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世界核心医学期刊文摘（儿科学分册） 2006年第2期2卷 36-37页

作者： papparella a. Pa.meggia.i P. Cobellis G. 贺文龙 Pedia.ric Surgery Clinic Second Univ. of Naples Med. School 80131 Naples Italy

Purpose: Dia.nostic la.a.oscopy ha. cha.ged the surgica. a.proa.h to nonpa.pa.le testes (NPT). The a.m of this study wa. to determine the va.ue of la.a.oscopy in ma.a.ing pa.ients with NPT a.d to suggest guidelines for the interpreta.ion of la.a.oscopic findings. The a.thors report the results of a.multicenter study of the Ita.ia. Society of Video Surgery in Infa.cy on la.a.oscopic ma.a.ement of NPT. Methods: Between 1993 a.d 2001, the a.thors collected records of 364 pa.ients with NPT who underwent la.a.oscopy, for a.tota. of 388 testicula. units. Results: Intra.bdomina. testes were found in 124 (34% ) ca.es, for a.tota. of 137 testes; 83 testicula. units were cla.sified a. low a.d 54 a. high. a.tota. of 155 (43% ) pa.ients ha. cord structures entering the interna. inguina. ring, 79 (22% ) ha. intra.bdomina. blind-ending cord structures, a.d 6 (1% ) ha. testicula. a.enesia. Conclusions: La.a.oscopy is a.va.ua.le tool in dia.nosing a.d trea.ing more tha. 50% of ca.es of NPT. The la.a.oscopic eva.ua.ion of a.domina. testes ca. provide indica.ions for the most suita.le surgica. technique; moreover, in 23% of pa.ients, it ma.es a.do-mina. explora.ion unnecessa.y. The va.ue of la.a.oscopy is even grea.er if the a.a.omica. a.pect of the interna. ring a.d sperma.ic cord structures is ca.efully eva.ua.ed.

关键词：腹腔镜治疗多中心研究睾丸疾病手术研究不可触及婴幼儿意大利视频协会腹腔镜诊断

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La.a.oscopic a.proa.h to Meckel's diverticulum

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World Journa. of Ga.troenterology 2014年第25期20卷 8173-8178页

作者： a.fonso papparella Fa.ia.o Nino Ca.mine Noviello a.tonio Ma.te Pio Pa.meggia.i a.ca.io Ma.tino Giova.ni Cobellis Depa.tments of Pa.dia.rics Paediatric Surgery Faculty of Medicine Paediatric Surgery-Second University of Naples80138 NaplesItaly Pa.dia.ric Surgery Unit-Sa.esi Children Hospita. 60121 AnconaItaly

a.M: To retrospective review the la.a.oscopic ma.a.ement of Meckel Diverticulum(MD) in two Ita.ia. Pedia.ric Surgery ***: Between Ja.ua.y 2002 a.d December 2012, 19 tra.s-umbilica. la.a.oscopic-a.sisted(TULa. procedures were performed for suspected MD. The children were hospita.ized for ga.trointestina. bleeding a.d/or recurrent a.domina. pa.n. Media. a.e a. dia.nosis wa. 5.4 yea.s(ra.ge 6 mo-15 yea.s). The study included 15 boys a.d 4 girls. a.l pa.ients underwent clinica. exa.ina.ion, routine la.ora.ory tests, a.domina. ultra.ound a.d technetium-99m pertechneta.e sca., a.d pa.ients with bleeding underwent ga.trointestina. endoscopy. The a.domina. explora.ion wa. performed with a.10 mm opera.ive la.a.oscope. Pneumoperitoneum wa. esta.lishedba.ed on the body weight. Systema.ic overview of the peritonea. ca.ity a.lowed the ileum to be gra.ped with a. a.ra.ma.ic instrument. The complete explora.ion a.d surgica. trea.ment of MD were performed extra.orporea.ly, a.ter intestina. exterioriza.ion through the umbilicus. a.l pa.ients' demogra.hics, ma.n clinica. fea.ures, dia.nostic investiga.ions, opera.ive time, histopa.hology reports, conversion ra.e, hospita. sta. a.d complica.ions were registered a.d ***: MD wa. identified in 17 pa.ients, while 1 ha. a. ilea. duplica.ion a.d 1 a.jejuna. hema.gioma. Fifteen pa.ients ha. pa.nless intestina. bleeding, while 4 ha. recurrent a.domina. pa.n a.d exhibited cyst like structures in a. ultra.ound study. Eleven pa.ients ha. a.positive technetium-99m pertechneta.e sca.. In the pa.ients with bleeding, ga.trointestina. endoscopy did not na.e the source of hemorrha.e. a.l pa.ients were subjected to a.TULa.surgica. procedure. a. intestina. resection/a.a.tomosis wa. performed in 14 pa.ients, while 4 ha. a.wedge resection of the diverticulum a.d 1 underwent sta.ling diverticulectomy. a.l surgica. procedures were performed without conversion to open la.a.otomy. Mea. opera.ive time wa. 75 min(ra.ge 40-115 min). No m

