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Red cell distribution width/platelet ratio estimates the 3-year risk of decompensation in Metabolic Dysfunction-Associated Steatotic Liver Disease-induced cirrhosis

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World Journal of Gastroenterology 2024年第7期30卷 685-704页

作者： Marcello Dallio Mario Romeo paolo vaia Salvatore Auletta Simone Mammone Marina Cipullo Luigi Sapio Angela Ragone Marco Niosi Silvio Naviglio Alessandro Federico Department of Precision Medicine Hepatogastroenterology DivisionUniversity of Campania Luigi VanvitelliNaples 80138Italy Department of Precision Medicine Clinical Biochemistry DivisionUniversity of Campania Luigi VanvitelliNaples 80138Italy

BACKGROUND For compensated advanced chronic liver disease(cACLD)patients,the first decompensation represents a dramatically worsening prognostic *** on the first decompensation event(DE),the transition to decompensated advanced chronic liver disease(dACLD)can occur through two modalities referred to as acute decompensation(AD)and non-AD(NAD),*** Significant Portal Hypertension(CSPH)is considered the strongest predictor of decompensation in these ***,due to its invasiveness and costs,CSPH is almost never evaluated in clinical ***,recognizing noninvasively predicting tools still have more appeal across healthcare *** red cell distribution width to platelet ratio(RPR)has been reported to be an indicator of hepatic fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease(MASLD).However,its predictive role for the decompensation has never been *** In this observational study,we investigated the clinical usage of RPR in predicting DEs in MASLD-related cACLD *** Fourty controls and 150 MASLD-cACLD patients were consecutively enrolled and followed up(FUP)semiannually for 3 *** baseline,biochemical,clinical,and Liver Stiffness Measurement(LSM),Child-Pugh(CP),Model for End-Stage Liver Disease(MELD),aspartate aminotransferase/platelet count ratio index(APRI),Fibrosis-4(FIB-4),Albumin-Bilirubin(ALBI),ALBI-FIB-4,and RPR were *** FUP,DEs(timing and modaities)were *** was assessed at the baseline and on DE occurrence according to the available Clinical Practice *** Of 150 MASLD-related cACLD patients,43(28.6%)progressed to dACLD at a median time of 28.9 months(29 NAD and 14 AD).Baseline RPR values were significantly higher in cACLD in comparison to controls,as well as MELD,CP,APRI,FIB-4,ALBI,ALBI-FIB-4,and LSM in dACLD-progressing compared to cACLD individuals[all P<0.0001,except for FIB-4(P:0.007)and ALBI(P:0.011)].Receiving operator curve a

关键词： Liver cirrhosis Red blood cell distribution width Red blood cell distribution width to platelet ratio Translational Medicine Prognostic biomarker

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Single-cell pan-omics, environmental neurology, and artificial intelligence:the time for holistic brain health research

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Neural Regeneration Research 2025年第6期20卷 1703-1704页

作者： paolo Abondio Francesco Bruno IRCCS Istituto delle Scienze Neurologiche di Bologna BolognaItaly Association for Neurogenetic Research(ARN) Lamezia TermeCatanzaroItaly

The brain,with its trillions of neural connections,different cellular types,and molecular complexities,presents a formidable challenge for researchers aiming to comprehend the multifaceted nature of neural *** traditional methods have provided valuable insights,emerging technologies offer unprecedented opportunities to delve deeper into the underpinnings of brain *** the everevolving landscape of neuroscience,the quest to unravel the mysteries of the human brain is bound to take a leap forward thanks to new technological improvements and bold interpretative frameworks.

关键词： function artificial landscape

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Inclusion of infrared dielectric screening in the GW method from polaron energies to charge mobilities

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npj Computational Materials 2022年第1期8卷 1300-1307页

作者： paolo Umari Dipartimento di Fisica e Astronomia Universitàdi Padovavia Marzolo 8I-35131PadovaItaly CNR-IOM Istituto Officina Dei Materiali Consiglio Nazionale Delle RicercheArea Science ParkStrada Statale 14km 163.5I-34149TriesteItaly

We introduce in the many-body GW scheme the modulation of the screened Coulomb interaction W arising from the macroscopic dielectric response in the *** derive expressions for the polaron binding energies,the renormalization of the effective masses and for the electron and hole relaxation *** and hole mobilities are then obtained from the incorporation of appropriate scattering ***-blende GaN and orthorhombic MAPbI3 are used as test beds finding fair agreement with results from rigorous electron-phonon coupling *** limited to polar phonons,our method has a negligible computational cost.

