检索结果-南通市图书馆

Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

Immunization with Cop-1 promotes neuroprotection and neurogenesis after ischemic stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2015年第11期10卷 1733-1734页

作者： Yolanda Cruz paola Suárez-meade Antonio Ibarra Facultad de Ciencias de la Salud Universidad Anáhuac México Norte Av.Universidad Anáhuac No.46 Col.Lomas Anáhuac C.P.52786 Huixquilucan Edo.de México Proyecto CAMINA A.C. Tlalpan No.4430 Col.Toriello Guerra C.P.14050México City México

Cerebrovascular diseases are considered to be amongst the most serious public health issues,since they are the third leading cause of death（WHO,2014）and the most common cause of disability *** monetary significance is evidenced by the economic burden imposed on health care systems,given that the cost of medical care for a patient that has suffered a stroke is around$25,741US dollars every 5 years（Luengo-Fernandez et al.,2012）.A stroke occurs as a result of a disturbance or interruption of cerebral blood flow that significantly reduces the supply of oxygen and glucose to the neural tissue. Consequently, several cell death mechanisms （secondary lesion mechanisms） such as necrosis, excitotoxicity, free radical production and inflammation are triggered （Castillo, 2000）.

关键词： Immunization with Cop-1 promotes neuroprotection and neurogenesis after ischemic stroke BDNF Figure

Analysis of the fluid-bed stability of FCC catalysts at high temperature in terms of bed elasticity

在线全文

学校读者我要写书评

暂无评论

Particuology 2008年第1期6卷 30-37页

作者： paola Lettieri Luca Mazzei Department of Chemical Engineering University College London Torrington Place London WC1E 7JE UK

The effect of temperature on the fluid-bed stability of three FCC catalysts has been analyzed through considerations on fluid-bed elasticity. Experimental findings on the effect of temperature on the elasticity modulus at minimum bubbling conditions, （E）mb, were analyzed using the hydrodynamic fluid-bed stability model developed by Foscolo and Gibilaro （1984） and adopting the interparticle-forces-based stability criterion developed by Mutsers and Rietema （1977）. For both models, the parameters which control changes in （E）mb with temperature are discussed, in order to establish the origin of the fluid-bed elasticity and analyze the ability of these models to discriminate between the relative importance of the hydrodynamic and interoarticle forces on the stability of the fluidized catalysts.

关键词： Fluidization FCC catalysts High temperature Stability Bed elasticity

Chemical composition and Zn bioavailability of the soil solution extracted from Zn amended variable charge soils

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2010年第9期22卷 1398-1406页

作者： Mariavittoria Zampella paola Adamo Department of Soil Plant Environmental and Animal Production Sciences University of Naples Federico II

A study on variable charge soils （volcanic Italian and podzolic Scottish soils） was performed to investigate the influence of soil properties on the chemical composition of soil solution. Zinc speciation, bioavallability and toxicity in the soil solution were examined. The soils were spiked with increasing amounts of Zn （0, 100, 200, 400 and 1000 mg/kg） and the soil solutions were extracted using rhizon soil moisture samplers. The pH, total organic carbon （TOC）, base cations, anions, total Zn and free Zn^2＋ in soil solution were analysed. A rapid bioassay with the luminescent bacterium Escherichia coli HB 101 pUCD607 was performed to assess Zn toxicity. The influence of soil type and Zn treatments on the chemical composition of soil solution and on Zn toxicity was considered and discussed. Different trends of total and free Zn concentrations, base cations desorption and luminescence of E. coli HB 101 pUCD607 were observed. The soil solution extracted from the volcanic soils had very low total and free Zn concentrations and showed specific Zn^2＋/Ca^2＋ exchange. The soil solution from the podzolic soil had much higher total and free Zn concentrations and showed no evidence of specific Zn^2＋/Ca^2＋ exchange. In comparison with the subalkaline volcanic soils, the acidic podzol showed enhanced levels of toxic free Zn^2＋ and consequently stronger effects on E. coli viability.

关键词： rhizosamplers chemical speciation fractionation ecotoxicological test

Extreme Cities and Bad Places

在线全文

学校读者我要写书评

暂无评论

International Journal of Disaster Risk Science 2012年第1期3卷 3-10页

作者： paola Viganò Department of Urbanism University IUAV of Venice(Istituto Universitario di Architettura di Venezia)30125 VeniceItaly

This article considers places where climate change-induced hazards will be particularly important,focusing on two examples,the lagoon location of Venice and the Garonne riverbank location of Bordeaux. The Venice lagoon territory is close to the coast and has a dispersed form of urban development. Our project experiments resulted in the formulation of a series of adaptation strategies to increased disaster risks,including returning current agricultural land and residential areas to their original state as wetlands and marshes before their reclamation during the early decades of the twentieth century. The scenarios introduce space as a relevant variable into the debate about the impact of climate change and adaptation. This article also deals with the recovery of “bad places,” such as the urban blight on the Garonne riverbanks of Bordeaux,and their relationship with sustainability and disaster risks. Increasingly,the emphasis on minimizing energy consumption and promoting recycling forces cities to reuse places of elevated risk. Only very recently in modern urban planning are polluted and risky areas frequently selected for new development projects to reclaim the vast areas of existing brownfields in the name of sustainability. Integrating disaster risk reduction into a new economic and social context has thus become an extremely important part of contemporary urban design and planning for these reclaimed(bad) areas. The research concludes that urban and territorial design should and can integrate the inevitability of risk. This is necessary for developing approaches and strategies that offer some rethinking about “wicked” problems,long-term time horizons,radical imagination,dynamic representations,and minute territorial readings in contemporary urban planning.

