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Using a Game to Engage Stakeholders in Extreme Event Attribution Science

International journal of Disaster Risk Science 2016年第4期7卷 353-365页

作者： Hannah R.parker Rosalind j.Cornforth Pablo Suarez Myles R.Allen Emily Boyd Rachel james Richard G.jones Friederike E.L.Otto Peter Walton Department of Meteorology University of Reading Walker Institute University of Reading Red Cross Red Crescent Climate Centre Pardee Center for the Study of the Longer-Range Future Boston University Environmental Change Institute University of Oxford Atmospheric Oceanic and Planetary PhysicsUniversity of Oxford Department of Geography and Environmental Science University of Reading Present Address:Lund University Centre for Sustainability Studies Met Office Hadley Centre School of Geography and the Environment University of Oxford

The impacts of weather and climate-related disasters are increasing,and climate change can exacerbate many *** communicating climate risk and integrating science into policy requires scientists and stakeholders to work *** dialogue between scientists and policymakers can be challenging given the inherently multidimensional nature of the issues at stake when managing climate *** on the growing use of serious games to create dialogue between stakeholders,we present a new game for policymakers called Climate Attribution Under Loss and Damage:Risking,Observing,Negotiating(CAULDRON).CAULDRON aims to communicate understanding of the science attributing extreme events to climate change in a memorable and compelling way,and create space for dialogue around policy decisions addressing changing risks and loss and damage from climate *** describe the process of developing CAULDRON,and draw on observations of players and their feedback to demonstrate its potential to facilitate the interpretation of probabilistic climate information and the understanding of its relevance to informing *** looking to engage with stakeholders can learn valuable lessons in adopting similar innovative *** suitability of games depends on the policy context but,if used appropriately,experiential learning can drive coproduced understanding and meaningful dialogue.

关键词： Climate change Extreme event attribution Loss and damage policy Participatory games Probabilistic event attribution(PEA) Risk management

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Appearance of aseptic vascular grafts after endovascular aortic repair on[(18)F]fluorodeoxyglucose positron emission tomography/computed tomography

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World journal of Radiology 2023年第8期15卷 241-249页

作者： Paige Bennett Maria Bernadette Tomas Christopher F Koch Kenneth j.nichols Christopher j Palestro Department of Radiology LIJMC Northwell HealthNew Hyde ParkNY 11040United States Department of Radiology Zucker School of Medicine at Hofstra/NorthwellHempsteadNY 11549United States Division of Nuclear Medicine and Molecular Imaging Department of RadiologyNorthwell HealthNew Hyde ParkNY 11040United States

BACKGROUND Diagnosis of prosthetic vascular graft infection with[(18)F]fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG PET/CT)allows for early detection of functional changes associated with infection,based on increased glucose utilization by activated macrophages and *** vascular grafts,like all foreign bodies,can stimulate an inflammatory response,which can present as increased activity on 18F-FDG PET/***,distinguishing aseptic inflammation from graft infection,though important,can be *** the case of endovascular aneurysm repair(EVAR),a minimally invasive procedure involving the transfemoral insertion of an endoprosthetic stent graft,the normal postoperative appearance of these grafts on 18F-FDG PET/CT can vary over time,potentially confounding study *** To investigate the visual,semiquantitative,and temporal characteristics of aseptic vascular grafts in patients status post *** In this observational retrospective cohort study,patients with history of EVAR who underwent 18F-FDG PET/CT for indications other than infection were identified *** patients were asymptomatic for graft infection-no abdominal pain,fever of unknown origin,sepsis,or leukocytosis-at the time of imaging and for≥2 mo after each PET/*** studies such as CT for each patient were also reviewed,and any patients with suspected or confirmed vascular graft infection were *** hundred two scans performed on 43 patients(34 males;9 females;age=77±8 years at the time of the final PET/CT)were retrospectively *** 43 patients had an abdominal aortic(AA)vascular graft,40 patients had a right iliac(RI)limb graft,and 41 patients had a left iliac(LI)limb *** patients had 1 PET/CT and 21 patients had from 2 to 9 PET/*** were imaged between 2 mo to 168 mo(about 14 years)post *** grafts were imaged within 6 mo of placement,including three that were imaged wit

关键词： Aseptic vascular grafts Endovascular aortic repair [(18)F]fluorodeoxyglucose positron emission tomography/computed tomography

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Coastal life is not under threat by the carbon dioxide emissions

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journal of Coastal Life Medicine 2014年第3期 239-252页

作者： Albert parker School of Aerospace Mechanical and Manufacturing Engineering RMIT UniversityBundooraVICAustralia

The near future of coastal life is threated by the claim of global warming alarmist that sea levels will rise by one to seven metres by 2100,destroying many coastal cities and *** paper shows that sea levels will more likely rise no more than just a few centimetres during this century as the Earth defrosts from the Little Ice Age 500 years ago with a mild warming.

