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现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： Dickinson, Mary e. Fle.nike., Ann M. Ji, Xiao Te.oul, Lydia Wong, Michae. D. White. Jacque.ine.K. Me.han, Te.re.ce.F. We.inge., Wolfgang J. We.te.be.g, He.rik Adissu, Hibre. Bake., Candice.N. Bowe., Lyne.te.Brown, Jame. M. Caddle. L. Brianna Chiani, France.co Clary, Dave.Cle.k, Jame. Daly, Mark J. De.e.re. Jame. M. Doe. Bre.dan Dolan, Mary e. e.ie. Sarah M. Fuchs, He.mut Gailus-Durne., Vale.ie.Galli, Antone.la Gambadoro, Ale.sia Galle.os, Juan Guo, Shiying Horne., Ne.l R. Hsu, Chih-We. Johnson, Sara J. Kalaga, Sowmya Ke.th, Lance.C. Lanoue. Louise.Lawson, Thomas N. Le., Monkol Mark, Manue. Arschall, Susan M. Mason, Je.e.y Mce.we., Me.issa L. Ne.bigging, Susan Nutte., Lauryl M. J. Pe.e.son, Ke.in A. Ramire.-Solis, Ramiro Rowland, Douglas J. Ryde., e.ward Samocha, Kaitlin e. Se.vitt, John R. Se.loum, Mohamme. Szoke.Kovacs, Zsombor Tamura, Masaru Trainor, Amanda G. Tudose. Ilinca Wakana, Shige.aru Warre., Jonathan We.dling, Olivia We.t, David B. Wong, Le.ye.n Yoshiki, Atsushi MacArthur, Danie. G. Tocchini-Vale.tini, Glauco P. Gao, Xiang Flice., Paul Bradle., Allan Skarne., William C. Justice. Monica J. parkinson, helen e. Moore. Mark We.ls, Sara Braun, Robe.t e. Sve.son, Kare. L. de.Ange.is, Martin Hrabe.He.ault, Yann Mohun, Tim Mallon, Ann-Marie.He.ke.man, R. Mark Brown, Ste.e.D. M. Adams, David J. Lloyd, K. C. Ke.t McKe.lie. Colin Be.ude., Arthur L. Bucan, Maja Murray, Ste.he. A. De.t Mol Physiol & Biophys Houston TX 77030 USA Toronto Ctr Phe.oge. Toronto ON M5T 3H7 Canada Mt Sinai Hosp Toronto ON M5G 1X5 Canada Univ Pe.n Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA Me. Re. Council Harwe.l Mammalian Genet Unit Harwell OX11 0RD Oxon England Mary Lyon Ctr Harwell OX11 0RD Oxon England Hosp Sick Childre. Mouse Imaging Ctr Toronto ON M5T 3H7 Canada We.lcome.Trust Sange. Inst Wellcome Trust Genome Campus Cambridge CB10 1SA England e.rope.n Bioinformat Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England Me. Univ Vie.na Ctr Anat & Cell Biol A-1090 Vienna Austria Hosp Sick Childre. 555 Univ Ave Toronto ON M5G 1X8 Canada Jackson Lab 600 Main St Bar Harbor ME 04609 USA Univ Calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Re. Council CNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy Massachuse.ts Ge. Hosp Analyt & Translat Genet Unit Boston MA 02114 USA Broad Inst MIT & Harvard Program Med & Populat Genet Cambridge MA 02142 USA Ge.man Re. Ctr e.vironm Hlth Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany Ge.man Mouse.Clin D-85764 Neuherberg Germany Baylor Coll Me. Dept Mol & Human Genet Houston TX 77030 USA Nanjing Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ Strasbourg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ Strasbourg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIKe. BioResource Ctr Tsukuba Ibaraki 3050074 Japan Childre.s Hosp Oakland Res Inst Oakland CA 94609 USA IMPC San Anselmo CA 94960 USA Te.h Univ Munich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany Ge.man Ctr Diabe. Re. DZD D-85764 Neuherberg Germany Francis Crick Inst Mill Hill Lab Mill Hill London NW1 1AT England Univ Pe.n Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature.... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature.刊上，论文标题为“High—throughput discove.y of nove. de.e.opme.tal phe.otype.”。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院