关键词： disaster urban contemporary

Genetic predisposition to pancreatic cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第31期20卷 10778-10789页

作者： paola Ghiorzo Department of Internal Medicine and Medical Specialties University of Genoa and IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazioanle per la Ricerca sul Cancro 16132 Genoa Italy

Pancreatic adenocarcinoma(PC) is the most deadly of the common cancers. Owing to its rapid progression and almost certain fatal outcome, identifying individuals at risk and detecting early lesions are crucial to improve outcome. Genetic risk factors are believed to play a major role. Approximately 10% of PC is estimated to have familial inheritance. Several germline mutations have been found to be involved in hereditary forms of PC, including both familial PC(FPC) and PC as one of the manifestations of a hereditary cancer syndrome or other hereditary conditions. Although most of the susceptibility genes for FPC have yet to be identified, next-generation sequencing studies are likely to provide important insights. The risk of PC in FPC is sufficiently high to recommend screening of high-risk individuals; thus, defining such individuals appropriately is the key. Candidate genes have been described and patients considered for screening programs under research protocols should first be tested for presence of germline mutations in the BRCA2, PALB2 and ATM genes. In specific PC populations, including in Italy, hereditary cancer predisposition genes such as CDKN2 A also explain a considerable fraction of FPC.

关键词： Pancreatic adenocarcinoma Susceptibility genes CDKN2A Melanoma Hereditary cancer syndromes Screening

Minimal Free Resolutions of Zero-dimensional Schemes in P1 ×P1

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Algebra Colloquium 2015年第1期22卷 97-108页

作者： paola Bonacini Lucia Marino Universita degli Studi di Catania ViMe A. Doria 6 95125 Catania Italy

Let X be a zero-dimensional scheme in p1 × p1. Then X has a minimal free resolution of length 2 if and only if X is ACM. In this paper we determine a class of reduced schemes whose resolutions, similarly to the ACM case, can be obtained by their Hilbert functions and depend only on their distributions of points in a grid of lines. Moreover, a minimal set of generators of the ideal of these schemes is given by curves split into the union of lines.

关键词： resolution Hilbert function separators

Plant virus-derived siRNAs“turn on”broad-spectrum plant immunity in wheat

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2021年第7期14卷 1038-1040页

作者： paola Leonetti Vitantonio Pantaleo Department of Biology Agricultural and Food SciencesInstitute for Sustainable Plant ProtectionBari UnitCNRBari 70126Italy

Viruses are the most abundant biological entities on Earth and the major carriers of disease and mortality as well as the drivers of global *** plant viruses potentially influence global processes is an emergent issue,particularly for their putative implications in *** infection and spread,plant viruses are capable of reprogramming host gene expression via RNA silencing by releasing viral suppressors of RNA silencing,viral small interfering RNAs(vsiRNAs),and by inducing the production of viral-associated small interfering RNAs(va-siRNAs).Recently,studies on various crop-virus pathosystems suggest that RNA silencing suppressors(RSSs)。

关键词： immunity mortality releasing

Thermal survival limits of young and mature larvae of a cold stenothermal chironomid from the Alps （Diamesinae： Pseudodiamesa branickii [Nowicki, 1873]）

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2017年第2期24卷 314-324页

作者： Valeria Lencioni paola Bernabo Section of Invertebrate Zoology and Hydrobiology MUSE-Museo delle Scienze Corso del Lavoro e della Scienza 3 38123 Trento Italy

The threats posed by climate change make it important to expand knowl- edge concerning cold and heat tolerance in stenothermal species from habitats potentially threatened by temperature changes. Thermal limits and basal metabolism variations were investigated in Pseudodiamesa branickii （Diptera： Chironomidae） under thermal stress between -20 and 37 ℃. Supercooling point （SCP）, lower （LLTs） and upper lethal temper- atures （ULTs）, and oxygen consumption rate were measured in overwintering young （lst and 2nd instar） and mature （3rd and 4th instar） larvae from an Alpine glacier-fed stream. Both young and mature larvae were freezing tolerant （SCPs = -7.1 ℃ and -6.4 ℃, re- spectively; LLT100 〈SCP and 〉 -20 ℃） and thermotolerant （ULTso = 31.7 ± 0.4, 32.5± 0.3, respectively）. However, ontogenetic differences in acute tolerance were observed. The LLT50 calculated for the young larvae （=-7.4 ℃） was almost equal to their SCP （= -7.1 ℃） and the overlapping of the proportion of mortality curve with the CPIF curve highlighted that the young larvae are borderline between freezing tolerance and freezing avoidance. Furthermore, a lower ULT100 in the young larvae （of ca. 1 ℃）, suggests that they are less thermotolerant than mature larvae. Finally, young larvae exhibit a higher oxygen consumption rate （mgO2/gAFDM/h） at any temperature tested and are overall less resistant to oxygen depletion compared to mature larvae at ≥ 10 ℃. These findings sug- gest that mature larvae enter into a dormant state by lowering their basal metabolism until environmental conditions improve in order to save energy for life cycle completion during stressful conditions.

关键词： basal metabolism glacier-fed streams larval development supercooling point thermotolerance