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World Journal of Hepatology 2018年第2期10卷 213-221页

作者： Michela Lizier Alessandra Castelli Cristina Montagna Franco Lucchini paolo vezzoni Francesca Faggioli Istituto di Ricerca Genetica e Biomedica CNR Human Genome Laboratory Humanitas Clinical and Research Center IRCCS Department of Genetics and Pathology Genetics Albert Einstein College of Medicine Centro Ricerche Biotecnologiche Università Cattolica del Sacro Cuore

There is wide agreement that cell fusion is a physiological process in cells in mammalian bone, muscle and placenta. In other organs, such as the cerebellum, cell fusion is controversial. The liver contains a considerable number of polyploid cells: They are commonly believed to originate by genome endoreplication, although the contribution of cell fusion to polyploidization has not been excluded. Here, we address the topic of cell fusion in the liver from a historical point of view. We discuss experimental evidence clearly supporting the hypothesis that cell fusion occurs in the liver, specifically when bone marrow cells were injected into mice and shown to rescue genetic hepatic degenerative defects. Those experiments-carried out in the latter half of the last century-were initially interpreted to show "transdifferentiation", but are now believed to demonstrate fusion between donor macrophages and host hepatocytes, raising the possibility that physiologically polyploid cells, such as hepatocytes, could originate, at least partially, through homotypic cell fusion. In support of the homotypic cell fusion hypothesis, we present new data generated using a chimera-based model, a much simpler model than those previously used. Cell fusion as a road to polyploidization in the liver has not been extensively investigated, and its contribution to a variety of conditions, such as viral infections, carcinogenesis and aging, remains unclear.

关键词： Cell fusion Hepatocytes TdTomato Lineage tracing Chimeras Extracellular vesicles

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