检索结果-南通市图书馆

Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer:a phase II trial of pembrolizumab

引用

Oncology Research 2025年第1期33卷 57-65页

作者： RYUL KIM JOO kyung park MINSUK KWON MINAE AN JUNG YONG HONG JOON OH park SUNG HEE LIM SEUNG TAE KIM Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Division of Gastroenterology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Department of Hematology-Oncology Ajou University School of MedicineSuwon-siGyeonggi-doKorea Samsung Advanced Institute of Health Science and Technology Sungkyunkwan University School of MedicineSeoulKorea

Background:Immune checkpoint inhibitors(ICIs)are effective in a subset of patients with metastatic solid ***,the patients who would benefit most from ICIs in biliary tract cancer(BTC)are still *** and methods:We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line ***:All patients had microsatellite stable(MSS)type *** of the 32 patients achieved partial response(PR),with an objective response rate(ORR)of 9.4%(95%confidence interval[CI],2.0–25.2)and nine showed stable disease(SD),exhibiting a disease control rate(DCR)of 37.5%(95%CI,21.1–56.3).For the 31 patients who had access to PD-1 ligand 1(PD-L1)combined positive score(CPS)testing(cut-off value≥1%),the ORR was not different between those who had PD-L1-positive(PD-L1+;1/11,9.1%)and PDL1-(2/20,10.0%)tumors(p=1.000).The tumor mutational burden(TMB)of PD-L1+BTC was comparable to that of PD-L1-BTC(p=0.630).TMB and any exonic somatic mutations were also not predictive of pembrolizumab *** analysis of blood and tumor samples demonstrated a relatively high natural killer(NK)cell proportion in the peripheral blood before pembrolizumab treatment in patients who achieved tumor ***,the tumors of these patients presented high enrichment scores for NK cells,antitumor cytokines,and Th1 signatures,and a low enrichment score for cancer-associated ***:This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.

关键词： Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing Biliary tract cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

In situ measurement of atmospheric carbon dioxide at Yanbian,China:Estimating its northeast Asian emission regions

引用

Science China Earth Sciences 2012年第10期55卷 1742-1748页

作者： JIN FenJi FANG YingYu CHEN Tie LI DongHao KIM Jooil park Mi-kyung park Sunyoung KIM kyung-Ryul School of Earth and Environmental Science Seoul National University Seoul 151-742 Republic of Korea Earth and Environmental Research Institute of Northeast Asia Yanbian University Yanji 133002 China Analytical and Testing Center Yanbian University Yanji 133002 China Research Institute of Oceanography Seoul National University Seoul 151-742 Republic of Korea

High-precision(±0.1 ppm) and high-frequency(hourly averaged) in situ measurements of atmospheric carbon dioxide(CO2) were made for the first time from August 2005 to July 2007 at Yanbian,China using a non-dispersive Infrared(NDIR) analyzer with National Oceanic and Atmospheric Administration/Earth System Research Laboratory(NOAA/ESRL) *** results of these measurements are presented in this paper and are used to investigate the regional representativeness of regional background data at Yanbian and determine the CO2 emission source regions in Northeast *** phase of the monthly variations at Yanbian reflects the special regional characteristics,which were overall in excellent agreement with other observatories in the middle-to-high latitudes in the Northern *** a hybrid receptor model to the regional emission source events in cold period(November-April),we estimated the distribution of the major CO2 emissions in the northeast *** results indicated that the strongest potential emission areas contributing to Yanbian are the Beijing & Tianjin metropolitan areas,southwestern part of Shandong Province including Jinan,and *** results of this study reveal the usefulness of in situ CO2 measurements at Yanbian in establishing the scientific foundation for monitoring the large CO2 emission areas in northern China and *** monitoring of CO2 at Yanbian within a regional network should provide significant contributions to both understanding the global/regional carbon cycle and constraining "top-down" emissions in Northeast Asia.

关键词： carbon dioxide emission regions in situ monitoring Northeast Asia regional background Yanbian

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Risk factor analysis for meta plastic gastritis in Koreans

引用

World Journal of Gastroenterology 2006年第16期12卷 2584-2587页

作者： Soonami Choi Yun Jeong Lim Sue kyung park Center for Health Promotion Samsung Medical CenterSeoulKorea Department of Internal Medicine Dongguk University International HospitalDongguk University College of MedicineGoyangKorea Department of Preventive Medicine Seoul National University College of MedicineSeoulKorea

