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Expression of prothymosin α predicts early recurrence and poor prognosis of hepatocellular carcinoma

Hepatobiliary & Pancreatic Diseases International 2015年第2期14卷 171-177页

作者： Sang Yun Ha Dae Hyun Song Soo Hyun Hwang Soo Youn Cho cheol-Keun park Department of Pathology Samsung Medical CenterSungkyunkwan University School of Medicine

BACKGROUND：Prothymosinα（PTMA）is a nuclear oncoprotein-transcription factor essential for cell cycle progression and *** was overexpressed in several human malignancies including hepatocellular carcinoma（HCC）.However,the prognostic significance of PTMA protein expression in HCC remains *** the present study,we evaluated PTMA protein expression by immunohistochemistry in order to elucidate the prognostic roles of PTMA in HCC ***： By immunohistochemistry, we investigated the expression of PTMA protein in tumor tissue from 226 HCC patients who underwent curative hepatectomy. Univariate and multivariate analyses were performed to evaluate its predic- tive value for tumor recurrence and survival of patients. The median follow-up period was 120 months. RESULTS： PTMA expression was observed in 162 （71.7%） of the 226 HCC patients and was significantly associated with higher Edmondson grade, microvascular invasion, intrahe- patic metastasis, higher American Joint Committee on Cancer （AJCC） T-stage, and lower albumin level. PTMA expression was an independent predictor of early recurrence （P=0.001）. PTMA expression showed an unfavorable influence on recurrence- free survival （RFS）（P〈0.001）. Subgroup analysis showed that among patients with tumor size _〈5.0 cm （140 patients）, patients at AJCC T-stage I （95 patients） and patients with a-fetoprotein ≤20 ng/mL （83 patients）, the differences in RFS between PTMA- positive and PTMA-negative groups were also statistically sig- nificant （P=0.017, P=0.002 and P=0.002, respectively）. In addi- tion, PTMA expression was an independent predictor of shorter RFS （P=0.011）. PTMA expression showed an unfavorable influ- ence on overall survival （P=0.014）, but was not an independent predictor of shorter overall survival （P=0.161）. CONCLUSIONS： PTMA protein expression might be a novel predictor of early recurrence and RFS in HCC patients, even those at early stage or with a-fetoprotein-negative after curative hep

关键词： prothymosin a hepatocellular carcinoma recurrence

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Early treadmill exercise increases macrophage migration inhibitory factor expression after cerebral ischemia/reperfusion

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Neural Regeneration Research 2019年第7期14卷 1230-1236页

作者： Min cheol Chang Chae Ri park Seung Hwa Rhie Woo Hyun Shim Dae Yul Kim Department of Rehabilitation Medicine College of MedicineYeungnam University Asan Institute for Life Sciences Asan Medical CenterUniversity of Ulsan College of Medicine Department of Rehabilitation Medicine Asan Medical CenterUniversity of Ulsan College of Medicine Department of Radiology Asan Medical CenterUniversity of Ulsan College of Medicine

The neuroprotective function of macrophage migration inhibitory factor(MIF) in ischemic stroke was rarely *** study aimed to investigate the effects of early treadmill exercise on recovery from ischemic stroke and to determine whether these effects are associated with the expression levels of MIF and brain-derived neurotrophic factor(BDNF) in the ischemic area.A total of 40 male Sprague-Dawley rats were randomly assigned to the ischemia and exercise group [middle cerebral artery occlusion(MCAO)-Ex,n = 10),ischemia and sedentary group(MCAO-St,n = 10),sham-surgery and exercise group(Sham-Ex,n= 10),or sham-surgery and sedentary group(Sham-St,n = 10).The MCAO-Ex and MCAO-St groups were subjected to MCAO for 60 minutes,whereas the Sham-Ex and Sham-St groups were subjected to an identical operation without *** in the MCAO-Ex and Sham-Ex groups then ran on a treadmill for 30 minutes once a day for 5 consecutive *** reperfusion,the hanging time tested by the wire hang test was longer and the relative fractional anisotropy determined by MRI was higher in the peri-infarct region of the MCAO-Ex group compared with the MCAO-St *** expression levels of MIF and BDNF in the peri-infarct region were upregulated in the MCAO-Ex *** MIF and BDNF levels were positively correlated with relative fractional anisotropy changes in the peri-infarct *** was no significant difference in the levels of MIF and BDNF in the peri-infarct region between the Sham-Ex and Sham-St *** study demonstrated that early exercise(initiated 48 hours after the MCAO) could improve motor and neuronal recovery after ischemic ***,the increased levels of MIF and BDNF in the peri-infarct region(penumbra) may be one of the mechanisms of enhanced neurological function *** experiments were approved by the Institutional Animal Care and Use Committee in Asan Medical Center in South Korea(2016-12-126).