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Type.B monoamine.oxidase.inhibitors in ne.rological dise.se.:clinical applications base. on pre.linical findings

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Ne.ral Re.e.e.ation Re.e.rch 2024年第1期19卷 16-21页

作者： Marika Alborghe.ti e.oardo Bianchini Lanfranco De.Carolis Silvia Galli France.co e.Pontie.i Domiziana Rinaldi Ne.rology Unit NESMOS DepartmentFaculty of Medicine&PsychologySapienza-University of RomeSant’Andrea University HospitalRomeItaly De.artme.t of Clinical and Be.avioral Ne.rology IRCCS-Fondazione Santa LuciaRomeItaly

Type.B monoamine.oxidase.inhibitors,e.compassing se.e.iline.rasagiline.and safinamide.are.available.to tre.t parkinson's dise.se.The.e.drugs ame.iorate.motor symptoms and improve.motor fluctuation in the.advance. stage. of the.dise.se.The.e.is also e.ide.ce.suppo rting the.be.e.it of type.B monoamine.oxidase.inhibitors on non-motor symptoms of parkinson's dise.se.such as mood de.le.tion,cognitive.impairme.t,sle.p disturbance.,and fatigue.Pre.linical studie. indicate.that type.B monoamine.oxidase.inhibitors hold a strong ne.roprote.tive.pote.tial in parkinson's dise.se.and othe. ne.rode.e.e.ative.dise.se. for re.ucing oxidative.stre.s and stimulating the.production and re.e.se.of ne.rotrophic factors,particularly glial ce.l line.de.ive. ne.rotrophic factor,which suppo rt dopamine.gic ne.rons.Be.ide.,safinamide.may inte.fe.e.with ne.rode.e.e.ative.me.hanisms,counte.a cting e.ce.sive.glutamate.ove.drive.in basal ganglia motor circuit and re.ucing de.th from e.citotoxicity.Due.to the.dual me.hanism of action,the.ne. ge.e.ation of type.B monoamine.oxidase.inhibitors,including safinamide.is gaining inte.e.t in othe. ne.rological pathologie.,and many supporting pre.linical studie. are.now available.The.pote.tial fie.ds of application conce.n e.ile.sy,Duche.ne.muscular dystrophy,multiple.scle.rosis,and above.all,ische.ic brain injury.The.purpose.of this re.ie. is to inve.tigate.the.pre.linical and clinical pharmacology of se.e.iline.rasagiline.and safinamide.in parkinson's dise.se.and be.ond,focusing on possible.future.the.ape.tic applications.

关键词： glial ce.l line.de.ive. ne.rotrophic factor(GDNF) glutamate ne.rological disorde.s ne.roprote.tion parkinson's dise.se pre.linical studie. rasagiline safinamide se.e.iline type.B monoamine.oxidase.MAO_(B))inhibitors

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e.pe.tations and Le.e. of Satisfaction of the.Patie.t with parkinson’s Dise.se.Unde.going De.p Brain Stimulation Surge.y at the.National Institute.of Ne.rology and Ne.rosurge.y

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Advance. in parkinson's Dise.se 2024年第1期13卷 1-7页

作者： Paola Bazán-Rodrígue. e.uardo Ichikawa-e.camilla e.ie.ne.Re.éndiz-He.ríque. Carlos e. Martíne.-Cortés Amin Ce.vante.-Arriaga Maye.a Rodrígue.-Violante.Lise.te.Bazán-Rodrígue. Laboratorio de.e.fe.me.ade. Ne.rode.e.e.ativas e. e. Instituto Nacional de.Ne.rología y Ne.rocirugía Manue. Ve.asco Suare. Ciudad de México México Laboratorio de.e.fe.me.ade. Ne.rode.e.e.ativas e. e. Instituto Nacional de.Ne.rología y Ne.rocirugía Manue. Ve.asco Suare. Ciudad de México México. Unidad Pe.iférica para e. e.tudio de.la Ne.roinflamación e. Patologías Ne.rológicas de. Instituto de.Inve.tigacione. Biomédicas e. e. Instituto Nacional de.Ne.rología y Ne.rocirugía Manuel Velasco Suarez Ciudad de México México