AIM： To conduct a retrospective study to determine the risk factors for development of metaplastic gastritis in Korean population. METHODS： The database of 113449 subjects who underwent a gastroscopy for the purpose of a regular check-up at center for health promotion, Samsung medical center during 5 years was collected and retrospectively analyzed. Among them, 5847 subjects who had endoscopically diagnosed as a metaplastic gastritis or 10076 normal as well as answered to questionnaire were included for present study. The subjects were divided into 2 groups; Group Ⅰ, normal and Group Ⅱ, metaplastic gastritis. Age, gender, Helicobacter pylori （H pylori） seropositivity, body mass index （BMI）, family history of cancer, smoking, alcohol consumption, total daily calories, folate and salt intake and dietary habit （out-eating, overeating, irregular eating） were retrieved from questionnaire or electronic medical record and compared between group Ⅰ and group Ⅱ. RESULTS： The prevalence of group Ⅱwas 11% （13578/113449） increasing its prevalence with age （P=0.000）. But, there was no significant association between 2 groups in BMI, family history of cancer, alcohol consumption, total daily calories, folate and salt intake and dietary habit （out-eating, overeating, irregular eating）. Old age （P=0.000）, male gender （P=0.000）, H pylori seropositivity （P= 0.010） and current smoker （P=0.000） were significantly more common in group II at multiple logistic regression model. CONCLUSION： Our data suggested that old age, male gender, H pylori seropositivity and smoking were risk factors for metaplastic gastritis, precancerous lesion of gastric cancer.

关键词： Intestinal metaplasia Risk factors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Spatio-temporal variability in sea surface wind stress near and off the east coast of Korea

引用

Acta Oceanologica Sinica 2005年第1期24卷 107-114页

作者： NAM SungHyun KIM Young Ho park kyung-Ae KIM Kuh Ocean Laboratory/RIO School of Earth and Environmental Sciences Seoul National University Seoul 151-742 KoreaOcean Laboratory/RIO School of Earth and Environmental Sciences Seoul National University Seoul 151-742 KoreaOcean Laboratory/RIO School of Earth and Environmental Sciences Seoul National University Seoul 151-742 KoreaOcean Laboratory/RIO School of Earth and Environmental Sciences Seoul National University Seoul 151-742 Korea

Sea surface wind stress variabilities near and off the east coast of Korea, are examined using 7 kinds of wind datasets from measurements at 2 coastal (land) stations and 2 ocean buoys,satellite scatterometer (QuikSCAT), and global reanalyzed products (ECMWF,NOGAPS,and NCEP/NCAR). Temporal variabilities are analyzed at 3 frequency bands; synoptic (2-20 d), intra-seasonal (20-90 d),and seasonal (>90 d).Synoptic and intra-seasonal variations are predominant near and off the Donghae City due to the passage of the mesoscale weather system. Seasonal variation is caused by southeastward wind stress during Asian winter monsoon. The sea surface wind stress from reanalyzed *** and KMA-B measurements off the coast show good agreement in the magnitude and direction,which are strongly aligned with the alongshore *** the land-based sites,wind stresses are much weaker by factors of 3-10 due to the mountainous landmass on the east parts of Korea *** first EOF modes(67%-70%) of wind stresses from reanalyzed and QuikSCAT data have similar structures of the strong southeastward wind stress in winter along the coast but show different curl structures at scales less than 200 km due to the orographic *** second EOF modes (23%-25%) show southwestward wind stress in every September along the east coast of the North Korea

关键词： sea surface wind stress spatio-temporal variability monsoon seasonal intra-seasonal synoptic band orographic effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhanced electrical and optical properties of single- layered MoS2 by incorporation of aluminum

引用

Nano Research 2018年第2期11卷 731-740页

作者： Kim, Hyung-Jun Yang, Suk Kim, Hojoong Moon, Jin Young park, kyung park, Yun-Jin Kwon, Jang-Yeon School of Integrated Technology Yonsei University Incheon Republic of Korea Yonsei Institute of Convergence Technology Incheon Republic of Korea

Electrical and optical enhancements of single-layer semiconducting materials such as transition metal dichalcogenides have recently been studied to achieve sensitive properties via external treatments, such as the formation of organic/ inorganic protecting layers on field-effect transistors （FETs）, thermal annealing, and nano-dot doping of sensors and detectors. Here, we propose a new analytical approach to electrical and optical enhancement through a passivation process using atomic layer deposition （ALD）, and demonstrate a synthesized MoS2 monolayer incorporated with A1 atoms in an A1203 passivation layer. The incorporated A1 atoms in the MoS2 monolayer are dearly observed by spherical aberration-corrected scanning transmission electron microscopy （Cs-STEM） and TEM-energy-dispersive X-ray spectroscopy results. We demonstrate that the chemically incorporated FETs exhibit highly enhanced mobilities of approximately 3.7 crn2-V-los-1, forty times greater than that of as-synthesized MoS2, with a three- fold improvement in the Dhotoluminescence properties.