关键词： ischemic stroke early exercise macrophage migration inhibitory factor brain-derived neurotrophic factor motor recovery neural regeneration

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Restoration of an Inner-City Stream and Its Impact on Air Temperature and Humidity Based on Long-Term Monitoring Data

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Advances in Atmospheric Sciences 2009年第2期26卷 283-292页

作者： Kyu Rang KIM Tae Heon KWON yeon-Hee KIM Hae-Jung KOO Byoung-cheol CHOI Chee-Young CHOI Applied Meteorology Research Laboratory National Institute of Meteorological Research Korea Meteorological Administration Applied Meteorology Research Laboratory National Institute of Meteorological ResearchKorea Meteorological Administration

Spatiotemporal changes in air temperature and humidity associated with the restoration of an innercity stream in Seoul, Korea, are investigated based on long-term monitoring data. The Cheonggye stream, covered under a concrete structure for 46 years, was restored in 2005 and runs 5.8 km eastward through a central region of Seoul. Long-term monitoring of the air temperature and relative humidity was made along the stream throughout the restoration and across the stream after the restoration. The area along the stream had a higher air temperature than the entire metropolitan area. The temperature anomaly between the monitoring area and the surrounding metropolitan area was 0.13℃ lower on average at the center of the stream after the restoration. The stream＇s effect on the air temperature was also evident in the temperature distribution along a street traversing the stream. The relative and specific humidities were increased due to the restoration. The restored stream modified the nearby urban climate in the opposite direction compared to urbanization. The results could be used as a model case in mitigating urban climate by a stream in future urban planning practices.

关键词： urban heat island stream restoration land-use vegetation Cheonggye stream

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Enhancement of photoresponsive electrical characteristics of multilayer MoS2 transistors using rubrene patches

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Nano Research 2015年第3期8卷 790-800页

作者： Eun Hei Cho Won Geun Song cheol Joon park Jeongyong Kim Sunkook Kim Jinsoo Joo Department of Physics Korea University Seou1136-713 R. O. Korea Department of Electronics and Radio Engineering Institute for Laser Engineering Kyung Hee University Yongin Gyeonggi-do 446-70 I R. O. Korea Center for Integrated Nanostructure Physics (CINAP) Institute for Basic Science (IBS) Department of Energy Science Sungkyunkwan University Suwon 440-746 R. O. Korea

Multilayer MoS2 is a promising active material for sensing, energy harvesting, and optoelectronic devices owing to its intriguing tunable electronic band structure. However, its optoelectronic applications have been limited due to its indirect band gap nature. In this study, we fabricated a new type of phototransistor using multilayer MoS2 crystal hybridized with p-type organic semiconducting rubrene patches. Owing to the outstanding photophysical properties of rubrene, the device characteristics such as charge mobility and photoresponsivity were considerably enhanced to an extent depending on the thickness of the rubrene patches. The enhanced photoresponsive conductance was analyzed in terms of the charge results of the nanoscale laser confocal time-resolved PL measurements. transfer doping effect, validated by the microscope photoluminescence （PL） and

关键词： MoS2 rubrene transistor photoresponsivity charge transfer

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FET-based nanobiosensors for the detection of smell and taste

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Science China(Life Sciences) 2020年第8期63卷 1159-1167页

作者： Dongseok Moon yeon Kyung Cha So-ong Kim Seongyeon Cho Hwi Jin Ko Tai Hyun park School of Chemical and Biological Engineering Institute of Chemical ProcessesSeoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Program for Bioengineering Seoul National UniversitySeoul 08826Republic of Korea

