher pascal Gervaz Sandrine Ostermann Franois Pugin Philippe morel Department of Surgery University Hospital Geneva

AIM: To evaluate the results of segmental duodenectomy (SD) and pancreaticoduodenectomy (PD) for duodenal gastrointestinal stromal tumor (GIST) and help clinicians with surgical management. METHODS: All patients who underwent surgery for non-metastatic GIST of the duodenum in a single institution since 2000 were prospectively followed up. Seven patients (median age 51 years, range: 41-73 years) were enrolled: five underwent SD and two underwent PD. RESULTS: All the patients had a complete resection (R0), with no postoperative morbidity and mortality. Among the SD group, GIST was classified as low risk in two patients, intermediate risk in two, and high risk in one, according to the Fletcher scale, (vs two high risk patients in the PD group). With a median followup of 41 (18-85) mo, disease-free survival (DFS) rateswere 100% after SD and 0% after PD (P < 0.05). The median DFS was 13 mo in the PD group. CONCLUSION: Whenever associated with clear surgical margins, SD is a reliable and curative option for most duodenal GISTs, and is compatible with longterm DFS.

关键词： Gastrointestinal stromal tumor Duodenal neoplasms Segmental duodenectomy Pancreaticoduodenectomy

Squamous cell carcinoma of the anus-an opportunistic cancer in HIV-positive male homosexuals

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World Journal of Gastroenterology 2011年第25期17卷 2987-2991页

作者： pascal Gervaz Alexandra Calmy Ymer Durmishi Abdelkarim S Allal Philippe morel Department of Surgery Geneva University Hospital and Medical School Departments of Infectious Diseases Geneva University Hospital and Medical School Department of Radiation Oncology Hopital Cantonal de Fribourg

Squamous cell carcinoma of the anus （SCCA） is a com- mon cancer in the human immunodeficiency virus （HIV）- infected population, and its incidence continues to in- crease in male homosexuals. Combined chemoradiation with mitomycin C and 5-fiuorouracil was poorly tolerated by severely immunocompromised patients in the early 1990s. In the era of highly active antiretroviral therapy （HAART）, however, recent data indicate that：（1） most HIV patients with anal cancer can tolerate standard chemotherapy regimens; and （2） this approach is associ- ated with survival rates similar to those of HIV-negative patients. However, HIV-positive patients with SCCA are much younger, more likely to develop local tumor recur- rence, and ultimately die from anal cancer than immune competent patients. Taken together, these findings suggest that anal cancer is an often fatal neoplasia in mid- dle-aged HIV-positive male homosexuals. In this popula- tion, SCCA is an opportunistic disease resulting in patients with suboptimal immune function from persistent infection and prolonged exposition to oncogenic human papillomaviruses （HPVs）. Large-scale cancer-prevention strategies （routine anuscopy and anal papanicolaou test- ing） should be implemented in this population. In addi- tion, definitive eradication of oncogenic HPVs within the anogenital mucosa of high-risk individuals might require a proactive approach with repeated vaccination.

关键词： Anal cancer Chemoradiation Highly activeantiretroviral therapy Human immunodeficiency virus Human papillomaviruse Outcome

Natural history of uncomplicated sigmoid diverticulitis

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World Journal of Gastrointestinal Surgery 2015年第11期7卷 313-318页

作者： Nicolas C Buchs Neil J Mortensen Frederic Ris Philippe morel pascal Gervaz Department of Colorectal Surgery Oxford University Hospitals Division of Visceral and Transplantation Surgery Department of Surgery Faculty of Medicine University Hospitals of Geneva

While diverticular disease is extremely common, the natural history(NH) of its most frequent presentation(i.e., sigmoid diverticulitis) is poorly investigated. Relevant information is mostly restricted to populationbased or retrospective studies. This comprehensive review aimed to evaluate the NH of simple sigmoid diverticulitis. While there is a clear lack of uniformity in terminology, which results in difficulties interpreting and comparing findings between studies, this review demonstrates the benign nature of simple sigmoid diverticulitis. The overall recurrence rate is relatively low, ranging from 13% to 47%, depending on the definition used by the authors. Among different risk factors for recurrence, patients with C-reactive protein > 240 mg/L are three times more likely to recur. Other risk factors include: Young age, a history of several episodes of acute diverticulitis, medical vs surgical management, male patients, radiological signs of complicated first episode, higher comorbidity index, family history of diverticulitis, and length of involved colon > 5 cm. The risk of developing a complicated second episode(and its corollary to require an emergency operation) is less than 2%-5%. In fact, the old rationale for elective surgery as a preventive treatment, based mainly on concerns that recurrence would result in a progressively increased risk of sepsis or the need for a colostomy, is not upheld by the current evidence.

