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Kaempferol attenuates cognitive deficit via regulating oxidative stress and neuroinflammation in an ovariectomized rat model of sporadic dementia

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Neural Regeneration Research 2018年第10期13卷 1827-1832页

作者： Somayeh Kouhestani Adele Jafari parvin babaei Cellular and Molecular Research Center Faculty of MedicineGuilan University of Medical Sciences Department of Physiology Faculty of MedicineGuilan University of Medical Sciences Neuroscience Research Center Guilan University of Medical Sciences

Alzheimer＇s disease（AD） is associated with oxidative stress, and ultimately results in cognitive deficit. Despite existing literature on the pathophysiology of AD, there is currently no cure for AD. The present study investigated the effects of kaempferol（Kmp） isolated from the extract of Mespilus germanica L.（medlar） leaves on cognitive impairment, hippocampal antioxidants, apoptosis, lipid peroxidation and neuro-inflammation markers in ovariectomized（OVX） rat models of sporadic AD. Kaempferol, as the main flavonoid of medlar extract has been previously known for anti-oxidative, anti-inflammatory and anti-neurotoxic effects. Thirty-two female Wistar rats were ovariectomized, and randomly divided into four groups： sham, OVX ＋ saline, OVX ＋ streptozotocin（STZ）＋ saline, OVX ＋ STZ ＋ Kmp. Animals received intracerebroventricular injection of STZ（3 mg/kg, twice with one day interval） to establish models of sporadic AD. Intraperitoneal injection of Kmp（10 mg/kg） for 21 days was performed in the OVX ＋ STZ ＋ Kmp group. Spatial learning and memory of rats were evaluated using a Morris water maze. Finally, brain homogenates were used for biochemical analysis by enzyme-linked immunosorbent assay. The results showed a significant improvement in spatial learning and memory as evidenced by shortened escape latency and searching distance in Morris water maze in the OVX ＋ STZ ＋ Kmp group compared with the OVX ＋ STZ group. Kmp also exhibited significant elevations in brain levels of antioxidant enzymes of superoxide dismutase and glutathione, while reduction in tumor necrosis factor-α and malondialdehyde. Our results demonstrate that Kmp is capable of alleviating STZ-induced memory impairment in OVX rats, probably by elevating endogenous hippocampal antioxidants of superoxide dismutase and glutathione, and reducing neuroinflammation. This study suggests that Kmp may be a potential neuroprotective agent against cognitive deficit in AD.

关键词： Alzheimer's disease oxidative stress neuroinflammation Mespilus germanica L. Kaempferol neural regeneration

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Exercise training modulates adipokine dysregulations in metabolic syndrome

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Sports Medicine and Health Science 2022年第1期4卷 18-28页

作者： parvin babaei Rastegar Hoseini Cellular&Molecular Research Center School of MedicineGuilan University of Medical SciencesRashtIran Neuroscience Research Center School of MedicineGuilan University of Medical SciencesRashtIran Department of Physiology School of MedicineGuilan University of Medical SciencesRashtIran Department of Sports Physiology Faculty of Sport SciencesRazi UniversityKermanshahIran

Metabolic syndrome(MetS)is a cluster of risk factors for various metabolic diseases,and it is characterized by central obesity,dyslipidemia,hypertension,and insulin *** core component for MetS is adipose tissue,which releases adipokines and influences physical *** consist of pro and anti-inflammatory cytokines and contribute to various physiological ***,a sedentary lifestyle promotes fat accumulation and secretion of pro-inflammatory ***,regular exercise has been known to exert various beneficial effects on metabolic and cognitive *** the mechanisms underlying exercise beneficial effects in MetS are not fully understood,changes in energy expenditure,fat accumulation,circulatory level of myokines,and adipokines might be *** review article focuses on some of the selected adipokines in MetS,and their responses to exercise training considering possible mechanisms.

关键词： Adipokines Insulin resistance Aerobic training Resistance training Metabolic syndrome

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Effect of BDNF and Adipose Derived Stem Cells Transplantation on Cognitive Deficit in Alzheimer Model of Rats

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Journal of Behavioral and Brain Science 2013年第1期3卷 156-161页

作者： parvin babaei Bahram Soltani Tehrani Cellular and Molecular Research Center Guilan University of Medical Science Rasht Iran Department of Pharmacology Guilan University of Medical science Rasht Iran

In this study, the potential for recovery mediated by co-treatment of brain-derived neurotrophic factor (BDNF) and adipose tissue derived stem cells (ASCs) on functional recovery after Ibotenic acid (Ibo) lesion of the nucleus basalis magnocellularis (NBM) was examined. Ibotenic acid was injected bilaterally into the NBM of experimental rats, then the animals received treatments as follows: ASCs (500 × 103), BDNF (5 ug/ul) and a combination of BDNF and ASCs. Two months after the treatment, cognitive recovery was assessed by the Morris water-maze. These results showed that ASCs transplantation may have therapeutic value in disease and conditions that result in memory loss, and co-treatment with BDNF doesn’t offer more efficacious cognitive function.

关键词： Alzheimer’s Disease Adipose Stem Cells Brain-Derived Neurotrophic Factor Learning and Memory

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