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Hepatitis E in hemodialysis and kidney transplant patients in south-east Italy

World Journal of Gastroenterology 2015年第11期21卷 3266-3273页

作者： Gaetano Scotto Filippo Aucella Giuseppe Grandaliano Domenico Martinelli Mario Querques Antonio Gesuete Barbara Infante paolo delli carri Salvatore Massa Giovanna Salatino Fabio Bulla Vincenzina Fazio Microbiology and Clinical Microbiology Master’s Degree in DentistryUniversity of Foggia Nephrology and Dialysis Unit IRCCS "Casa Sollievo della Sofferenza" San Giovanni Rotondo (FG) Nephrology and Dialysis Unit University of Foggia Institute of Hygiene University of Foggia Division of Nephrology Hospital of Foggia Department of Agricultural Food and Environmental SciencesUniversity of Foggia Clinic of Infectious Diseases University of Foggia Clinical Chemistry Laboratory Unit of VirologyHospital of Foggia

AIM:To investigate the serovirological prevalence and clinical features of hepatitis E virus(HEV) infection in end-stage renal failure patients and in the healthy ***:HEV infection is a viral disease that can cause sporadic and epidemic *** studies unexpectedly showed a high prevalence of HEV antibodies in immunosuppressed subjects,including hemodialysis(HD)patients and patients who had undergone kidney transplant.A cohort/case-control study was carried out from January 2012 to August 2013 in two hospitals in southern Italy(Foggia and *** Rotondo,Apulia).The seroprevalence of HEV was determined in 801 subjects;231 HD patients,120 renal transplant recipients,and450 health *** HD patients and the recipients of renal transplants were attending the Departments of Nephrology and Dialysis at two hospitals located in Southern Italy,and were included progressively in this *** samples were tested for HEV antibodies(Ig G/Ig M);in the case of positivity they were confirmed by a Western blot assay and were also tested for HEV-RNA,and the HEV genotypes were ***:A total of 30/801(3.7%)patients were positive for anti-HEV Ig(Ig G and/or Ig M)and by Western *** healthy population presented with a prevalence of 2.7%,HD patients had a prevalence of 6.0%,and transplant recipients had a prevalence of 3.3%.The overall combined HEV-positive prevalence in the two groups with chronic renal failure was 5.1%.The rates of exposure to HEV(positivity of HEV-Ig G/M in the early samples)were lower in the healthy controls,but the difference among the three groups was not statistically significant(P>0.05).Positivity for anti-HEV/Ig M was detected in 4/30(13.33%)anti-HEV Ig positive individuals,in 2/14 HD patients,in1/4 transplant individuals,and in 1/12 of the healthy *** relative risk of being HEV-Ig M-positive was significantly higher among transplant recipients compared to the other two groups(OR=65.4,95%CI:7.

关键词： Hepatitis E virus infection Prevalence Immunosuppr

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Lamb-dip saturated-absorption cavity ring-down rovibrational molecular spectroscopy in the near-infrared

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Photonics Research 2022年第8期10卷 1803-1809页

作者： ROBERTO AIELLO VALENTINA DI SARNO MARIA GIULIA delli SANTI MAURIZIO DE ROSA IOLANDA RICCIARDI GIOVANNI GIUSFREDI paolo DE NATALE LUIGI SANTAMARIA PASQUALE MADDALONI Consiglio Nazionale delle Ricerche-Istituto Nazionale di Ottica Via Campi Flegrei 3480078 PozzuoliItaly Istituto Nazionale di Fisica Nucleare Sez.di NapoliComplesso Universitario di M.S.AngeloVia Cintia80126 NapoliItaly ppqSense S.r.l. Via Gattinella 2050013 Campi BisenzioItaly Consiglio Nazionale delle Ricerche-Istituto Nazionale di Ottica Largo E.Fermi 650125 FirenzeItaly Agenzia Spaziale Italiana Contrada Terlecchia75100 MateraItaly

The high-detection-sensitivity saturated-absorption cavity ring-down(SCAR)technique is extended to Lambdip spectroscopy of rovibrational molecular transitions in the near-infrared ***-comb-referenced sub-Doppler saturation measurements,performed on the acetylene(ν_(1)+ν_(3)+ν_(4)←ν_(4))R(14)e line at6562 cm^(-1),are analyzed by a SCAR global line profile fitting routine,based on a specially developed theoretical *** to a conventional cavity ring-down evaluation,our approach yields dip profiles with a linewidth freed from saturation broadening effects,reduced by 40%,and a signal-to-noise ratio increased by 90%.Ultimately,an overall(statistical and systematic)fractional uncertainty as low as 7×10^(-12)is achieved for the absolute line-center *** the same time,our method is also able to accurately infer the linear(nonsaturated)behavior of the gas absorption,providing Lamb-dip-based line strength measurements with a relative uncertainty of 0.5%.

关键词： saturated cavity absorption

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