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Bioreactivity of Stent Material: <i>In Vitro</i>Impact of New Twinning-Induced Plasticity Steel on Platelet Activation

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j.urnal of Biomaterials and Nanobiotechnology 2019年第4期10卷 175-189页

作者： Carole Verhaegen Sophie Lepropre Marie Octave Davide Brusa Luc Bertrand Christophe Beauloye pascal j. jacques j.elle Kefer Sandrine Horman Pôle de Recherche Cardiovasculaire Université catholique de Louvain (UCLouvain) Brussels Belgium Plateforme de Cytométrie de Flux Université catholique de Louvain (UCLouvain) Brussels Belgium Division of Cardiology Cliniques Universitaires Saint-Luc Université catholique de Louvain (UCLouvain) Brussels Belgium Department of Materials and Process Engineering Institute of Mechanics Materials and Civil Engineering Université catholique de Louvain (UCLouvain) Brussels Belgium

A current challenge concerns developing new bioresorbable stents that combine optimal mechanical properties and biodegradation rates with limited thrombogenicity. In this context, twinning-induced plasticity (TWIP) steels are good material candidates. In this work, the hemocompatibility of a new TWIP steel was studied in vitro via hemolysis and platelet activation assessments. Cobalt chromium (CoCr) L605 alloy, pure iron (Fe), and magnesium (Mg) WE43 alloy were similarly studied for comparison. No hemolysis was induced by TWIP steel, pure Fe, or L605 alloy. Moreover, L605 alloy did not affect CD62P exposure, αIIbβ3 activation at the platelet surface, or phosphorylation of protein kinase C (PKC) substrates upon thrombin stimulation. In contrast, TWIP steel and pure Fe significantly decreased platelet response to the agonist. Given that similar inhibitory effects were obtained when using a conditioned medium previously incubated with TWIP steel, we postulated TWIP steel corrosion to be likely to release components counteracting platelet activation. We showed that the main ion form present in the conditioned medium is Fe3+. In conclusion, TWIP steel resorbable scaffold displays anti-thrombogenic properties in vitro, which suggests that it could be a promising platform for next-generation stent technologies.

关键词： Stent TWIP Steel Platelet Biomaterial Hemocompatibility

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： pascal j.Goldschmidt-Clermont Aisha Khan George j.msheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander j.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi j.mes D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Proj.ct to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular j.nction Schwann cell

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Edge effects on plant diversity in tropical forest ecosystems at Periyar Wildlife sanctuary in the Western Ghats of India

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j.urnal of Forestry Research 2013年第3期24卷 403-418页

作者： Somaiah Sundarapandian pascal j. Karoor Department of Ecology and Environmental Sciences School of Life Sciences Pondicherry UniversityPuducherry India

Forest resource conservation has been widely accepted as a key to sustain the local and regional economic development. The forest edges are affected by anthropogenic activities including deforestation, forest fragmentation, selective logging, extraction of non-timber forest products, collection of medicinal plants, recreations, hydroelectric pro- j.cts and its associated developmental activities, which alter the biodiver- sity. The present study intends to evaluate the edge effect on vegetation structure and species compositions in the tropical forest ecosystems at Periyar Wildlife Sanctuary in the Western Ghats. High species richness （number of species） and Shannon＇s diversity indices were observed in the site IlI （completely undisturbed forest） compared to site I （adj.cent to the village/edge of the forest, which is next to the teal（ plantation, severely disturbed forest） and site II （in between the undisturbed forest and mod- erately disturbed forest） while density of tree species showed greater value in site II. Single species such as Tectona grandis （IVI of 80） and Terminaliapaniculata （IVI of 112） were the dominant tree species in site I and site II, respectively, whereas, in site III Terminalia bellirica, Bishofia j.vanica and Syzgium gardneri shared the dominance. Perturba- tion leads to alien plant invasion particularly Lantana camara, Eupato- rium odoratum and Ageratum conizoides. Site II is at forest transition level because the site is dominated by both natural species as well as plantation species such as Tectona grandis. This site seems to be a buffer zone on natural forest and plantations. Further studies are required to analyse the real patterns of regeneration and dynamic change due to human impact by long term monitoring with the establishment of perma- nent plots.