关键词： Sea level rate of rise Sea level accelerations Tide gauge measurements Global mean sea level reconstructions

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3D extrusion of multi-biomaterial lattices using an environmentally informed workflow

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Frontiers of Architectural Research 2022年第4期11卷 691-708页

作者： Vasiliki Panagiotidou Andreas Koerner Marcos Cruz Brenda parker Bastian Beyer Sofoklis Giannakopoulos Bio-Integrated Design Lab The Bartlett School of ArchitectureUniversity College LondonLondonWC1E 6BTUnited Kingdom

The conventional building material palette has been proven limited in terms of adaptability to our current environmental challenges. Innovations in computational design and digital manufacturing have supported the broadening of biomaterial applications as an alternative. While biomaterials are characteristically responsive to stimuli such as temperature and humidity, their unpredictable behaviour is a hurdle to standardization and architectural utilisation. To examine the nexus between material formulation, computation and manufacturing, multi-biomaterial lattice structures were produced through an environmentally informed workflow. Customized biomaterial development resulted in three candidate biopolymer blends with varying levels of hydro-responsiveness and transparency. The computational strategy included a machine learning clustering algorithm to customise results and dictate material distribution outputs. To test the workflow, environmental data of solar radiation exposure and solar heat gain from a specific location was used to inform the material deposition via pneumatic extrusion for the design and digital fabrication of a deformation-controlled prototype of 350 mm × 350 mm. This led to a series of multi-biomaterial wall panel components that can be applied at architectural scale. In future, these techniques can support the incorporation of living elements to be embedded within the built environment for truly animate architecture.

关键词： Hydrogels Multi-biomaterials Hygroscopic properties Pneumatic extrusion Environmentally informed deposition Integrated workflows

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Feasibility of pancreatectomy following high-dose proton therapy for unresectable pancreatic cancer

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World journal of Gastrointestinal Surgery 2017年第4期9卷 103-108页

作者： Kathryn E Hitchcock R Charles nichols Christopher G Morris Debashish Bose Steven j Hughes john A Stauffer Scott A Celinski Elizabeth A johnson Robert A Zaiden Nancy P Mendenhall Michael S Rutenberg Department of Radiation Oncology University of Florida Department of Surgical Oncology UF Health Cancer Center-Orlando Health Department of Surgery University of Florida Department of Surgery Mayo Clinic Department of Surgery Baylor University Medical Center at Dallas Department of Hematology/Oncology Mayo Clinic Department of Hematology/Oncology Baptist Health

AIM To review surgical outcomes for patients undergoing pancreatectomy after proton therapy with concomitant capecitabine for initially unresectable pancreatic *** From April 2010 to September 2013,15 patients with initially unresectable pancreatic cancer were treated withproton therapy with concomitant capecitabine at 1000 mg orally twice daily. All patients received 59.40 Gy(RBE) to the gross disease and 1 patient received 50.40 Gy(RBE) to high-risk nodal targets. There were no treatment interruptions and no chemotherapy dose reductions. Six patients achieved a radiographic response sufficient to justify surgical exploration,of whom 1 was identified as having intraperitoneal dissemination at the time of surgery and the planned pancreatectomy was aborted. Five patients underwent resection. Procedures included:Laparoscopic standard pancreaticoduodenectomy(n = 3),open pyloris-sparing pancreaticoduodenectomy(n = 1),and open distal pancreatectomy with irreversible electroporation(IRE) of a pancreatic head mass(n = 1). RESULTS The median patient age was 60 years(range,51-67). The median duration of surgery was 419 min(range,290-484),with a median estimated blood loss of 850 cm^3(range,300-2000),median ICU stay of 1 d(range,0-2),and median hospital stay of 10 d(range,5-14). Three patients were re-admitted to a hospital within 30 d after discharge for wound infection(n = 1),delayed gastric emptying(n = 1),and ischemic gastritis(n = 1). Two patients underwent R0 resections and demonstrated minimal residual disease in the final pathology specimen. One patient,after negative pancreatic head biopsies,underwent IRE followed by distal pancreatectomy with no tumor seen in the specimen. Two patients underwent R2 resections. Only 1 patient demonstrated ultimate local progression at the primary site. Median survival for the 5 resected patients was 24 mo(range,10-30).CONCLUSION Pancreatic resection for patients with initially unresectable cancers is feasible after