关键词： dielectric polaron negligible

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Optimal weakening and damping using polynomial control for seismically excited nonlinear structures

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Earthquake Engineering and Engineering Vibration 2009年第4期8卷 607-616页

作者： Gian paolo Cimellaro Department of Structural & Geotechnical Engineering(DISTR)

This paper presents an approach for the optimal design of a new retrofit technique called weakening and damping that is valid for civil engineering inelastic structures. An alternative design methodology is developed with respect to the existing ones that is able to determine the locations and the magnitude of weakening and/or softening of structural elements and adding damping while insuring structural stability. An optimal polynomial controller that is a summation of polynomials in nonlinear states is used in Phase I of the method to reduce the peak response quantities of seismically excited nonlinear or hysteretic systems. The main advantage of the optimal polynomial controller is that it is able to automatically stabilize the structural system. The optimal design of a shear-type structure is used as an example to illustrate the feasibility of the proposed approach, which leads to a reduction of both peak inter-story drifts and peak total accelerations.

关键词： weakening and damping optimal design optimal polynomial controller inter-story drift acceleration

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Psycho-gastroenterological profile of an Italian population of children with disorders of gut-brain interaction:A case-control study

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World Journal of Clinical Pediatrics 2025年第1期14卷 69-77页

作者： Valentina Giorgio Ilaria Venezia Licia Pensabene Elisa Blasi Donato Rigante paolo Mariotti Giuseppe Stella Gaia Margiotta Giovanna Quatrale Giuseppe Marano Marianna Mazza Antonio Gasbarrini Eleonora Gaetani Pediatric Unit Department of WomenChildren and Public Health SciencesFondazione Policlinico Universitario“A.Gemelli”IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Child Neuropsychiatry Unit ASST Santi Paolo e CarloSan Paolo HospitalMilan 20142Italy Child Neuropsychiatry Unit Department of WomenChildren and Public Health SciencesFondazione Policlinico Universitario“A.Gemelli”IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Department of Medical and Surgical Sciences Pediatric UnitUniversity Magna GraeciaCatanzaro 88100Italy Unit of Psychiatry Fondazione Policlinico Universitario“A.Gemelli”IRCCSRome 00168Italy Department of Neurosciences UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Internal Medicine and Gastroenterology Fondazione Policlinico Universitario"A.Gemelli"IRCCSRome 00168Italy Department of Medical and Surgical Sciences Fondazione Policlinico Universitario"A.Gemelli"IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy

BACKGROUND Disorders of gut-brain interaction(DGBI)are common,but knowledge about their physiopathology is still poor,nor valid tools have been used to evaluate them in *** To develop a psycho-gastroenterological questionnaire(PGQ)to assess the psycho-gastroenterological profile and social characteristics of a pediatric population with and without *** One hundred and nineteen Italian children(age 11-18)were included:28 outpatient patients with DGBI(Rome IV criteria)and 91 healthy *** filled the PGQ,faces pain scale revised(FPS-R),Bristol stool chart,ga-strointestinal symptoms rating scale,state-trait anxiety inventory,Toronto alexithymia scale 20,perceived self-efficacy in the management of negative emotions and expression of positive emotions(APEN-G,APEP-G),irritable bowel syndrome-quality of life questionnaire,school performances,tobacco use,early life events,degree of *** Compared to controls,patients had more medical examinations(35%of them went to the doctor more than five times),a higher school performance(23%vs 13%,P<0.05),didn’t use tobacco(never vs 16%,P<0.05),had early life events(28%vs 1%P<0.05)and a higher percentage of pain classified as 4 in the FPS-R during the examination(14%vs 7%,P<0.05).CONCLUSION Pediatric outpatients with DGBI had a higher prevalence of early life events,a lower quality of life,more medical examinations rising health care costs,lower anxiety levels.