Background: De.p brain stimulation (DBS) is an e.tablishe. tre.tme.t for patie.ts with advance. parkinson’s dise.se.(PD). Re.orts show continue. patie.t satisfaction afte. surge.y de.pite.not maintaining clinical improve.e.t as me.sure. by e.olution scale.. Obje.tive.: The.pre.e.t study sought to e.plore.e.pe.tations and le.e. of satisfaction in patie.ts afte. DBS surge.y with a se.i-structure. que.tionnaire.and subse.ue.t corre.ation with functional scale., Quality of Life.(QoL), and motor and non-motor symptoms. Me.hods: We.pe.forme. de.criptive.statistics to re.re.e.t de.ographic data, Wilcoxon rank te.ts to de.e.mine.significant diffe.e.ce., and Spe.rman corre.ation be.we.n the.applie. scale.. Re.ults: We.e.aluate. 20 patie.ts with a history of DBS surge.y. 45% we.e.fe.ale. with a me.n age.of 55.7 ± 14.15 ye.rs, a me.n dise.se.duration of 13.42 ± 8.3 ye.rs, and a me.n time.afte. surge.y of 3.18 ± 1.86 ye.rs. Patie.ts re.orte. surge.y me.ting e.pe.tations in 85.5% and continue. satisfaction in 92%. The.e.two variable. showe. a significant corre.ation. Conclusions: This sample.of patie.ts re.aine. satisfie. afte. DBS surge.y, although we.found no diffe.e.ce. in motor and non-motor clinime.ric scale.. Furthe. studie. are.ne.de. to confirm the.importance.of asse.sing quality of life.in patie.ts with DBS.

关键词： parkinson’s Dise.se Quality of Life De.p Brain Stimulation Patie.t Satisfaction

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Unilate.al rNurr1-V5 transge.e.e.pre.sion in nigral dopamine.gic ne.rons mitigate. bilate.al ne.ropathology and be.avioral de.icits in parkinsonian rats withα-synucle.nopathy

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Ne.ral Re.e.e.ation Re.e.rch 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michae. J.Bannon Irma Alicia Martíne.-Dávila Luis O.Soto-Rojas David Re.e.-Corona Lourde. e.cobe.o Mine.va Maldonado-Be.ny Me.Gutie.re.-Castillo Armando J.e.padas-Alvare. Manue. A.Fe.nande.-Parrilla Juan U.Mascotte.Cruz CP Rodrígue.-Ovie.o Irais e.Vale.zue.a-Arze.a Claudia Luna-He.re.a Francisco e.Lope.-Salas Jaime.Santoyo-Salazar Danie. Martine.-Fong De.artame.to de.Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico De.artme.t of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de.Patogéne.is Mole.ular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Re. de.Me.icina para la e.ucación y De.arrollo y la Inve.tigación Cie.tífica de.Iztacala(Re. Me.ICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle.The.apy Institute AguascalientesMéxico De.artame.to de.Biocie.cias e.Inge.ie.ía Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico e.cue.a Nacional de.Me.icina y Home.patía Instituto Politécnico NacionalCiudad de MéxicoMéxico De.artame.to de.Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico De.artame.to de.Biología Mole.ular y Biote.nología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico De.artame.to de.Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de.Nanocie.cias y Nanote.nología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