关键词： Pancreatic cancer Pancreatectomy Pancreas Proton therapy Radiotherapy

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The role of seaweed as a potential dietary supplementation for enteric methane mitigation in ruminants: Challenges and opportunities

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Animal Nutrition 2021年第4期7卷 1371-1387页

作者： Byeng R.Min David parker David Brauer Heidi Waldrip Catherine Lockard Kristin Hales Alexia Akbay Simona Augyte College of Agriculture Environment and Nutrition SciencesTuskegee UniversityTuskegeeAL 36088USA United States Department of Agriculture(USDA) Agriculture Research Service(ARS)2300 Experiment Station Dr.BushlandTX 79012USA Department of Animal and Food Sciences Texas Tech UniversityLubbockTX 79409USA Symbrosia Inc Kailua-KonaHI 96740USA

Seaweeds are macroalgae,which can be of many different morphologies,sizes,colors,and chemical *** include brown,red,and green *** seaweeds have been more investigated and exploited in comparison to other seaweed types for their use in animal feeding studies due to their large sizes and ease of *** in vitro and in vivo studies suggest that plant secondary compound-containing seaweeds(e.g.,halogenated compounds,phlorotannins,etc.)have the potential to mitigate enteric methane(CH_(4))emissions from ruminants when added to the diets of beef and dairy *** seaweeds including Asparagopsis *** rich in crude protein and halogenated compounds compared to brown and green *** halogenated-containing red seaweeds are used as the active ingredient in ruminant diets,bromoform concentration can be used as an indicator of antimethanogenic ***-containing brown seaweed has also the potential to decrease CH_(4) ***,numerous studies examined the possible anti-methanogenic effects of marine seaweeds with inconsistent *** work reviews existing data associated with seaweeds and in vitro and in vivo rumen fermentation,animal performance,and enteric CH4 emissions in *** understanding of the seaweed supplementation related to rumen fermentation and its effect on animal performance and CH_(4) emissions in ruminants may lead to novel strategies aimed at reducing greenhouse gas emissions while improving animal productivity.

关键词： Seaweed Bromoform Methane Phlorotannins Ruminant Cattle

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Fusion genes in solid tumors: an emerging target for cancer diagnosis and treatment

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Chinese journal of Cancer 2013年第11期32卷 594-603页

作者： Brittany C.parker Wei Zhang Department of Pathology Unit 85The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA The University of Texas Graduate School of Biomedical Sciences HoustonTX 77030USA

Studies over the past decades have uncovered fusion genes, a class of oncogenes that provide immense diagnostic and therapeutic advantages because of their tumor-specific expression. Originally associated with hemotologic cancers, fusion genes have recently been discovered in a wide array of solid tumors, including sarcomas, carcinomas, and tumors of the central nervous system. Fusion genes are attractive as both therapeutic targets and diagnostic tools due to their inherent expression in tumor tissue alone. Therefore, the discovery and elucidation of fusion genes in various cancer types may provide more effective therapies in the future for cancer patients.