关键词： Disorders of gut-brain interaction Functional gastrointestinal disorders Psycho-gastroenterological profile Gut-brain axis Rome IV criteria Pediatric patients

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Does divergence from normal patterns of integration increase as chromosomal fusions increase in number?A test on a house mouse hybrid zone

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Current Zoology 2020年第5期66卷 527-538页

作者： Carmelo FRuciANO paolo Colangelo Riccardo Castiglia paolo Franchini Institut de Biologie de KEcole Normale Superieure(IBENS) Ecole Normale SuperieureCNRSPSL Universite ParisParis75005France School of Biological Sciences University of PortsmouthPortsmouthP012DYUK National Research Council Research Institute on Terrestrial EcosystemsMontelibretti(RM)00010Italy Department of Biology and Biotechnology"Charles Darwin" "La Sapienza"University of RomeRome00161Italy Department of Biology Lehrstuhl fiir Zoologie und EvolutionsbiologieUniversity of KonstanzKonstanz78457Germany

Chromosomal evolution is widely considered an important driver of speciation because it can promote the establishment of reproductive *** reorganization is also expected to affect the mea n phe no type,as well as its developme nt and patter ns of phenotypic in tegrati on,through processes such as variation in genetic linkage between quantitative trait loci or between regulatory regions and their *** we explore the relationship between chromosomal evolution and phenotypic integration by analyzing a well-known house mouse parapatric contact zone between a highly derived Robertsonian(Rb)race(2n=22)and populations with standard karyotype(2n=40).Populations with hybrid karyotypes are scattered throughout the hybrid zone connecting the two parental *** mandible shape data and geometric morphometries,we test the hypothesis that patter ns of in tegration progressively diverge from the"normal"integration pattern observed in the standard race as they accumulate Rb *** find that the main pattern of integration observed between the posterior and anterior part of the mandible can be largely attributed to *** find no support for a gradual increase in divergence from normal patterns of integration as fusions ***,however,we find that the derived Rb race(2n=22)has a distinct allometric trajectory compared with the standard *** results suggest that either individual fusions disproportionately affect patterns of integration or that there are mechanisms which"purge"extreme variants in hybrids(*** fitness of hybrid shape).

关键词： chromosomal races geometric morphometries hybrid zone integration modularity Robertsonian fusions

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Experiments and modeling of discharge characteristics in water-mist sprays generated by pressure-swirl atomizers

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Journal of Thermal Science 2012年第6期21卷 539-548页

作者： paolo E.Santangelo Department of Fire Protection Engineering University of Maryland3106 J.M.Patterson BuildingCollege ParkMD 20742USA

Pressure-swirl atomizers are often employed to generate a water-mist spray,typically employed in fire *** the present study,an experimental characterization of dispersion(velocity and cone angle)and atomization(drop-size axial evolution)was carried out following a previously developed methodology,with specific reference to the initial region of the ***-based techniques were used to quantitatively evaluate the considered phenomena:velocity field was reconstructed through a Particle Image Velocimetry analysis;drop-size distribution was measured by a Malvern Spraytec device,highlighting secondary atomization and subsequent coalescence along the spray ***,a comprehensive set of relations was validated as predictive of the involved parameters,following an inviscid-fluid *** proposed model pertains to early studies on pressure-swirl atomizers and primarily yields to determine both initial velocity and cone *** spray thickness is also predicted and a classic correlation for Sauter Mean Diameter is shown to provide good agreement with experimental *** analysis was carried out at the operative pressure of 80 bar;two injectors were employed featuring different orifice diameters and flow numbers,as a sort of parametric approach to this spray typology.

关键词： Water mist Pressure-swirl atomizers Atomization Velocity Cone angle

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Methodology and application of Escherichia coli F4 and F18 encoding infection models in post-weaning pigs

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Journal of Animal Science and Biotechnology 2019年第3期10卷 559-578页

作者： Diana Luise Charlotte Lauridsen paolo Bosi paolo Trevisi Department of Agricultural and Food Sciences (DISTAL) Alma Mater Studiorum-University of BolognaBolognaItaly Faculty of Science and Technology Department of Animal ScienceAarhus UniversityTjeleDenmark

