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Use of probiotics in the fight against Helicobacter pylori

World Journal of Gastrointestinal Pathophysiology 2014年第4期5卷 384-391页

作者： Paolo Ruggiero Novartis Vaccines and Diagnostics Research CenterI-53100 Siena Italy

After the discovery of Helicobacter pylori(H. pylori), and the evidence of its relationship with gastric diseas-es, antibiotic-based therapies were developed, which efficacy was however limited by antibiotic resistance and lack of patient compliance. A vaccine would over-come these drawbacks, but currently there is not any H. pylori vaccine licensed. In the frame of the studies aimed at finding alternative therapies or at increasing the efficacy of the current ones and/or reducing their side effects, the investigation on the use of probiotics plays an interesting role. In vitro and preclinical stud-ies have shown the feasibility of this approach. Several clinical trials indicated that administration of probiot-ics can reduce the side effects of H. pylori eradication treatment, increasing tolerability, and often increases the overall efficacy. The results of these trials vary, likely reflecting the variety of probiotics assessed and that of the eradication treatment, as well as the differ-ences in the geographic area that imply different H. py-lori strains distribution, host susceptibility, and therapy efficacy. In conclusion, the use of probiotics appears promising as an adjuvant for the current H. pylori erad-ication treatment, though it still requires optimization.

关键词： Helicobacter pylori Treatment Probiotics Lactobacilli Bifidobacteria

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Red wine and green tea reduce H pylori- or VacA-induced gastritis in a mouse model

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World Journal of Gastroenterology 2007年第3期13卷 349-354页

作者： Paolo Ruggiero Giacomo Rossi Francesco Tombola Laura Pancotto Laura Lauretti Giuseppe Del Giudice Mario Zoratti Novartis Vaccines & Diagnostics s.r.l. Research Center SienaItaly Department of Veterinary Science University of Camerino Matelica Italy Department of Biomedical Sciences University of PadovaItaly CNR Institute of Neuroscience Section for Biomembranes Padova Italy CNR Institute of Neuroscience Section for Biomembranes Padova Italy

AIM: To investigate whether red wine and green tea could exert anti-H pylori or anti-VacA activity in vivo in a mouse model of experimental infection.METHODS: Ethanol-free red wine and green tea concentrates were administered orally as a mixture of the two beverages to H pylori infected mice, or separately to VacA-treated mice. Gastric colonization and gastric in? ammation were quantifi ed by microbiological, histopathological, and immunohistochemical analyses. RESULTS: In H pylori -infected mice, the red wine and green tea mixture significantly prevented gastritis and limited the localization of bacteria and VacA to the surface of the gastric epithelium. Similarly, both beverages significantly prevented gastric epithelium damage in VacA-treated mice; green tea, but not red wine, also altered the VacA localization in the gastric epithelium. CONCLUSION: Red wine and green tea are able to prevent H pylori -induced gastric epithelium damage, possibly involving VacA inhibition. This observation supports the possible relevance of diet on the pathological outcome of H pylori infection.

关键词：红葡萄酒绿茶幽门活性饮料组织病理学

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Recent trends in endoscopic management of achalasia

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World Journal of Gastrointestinal Endoscopy 2014年第9期6卷 407-414页

作者： Salvatore Tolone paolo Limongelli Gianmattia del Genio Luigi Brusciano Antonio Russo Lorenzo Cipriano Marco Terribile Giovanni Docimo Roberto ruggiero Ludovico Docimo XI Division of General and Obesity Surgery Second University of Naples

Esophageal achalasia is a chronic and progressive motility disorder characterized by absence of esophageal body peristalsis associated with an impaired relaxation of lower esophageal sphincter(LES) and usually with an elevated LES pressure, leading to an altered passage of bolus through the esophago-gastric junction. A definitive cure for achalasia is currently unavailable. Palliative treatment options provide only food and liquid bolus intake and relief of symptoms. Endoscopic therapy for achalasia aims to disrupt or weaken the lower esophageal sphincter. Intra-sphincteric injection of botulinum toxin is reserved for elderly or severely ill patients. Pneumatic dilation provides superior results than botulinum toxin injection and a similar mediumterm efficacy almost comparable to that attained after surgery. Per oral endoscopic myotomy is a promising option for treating achalasia, but it requires increased experience and further objective and long-term follow up. This article will review different endoscopic treatments in achalasia, and summarize the short-term and long-term outcomes.

关键词： sphincter botulinum esophageal dilation bolus impaired disrupt altered intake comparable

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Flow cytometry assay of myeloid dendritic cells (mDCs)in peripheral blood during acute hepatitis C:Possible pathogenetic mechanisms

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World Journal of Gastroenterology 2006年第7期12卷 1105-1109页

作者： Alessandro Perrella Luigi Atripaldi Pasquale Bellopede Tommaso Patarino Costanza Sbreglia Giovanni Tarantino paolo Sorrentino paolo Conca Luca ruggiero Oreste Perrella Department Infectious Disease and Immunology Hospital D.CotugnoNaplesItaly Department Institute for Cancer Genetics Columbia University

瞄准：到驴骨髓的的树枝状的房间(CD11c+) 的表示子集在在感染的自然科学的尖锐 HCV 肝炎和它的可能的参与期间。方法：我们与尖锐丙肝(AHC )( 组 A ) 注册了 11 个病人，有尖锐肝炎 A (啊哈) 的 10 个病人(同样易传染的控制 -- 组 B )... 详细信息

瞄准：到驴骨髓的的树枝状的房间(CD11c+) 的表示子集在在感染的自然科学的尖锐 HCV 肝炎和它的可能的参与期间。方法：我们与尖锐丙肝(AHC )( 组 A ) 注册了 11 个病人，有尖锐肝炎 A (啊哈) 的 10 个病人(同样易传染的控制 -- 组 B ) 并且在这的 10 个健康施主(组 C ) 学习。所有病人经历了选择流动血细胞计数 gating 策略估计骨髓的的树枝状的房间(mDCs ) 的外部数字在尖锐肝炎期间理解可能的角色和差别。结果：有尖锐 HCV 肝炎的 11 个病人中的八个没与健康个人相比显示出 mDCs 的任何增加，当 mDCs 的重要减少在绝对房间计数被发现时(z =-2.37；P<0.05 ) 并且百分比(z =-2.30；P<0.05 ) 同样与啊哈相比。相反，留下组 A 的三个病人有是的一个更高的 mDCs 数字和百分比发生在组 B。在六个月以后，有趣地，那些病人没证明 mDCs 子集的任何增加长期地被感染。当三在 HAV 急性感染随外部 mDCs 的增加使遭到，，时，解决了病。结论：mDCs 的增加的缺乏可能在尖锐丙肝期间是涉及感染的 chronicization 的一个重要因素。

关键词：血细胞记数骨髓树状细胞外周血丙型肝炎

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