关键词：融合基因癌症患者治疗性实体瘤肿瘤组织中枢神经系统诊断工具特异性表达

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Assemblage-based biomonitoring of freshwater ecosystem health via multimetric indices:A critical review and suggestions for improving their applicability

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Water Biology and Security 2022年第3期1卷 28-42页

作者： Robert L.Vadas jr. Robert M.Hughes Yeon jae Bae Min jeong Baek Orestes Carlos Bello Gonzáles Marcos Callisto Débora ReisdeCarvalho Kai Chen Maria T.Ferreira Pablo Fierro jon S.Harding Dana M.Infante C.j.Kleynhans Diego R.Macedo Isabela Martins Norman Mercado Silva Nabor Moya Susan j.nichols Paulo S.Pompeu Renata Ruaro Deborah R.O.Silva R.jan Stevenson Bianca de Freitas Terra Christa Thirion Douglas Ticiani Lizhu Wang Chris O.Yoder 2909 Boulevard Rd SEOlympiaWA98501-3971USA Amnis Opes Institute 2895 SE GlennCorvallisOR97333USA Department of Fisheries Wildlife&Conservation SciencesOregon State UniversityCorvallisOR97331USA Division of Environmental Science&Ecological Engineering Korea University145 Anam-roSeongbuk-guSeoul02841South Korea National Institute of Biological Resources Ministry of Environment42 Hwangyeong-roSeo-guIncheon22689South Korea Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de Morelos1001Col.ChamilpaC.P62209CuernavacaMorelosMexico Departamento de Genética Ecologia e EvoluçaoInstituto de Ciências BiologicaUniversidade Federal de Minas GeraisAvenida Ant^onio Carlos 6627CEP31270-901Belo HorizonteMGBrazil Departamento de Ecologia e Conservaçao Universidade Federal de Lavras37200-900LavrasMGBrazil State Key Laboratory of Marine Resource Utiliization in South China Sea Hainan UniversityHaikou570228China Forest Research Centre&Associate Laboratory TERRA University of LisbonTapada da Ajuda1349-017LisbonPortugal Instituto de Ciencias Marinas y Limnologicas Universidad Austral de ChileValdiviaChile School of Biological Sciences University of CanterburyPrivate Bag 4800Christchurch8140New Zealand Department of Fisheries&Wildlife Michigan State University1405 South Harrison Road#318East LansingMI48823USA Department of Water Affairs and Forestry(retired) 8th Avenue 771Wonderboom South0084PretoriaSouth Africa Departamento de Geografia Instituto de GeociênciasUniversidade Federal de Minas GeraisAvenida Antônio Carlos 6627CEP31270-901Belo HorizonteMGBrazil Instituto Guaicuy 109 Rua BrasopolisBelo HorizonteMG31150-170Brazil Centro de Investigación en Biodiversidad y Conservación Universidad Autónoma del Estado de MorelosAvenida Universidad 1001Col.ChamilpaC.P.62209CuernavacaMorelosMexico Instituto Experimental de Biología Universidad San Francisco Xavier de ChuquisacaSucreBolivia Centre for Applied Water Science Un

Freshwater biota are more comprehensive and direct indicators of biological impacts,and more meaningful to the public than water quality or physical habitat *** biotic data and the multiple biological indicators developed from them offer a much richer array of data for assessing the impacts of pollution controls than a limited set of physical or chemical *** recent decades,assemblage-based assessments by ecologists,environmental scientists,and water quality agencies have been employed globally for determining the condition of,and threats to,freshwater ecosystems.A key step in this advance has been the development of multimetric indices(MMIs)or indices of biotic integrity(IBIs)based on quantitative assessments of algae,macrophyte,macroinvertebrate,fish or riparian bird *** Europe,where biological assemblages are mandated for assessing freshwater ecosystem health,many indices are ***,the proliferation of MMIs globally has not always occurred through the application of rigorous study designs and monitoring protocols,nor have they always effectively incorporated functional metrics,stressor assessments,and statistical ***,in this review,we discuss eleven major concerns with the development and application(including logistical limitations)of multimetric indicators based on freshwater biota to encourage more rigorous and widely applicable(transferable)MMI use and ***,our concerns focus on reference conditions;sampling effort,methods,and season;trophic guild definition;metric comprehensiveness,options,screening and scoring;and MMI *** could also benefit from increased attention to ecological mechanisms and metric development,to further improve our understanding of anthropogenic impacts as well as rehabilitation effects on freshwater ecosystems *** closer attention to study designs,ecological mechanisms and metric development should further improve our understa

关键词： IBI MMI Fish Macroinvertebrates Algae Streams Rivers Lakes Wetlands Biological monitoring

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Antagonism of Transcription Factor MYC2 by EDS1/PAD4 Complexes Bolsters Salicylic Acid Defense in Arabidopsis Effector-Triggered Immunity

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Molecular Plant 2018年第8期11卷 1053-1066页

作者： Haitao Cui jingde Qiu Yue Zhou Deepak D. Bhandari Chunhui Zhao jaqueline Bautor jane E. parker Department of Plant-Microbe Interactions Max-Planck Institute for Plant Breeding Research Carl-von-Linne Weg 10 50829 Cologne Germany Department of Plant Developmental Biology Max-Planck Institute for Plant Breeding Research 50829 Cologne Germany Key Laboratory of Ministry of Education for Genetics Breeding and Multiple Utilization of Crops Plant Immunity Center Fujian Agriculture University Fuzhou 350002 China These authors contributed equaily to this article.

