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eR exit pathways and the control of proteostasis:Crucial role of the UPR,COPII,and eR-phagy in the secretory pathway

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BIOCeLL 2022年第5期46卷 1131-1137页

作者： GIUSePPINA AMODIO VALeNTINA PAGLIARA paolo ReMONDeLLI ORNeLLA MOLTeDO Dipartimento di Medicina Chirurgia e Odontoiatria“Scuola Medica Salernitana”Universitàdegli Studi di SalernoBaronissi84034Italy2 Dipartimento di FarmaciaUniversitàdegli Studi di SalernoFisciano84084Italy

The endoplasmic reticulum(eR)is the site of entry of all proteins that function in the secretory pathway including the extracellular *** it controls the folding of newly synthesized secretory proteins,the eR is indispensable for the maintenance of proteostasis in the secretory *** the eR and,in part,in post-eR compartments,the quality control of protein folding is under the regulation of the unfolded protein response(UPR)*** UPR strategy is to enhance protein folding,increase the eR degradation pathway of misfolded proteins,and allow the exit from the eR of only correctly folded *** latter is controlled by the multimeric complex COPII,which also provides some of the components for eR-phagy the only route for the disposal of protein *** this overview,we wish to contribute to the introduction of new perspectives in the study of the mechanisms underlying the control of proteostasis within the secretory pathway.

关键词： Proteostasis eR stress Unfolded protein response COPII eR-phagy

Hollow micro- and nano-particles by gas foaming

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Nano Research 2014年第7期7卷 1018-1026页

作者： Silvia Orsi ernesto Di Maio Salvatore lannace paolo A. Netti Center for Advanced Biomaterials for Health Care Istituto Italiano di Tecnologia (IIT@CRIB) Largo Barsanti e Matteucci 50 Napoli 80125 Italy Dipartimento di Ingegneria Chimica dei Materiali e della Produzione Industfiale and Interdisciplinary Research Centre on Biomaterials (CRIB) Universita degli Studi di Napoli Federico II P.le Tecchio 80 Napoli 80125 Italy Institute for Polymers Composites and Biomaterials Consiglio Nazionale delle Ricerche P.le E. Fermi 1 Portici (Na) 80055 Italy

This paper presents the results of a first successful attempt to produce hollow micro- and nano-particles of a large variety of materials, dimensions, shapes and hollow attributes by using an environmentally friendly and cheap technology, common in polymer processing and known as gas foaming. The central role played by ad hoc polymeric hollow micro- and nano-particles in a variety of emerging applications such as drug delivery, medical imaging, advanced materials, as well as in fundamental studies in nanotechnology highlights the wide relevance of the proposed method. Our key contribution to overcome the physical lower bound in the micro- and nano-scale gas foaming was to embed, prior to foaming, bulk micro- and nano-particles in a removable and deformable barrier film, whose role is to prevent the loss of the blowing agent, which is otherwise too fast to allow bubble formation. Furthermore, the barrier film allows for non-isotropic deformation of the particle and/or of the hollow, affording non-spherical hollow particles. In comparison with available methods to produce hollow micro- and nano-particles, our method is versatile since it offers independent control over the dimensions, material and shape of the particles, and the number, shape and open/closed features of the hollows. We have gas- foamed polystyrene and poly-（lactic-co-glycolic） acid particles 200 ~m to 200 nm in size, spherical, ellipsoidal and discoidal in shape, obtaining open or closed, single or multiple, variable in size hollows.