The enterotoxigenic Escherichia coli (ETEC) expressing F4 and F18 fimbriae are the two main pathogens associated with post-weaning diarrhea (PWD) in *** growing global concern regarding antimicrobial resistance (AMR) has encouraged research into the development of nutritional and feeding strategies as well as vaccination protocols in order to counteract the PWD due to ETEC.A valid approach to researching effective strategies is to implement piglet in vivo challenge models with ETEC ***,the proper application and standardization of ETEC F4 and F18 challenge models represent an urgent *** current review provides an overview regarding the current piglet ETEC F4 and F18 challenge models;it highlights the key points for setting the challenge protocols and the most important indicators which should be included in research studies to verify the effectiveness of the ETEC *** on the current review,it is recommended that the setting of the model correctly assesses the choice and preconditioning of pigs,and the timing and dosage of the ETEC ***,the evaluation of the ETEC challenge response should include both clinical parameters (such as the occurrence of diarrhea,rectal temperature and bacterial fecal shedding) and biomarkers for the specific expression of ETEC F4/F18 (such as antibody production,specific F4/F18 immunoglobulins (lgs),ETEC F4/F18 fecal enumeration and analysis of the F4/F18 receptors expression in the intestinal brush borders).On the basis of the review,the piglets' response upon F4 or F18 inoculation differed in terms of the timing and intensity of the diarrhea development,on ETEC fecal shedding and in the piglets' immunological antibody *** information was considered to be relevant to correctly define the experimental protocol,the data recording and the sample *** challenge settings and evaluation of the response parameters will allow future research studies to comply w

关键词： Biomarkers Challenge ETEC Piglet Post-weaning

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"Charge while driving"for electric vehicles:road traffic modeling and energy assessment

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Journal of Modern Power Systems and Clean Energy 2015年第2期3卷 277-288页

作者： Francesco paolo DEFLORIO Luca CASTELLO Ivano PINNA paolo GUGLIELMI Politecnico di Torino 10129 TurinItaly

The aim of this research study is to present a method for analyzing the performance of the wireless inductive charge-while-driving(CWD)electric vehicles,from both traffic and energy points of *** accurately quantify the electric power required from an energy supplier for the proper management of the charging system,a traffic simulation model is *** model is based on a mesoscopic approach,and it is applied to a freight distribution *** changing and positioning are managed according to a cooperative system among vehicles and supported by advanced driver assistance systems(ADAS).From the energy point of view,the analyses indicate that the traffic may have the following effects on the energy of the system:in a low traffic level scenario,the maximum power that should be supplied for the entire road is simulated at approximately 9 MW;and in a high level traffic scenario with lower average speeds,the maximum power required by the vehicles in the charging lane increases by more than 50%.

关键词： Wireless charging Cooperative driving Traffic simulation Mesoscopic Energy estimation

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Flash flood sediment transport in a steep sand-bed ephemeral stream

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International Journal of Sediment Research 2011年第2期26卷 193-209页

作者： paolo BILLI Dipartimento di Scienze della Terra Universita di Ferrara

This paper reports about flow and sediment transport measurements undertaken during the rainy season(July-August) 2008 on Gereb Oda,a steep,sand-bed ephemeral stream,draining the western margin of the Kobo structural basin in northern *** Oda streambed is dry for most of the year since it is subjected only to sporadic flash floods in response to individual,high intensity and spatially confined *** about hydraulic and sediment transport processes in steep sand-bed,ephemeral stream is very poor and,though only two flash floods occurred during the field campaign,the data gathered may contribute to improve our knowledge on these kind of *** numbers were calculated in order to verify the occurrence of supercritical flow conditions as postulated by a few authors from the analysis of sedimentary structures *** data are also compared to simple models to predict flow velocity and discharge since flow recording systems are seldom installed on ephemeral streams in remote areas and developing *** rivers are known for their very high suspended sediment transport,but very little bedload data exist for sand-bed,ephemeral *** variation of suspended sediment concentration with discharge is analysed and simple rating curves for both suspended and bed load transport are derived.A few equations to predict bedload are tested against Gereb Oda data and the relationship between en masse bedload transport processes as thin sand sheets and the development of horizontal lamination through the migration of leaf-shaped,sheet-like bedforms is ***,large boulders were observed to move at flow depths of the same order of magnitude of their size.A few functions to predict the threshold conditions for large particles entrainment are used to verify if and to what extent they match Gereb Oda field *** increased density of the water-sediment mixture,for the very high suspended sediment concentr

关键词： Ephemeral stream Bedload Suspended load Flash flood Ethiopia

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