关键词： MoS2 aluminum incorporation chemical vapor deposition atomic layer deposition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recurrent cervical esophageal stenosis after colon conduit failure:Use of myocutaneous flap

引用

World Journal of Gastroenterology 2013年第2期19卷 307-310页

作者： Young Jo Sa Young Du Kim Chi kyung Kim Jong kyung park Seok Whan Moon Department of Thoracic and Cardiovascular Surgery St.Paul HospitalThe Catholic University of KoreaSeoul 130-709South Korea Department of General Surgery St.Paul HospitalThe Catholic University of KoreaSeoul 130-709South Korea

A 53-year-old male developed cervical esophageal stenosis after esophageal bypass surgery using a right colon *** esophageal bypass surgery was performed to treat multiple esophageal strictures resulting from corrosive ingestion three years prior to *** the patient underwent several endoscopic stricture dilatations after surgery,he continued to suffer from recurrent esophageal *** planned cervical patch esophagoplasty with a pedicled skin flap of sternocleidomastoid(SCM) *** recovery was successful,and the patient could eat a solid meal without difficulty and has been well for 18 *** flap esophagoplasty is an easier and safer method of managing complicated and recurrent cervical esophageal strictures than other operations.

关键词： Cervical esophageal stenosis Corrosive stricture Esophagus Esophageal conduit Esophagoplasty Myocutaneous flap Surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

引用

World Journal of Gastroenterology 2008年第27期14卷 4359-4364页

作者： Young Hye Byun Jun Haeng Lee Moon kyung park Ji Hyun Song Byung-Hoon Min Dong kyung Chang Young- Ho Kim Hee Jung Son Poong-Lyul Rhee Jae J Kim Jong Chul Rhee Ji Hye Hwang Dong Il park Sang Goon Shim In kyung Sung Department of Medicine Sungkyunkwan University School of Medicine Samsung Medical Center Department of Physical Medicine and Rehabilitation Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Medicine Sungkyunkwan University School of Medicine Masan Samsung Hospital Department of Internal Medicine Konkuk University College of Medicine

AIM: To determine the prevalence and risk factors of work-related musculoskeletal disorders in gastrointestinal endoscopists in Korea. METHODS: A survey of musculoskeletal symptoms, using a self-administered questionnaire, was conducted on 55 endoscopists practicing in general hospitals or health promotion centers. RESULTS: Forty-nine (89.1%) endoscopists reported musculoskeletal pain on at least one anatomic location and 37 (67.3%) endoscopists complained of pain at rest. Twenty-six (47.3%) endoscopists had severe musculoskeletal pain defined as a visual analogue score greater than 5.5. Factors related to the development of severe pain were (1) standing position during upper endoscopy, (2) specific posture/ habit during endoscopic procedures, and (3) multiple symptomatic areas. Finger pain was more common in beginners, whereas shoulder pain was more common in experienced endoscopists. Sixteen percent of symptomatic endoscopists have modified their practice or reduced the number of endoscopic examinations. Only a few symptomatic endoscopists had sought professional consultation with related specialists. CONCLUSION: The prevalence of musculoskeletal pain in endoscopists is very high. The location of pain was different between beginners and experienced endoscopists. Measures for the prevention and adequate management of endoscopy-related musculoskeletal symptoms are necessary.

关键词： Endoscopy Endoscopist Musculoskeletal symptom

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

分布式无线通信系统中STBC和V-BLAST的组合方案

引用

清华大学学报（自然科学版） 2007年第1期47卷 36-39页

作者：韩双锋周世东王京 park kyung 清华大学电子工程系北京100084 韩国电子通信研究院北京研究中心北京100027

在分布式天线分簇放置的单用户分布式无线通信系统中,为了有效地实现下行分集与复用的折中,提出了一种空时分组码(space-time block code,STBC)和垂直分层发送方案(vertical bell-labs layered space time,V-BLAST)的组合方案。在发送... 详细信息

在分布式天线分簇放置的单用户分布式无线通信系统中,为了有效地实现下行分集与复用的折中,提出了一种空时分组码(space-time block code,STBC)和垂直分层发送方案(vertical bell-labs layered space time,V-BLAST)的组合方案。在发送端根据反馈的发送相关矩阵的特征值,提出了天线选择和功率、速率分配的方案,使得系统误符号率(symbol error rate,SER)的上界最小。仿真结果表明:不同方案实际SER性能之间的关系和通过SER上界得到的关系完全一致。该方案简化了下行发送方案的设计,适合于实际应用。