关键词： Diverticulitis Colon Cohort Recurrence Natural his

Perforated duodenal diverticulum, a rare complication of a common pathology: A seven-patient case series

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World Journal of Gastrointestinal Surgery 2013年第3期5卷 47-50页

作者： Andrea Rossetti Nicolas Christian Buchs pascal Bucher Stephane Dominguez Philippe morel Division of Visceral Surgery and Transplantation Department of Surgery University Hospital of Geneva Clinic for Visceral and Vascular Surgery

Duodenal diverticula (DD) are frequently encountered and are usually asymptomatic, with an incidence at autopsy of 22%. Perforation of DD is a rare complication (around 160 cases reported) with potentially dramatic consequences. However, little evidence regarding its treatment is available in the literature. The aim of this study was to review our experience of perforated DD, with a focus on surgical management. Between January 2001 and June 2011, all perforated DD were retrospectively reviewed at a single centre. Seven cases (5 women and 2 men; median age: 72.4 years old, rang: 48-91 years) were found. The median American Society of Anesthesiologists' score in this population was 3 (range: 3-4). The perforation was located in the second portion of duodenum (D2) in six patients and in the third portion (D3) in one patient. Six of these patients were treated surgically: five patients underwent DD resection with direct closure and one was treated by surgical drainage and laparostomy. One patient was treated conservatively. One patient died and one patient presented a leak that was successfully treated conservatively. The median hospital stay was 21.1 d (range: 15-30 d). Perforated DD is an uncommon presentation of a common pathology. Diverticular excision with direct closure seems to offer the best chance of survival and was associated with a low morbidity, even in fragile patients.

关键词： Duodenal perforation Duodenum Duodenal diverticulum Surgical management

An integrated approach for increasing breeding efficiency in apple and peach in Europe

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Horticulture Research 2018年第1期5卷 825-838页

作者： Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg IRHS INRAAgrocampus-OuestUniversitéd’AngersSFR 4207 QuaSaVUniversitéBretagne Loire42 rue Georges MorelBeaucouzé49071France IRTA(Institut de Recerca i Tecnologia Agroalimentàries) BarcelonaSpain Centre for Research in Agricultural Genomics(CRAG)CSIC-IRTA-UAB-UB Campus UABBellaterraBarcelonaSpain Universitàdegli Studi di Milano-DiSAA Via Celoria 2Milan20133Italy Biometris Wageningen University and ResearchDroevendaalsesteeg 1Wageningen6708PBThe Netherlands IRTA-Mas Badia Mas BadiaLa Tallada17134Spain Parco Tecnologico Padano Via EinsteinLoc.Cascina CodazzaLodi26900Italy Dipartimento di Scienze Agrarie Alma Mater Studiorum-Universitàdi BolognaBolognaItaly UMR AGAP INRAMontpellier34398France GAFL INRAMontfavet84143France Agroscope Research Division Plant BreedingSchloss 1Wädenswil8820Switzerland Julius Kühn-Institute(JKI) Federal Research Centre for Cultivated Plants Institute for Breeding Research on Fruit CropsPillnitzer Platz 3aDresden01326Germany Research and Innovation Center Fondazione Edmund MachSan Michele all’AdigeTrentoItaly CREA-VE Center of Viticulture and Enologyvia XXVIII Aprile 26Conegliano(TV)31015Italy Plant Breeding Wageningen University and ResearchDroevendaalsesteeg 1P.O.Box 386Wageningen6700AJThe Netherlands Hendrix Genetics Research Technology&ServicesBoxmeer5830 ACThe Netherlands

Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and *** bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private *** complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for *** breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank *** also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection *** FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the *** review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond.

关键词： breeding germplasm breed