Various nanobiosensors composed of biomaterials and nanomaterials have been developed,due to their demonstrated advantage of showing high *** various biomaterials for biological recognition elements of the nanobiosensor,sensory receptors,such as olfactory and taste receptors,are promising biomaterials for developing nanobiosensors,because of their high selectivity to target ***-effect transistors(FET)with nanomaterials such as carbon nanotube(CNT),graphene,and conducting polymer nanotube(CPNT),can be combined with the biomaterials to enhance the sensitivity of ***,many efforts have been made to develop nanobiosensors using biomaterials,such as olfactory receptors and taste receptors for detecting various smells and *** review focuses on the biomaterials and nanomaterials used in nanobiosensor systems and studies of various types of nanobiosensor platforms that utilize olfactory receptors and taste receptors which could be applied to a wide range of industrial fields,including the food and beverage industry,environmental monitoring,the biomedical field,and anti-terrorism.

关键词： nanobiosensor olfactory receptor taste receptor field-effect transistor(FET)

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Antiviral efficacy of adefovir dipivoxil versus lamivudine in patients with chronic hepatitis B sequentially treated with lamivudine and adefovir due to lamivudine resistance

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World Journal of Gastroenterology 2007年第30期13卷 4072-4079页

作者： yeon Seok Seo Ji Hoon Kim Jong Eun yeon Jong-Jae park Jae Seon Kim Kwan Soo Byun Young-Tae Bak Chang Hong Lee Division of Gastroenterology and Hepatology Department of Internal Medicine Korea University College of Medicine Seoul Korea Division of Gastroenterology and Hepatology Department of Internal Medicine Konkuk University College of Medicine Seoul Korea

AIM： To compare the antiviral efficacy of adefovir （ADV） in lamivudine （LMV）-resistant patients with LMV treatment in nucleoside-naive patients, using serum samples collected sequentially during the course of treatment progressing from LMV to ADV.METHODS： Forty-four patients with chronic hepatitis B （CHB） were included. The patients were initially treated with LMV and then switched to ADV when LMV resistance developed. Antiviral efficacy was assessed by measuring the following： reduction in serum HBV DNA from baseline, HBV DNA negative conversion （defined as HBV DNA being undectable by the hybridization assay）, and HBV DNA response （either HBV DNA level ≤ 10^s copies/mL or a ≥ 2 log10 reduction from baseline HBV DNA level）.RESULTS： After two and six months of treatment, HBV DNA reduction was greater with LMV compared to ADV treatment （P = 0.021）. HBV DNA negative conversion rates were 64% and 27% after one month of LMV and ADV treatment respectively （P = 0.001）. Similarly, HBV DNA response rates were 74% and 51% after two months of LMV and ADV treatment respectively （P = 0.026）. The time taken to HBV DNA negative conversion and to HBV DNA response were both delayed in ADV treatment compared with LMV.CONCLUSION： The antiviral efficacy of ADV in LMV-resistant patients is slower and less potent than that with LMV in nucleoside-naive patients during the early course of treatment.

关键词： Chronic hepatitis B Lamivudine Adefovir Treatment efficacy

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Risk factors for rebleeding after angiographically negative acute gastrointestinal bleeding

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World Journal of Gastroenterology 2009年第32期15卷 4023-4027页

作者： Ijin Joo Hyo-cheol Kim Jin Wook Chung Hwan Jun Jae Jae Hyung park Department of Radiology Seoul National University College of Medicine Institute of Radiation Medicine Seoul National University Medical Research Center Clinical Research Institute Seoul National University HospitalSeoul 110-744South Korea

AIM:To identify possible predictive factors for rebleeding after angiographically negative findings in patients with acute non-variceal gastrointestinal ***: From January 2000 to July 2007, 128 patients with acute non-variceal gastrointestinal bleeding had negative f indings after initial angiography. Clinical and laboratory parameters were analyzed ***: Among 128 patients, 62 had no recurrent gastrointestinal bleeding and 66 had recurrent gastrointestinal bleeding within 30 d. As determined by the use of multivariate analysis, an underlying malignancy, liver cirrhosis and hematemesis were significant factors related to recurrent gastrointestinal ***: Clinical factors including underlying malignancy, liver cirrhosis, and hematemesis are important predictors for rebleeding after angiographically negative findings in patients with acute non-variceal gastrointestinal bleeding.