关键词： anthropogenic disturbance biodiversity edge effect tropi-cal forest Western Ghats

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HEALTHCARE: A COMPLEX SERVICE SYSTEM

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j.urnal of Systems Science and Systems Engineering 2009年第3期18卷 257-282页

作者： j.mes M. TIEN pascal j. GOLDSCHMIDT-CLERMONT Dean College of Engineering University of Miami Coral GablesFlorida USA Dean Miller School of Medicine University of Miami Coral GablesFlorida USA

Healthcare is indeed a complex service system, one requiring the technobiology approach of systems engineering to underpin its development as an integrated and adaptive system. In general, healthcare services are carried out with knowledge-intensive agents or components which work together as providers and consumers to create or co-produce value. Indeed, the engineering design of a healthcare system must recognize the fact that it is actually a complex integration of human-centered activities that is increasingly dependent on information technology and knowledge. Like any service system, healthcare can be considered to be a combination or recombination of three essential components - people （characterized by behaviors, values, knowledge, etc.）, processes （characterized by collaboration, customization, etc.） and products （characterized by software, hardware, infrastructures, etc.）. Thus, a healthcare system is an integrated and adaptive set of people, processes and products. It is, in essence, a system of systems which obj.ctives are to enhance its efficiency （leading to greater interdependency） and effectiveness （leading to improved health）. Integration occurs over the physical, temporal, organizational and functional dimensions, while adaptation occurs over the monitoring, feedback, cybernetic and learning dimensions. In sum, such service systems as healthcare are indeed complex, especially due to the uncertainties associated with the human-centered aspects of these systems. Moreover, the system complexities can only be dealt with methods that enhance system integration and adaptation.

关键词： Services healthcare system integration system adaptation system complexity system of systems customization co-production decision informatics real-time decision making

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Fast, green microwave-assisted synthesis of single crystalline Sb_2Se_3 nanowires towards promising lithium storage

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j.urnal of Energy Chemistry 2019年第3期28卷 27-33页

作者： Wen Luo j.an-jacques Gaumet Pierre Magri Sébastien Diliberto Feng Li pascal Franchetti j.afar Ghanbaj. Liqiang Mai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Laboratoire de Chimie et Physique: Approche Multi-échelles des Milieux Complexes Institut Jean Barriol Université de Lorraine Institut j.an Lamour UMR CNRS 7198 Université de Lorraine Campus Artem

In this work, a fast(0.5 h), green microwave-assisted synthesis of single crystalline Sb_2Se_3 nanowires was developed. For the first time we demonstrated a facile solvent-mediated process, whereby intriguing nanostructures including antimony selenide(Sb_2Se_3) nanowires and selenium(Se) microrods can be achieved by merely varying the volume ratio of ethylene glycol(EG) and H_2O free from expensive chemical and additional surfactant. The achieved uniform Sb_2Se_3 nanowire is single crystalline along [001]growth direction with a diameter of 100 nm and a length up to tens of micrometers. When evaluated as an anode of lithium-ion battery, Sb_2Se_3 nanowire can deliver a high reversible capacity of 650.2 m Ah g^(-1) at 100 mA g^(-1) and a capacity retention of 63.8% after long-term 1000 cycles at 1000 mA g^(-1), as well as superior rate capability(389.5 m Ah g^(-1) at 2000 mA g^(-1)). This easy solvent-mediated microwave synthesis approach exhibits its great universe and importance towards the fabrication of high-performance metal chalcogenide electrode materials for future low-cost, large-scale energy storage systems.

关键词： Microwave synthesis Sb2Se3 nanowires Solvent-mediated process Lithium-ion battery High-performance anode

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Insights into the efficiency and stability of Cu-based nanowires for electrocatalytic oxygen evolution

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Nano Research 2018年第8期11卷 4323-4332页

作者： j.n Yu Qi Cao Bin Feng Changli Li j.ngyuan Liu j. Kenj. Clark j.an-jacques Delaunay Department of Mechanical Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan Institute of Engineering Innovation The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan School of Materials Science and Engineering Tsinghua University Beijing 100084 China Department of Chemical System Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan

Copper oxide nanowires with varying oxidation states are prepared and their activity for water oxidation is studied. The nanowires with a CuO phase are found to be the most active, and their degree of crystallinity is important in achieving efficient water oxidation. For the crystalline CuO nanowires in a weakly basic Na2CO3 electrolyte, a Tafel slope of 41 mV/decade, an overpotential of approximately 500 mV at - 10 mA/crn2 （without compensation for the solution resistance）, and a faradaic efficiency of nearly 100% are obtained. This electrode maintains a stable current for over 15 lx The low overpotential of 500 mV at 10 mA/cm2, small Tafel slope, long-term stability, and low cost make CuO one of the most promising catalysts for water oxidation. Moreover, the evolution of the CuO nanowire morphology over time is studied by electron microscop）-revealing that the diffusion of Cu ions from the interior of the nanowires to their surface causes the aggregation of individual nanowires over time. However, despite this aggregation, the current density remains nearly constant, because the total electrochemically active surface area of CuO does not change.