In plant immunity, pathogen-activated intracellular nucleotide binding/leucine rich repeat （NLR） receptors mobilize disease resistance pathways, but the downstream signaling mechanisms remain obscure. Enhanced disease susceptibility 1 （EDS1） controls transcriptional reprogramming in resistance triggered by Toll-lnterleukinl-Receptor domain （TIR）-family NLRs （TNLs）. Transcriptional induction of the salicylic acid （SA） hormone defense sector provides one crucial barrier against biotrophic pathogens. Here, we present genetic and molecular evidence that in Arabidopsis an EDS1 complex with its partner PAD4 inhibits MYC2, a master regulator of SA-antagonizing jasmonic acid （jA） hormone pathways. In the TNL immune response, EDSl/PAD4 interference with MYC2 boosts the SA defense sector independently of EDS1-induced SA synthesis, thereby effectively blocking actions of a potent bacterial jA mimic, coronatine （COR）. We show that antagonism of MYC2 occurs after COR has been sensed inside the nucleus but before or coincident with MYC2 binding to a target promoter, pANAC019. The stable interaction of PAD4 with MYC2 in planta is competed by EDS1-PAD4 complexes. However, suppression of MYC2-promoted genes requires EDS1 together with PAD4, pointing to an essential EDS1-PAD4 heterodimer activity in MYC2 inhibition. Taken together, these results uncover an immune receptor signaling circuit that intersects with hormone pathway crosstalk to reduce bacterial pathogen growth.

关键词： NLR receptor stress hormone network Pseudomonas syringae AvrRps4 RRS1/RPS4 coi1

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Psychological impact of coronavirus disease 2019 (COVID-19) social distancing mandates on trauma survivors

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Global Health journal 2022年第3期6卷 174-179页

作者： Maggie M.parker Stephanie F.Dailey ADiona Emmanuel Andrew Campbell Graduate School of Education and Human Development George Washington UniversityWashington D.C.20052USA College of Education and Human Development George Mason UniversityFairfaxVA 22030USA Psychology and Counseling Department Hood CollegeFrederickMD 21701USA

Objective:Despite recognition that coronavirus disease 2019(COVID-19)pandemic created an unprecedented impact on global mental health,information on the psychological health among trauma survivors during the COVID-19 pandemic is *** sought to examine psychological outcomes among individuals with preexisting traumatic experiences during ***:We sampled 1242 adults in the mid-Atlantic region of the United States under a state-issued Phase 1 stay-at-home mandate to examine associations between pre-pandemic trauma exposure as measured by the Brief Trauma Questionnaire(BTQ)and anxiety and depression,as measured by the Patient Reported Outcome Scale Anxiety and Depression(PROMIS-A and PROMIS-D).Results:Pre-pandemic trauma exposure among the sample was reported,with 281(22.6%)participants identifying as experiencing one trauma,209(16.8%)reporting two,and 468(37.7%)reporting three or *** reported experiences of trauma increased,so did participant anxiety and depressive ***-way Analysis of Variance indicated that reported trauma was significantly positively correlated with anxiety(P<0.01)and depressive symptomatology(P<0.01).Conclusion:Findings highlight the immense psychological toll of the COVID-19 pandemic,specifically with individuals who were previously exposed to *** health officials can encourage physicians,employers,and universities to screen patients,employees,and students to assess previous trauma,psychological functioning,and risk *** between physicians and mental health providers including psychiatrists,psychologists,counselors,and social workers to provide evidence informed rapid coordination of care can better meet the global mental health crisis that is arising as a result of this unprecedented global trauma.

关键词： Coronavirus disease 2019(COVID-19) Trauma Risk factors Psychological distress Mental health

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