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On-the-fly precision spectroscopy with a dual-modulated tunable diode laser and Hz-level referencing to a cavity

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Advanced Photonics 2024年第4期6卷 36-44页

作者： Shuangyou Zhang Toby Bi pascal Del’Haye Max Planck Institute for the Science of Light ErlangenGermany Friedrich-Alexander Universität Erlangen-Nürnberg Department of PhysicsErlangenGermany

Advances in laser spectroscopy have enabled many scientific breakthroughs in physics,chemistry,biology,and *** frequency combs pushed measurement limits with ultrahigh-frequency accuracy and fast-measurement speed,while tunable-diode-laser spectroscopy is used in scenarios that require high power and continuous spectral *** these advantages of tunable-diode-laser spectroscopy,it is challenging to precisely determine the instantaneous laser frequency because of fluctuations in the scan ***,we demonstrate a simple spectroscopy scheme with a frequencymodulated diode laser that references the laser on-the-fly to a fiber *** fiber cavity's free spectral range is on-the-fly calibrated with sub-10-Hz frequency *** achieve a relative precision of the laser frequency of 2×10^(-8)for an 11-THz frequency range at a measurement speed of 1 THz∕*** is an improvement of more than 2 orders of magnitude compared to existing diode-laser-spectroscopy *** scheme provides precise frequency calibration markers,while simultaneously tracking the instantaneous scan speed of the *** demonstrate the versatility of our method through various applications,including dispersion measurement of a fiber,ultrahigh-Q microresonators,and spectroscopy of a hydrogen fluoride gas *** simplicity,robustness,and low cost of this spectroscopy scheme are valuable for out-of-the-lab applications like lidar and environmental monitoring.

关键词： tunable laser spectroscopy radio-frequency modulation integrated photonics gas spectroscopy frequency comb

TRADE DEPENDENCIES AND TRANSACTION COSTS: THE OC-CUPATION OF DECELEA HIGHLIGHTS BOTH THE BENEFITS AND THE DRAWBACKS OF A MARITIME ECONOMY

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Journal of Ancient Civilizations 2024年第1期39卷 29-50,123页

作者： pascal Warnking Trier University and LEIZA

Thucydides asserts that the occupation of Decelea by the Spartans in 413 BC made the grain supply for Athens costly by forcing the transport from land onto the *** calls into question the well-established consensus that sea transport was far cheaper than land *** paper contends that the cost of protecting supply lines-specifically the expenses associated with the warships which escorted the supply ships-rendered the grain transported on the new route exceptionally *** this paper,the benefits and drawbacks of a maritime economy,including transaction costs,trade dependencies,and the capabilities of warships and supply ships are discussed.

关键词： convoy Decelea maritime dependencies maritime economy sea routes shipping costs transaction costs

An inverse method for characterization of dynamic response of 2D structures under stochastic conditions

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Chinese Journal of Aeronautics 2024年第3期37卷 440-455页

作者： Xuefeng LI Abdelmalek ZINE Mohamed ICHCHOU Noureddine BOUHADDI pascal FOSSAT Laboratory of Tribology and Systems Dynamic Central School of LyonEcully 69134France Institut Camille Jordan Central School of LyonEcully 69134France Department of Applied Mechanics University of Burgundy Franche-ComtéBesancon 25000France

The reliable estimation of the wavenumber space(k-space)of the plates remains a longterm concern for acoustic modeling and structural dynamic behavior *** current analyses of wavenumber identification methods are based on the deterministic *** this end,an inverse method is proposed for identifying wave propagation characteristics of twodimensional structures under stochastic conditions,such as wavenumber space,dispersion curves,and band *** proposed method is developed based on an algebraic identification scheme in the polar coordinate system framework,thus named Algebraic K-Space Identification(AKSI)***,a model order estimation strategy and a wavenumber filter are proposed to ensure that AKSI is successfully *** main benefit of AKSI is that it is a reliable and fast method under four stochastic conditions:(A)High level of signal noise;(B)Small perturbation caused by uncertainties in measurement points’coordinates;(C)Non-periodic sampling;(D)Unknown structural *** validate the proposed method,we numerically benchmark AKSI and three other inverse methods to extract dispersion curves on three plates under stochastic *** experiment is then performed on an isotropic steel *** investigations demonstrate that AKSI is a good in-situ k-space estimator under stochastic conditions.

