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Tribological behavior of shape-specific microplate-enriched synovial fluids on a linear two-axis tribometer

Friction 2024年第3期12卷 539-553页

作者： Agnese FRAGASSI Antonietta GRECO Martina DI FRANCESCO Luca CESERACCIU Aiman ABU AMMAR Israel DVIR Thomas Lee MOORE Haytam KASEM paolo decuzzi Laboratory of Nanotechnology for Precision Medicine Fondazione Istituto Italiano di TecnologiaGenova 16163Italy Department of Chemistry and Industrial Chemistry University of GenovaGenoa 16146Italy Materials Characterization Facility Istituto Italiano di TecnologiaGenova 16163Italy Department of Pharmaceutical Engineering Azrieli College of Engineering JerusalemJerusalem 9103501Israel Department of Mechanical Engineering Azrieli College of Engineering JerusalemJerusalem 9103501Israel

Nano-and micro-particles are being increasingly used to tune interfacial frictional properties in diverse applications,from friction modifiers in industrial lubrication to enhanced biological fluids in human osteoarthritic ***,we assessed the tribological properties of a simulated synovial fluid enriched with non-spherical,poly lactic-co-glycolic acid(PLGA)microparticles(μPL)that have been previously demonstrated for the pharmacological management of osteoarthritis(OA).Three different μPL configurations were fabricated presenting a 20μm×20μm square base and a thickness of 5μm(thin,5H μPL),10μm(10H μPL),and 20μm(cubical,20H μPL).After extensive morphological and physicochemical characterizations,the apparent Young’s modulus of the μPL was quantified under compressive loading returning an average value of~6 kPa,independently of the particle ***,using a linear two-axis tribometer,the static(μ_(s))and dynamic(μ_(d))friction coefficients of the μPL-enriched simulated synovial fluid were determined in terms of particle configuration and concentration,varying from 0(fluid only)to 6×10^(5) μPL/*** particle morphology had a modest influence on friction,possibly because the μPL were fully squeezed between two mating surfaces by a 5.8 N normal load realizing boundary-like lubrication ***,friction was observed to depend on the dimensionless parameterW,defined as the ratio between the total volume of the μPL enriching the simulated synovial fluid and the volume of the fluid *** coefficients of friction were documented to grow withWreaching a plateau of μ_(s)~0.4 and μ_(d)~0.15,already at Ω~2×10^(-3).Future investigations will have to systematically analyze the effect of sliding velocity,normal load,and rigidity of the mating surfaces to elucidate in full the tribological behavior of μPL in the context of osteoarthritis.

关键词： osteoarthritis microparticles tribology synovial fluid pin on plate

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Vascular-confined multi-passage discoidal nanoconstructs for the low-dose docetaxel inhibition of triple-negative breast cancer growth

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Nano Research 2022年第1期15卷 482-491页

作者： Alessia Felici Daniele Di Mascolo Miguel Ferreira Simone Lauciello Luca Bono Andrea Armirotti Arunkumar Pitchaimani Anna Lisa Palange paolo decuzzi Laboratory of Nanotechnology for Precision Medicine Fondazione Istituto Italiano di TecnologiaGenoa 16163Italy Department of Informatics BioengineeringRobotics and System EngineeringUniversity of GenoaGenoa 16126Italy Nanochemistry Laboratory Fondazione Istituto Italiano di TecnologiaGenoa 16163Italy Analytical Chemistry Laboratory Fondazione Istituto Italiano di TecnologiaGenoa 16163Italy