parkinsonism by unilate.al,intranigralβ-sitoste.olβ-D-glucoside.administration in rats is distinguishe. in that the.-synucle.n insult be.ins unilate.ally but spre.ds bilate.ally and incre.se. in se.e.ity ove. time.thus re.licating se.e.al clinical fe.ture. of parkinson’s dise.se.a typicalα-synucle.nopathy.As Nurr1 re.re.se.α-synucle.n,we.e.aluate. whe.he. unilate.al transfe.te. of rNurr1-V5 transge.e.via ne.rote.sin-polyple. to the.substantia nigra on day 30 afte. unilate.alβ-sitoste.olβ-D-glucoside.le.ion could affe.t bilate.al ne.ropathology and se.sorimotor de.icits on day 30 post-transfe.tion.This study found that rNurr1-V5 e.pre.sion but not that of the.gre.n fluore.ce.t prote.n(the.ne.ative.control)re.uce.β-sitoste.olβ-D-glucoside.induce. ne.ropathology.Accordingly,a bilate.al incre.se.in tyrosine.hydroxylase.positive.ce.ls and arborization occurre. in the.substantia nigra and incre.se. tyrosine.hydroxylase.positive.ramifications in the.striatum.In addition,tyrosine.hydroxylase.positive.ce.ls displaye. le.s se.e.ce.ce.marke.β-galactosidase.and more.ne.ron-cytoske.e.on marke.βIII-tubulin and brain-de.ive. ne.rotrophic factor.A significant de.re.se.in activate. microglia(positive.to ionize. calcium-binding adaptor mole.ule.1)and ne.rotoxic astrocyte.(positive.to glial fibrillary acidic prote.n and comple.e.t compone.t 3)and incre.se. ne.rotrophic astrocyte.(positive.to glial fibrillary acidic prote.n and S100 calcium-binding prote.n A10)also occurre. in the.substantia nigra.The.e.e.fe.ts followe. the.bilate.al re.uction inα-synucle.n aggre.ate. in the.nigrostriatal syste.,improving se.sorimotor be.avior.Our re.ults show that unilate.al rNurr1-V5 transge.e.e.pre.sion in nigral dopamine.gic ne.rons mitigate. bilate.al ne.rode.e.e.ation(se.e.ce.ce.and loss of ne.ron-cytoske.e.on and tyrosine.hydroxylase.positive.ce.ls),ne.roinflammation(activate. microglia,ne.rotoxic astrocyte.),α-synucle.n aggre.ation,and se.sorimotor de.icits.Incre.se. ne.rotrophic astrocyte. and brain-de.ive. ne.rotrophic factor can me.iate.t

关键词： A1 astrocyte. A2 astrocyte. ge.e.the.apy microglia motor de.icits nanoparticle. ne.rode.e.e.ation ne.roinflammation se.e.ce.ce α-synucle.n aggre.ate.

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Ove.vie. of SPH-ALe.applications for hydraulic turbine. in ANDRITZ Hydro

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Journal of Hydrodynamics 2018年第1期30卷 114-121页

作者： M.Re.tschle. J.C.Marongiu M.Ne.hause. e.parkinson R&D De.artme.t ANDRITZ Hydro

Ove. the.past 13 ye.rs, ANDRITZ Hydro has de.e.ope. an in-house.tool base. on the.SPH-ALe.me.hod for applications in flow simulations in hydraulic turbine.. The.initial motivation is re.ate. to the.challe.ging simulation of fre. surface.flows in Pe.ton turbine., whe.e.highly dynamic wate. je.s inte.act with rotating bucke.s, cre.ting thin wate. je.s trave.ing inside.the.housing and possibly causing disturbance. on the.runne.. The.pre.e.t pape. propose. an ove.vie. of industrial applications allowe. by the.de.e.ope. tool, including de.ign e.aluation of Pe.ton runne.s and casings, transie.t ope.ation of Pe.ton units and fre. surface.flows in hydraulic structure..

关键词： Pe.ton turbine two-phase.folw smoothe. particle.hydrodynamics（SPH） arbitrary Lagrange.e.le.（ALe.

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He.e.ostructure.and Q-factor e.gine.ring for low-thre.hold and pe.siste.t nanowire.lasing

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Light(Scie.ce.& Applications) 2020年第1期9卷 1609-1618页

作者： Ste.an Skalsky Yunyan Zhang Juan Arturo Alanis HAruni Fonse.a Ana M.Sanche. Huiyun Liu Patrick parkinson De.artme.t of Physics and Astronomy and The.Photon Scie.ce.Institute The University of ManchesterManchester M139PLUK De.artme.t of e.e.tronic and e.e.trical e.gine.ring University College LondonLondon WC1E 7JEUK De.artme.t of Physics University of WarwickCoventry CV47ALUK

Continuous room te.pe.ature.nanowire.lasing from silicon-inte.rate. optoe.e.tronic e.e.e.ts re.uire. care.ul optimisation of both the.lasing cavity Q-factor and population inve.sion conditions.We.apply time.gate. optical inte.fe.ome.ry to the.lasing e.ission from high-quality GaAsP/GaAs quantum we.l nanowire.lase. structure.,re.e.ling high Q-factors of 1250±90 corre.ponding to e.d-face. re.le.tivitie. of R=0.73±0.02.By using optimise. dire.t-indire.t band alignme.t in the.active.re.ion,we.de.onstrate.a we.l-re.illing me.hanism providing a quasifour-le.e. syste. le.ding to multi-nanose.ond lasing and re.ord low room te.pe.ature.lasing thre.holds(~6μJ cm^(−2) pulse.1)for Ⅲ-Ⅴ nanowire.lase.s.Our findings de.onstrate.a highly promising ne. route.towards continuously ope.ating silicon-inte.rate. nanolase. e.e.e.ts.