关键词： Meckel's diverticulum La.a.oscopy One troca. surgery Ga.trointestina. bleeding Minima. inva.ive surgery Ilea. duplica.ion Jejuna. hema.gioma

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Morphologic cha.ges due to huma. chorionic gona.otropin in the ra. testis: Role of va.cula. endothelia. growth fa.tor

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Open Journa. of Pedia.rics 2013年第2期3卷 85-91页

作者： a.fonso papparella Fa.ia.o Nino Ca.mine Noviello Mercedes Roma.o Serenella.papparella Orla.do Pa.iello a.tonio a.ostino Sinisi Depa.tment of Endocrinology II University of Naples Naples Italy Depa.tment of Pa.hology a.d a.ima. Hea.th Section of Pathologic Anatomy Faculty of Veterinary Medicine University of Naples Federico II Naples Italy Depa.tment of Pedia.ric Surgery II University of Naples Naples Italy Depa.tment of Pedia.ric Surgery Salesi Pediatric Hospital Ancona Italy

Introduction: Huma. chorionic gona.otropin (hCG) ha. a. importa.t role in the regula.ion of reproductive system a.d a.high ca.a.ity to stimula.e a.giogenesis by secretion of va.cula. endothelia. growth fa.tor (VEGF). It could be a.so used for medica. trea.ment of cryptorchidism, a. it stimula.es Leydig cells to produce testosterone, but its use ha. been discussed. a.m of the study wa. to eva.ua.e the testicula. morphologica. cha.ges due to cyclic a.ministra.ion of hCG possibly rela.ed to VEGF effect. Methods: 80 pre-pubera. ma.e Spra.ue-Da.ley ra.s were ra.domly divided in two groups hCG (50 U/I/ Kg) (n = 55/S) a.d pla.ebo (n = 25/C) trea.ed. The a.ima.s were sa.rificed respectively a.ter one (S1 n = 10;C1 n = 5), two (S2 n = 10;C2 n = 5) a.d three weeks of hCG or pla.ebo trea.ment (S3 n = 35;C3 n = 15);a.blood serum wa. obta.ned for eva.ua.ion of pla.ma.ic testosterone. The testis, prosta.es, epididymides a.d semina. vesicles were dra.n a.d weighted. Specimens were fixed in forma.in a.d coloured by hema.oxylin-eosin. Morphometric a.a.ysis of Leydig cell number, nuclea. a.ea.a.d perimeter wa. ca.ried out. Immunoistochemistry for VEGF ha. been performed with the a.idin-biotin peroxida.e technique. Sta.istica. differences between groups, ea.h of different a.e, were ca.cula.ing using Student’s T-test. Results: a.ter the first week of hCG trea.ment it ha. been observed a. increa.ed testicula. weight a.d volume (+/﹣6%) in experimenta. respect to control group. This result wa. not observed a.ter the second a.d third week of trea.ment. Significa.t va.ia.ions were a.so observed in the mea. prosta.e weight, wherea. mea. semina. vesicles weight wa. significa.t in the S2 a.d S3 groups respect to control. In the hCG trea.ed ra.s it ha. been observed a.poor differentia.ion of the seminiferous epithelium, with high Leydig cell evidence a.d increa.ed intertubula. eosinophilic ma.eria.. a. interstitia. edema.wa. demonstra.ed without infla.ma.ory cell cha.ges. Morphometric a.a.ysis

关键词： Cryptorchidism hCG VEGF Hormona. Trea.ment

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