Taxane efficacy in triple negative breast cancer(TNBC)is limited by insufficient tumor accumulation and severe off-target *** offer a unique opportunity to enhance the anti-cancer potency of this ***,1,000 nm×400 nm discoidal polymeric nanoconstructs(DPN)encapsulating docetaxel(DTXL)and the near infrared compound Iipid-Cy5 were *** were obtained by filling multiple times cylindrical wells in a poly(vinyl alcohol)template with a polymer mixture comprising poly(lactic-co-glycolic acid)(PLGA)and poly(ethylene glycol)diacrylate(PEG-DA)chains together with therapeutic and imaging *** resulting“multi-passage”DPN exhibited higher DTXL loading,Iipid-Cy5 stability,and stiffness as compared to the conventional"single-passage"*** microscopy confirmed that DTXL-DPN were not taken up by MDA-MB-231 cells but would rather sit next to the cell membrane and slowly release DTXL *** DPN had no toxicity on TNBC cells,whereas DTXL-DPN presented a cytotoxic potential comparable to free DTXL(IC_(50)=2.6 nM±1.0 nM vs.7.0 nM±1.09 nM at 72 h).In orthotopic murine models,DPN accumulated in TNBC more efficiently than *** only 2 mg/kg DTXL,intravenously administered every 2 days for a total of 13 treatments,DTXL-DPN induced tumor regression and were associated to an overall 80%survival rate as opposed to a 30%survival rate for free-DTXL,at 120 *** untreated mice succumbed before 90 ***,this data demonstrates that vascular confined multi-passage DPN,biomimicking the behavior of circulating platelets,can efficiently deliver chemotherapeutic molecules to malignant tissues and effectively treat orthotopic TNBC at minimal taxane doses.

关键词： hydrogel particles template strategy vascular targeting biomimicry cancer therapy

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Time dependent dispersion of nanoparticles in blood vessels

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Journal of Biomedical Science and Engineering 2010年第5期3卷 517-524页

作者： Francesco Gentile paolo decuzzi 不详

The dispersion of intravasculary injected nanoparticles can be efficiently described by introducing an effective diffusion coefficient Deff which quantifies the longitudinal mass transport in blood vessels. Here, the original work of Gill and Sankarasubramanian was modified and extended to include 1) the variati- on over time of Deff;2) the permeability of the blood vessels and 3) non-Newtonian rheology of blood. A general solution was provided for Deff depending on space (?), time (?), plug radius (?c) and a subset of permeability parameters. It was shown that increasing the vessel plug radius (thus hematocrit) or permeability leads to a reduction in Deff, limiting the transport of nanoparticles across those vessels. It was also shown that the asymptotic time beyond which the solution attains the steady state behaviour is always independent of the plug radius and wall permeability. The analysis presented can more accurately predict the transport of nanoparticles in blood vessels, compared to previously developed models.

关键词： Nanoparticle Transport Casson Fluid Permeable Blood Vessels Drug Delivery

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A doublet mechanics model for the ultrasound characterization of malignant tissues

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Journal of Biomedical Science and Engineering 2011年第5期4卷 362-374页

作者： Francesco Gentile Jason Sakamoto Raffaella Righetti paolo decuzzi Mauro Ferrari 不详

Non invasive ultrasound-based imaging systems are being more commonly used in clinical bio-microscopy applications for both ex vivo and in vivo analysis of tissue pathological and physiological states. These modalities usually employ high-frequency ultrasound systems to overcome spatial resolution limits of conventional clinical diagnostic approaches. Biological tissues are non continuous, non homogeneous and exhibit a multiscale organization from the sub-cellular level (￡1 mm) to the organ level (31 cm). When the ultrasonic wavelength used to probe the tissues becomes comparable with the tissue's microstructure scale, the propagation and reflection of ultrasound waves cannot be fully interpreted employing classical models developed within the continuum assumption. In this study, we present a multiscale model for analyzing the mechanical response of a non-continuum double-layer system exposed to an ultrasound source. The model is developed within the framework of the Doublet Mechanics theory and can be applied to the non-invasive analysis of complex biological tissues.