关键词： Inverse method Dispersion relation Wavenumber space Periodic plates Stochastic conditions Wave propagation characterization

Secukinumab demonstrates high efficacy and a favorable safety profile over 52 weeks in Chinese patients with moderate to severe plaque psoriasis

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Chinese Medical Journal 2020年第22期133卷 2665-2673页

作者： Lin Cai Jian-Zhong Zhang Xu Yao Jun Gu Quan-Zhong Liu Min Zheng Shi-Fa Zhang Jin-Hua Xu Cheng-Xin Li Hao Cheng Qing Guo Wei-Li Pan Shen-Qiu Li Ruo-Yu Li Zai-Pei Guo Zhi-Qi Song Shan-Shan Li Xiu-Qin Dong Linda Wang Rong Fu pascaline Regnault pascal charef Ratal Mazur Manmath Patekar Department of Dermatology.Peking University People's Hospital Beijing 100044China Institute of Dermatology Chinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100730China Department of Dermatology Changhai HospitalShanghai 200433China Department of Dermatology Tianjin Medical University General HospitalTianjin 300052China Department of Dermatology Second Affiliated Hospital School of MedicineZhejiang UniversityHangzhouZhejiang 311215China Department of Dermatology General Hospital of Northern Theater CommandShenyangLiaoning 110016China Department of Dermatology Huashan HospitalFudan UniversityShanghai 200040China Department of Dermatology and Venereology Chinese People's Liberation Army General HospitalBeijing 100853China Department of Dermatology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouZhejiang 310016China Department of Dermatology Sun Yat-Sen Memorial HospitalGuangzhouGuangdong 510120China Department of Dermatology Zhejiang Provincial People's HospitalZhejiangHangzhouZhejiang 310014China Department of Dermatology Tongji HospitalTongji Medical College of Huazhong University of Science&TechnologyWuhanHubei 430030China Department of Dermatology Peking University First HospitalBeijing 100034China Department of Dermatology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Dermatology First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116011China Department of Dermatology The First Hospital of Jilin UniversityChangchunJilin 130021China Department of Dermatology Guangdong General HospitalGuangzhouGuangdong 510080China Beijing Novartis Pharma Co.Ltd. Shanghai 201203China Novartis Pharma AG Basel 6463Switzerland

Background:Psoriasis is a chronic inflammatory skin disease,affecting about 0.6%of the Chinese *** patients are not well controlled by conventional treatments,thus there is need for new treatment *** this study,we assessed the efficacy and safety of secukinumab in Chinese patients with moderate to severe plaque ***:This study was a 52-week,multicentre,randomized,double-blind,placebo-controlled,parallel-group,Phase 3 trial.A sub-population of study participants(≥18 years)of Chinese ethnicity were randomized to receive subcutaneous injections of 300 or 150 mg secukinumab,or *** co-primary endpoints were psoriasis area severity index(PASI)75 and Investigator’s Global Assessment(IGA)0/1 at Week ***:A total of 441 Chinese patients were enrolled in this ***-primary outcomes were achieved;300 and 150 mg secukinumab were superior to placebo as shown in the proportion of patients that achieved PASI 75(97.7%and 87.2%vs.3.7%,respectively;P<0.001),and IGA 0/1(82.3%and 69.7%vs.2.7%;P<0.001)at Week *** efficacy was maintained until Week *** was no increase in overall adverse events with secukinumab relative to placebo throughout the 52-week ***:Secukinumab is highly effective and well tolerated in Chinese patients with moderate to severe plaque psoriasis.