关键词： Angiography Gastrointestinal hemorrhage Predictive factor

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The Development of Metabolic Derangement in Male Offspring after Perinatal Exposure to Di-(2-Ethylhexyl) Phthalate

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Biomedical and Environmental Sciences 2018年第7期31卷 531-534页

作者： Yun-jung Yang Moon-seo park Eui-Jin Lee yeon-pyo Hong Department of Preventive Medicine College of Medicine Chung-Ang University Institute of Biomedical Science Catholic Kwandong University International St. Mary’s Hospital Institute for Catholic Integrative Medicine Incheon St. Mary’s Hospital College of Medicine The Catholic University of Korea

The prevalence of obesity and type 2 diabetes mellitus（T2DM）has been increasing throughout the world over the past 20 *** chemicals known to regulate the endocrine system have been considered as a risk factor for th... 详细信息

关键词： PND Phthalate The Development of Metabolic Derangement in Male Offspring after Perinatal Exposure to Di Ethylhexyl

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Characterization of flexible copper laminates fabricated by Cu electro-plating process

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中国有色金属学会会刊：英文版 2009年第4期19卷 965-969页

作者： Chang-Min LEE Jun-Hyung LIM Soo-Min HWANG Eui-cheol park Jong-Hyun SHIM Jin-Hyun park Jinho JOO Seung-Boo JUNG School of Advanced Materials Science and Engineering Sungkyunkwan University

Flexible copper clad laminates(FCCLs) were fabricated using the electro-plating process and the combined effect of the current density and plating time on their surface morphology,texture,hardness,electrical resistivity and folding behavior was *** achieve Cu layers with similar thicknesses,the current density was varied in the range of 0.2-3 A/dm2 and the plating time was controlled in the range of 0.5-7.5 h to compensate for the variation of the current *** surface morphology,hardness,and folding behavior were characterized by atomic force microscopy,nanoindentation technique and Massachusett Institute of Technology folding endurance test,*** X-ray diffraction patterns indicated that the Cu phase was formed without any secondary phases;however,the preferred orientation changed from(220) to(111) as the current density increased over 1 A/*** addition,it was observed that the root-mean-square and hardness values decreased when the current density increased and the plating time decreased *** electrical resistivity was as low as approximately 21 nΩ·m and the number of cycles without failure in the folding test was over 15 000,which were comparable to those of commercial FCCLs.

关键词：电镀工艺层压板铜层制备表征电流密度原子力显微镜纳米压痕技术

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Ruptured splenic artery aneurysms in pregnancy and usefulness of endovascular treatment in selective patients:A case report and review of literature

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World Journal of Clinical Cases 2022年第25期10卷 9057-9063页

作者： Sang Hun Lee Songsoo Yang Inkyu park yeong cheol Im Gyu Yeol Kim Department of Obstetrics and Gynecology Ulsan University and Ulsan University HospitalUlsan 44033South Korea Department of Surgery Ulsan University and Ulsan University HospitalUlsan 44033South Korea

BACKGROUND The rupture of a splenic artery aneurysm(SAA)in pregnancy is an uncommon ***,it is associated with high mortality rates in pregnant women and fetuses even after surgical *** the endovascular treatment of SAAs is currently preferred as it can improve the outcomes even in emergent cases,the endovascular treatment of a ruptured SAA during pregnancy has not been reported until *** SUMMARY We report a case of a 33-year-old woman with the sudden onset of epigastric pain due to a ruptured SAA at the mid-portion of the splenic artery at 18 wk of *** emergent initial resuscitation,the patient was diagnosed with a ruptured SAA through digital *** upon diagnosis,she underwent emergent endovascular embolization of the splenic artery for the rupture on the ***,surgery was performed to remove the hematoma under stable *** the fetus was found to be dead during resuscitation,the woman recovered without complications and was discharged 15 d *** Endovascular treatment might be a valuable alternative to surgery/lead to safer surgery for selected pregnant patients with ruptured SAAs.

关键词： Splenic artery Aneurysm Pregnancy Endovascular treatment Case report

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