关键词： Nanomechanics Doublet Mechanics Ultrasound Spectroscopy Biopsy Microscopic Elastography Ultrasound Biomicroscopy

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Experimental evaluation of mechanical compression of lattice trusses made with Ti6Al4V for aerospace use

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Chinese Journal of Aeronautics 2024年第5期37卷 520-532页

作者： Carlo Giovanni FERRO Sara VARETTI paolo MAGGIORE Department of Mechanical and Aerospace Engineering Politecnico di TorinoCorso Duca degli AbruzziTorino 10124Italy

Lattice structures are three-dimensional structures composed of repeated geometrical shapes with multiple interconnected nodes,providing high strength-to-weight ratios,customizable properties,and efficient use of materials.A smart use of materials leads to reduced fuel consumption and lower operating costs,making them highly desirable for aircraft ***,the customizable properties of lattice structures allow for tailoring to specific design requirements,leading to improved performance and safety for *** advantages make lattice structures an important focus for research and development in the aviation *** paper presents an experimental evaluation of the mechanical compression properties of lattice trusses made with Ti6Al4V,designed for use in an anti-ice *** truss structures were manufactured using additive manufacturing techniques and tested under compressive loads to determine mechanical *** showed that lattice trusses exhibited high levels of compressive strength,making them suitable for use in applications where mechanical resistance and durability are critical,such as in anti-ice *** also highlight the potential of additive manufacturing techniques for the fabrication of lattice trusses with tailored mechanical *** study provides valuable insights into the mechanical behavior of Ti6Al4V lattice trusses and their potential applications in anti-ice systems,as well as other areas where high strength-to-weight ratios are *** results of this research contribute to the development of lightweight,efficient,and durable anti-ice systems for use in aviation and other industries.

关键词： Additive Manufacturing(AM) Selective Laser Sintering(SLM) Anti ice systems Lattice structures Aircraft on board systems Design of Experiments(DOE)

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Friction and wear performance of polyether ether ketone(PEEK)polymers in three lubrication regimes

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Friction 2024年第4期12卷 670-682页

作者： Davide MASSOCCHI Nora LECIS Marco LATTUADA Davide SCAGLIA Steven CHATTERTON paolo PENNACCHI Department of Mechanical Engineering Politecnico di MilanoMilan 20156Italy Eni SpA Downstream product R&DLombardia 20097Italy Eurobearings S.R.L. Lombardia 29016Italy

This experimental study investigates the friction and wear of three coatings commonly used in industrial applications,particularly in hydrodynamic *** three materials under investigation were Babbitt,polyether ether ketone(PEEK)reinforced with 15%carbon fibers,and PEEK reinforced with 20%carbon *** first polymer material was extruded,while the other was produced by fused deposition modelling(FDM).The materials were subjected to sliding tests in a pin-on-disc configuration,with a steel ball serving as the counter *** tests were conducted at room temperature,with a load of 10 N and under three different lubrication conditions:dry,grease,and *** linear speed was set at 0.3 m/s for the dry and semi-solid lubrication tests,while for the oil tests,the speed was set at 0.25 m/*** greases used had consistency grades of NGLI 000 and NGLI *** ISO VG 68 circulation oil was used for the oil lubrication ***,thermodynamic analyses were performed under the most severe conditions(i.e.,dry)to investigate the steel-Babbitt and steel-PEEK contact.

关键词： hydrodynamic bearings polyether ether ketone(PEEK)polymers additive manufacturing grease lubrication sliding oil lubrication ball-on-disk tribology

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Double-nylon purse-string suture technique: Another addition to the endoscopist's toolbox for full-thickness defect closure

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World Journal of Gastroenterology 2024年第25期30卷 3152-3154页

作者： Angad Walia Roberto paolo Trasolini Neal Shahidi Department of Medicine University of British ColumbiaVancouver V6Z2K5BCCanada

Iatrogenic perforation is the most feared adverse event in *** the expansion of interventional endoscopy in favor of traditional surgery,it is now more crucial than ever to develop effective defect closure *** has culminated in the dissemination of multiple novel closure technologies,including through-the-scope clips,over-the-scope clips,through-the-scope suturing and over-the-scope suturing *** this editorial,we comment on the recent publication by Wang and colleagues discussing the performance of the double-nylon purse-string suture technique in the closure of large(>3 cm)gastric full-thickness *** technique offers a promising,practical and cost-effective approach to closure of large full-thickness defects that can be readily imple-mented across diverse healthcare settings.

关键词： Cancer Endoscopy Endoscopic full-thickness resection Perforation

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Is tuberous sclerosis complex-associated autism a preventable andtreatabledisorder?