关键词：分布式无线通信系统空时分组码分层发送方案天线选择功率和速率分配

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clinical and pathological differences between serum immunoglobulin G4-positive and -negative type 1 autoimmune pancreatitis

引用

World Journal of Gastroenterology 2013年第25期19卷 4031-4038页

作者： Woo Hyun Paik Ji Kon Ryu Jin Myung park Byeong Jun Song Joo kyung park Yong-Tae Kim Kyoungbun Lee Department of Internal Medicine Liver Research Institute Division of Gastroenterology Department of Internal Medicine Seoul National University College of Medicine Department of Pathology Seoul National University College of Medicine

AIM: To identify clinical and pathological differences between serum immunoglobulin G4 (IgG4)-positive (SIP) and IgG4-negative (SIN) type 1 autoimmune pancreatitis (AIP) in South Korea. METHODS: AIP was diagnosed by the international consensus diagnostic criteria. The medical records and pathology were retrospectively reviewed and IgG4-positive cells were counted in a high power field (HPF). Type I AIP was defined as a high serum level of IgG4or histological finding. SIN type 1 AIP was defined as a histological evidence of type 1 AIP and a normal serum IgG4 level. The clinical and pathological findings were compared between the two groups. The analysis was performed using Student's t test, Fischer's exact test and Mann-Whitney's U test. A P value of < 0.05 was considered statistically significant. As repeated com- parison was made, P values of less than 5% (P < 0.05) were considered significant. RESULTS: Twenty five patients with definite type 1 AIP (19 histologically and six serologically diagnosed cases) were enrolled. The mean tissue IgG4 concentrations were significantly higher in SIP than SIN group (40 cells per HPF vs 18 cells per HPF, P = 0.02). Among eight SIN patients, the tissue IgG4 concentrations were less than 15 cells per HPF in most of cases, except one. The sensitivity of serum IgG4 was 68% (17 SIP and eight SIN AIP). Other organ involvement was more frequent- ly associated with SIP than SIN AIP (59% vs 26%, P = 0.016). However, the relapse rate and diffuse swelling of the pancreas were not associated with serum IgG4 level. The concentrations of IgG4-positive cells per HPF were higher in SIP than SIN AIP (40 vs 18, P = 0.02). CONCLUSION: The sensitivity of serum IgG4 was 68% in type 1 AIP. High serum IgG4 level was associated with other organ involvement and tissue IgG4 concentration but did not affect the relapse rate in type 1 AIP.

关键词： Autoimmunity Chronic pancreatitis Immunoglobulin G4-related systemic disease Lymphoplas-macytic sclerosing pancreatitis Immunoglobulin G4

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bleeding after endoscopic papillectomy and its risk factors:A single center experience of 196 cases

引用

Hepatobiliary & Pancreatic Diseases International 2024年第6期23卷 613-619页

作者： Jin Ho Choi Won Chul Kim Joo kyung park Jong Kyun Lee Kyu Taek Lee Kwang Hyuck Lee Department of Medicine Division of GastroenterologySamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Korea

Background:Endoscopic papillectomy(EP)is an effective method to remove an ampulla of Vater(AoV)adenoma with minimal *** reviewed the clinical outcomes and prognosis of patients undergoing EP,including tumor recurrence and adverse ***:A total of 196 patients who underwent EP from January 2004 to December 2017 were *** information was collected through electronic medical records,and risk factors to predict postprocedural bleeding were analyzed using a multivariate logistic regression ***:A total of 93.9%patients(184/196)underwent complete *** the follow-up period,14.7%patients(27/184)experienced tumor recurrence,and two of seven surgically resected tumors were malignant.A total of 45.4%patients(89/196)experienced adverse events related to *** bleeding occurred in 16.3%of the patients(32/196),and they were all successfully treated with endoscopic hemostasis and conservative *** most frequent site of delayed bleeding was the distal end of the papillary orifice,and 56.3%(18/32)patients of delayed bleeding were classified as having mild severity,the others had moderate *** adenomatous polyposis(FAP)[odds ratio(OR)=3.80,95%confidence interval(CI):1.01-14.29;P<0.05]and male sex(OR=2.82,95%CI:1.04-7.63;P=0.04)showed statistical significance in predicting delayed post-EP ***:EP for AoV adenoma was a highly effective and safe *** risk of post-EP delayed bleeding was increased in patients with FAP syndrome and male patients,and post-EP bleeding occurred most commonly in the distal part of the AoV.

关键词： Ampullary neoplasm Endoscopic papillectomy Post-procedural bleeding Risk factor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：