关键词： Chinese Psoriasis IL-17 Dermatology Clinical trial PASI

Modelling of the variation of granular base materials resilient modulus with material characteristics and humidity conditions

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Journal of Road Engineering 2024年第1期4卷 27-35页

作者： Jean-pascal Bilodeau Erdrick Leandro Perez-Gonzalez Ali Saeidi Departement de Genie Civil et Genie des Eaux Universite LavalQuebecG1V 0A6Canada Departement des Sciences Appliquees Universite du Quebeca ChicoutimiChicoutimiG7H 2B1Canada

This study aims to quantify the susceptibility of granular materials used in pavements to changes in moisture content and propose a correlation model to incorporate this susceptibility into seasonal *** fines content and the percentage of fractured coarse aggregates were identified as direct indicators of the resilient modulus susceptibility to changes in water *** results showed that the percentage of fractured coarse aggregates particles(FR)has a more significant impact on the resilient modulus(Er)of crushed granular materials used in pavement construction than the combined indicator of the fines content and sample volumetrics(nf).Crushed granular materials with a higher percentage of fractured coarse aggregates are relatively insensitive to changes in the degree of saturation,but become more sensitive as the fine fraction porosity *** adjusted model was proposed based on the existing formulation,but considers a complex parameter to describe and adjust the sensitivity of base granular materials to variations in moisture content with respect to fabrication charac-teristics,fines content and volumetric *** model shows that the variation of Er values is below10%for fully crushed granular ***,it reaches approximately±12%for materials with 75%of crushed coarse aggregates andþ40%and-25%for materials with FR=50%.This model could help select good ag-gregates characteristics and adjust grain-size distribution for environments where significant moisture content variations can occur in the pavement system,such as in the Province of Quebec(Canada).As it is based on pa-rameters that can be easily determined or estimated,it also represents a valuable tool for detailed design and analysis that can consider material characteristics.

关键词： Resilient modulus Degree of saturation Humidity conditions Unbound granular materials Pavement base

Defense and senescence interplay in legume nodules

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Plant Communications 2024年第4期5卷 112-126页

作者： Fathi Berrabah Farouk Benaceur Chaoyan Yin Dawei Xin Ke´vin Magne Marie Garmier Veronique Gruber pascal Ratet Faculty of Sciences University Amar Telidji03000 LaghouatAlgeria Research Unit of Medicinal Plants(RUMP) National Center of Biotechnology ResearchCRBt25000 ConstantineAlgeria Universite´Paris-Saclay CNRSINRAEUniversity of EvryInstitute of Plant Sciences Paris-Saclay(IPS2)91190 Gif-sur-YvetteFrance Universite´Paris Cite´ Institute of Plant Sciences Paris-Saclay(IPS2)91190 Gif-sur-YvetteFrance Key Laboratory of Soybean Biology in the Chinese Ministry of Education College of AgricultureNortheast Agricultural UniversityHarbin 150030China These authors contributed equally to this article.

Immunity and senescence play a crucial role in the functioning of the legume symbiotic *** miss-regulation of one of these processes compromises the symbiosis leading to death of the endosymbiont and the arrest of the nodule *** relationship between immunity and senescence has been exten-sively studied in plant organs where a synergistic response can be ***,the interplay be-tween immunity and senescence in the symbiotic organ is poorly discussed in the literature and these phe-nomena are often mixed *** studies revealed that the cooperation between immunity and senescence is not always observed in the nodule,suggesting complex interactions between these two pro-cesses within the symbiotic ***,we discuss recent results on the interplay between immunity and senescence in the nodule and the specificities of this relationship during legume-rhizobium symbiosis.

关键词： immunity senescence symbiosis nodules legumes rhizobia

Substrate topography as a powerful tool to modify glial cell biology and interactions

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Neural Regeneration Research 2025年第5期20卷 1390-1391页

作者： pascal Achenbach Haktan Altinova Gary A.Brook Institute of Neuropathology RWTH Aachen University Hospital Department of Neurosurgery RWTH Aachen University Hospital Aachen Germany Berlin State Office for Health and Social Affairs(LAGeSo) BerlinGermany

Traumatic injuries to the central nervous system(CNS) result in disruption of the intricate network of axons which connect functionally related neurons that are widely distributed throughout the brain and spinal *** normal conditions,maintenance of this complex system is structurally and functionally supported by astrocytes (ACs)and other glial cells,the processes of which form a framework surrounding neuronal cell bodies,dendrites,axons,and synapses.