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World Journal of Pediatrics 2024年第1期20卷 40-53页

作者： paolo Curatolo Mirte Scheper Leonardo Emberti Gialloreti Nicola Specchio Eleonora Aronica Child Neurology and Psychiatry Unit Systems Medicine DepartmentTor Vergata UniversityRomeItaly Department of Neuropathology Amsterdam NeuroscienceAmsterdam UMC Location University of AmsterdamAmsterdamTheNetherlands Department of Biomedicine and Prevention University of Rome Tor VergataVia Montpellier 100133 RomeItaly Clinical and Experimental Neurology Bambino Gesù Children's HospitalIRCCSFull Member of European ReferenceNetworkEpiCAREPiazza S.Onofrio400165 RomeItaly Stichting Epilepsie Instellingen Nederland(SEIN) HeemstedeAmsterdamThe Netherlands

Background Tuberous sclerosis complex(TSC)is a genetic disorder caused by inactivating mutations in the TSCl and TSC2 genes,causing overactivation of the mechanistic(previously referred to as mammalian)target of rapamycin(mTOR)signaling pathway in fetal *** mTOR pathway plays a crucial role in several brain processes leading to TSC-related epilepsy,intellectual disability,and autism spectrum disorder(ASD).Pre-natal or early post-natal diagnosis of TSC is now possible in a growing number of pre-symptomatic *** sources We searched PubMed for peer-reviewed publications published between January 2010 and April 2023 with the terms“tuberous sclerosis",“autism",or“autism spectrum disorder""animal models",“preclinical studies",“neurobiology",and“treatment".Results Prospective studies have highlighted that developmental trajectories in TSC infants who were later diagnosed with ASD already show motor,visual and social communication skills in the first year of life *** genetic,cellular,electroencephalography and magnetic resonance imaging biomarkers can identify pre-symptomatic TSC infants at high risk for having autism and *** Preventing epilepsy or improving therapy for seizures associated with prompt and tailored treatment strategies for autism in a sensitive developmental time window could have the potential to mitigate autistic symptoms in infants with TSC.

关键词： Animal model-Autism spectrum disorders Developmental and epileptic encephalopathy Mechanisms mTOR Risk Tuberos sclerosis complex

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Optimal therapy for HIV infection containment and virions inhibition

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Infectious Disease Modelling 2024年第1期9卷 10-26页

作者： paolo Di Giamberardino Daniela Iacoviello Muhammad Zubair Dept.of Computer Control and Management EngineeringSapienzaUniversity of RomeVia Ariosto 2500185RomeItaly

Prevention and early diagnosis are the best and most effective ways for defeating *** is still no vaccine,but treatments with antiretroviral drugs are now available which,in many cases,allow the infection to become ***,research has highlighted side effects of these drugs and the fact that a flare-up of the infection occurs if the therapy is *** recent years,the presence of virus reserves located in various parts of the body,including the brain,has been *** possibility of controlling the infection of healthy cells and of interrupting the proliferation of virions inside the brain has been studied,proposing optimal control strategies.

关键词： Epidemic modeling HIV-AIDS Optimal control

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Current trends on the use of deep learning methods for image analysis in energy applications

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Energy and AI 2024年第1期15卷 342-355页

作者： Mattia Casini paolo De Angelis Eliodoro Chiavazzo Luca Bergamasco Department of Energy Politecnico di TorinoCorso Duca degli Abruzzi 24Turin10129Italy

Deep learning methods for image analysis are attracting increasing interest for application in a wide range of different research *** we aim to systematically analyze and discuss the most relevant examples for the energy *** this,we perform a comprehensive literature screening on applications of deep learning methods for image analysis,classify the results in application macro-areas,and discuss the emerging trends on the available energy-related *** results of the analysis show that,while the exploitation of these methods for energy applications still appears to be at an early stage,the interest during the last years,in terms of number of published works,has considerably *** provide a systematic overview on the available energy-related examples,we present a schematic correlation chart mapping algorithms,tasks,and *** reported analysis is intended to provide an up-to-date overview on the current application trends and potential developments for energy applications in the next future.

关键词： Deep learning Image analysis Convolutional neural networks Energy applications

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