关键词： oxygen evolution reaction crystalline CuO active phase copper ion diffusion

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SUSY searches at ATLAS

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Frontiers of physics 2013年第3期8卷 248-256页

作者： pascal Pralavoriot CPPM University Aix-Marseille and CNRS/IN2P3 Marseille France

Despite the absence of experimental evidence, weak scale supersymmetry remains one of the best motivated and studied Standard Model extensions. The ATLAS experiment at the LHC searches for signs of supersymmetry in a large variety of signatures involving events with abnormal production of missing transverse momentum, j.ts, leptons, third generation fermions, gauge bosons or massive long-lived particles. A summary of the most recent results obtained in these searches is presented.

关键词： supersymmetry (SUSY) ATLAS LHC

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Improving intermittent androgen deprivation therapy： lessons learned from basic and translational research

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Asian j.urnal of Andrology 2014年第4期16卷 505-510页

作者： Rahul A Parikh Laura E pascal Benj.min j.Davieses Zhou Wang Division of Hematology/OncologyUniversity of Pittsburgh School of Medicine Hillman Cancer Centre University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA. Department of Urology University of Pittsburgh School of Medicine Hillman Cancer Centre University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA. Department of Pharmacology and Chemical Biology University of Pittsburgh School of Medicine Hillman Cancer Centre University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA.

Intermittent androgen deprivation therapy （IADT） is an alternative to continuous androgen deprivation therapy （ADT） in prostate cancer patients with nonmetastatic disease. ADT is associated with numerous side effects such as hot flashes, sexual dysfunction, anemia, fatigue, loss of muscle mass, osteoporosis, metabolic syndrome and premature cardiovascular disease. IADT was developed with the intention of improving the quality of life and to delay progression of prostate cancer to castration resistance. The benefits of slightly improved quality of life by IADT compared to ADT were demonstrated in multiple clinical trials. IADT was noted to be noninferior to ADT in patients with biochemical recurrence of prostate cancer but in studies performed in patients with metastatic prostate cancer, the results were inconclusive. Our recent studies suggested that the administration of 5 alpha-reductase inhibitors during the off-cycle of IADT can significantly prolong the survival of mice bearing androgen-sensitive prostate tumors when off-cycle duration was short. This review discusses the survival benefit of 5 alpha-reductase inhibition in IADT in animal models and the potential translation of this finding into clinic.

关键词： 5 alpha-reductase inhibitor androgen-responsive genes intermittent androgen deprivation therapy (IADT) prostatecancer testosterone

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Sperm traits differ between winged and wingless males of the ant Cardiocondyla obscurior

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Integrative Zoology 2016年第6期11卷 427-432页

作者： Alexandra SCHREMPF Astrid MOSER jacques DELABIE j.rgen HEINZE Zoology/Evolutionary Biology University of RegensburgRegensburgGermany Myrmecological Laboratory Cocoa Research Center CEPLACItabunaBrazil

Size and shape of sperm cells vary tremendously throughout the animal *** adaptive significance of this variation is not fully *** addition to sperm-female interactions and the environmental conditions,the risk of sperm competition might affect number,morphology and other“quality”traits of *** the male-diphenic ant Cardiocondyla obscurior,winged sneaker males have limited sperm number,because their testes degenerate shortly after adult emergence,as is typical for males of social *** contrast,wingless fighter males continuously replenish their sperm supply due to their exceptional lifelong spermatogene*** winged males usually have to compete with several other winged males for virgin queens,wingless males are able to monopolize queens by killing all other ***,this presents a unique system to investigate how alternative reproductive tactics and associated physiology affect sperm morphology and *** found that sperm-limited males invest into sperm number instead of sperm *** in sperm length is smaller in winged males,probably reflecting that they have to compete with several other ***,sperm viability is equally high in both male phenotypes.

关键词： alternative reproductive tactic social insect sperm length sperm viability

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How everything started:A retrospective

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Geoscience Frontiers 2014年第5期5卷 627-634页

作者： jacques Touret Institut de Mineralogie.de Physique des Materiaux.et de Cosmochimie IMPMC).Sorbonne Universites-UPMC Univ Paris 06 UMR CNRS 7590 Museum National d'Histoire Naturelle.IRD UMR 206.4 Place j.ssieu F-75005 Paris France

Recalling some of the most important events and persons during his education and career, the author sketches his growth from a young engineer, educated in the sanctuary of solid state reactions, to an involved fully devoted scientific career for the study of fluids in the deep Earth. Most important in this respect was the discovery of C02 inclusions in granulites, which triggered years of discussion on fluid- absent or fluid-assisted granulite metamorphism. To some extent, this debate is a continuation of the former granite controversy, but it shows also how the famous battle of ＂soaks against pontiffs＂ could have been easily avoided.

关键词： Granite controversyMetamorphic petrologyFluid inclusionsj TouretGranulites

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