关键词： injuries topography system

Demystifying polyphosphate-accumulating organisms relevant to wastewater treatment: A review of their phylogeny, metabolism, and detection

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Environmental Science and Ecotechnology 2024年第5期21卷 1-16页

作者： Lucia Ruiz-Haddad Muhammad Ali Mario Pronk Mark C.Mvan Loosdrecht pascal E.Saikaly Environmental Science and Engineering Program Biological and Environmental Science and Engineering(BESE)DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal23955-6900Saudi Arabia Water Desalination and Reuse Center Biological and Environmental Science and Engineering(BESE)DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal23955-6900Saudi Arabia Department of Civil Structural&Environmental EngineeringTrinity College DublinThe University of DublinDublin2Ireland Department of Biotechnology Delft University of TechnologyDelft2629 HZthe Netherlands

Currently,the most cost-effective and efficient method for phosphorus(P)removal from wastewater is enhanced biological P removal(EPBR)via polyphosphate-accumulating organisms(PAOs).This study integrates a literature review with genomic analysis to uncover the phylogenetic and metabolic diversity of the relevant PAOs for wastewater *** findings highlight significant differences in the metabolic capabilities of PAOs relevant to wastewater ***,Candidatus Dechloromonas and Candidatus Accumulibacter can synthesize polyhydroxyalkanoates,possess specific enzymes for ATP production from polyphosphate,and have electrochemical transporters for acetate and *** contrast,Tetrasphaera,Candidatus Phosphoribacter,Knoellia,and Phycicoccus possess PolyP-glucokinase and electrochemical transporters for sugars/amino ***,this review explores various detection methods for polyphosphate and PAOs in activated sludge wastewater treatment ***,FISH-Raman spectroscopy emerges as one of the most advanced detection ***,this review provides critical insights into PAO research,underscoring the need for enhanced strategies in biological phosphorus removal.

关键词： Polyphosphate-accumulating organisms(PAOs) Enhanced biological phosphorus removal (EBPR)Tetrasphaera Ca.accumulibacter Ca.phosphoribacter Knoellia Phycicoccus

A multi-photon(7×7)-focus 3D laser printer based on a 3D-printed diffractive optical element and a 3D-printed multi-lens array

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Light(Advanced Manufacturing) 2024年第1期5卷 26-39页

作者： pascal Kiefer Vincent Hahn Sebastian Kalt Qing Sun Yolita M.Eggeler Martin Wegener DMM2O-Cluster of Excellence Karlsruhe Institute of Technology(KIT)and Heidelberg University76128 KarlsruheGermany Institute of Applied Physics(APH) Karlsruhe Institute of Technology(KIT)76128 KarlsruheGermany Institute of Nanotechnology(INT) Karlsruhe Institute of Technology(KIT)76128 KarlsruheGermany Laboratory for Electron Microscopy(LEM) Karlsruhe Institute of Technology(KIT)76128 KarlsruheGermany

One of the challenges in the field of multi-photon 3D laser printing lies in further increasing the print speed in terms of voxels/***,we present a setup based on a 7×7 focus array(rather than 3×3 in our previous work)and using a focus velocity of about 1 m/s(rather than 0.5 m/s in our previous work)at the diffraction limit(40×/NA1.4 microscope objective lens).Combined,this advance leads to a ten times increased print speed of about 108 voxels/*** demonstrate polymer printing of a chiral metamaterial containing more than 1.7×10^(12) voxels as well as millions of printed microparticles for potential pharmaceutical *** critical high-quality micro-optical components of the setup,namely a diffractive optical element generating the 7×7 beamlets and a 7×7 lens array,are manufactured by using a commercial two-photon grayscale 3D laser printer.

关键词： 3D laser printing Direct laser writing Multi-photon absorption Multi-focus optics Diffractive optical element Lens array