关键词： hollow nanoparticles microparticles gas foaming

Update on Chloroplast Research： New Tools, New Topics, and New Trends

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Molecular Plant 2011年第1期4卷 1-16页

作者： Ute Armbruster paolo Pesaresi Mathias Pribil Alexander Hertle Dario Leister Lehrstuhl for Molekularbiologie der Pflanzen (Botanik) Department Biologie I Ludwig-Maximilians-Universitat M6nchen Groβhaderner Str. D-82152 Planegg-Martinsried Germany b Dipartimento di Scienze Biomolecolari e Biotecnologie Universita degli studi di Milano 1-20133 Milano Italy

Chloroplasts, the green differentiation form of plastids, are the sites of photosynthesis and other important plant functions. Genetic and genomic technologies have greatly boosted the rate of discovery and functional character- ization of chloroplast proteins during the past decade. Indeed, data obtained using high-throughput methodologies, in particular proteomics and transcriptomics, are now routinely used to assign functions to chloroplast proteins. Our knowl- edge of many chloroplast processes, notably photosynthesis and photorespiration, has reached such an advanced state that biotechnological approaches to crop improvement now seem feasible. Meanwhile, efforts to identify the entire com- plement of chloroplast proteins and their interactions are progressing rapidly, making the organelle a prime target for systems biology research in plants.

关键词： Chloroplast biology genetics genomics molecular biology proteomics transcriptome analysis

Ming Qing Studies 2019

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Frontiers of History in China 2019年第4期14卷 I0009-I0009页

作者： paolo santangelo Sapienza University of Rome

We are glad to infomi you that MING QING STUD IeS 2019 hus been issued in November 2019 by WriteUp Site:http://***/***.M IN G Q ING STU D IeS is an annual publication focused on late imperial China and the broader geo-cultural area of east Asia during the premodem and modem *** scope is to provide a forum for scholars from a variety of fields seeking to bridge the gap between'oriental'and western *** may concern any discipline,including sociology,literature,psychology,anthropology,history,geography,linguistics,semiotics,political science,and *** by young and post-graduated scholars are particularly welcome.

关键词： modem seeking welcome

How to model the effect of mechanical erosion control practices at a catchment scale?

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International Soil and Water Conservation Research 2021年第3期9卷 370-380页

作者： elizeu Jonas Didoné Jean paolo Gomes Minella Daniel Gustavo Allasia Piccilli Federal University of Santa Maria Department of Soil Science1000 Avenue RoraimaCamobiCEP 97105-900Santa MariaRSBrazil Federal University of Santa Maria Department of Environmental and Sanitary Engineering1000 Avenue RoraimaCamobiCEP 97105-900Santa MariaRSBrazil

Conservation agriculture practices are a crucial factor in mitigating and controlling erosion by *** address water erosion estimates,most environmental models use the USLe,RUSLe,and MUSLe *** practices that affect soil erosion by modifying the flow pattern,such as contour farming,strip farming,or terracing,are represented within these models as a support practice(P)***,due to the difficulty in accurately mapping the P-factor,many studies choose to ignore it,using only the default value P-factor 1 which represents the absence of sowing at the level or cultivation in *** study proposes a methodology that evaluates the current P-factor based on the angle between the crop row orientation and the elevation contour *** method was tested in four areas under soybean crop fields in southern Brazil,totaling 25 km^(2).The reason for choosing four areas is to select different characteristics of rural properties and topographic *** ideal values of the P-factor are expected to be between 0.5 and 0.6;however,in our case,a P-factor greater than 0.8 was obtained in 60%of the area,indicating the low occurrence of contour farming reduces erosion *** results show that policymakers could potentially use this methodology(angle between the crop rows and contour lines)to run soil-erosion risk scenarios for a broader application of contour *** allows the P-factor to be quantified via a thematic map instead of assigning uniform P-factor *** a detailed study of the P-factor on the slopes,there is a better understanding of where to target support practices to reduce erosion.