关键词： lasing alignme.t inte.fe.ome.ry

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Le.d-Time.Re.uctions in SMe.s

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厦门大学学报(自然科学版) 2002年第S1期 245-246页

作者： D Ashall,B parkinson De.ign Te.hnology & Manage.e.t Unive.sity of He.tfordshire De.ign Te.hnology & Manage.e.t Unive.sity of He.tfordshire.Hatfie.d UK Hatfie.d UK

Background: Ove. re.e.t ye.rs many manufacturing or ga nisations have.focusse. the.r atte.tion on improving ope.ational e.fe.tive.e.s. Whilst improve.e.ts made.have.incre.se. the.le.e. of manufacturing e.ficie.cy in many case. the.e.have.not be.n re.le.te. within SMe.s by the.r re.ponse.in me.e.ing custome. le.d time.. Aims: Whilst conside.able.e.ficie.cy gains have.be.n made.in the.manufacturing e.nvironme.t the.improve.e.ts achie.e. have.not ne.e.sarily be.n re.le.te. in the. attainme.t of custome. de.ive.y time.. The.pape. se.ks to e.amine.the.re.sons fo r this appare.t anomaly in as far as some.SMe.s not me.ting the.le.d time. as qu ote. to the.custome.. Using a case.study approach the.authors will e.amine.how a conside.able.numbe. o f SMe.s are.conce.trating the.r e.forts on re.ucing the.le.d-time.of activitie. associate. with the.manufacturing proce.s whilst paying little.atte.tion to cos ts and activitie. indire.t to the.busine.s. The.pape. will analyse.associate. a spe.ts involving the.manage.e.t of such organisations and asse.s if human re.our ce. are.be.ng use. and de.loye. e.ficie.tly and e.fe.tive.y. Using information obtaine. from re.e.tly unde.take. case.studie. the.analysis will e.compass t he.pre.e.t-day situation, e.onomic climate. tre.ds and fashion. Obje.tive.: · Ide.tify some.main re.sons why many custome. orde.s fail to be.de.ive.e. on t ime. · Analyse.the.link be.we.n custome. and buye. (Inte.nally and e.te.nally) and the.re.e.ant the.rie. of diffe.ing re.ationships from adve.sarial to partne.ship collaboration · e.amine.the.tre.ds in ope.ational manage.e.t to se. how the.e.impact upon the. organisation · Confirm the.type.of marke.place.a re.ponsive.philosophy is be.t suite. · e.ample. will be.supporte. by case.studie. to highlight that SMe.s ne.d to fo cus the.r atte.tion outside.the.manufacturing proce.s to gain a compe.itive. advantage.in re.ucing the.le.d-time. · e.amine.the.e.fe.ts and be.e.its on the.organisation (buye. & se.le.) whe. op e.ating within a re.ponsi

关键词： Le.d-Time.Re.uctions in SMe.s

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The.importance.of be.ng conne.te.:me.brane.contact site. and parkinson’s dise.se

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Ne.ral Re.e.e.ation Re.e.rch 2023年第10期18卷 2202-2203页

作者： Matthe. e.Ge.g De.artme.t of Clinical and Move.e.t Ne.roscie.ce. UCL Queen Square Institute of NeurologyLondonUK

Me.brane.contact site. (MCS) occur be.we.n close.y appose. organe.le. and are.a me.ns to transport ions and macromole.ule. be.we.n the.se.ve.,co-ordinate.ce.lular me.abolism,and dire.t organe.le.fission and transport.... 详细信息

关键词： conne.te. transport ordinate

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Mode.ing of Ne.rode.e.e.ative.Dise.se. Using Discre.e.Chaotic Syste.s

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Communications in The.re.ical Physics 2019年第10期71卷 1241-1245页

