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Antiviral Activity of Medicinal Plants against Human Coronavirus: a systematic scoping review of in vitro and in vivo experimentations

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Journal of Traditional Chinese Medicine 2022年第3期42卷 332-343页

作者： parva namiranian Omid Sadatpour Sadegh Azimzadeh Jamalkandi Mohammad Hossein Ayati Mehrdad Karimi Department of Traditional Medicine School of Persian MedicineTehran University of Medical SciencesTehranIran Department of Immunology School of MedicineTehran University of Medical SciencesTehranIran Chemical Injuries Research Center Systems Biology and Poisonings InstituteBaqiyatallah University of Medical SciencesTehranIran

OBJECTIVE:To investigate the in vitro and in vivo studies of natural compounds and medicinal plants with anti-coronavirus ***:A systematic review was performed based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Animal Research:Reporting of in vivo experiments guidelines to find data for medicinal plants and natural products effective against human coronaviruses in in vitro or in vivo *** published up to September 6,2020 were ***(in vitro or in vivo)reporting the effect of medicinal plants and natural products or their derivatives on human coronavirus were included RESULTS:Promising anti-coronavirus effects are seen with different herbal compounds like some diterpenoids,sesquiterpenoids,and three compounds in tea with 3 CLpro inhibiting effect of Severe Acute Respiratory Syndrome Coronavirus(SARS-Co V);Hirsutenone,Six cinnamic amides and bavachinin are PLpro inhibitors and Tanshinones are active on both 3 CLpro and *** flavonoid compounds of Citrus fruits act on Immunoregulation and target angiotensin-converting enzyme 2 which is used by SARS-COV for *** helicase is possibly inhibited by two compounds myricetin and ***:This review shows that complementary medicine have the potential for new drug discovery against *** research is needed before definitive conclusions can be made concerning the safety and efficacy of the use of these medicinal plants.

关键词： Coronavirus medicine,Persian medicine,Chinese traditional plants,medicinal new drug discovery

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