关键词： Conservation practices Modeling P-Factor Planting efficiency

DISTRIBUTION,CHRONOLOGY AND CULTURAL SIGNIFICANCe OF THe“MeTOPAL”WAReS OF NORTHeRN ITALY

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Natural Disaster Reduction in China 1987年第1期 183-187页

作者： BeRNARDINO BAGOLINI e paolo BIAGI Dipartimentodi Storia della Civiltà europea-Università di Trento Dipartimentodelle Scienze Storico-Archeologiche e Orientalistiche-Università di Venezia

The Authors examine the North Italian Chalcolithic sites which produced‘metopal’orna-mented pots and discuss their chronological *** also consider the affinities which exist withthe more or less contemporary Chalcol... 详细信息

关键词： DISTRIBUTION,CHRONOLOGY AND CULTURAL SIGNIFICANCe OF THe MeTOPAL WAReS OF NORTHeRN ITALY

A “Hard to Die” Series expansion and Lucas Polynomials of the Second Kind

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Applied Mathematics 2015年第8期6卷 1235-1240页

作者： Pierpaolo Natalini paolo e. Ricci Dipartimento di Matematica e Fisica Università degli Studi Roma Tre Roma Italia International Telematic University UNINeTTUNO Roma Italia

We show how to use the Lucas polynomials of the second kind in the solution of a homogeneous linear differential system with constant coefficients, avoiding the Jordan canonical form for the relevant matrix.

关键词： Homogeneous Linear Differential Systems with Constant Coefficients exponential Matrix Lucas Polynomials of the Second Kind

RINVeNIMeNTO DI MANUFATTI MeSOLITICI SULLA COLLINA DI CILIVeRGHe(Brescia)

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Natural Disaster Reduction in China 1987年第1期 269-272+274页

作者： CARLO BARONI e paolo BIAGI Museo Civico di Scienze Naturali di Brescia Dipartimentodelle Scienze Storico-Archeologiche e Orientalistiche Università di Venezia

A Mesolithic assemblage from the Ciliverghe Hill(Brescia-Northern Italy).The flintindustry from Ciliverghe is attributed to a Late Mesolithic Castelnovian complex which flourished inNorthern Italy between the first half of the Ⅵ and the second half of the Ⅴ millennium bc.A similarassemblage had already been recovered from Monte Netto di Poncarale,an isolated hill rising fromthe northern Po Plain.

关键词： DI Brescia RINVeNIMeNTO DI MANUFATTI MeSOLITICI SULLA COLLINA DI CILIVeRGHe

Determination of estrogenic activity in the river Chienti(Marche Region, Italy) by using in vivo and in vitro bioassays

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Journal of environmental Sciences 2016年第5期28卷 48-53页

作者： paolo Cocci Francesco Alessandro Palermo Luana Quassinti Massimo Bramucci Antonino Miano Gilberto Mosconi School of Biosciences and Veterinary Medicine University of Camerino School of Pharmacy University of Camerino

environmental estrogen-like compounds（i.e. xenoestrogens） are a variety of pollutants,ranging from synthetic to natural occurring molecules, that are found in surface and waste waters over a wide range of concentrations. In aquatic environment, the overall estrogenic activity is often due to the presence of a mixture of chemicals and their degraded products which can induce synergistic effects. Current strategies for monitoring estrogen-like chemicals are based on the use of a battery of in vivo and in vitro ecotoxicological tests. In this regard, the aim of the present work was to carry out a bio-monitoring study for testing estrogenicity of the Chienti river（Marche Region, Italy） by using both an e-screen and a vitellogenin（Vtg） induction assay in juvenile goldfish. Three sites were used for analysis,localized at the mouth（sampling point 1）, in the middle（sampling point 2） and at the origin（sampling point 3） of Chienti river. For most of the water samples（i.e. samples collected at sampling points 2 and 3）, clear estrogenic activity was detected in the e-screen assay suggesting different proliferation activities in function of the collecting site. In contrast, the Vtg eLISA demonstrated that water samples collected from each sampling point were estrogenic. Overall, we showed for the first time that the estrogenic activities in water samples from the Chienti river were significant in both in vivo and in vitro; we also observed a different sensitivity between bioassays.

关键词： Xenoestrogens Chienti river Bioassays e-screen Vitellogenin Carassius auratus