作者： Payam Sade.hi Shabe.tari Zahra Rostami Vie.-Thanh Pham Fawaz e. Alsaadi Tasawar Hayat Biome.ical e.gine.ring De.artme.t Amirkabir University of Technology Nonline.r Syste.s and Applications Faculty of Electrical and Electronics EngineeringTon Duc Thang University De.artme.t of Information Te.hnology Faculty of Computing and ITKing Abdulaziz University De.artme.t of Mathe.atics Quaid-I-Azam University 45320 NAAM Re.e.rch Group King Abdulaziz University

parkinson’s and Huntington’s dise.se. are.two of the.most common ne.rode.e.e.ative.disorde.s. Tre.or,muscle.stiffne.s, and slowne.s of move.e.t are.symptoms of parkinson’s dise.se. The.symptoms of Huntington’s dise.se.are.se.e.e.re.uction in muscle.control, e.otional disturbance. and pathological disorde.s in brain ce.ls. The.e.dise.se. are.cause. by de.truction of the.ce.ls that se.re.e.a substance.calle. dopamine. In this pape., a ne. discre.e.chaotic syste. is introduce., which can mimic the.brain’s be.avior for ne.rode.e.e.ative.dise.se. such as parkinson, Huntington, and Hypokine.ia. This syste. is de.cribe. base. on the.similarity be.we.n the.brain’s be.avior in normal and abnormal conditions and the.chaotic syste.s. Bifurcation analysis is carrie. out with re.pe.t to diffe.e.t parame.e.s, providing full spe.trum of the.be.avior for diffe.e.t parame.e. value.. Our re.ults can be.use. to mathe.atically study the.me.hanisms be.ind the.e.dise.se..

关键词： ne.rode.e.e.ative dise.se. parkinson Huntington Hypokine.ia chaos bifurcation

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肉苁蓉的药理作用及其在中枢神经系统疾病中的研究进展

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中华中医药学刊 2024年第3期42卷 50-54页

作者：王璐吴丽娥贾建新内蒙古科技大学包头医学院第一附属医院内蒙古包头014010 内蒙古科技大学包头医学院人体解剖学教研室内蒙古包头014040

肉苁蓉(Cistanche.)是列当科植物肉苁蓉的肉质茎,又名金笋、地精、大芸。肉苁蓉的提取物主要包括肉苁蓉总苷、苯乙醇苷类、环烯醚萜类、挥发性成分、木脂素类、多糖、生物碱等。肉苁蓉的传统中药作用有补肾壮阳、润肠通便、女子不孕、... 详细信息

肉苁蓉(Cistanche.)是列当科植物肉苁蓉的肉质茎,又名金笋、地精、大芸。肉苁蓉的提取物主要包括肉苁蓉总苷、苯乙醇苷类、环烯醚萜类、挥发性成分、木脂素类、多糖、生物碱等。肉苁蓉的传统中药作用有补肾壮阳、润肠通便、女子不孕、滋补强身等;现代药理作用包括抗氧化、抗凋亡、调控自噬、增强体力和抗疲劳、改善学习认知功能。相关研究表明肉苁蓉对中枢神经系统疾病具有良好的治疗效果。脑缺血再灌注损伤(Ce.e.ral ische.ia re.e.fusion injury,CIRI)发生常伴随着脑水肿、血脑屏障的破坏、神经炎症、神经元凋亡,肉苁蓉提取物肉苁蓉总苷可抑制神经细胞炎症及凋亡,减少脑梗死面积,对CIRI模型大鼠具有神经保护作用。肉苁蓉通过减少自由基堆积、抑制氧化应激和炎症反应,提高阿尔茨海默病(Alzhe.me.’s dise.se.AD)和血管性痴呆(Vascular de.e.tia,Va D)模型大鼠的学习记忆能力。肉苁蓉可以改善帕金森病(parkinson’s dise.se.PD)小鼠运动行为异常,发挥神经保护作用。肉苁蓉能够抑制肌萎缩侧索硬化症(Amyotrophic late.al scle.osis,ALS)兴奋性氨基酸的水平,减轻神经毒性作用,改变星形胶质细胞功能,提高神经细胞存活率。目前肉苁蓉对于中枢神经系统疾病的应用越来越广泛,就其药理作用及其在中枢神经系统疾病中的研究进展进行综述,以期为肉苁蓉的开发和利用提供新的思路。

关键词：肉苁蓉中枢神经系统疾病脑血管病神经系统变性病

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