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Broccoli products supplemented beers provide a sustainable source of dietary sulforaphane

Food Bioscience 2023年第1期51卷 413-419页

作者： paola sanchez-bravo Angel Abellan Pedro JZapata Cristina García-Viguera Raúl Domínguez-Perles María Jose Gimenez Lab.Fitoquímica y Alimentos saludables(LabFAS) Centro de Edafología y Biología Apliada del Segura(CEBAS)-CSICUniversity Campus-2530100EspinardoMurciaSpain Department of Food Technology EPSOUniveristy Miguel HernandezCtra Beniel km 3.203312OrihuelaAlicanteSpain

Broccoli is a highly consumed vegetable due to its content of bioactive nutrients and non-nutrients,including glucosinolates and ***,the consumption of craft beer has been boosted by the seek for enhanced sensory and functional *** this frame,broccoli have been proven as an ingredient to develop healthy *** objective of the work was to evaluate alternative broccoli materials(sprouts and byproducts powder)to go further from previous results,in a way contributing to the sustainability and circularity of the agro-food chain using underexploited material to supplement beers,which could be a sustainable dietary source of bioactive sulforaphane(SFN).The results showed high concentrations of SFN in beers supplemented with broccoli sprouts and powder(5.00 and 2.54 mg/L,respectively,previous to bottling).These concentrations remained stable until bottling,where they were reduced by>50%.After 150 storage days,the concentrations of SFN were 1.08 and 0.30 mg/L in beers supplemented with sprouts and powder,*** sensory analysis revealed the positive attributes(colour,floral,fruity,and aftertaste as a result of the profile of volatile compounds)of beers developed using sprouts,and significant values of cooked vegetables,alcoholic,and earthy leather,which could be considered negative in *** latter negative tips are the ones offering sensory traits associated to ITC to broccoli-based ***,the addition of broccoli in the format of fresh sprouts is more appropriate according to the SFN content and sensory features,providing a functional alternative that could be appreciated by consumers.

关键词： Healthy foods Beverages Brassica Isothiocyanates UHPLC-ESI-MS/MS Sensory properties

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Low concentrations of atrazine,glyphosate,2,4-dichlorophenoxyacetic acid,and triadimefon exposures have diverse effects on Xenopus laevis organ morphogenesis

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Journal of Environmental Sciences 2010年第9期22卷 1305-1308页

作者： Jenny R.Lenkowski Gabriela sanchez-bravo Kelly A.McLaughlin Department of Biology Tufts University

Many chemicals are released into the environment, and chemical contamination has been suggested as a contributing factor to amphibian declines. To add to a growing body of knowledge about the impact of individual chemicals on non-target organisms, we examined the specificity of deformities induced by exposure to four pesticides （atrazine, 2,4-dichloropheoxyacetic acid （2,4-D）, triadimefon, and glyphosate） in the model amphibian species, Xenopus laevis. We focused on the period of organ morphogenesis, as it is frequently found to be particularly sensitive to chemical exposure yet also commonly overlooked. We found similar levels of intestine malformations and edemas, as well as disruption of skeletal muscle, in atrazine and triadimefon exposed tadpoles. The effects of 2,4-D were only apparent at the highest concentrations we examined; glyphosate did not induce dramatic malformations at the concentrations tested. While researchers have shown that it is important to understand how chemical mixtures affect non-target organisms, our results suggest that it is first crucial to determine how these chemicals act independently in order to be able to identify consequences of individual pesticide exposure.

关键词： amphibian pesticide organ morphogenesis teratogenesis toxicology Xenopus laevis

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IKKβ overexpression together with a lack of tumour suppressor genes causes ameloblastic odontomas in mice

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International Journal of Oral Science 2020年第1期12卷 31-39页

作者： Angustias Page Ana bravo Cristian Suarez-Cabrera Raquel sanchez-Baltasar Marta Oteo Miguel Angel Morcillo MLlanos Casanova Jose CSegovia Manuel Navarro Angel Ramirez Molecular Oncology Unit.Centro de Investigaciones Energéticas Medioambientales y Tecnológicas(CIEMAT)MadridSpain Instituto de Investigación 12 de Octubre i+12 MadridSpain Centro de Investigación Biomédica en Red de Cáncer(CIBERONC) MadridSpain Department of Anatomy Animal Production and Veterinary Clinical SciencesLaboratory of Pathology Phenotyping of Genetically Engineered MiceFaculty of Veterinary MedicineUniversity of Santiago de CompostelaLugoSpain Biomedical Applications and Pharmacokinetics Unit Centro de Investigaciones EnergéticasMedioambientales y Tecnológicas(CIEMAT)MadridSpain Hematopoietic Innovative Therapies Division.Centro de Investigaciones Energéticas Medioambientales y Tecnológicas(CIEMAT).Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)MadridSpain Unidad Mixta de Terapias Avanzadas Fundación Instituto de Investigaciones Sanitarias Fundación Jiménez DíazMadridSpain

Odontogenic tumours are a heterogeneous group of lesions that develop in the oral cavity region and are characterized by the formation of tumoural structures that differentiate as teeth. Due to the diversity of their histopathological characteristics and clinical behaviour, the classification of these tumours is still under debate. Alterations in morphogenesis pathways such as the Hedgehog,MAPK and WNT/β-catenin pathways are implicated in the formation of odontogenic lesions, but the molecular bases of many of these lesions are still unknown. In this study, we used genetically modified mice to study the role of IKKβ(a fundamental regulator of NF-κB activity and many other proteins) in oral epithelial cells and odontogenic tissues. Transgenic mice overexpressing IKKβ in oral epithelial cells show a significant increase in immune cells in both the oral epithelia and oral submucosa. They also show changes in the expression of several proteins and mi RNAs that are important for cancer development. Interestingly, we found that overactivity of IKKβ in oral epithelia and odontogenic tissues, in conjunction with the loss of tumour suppressor proteins(p53, or p16 and p19), leads to the appearance of odontogenic tumours that can be classified as ameloblastic odontomas, sometimes accompanied by foci of secondary ameloblastic carcinomas. These tumours show NF-κB activation and increased β-catenin *** findings may help to elucidate the molecular determinants of odontogenic tumourigenesis and the role of IKKβ in the homoeostasis and tumoural transformation of oral and odontogenic epithelia.

关键词： IKKβ tumour suppressor

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When Giant Lymphangioma Meets Hydrops Fetalis: An Uncommon Case Report of Lower Extremity Involvement

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Maternal-Fetal Medicine 2024年第4期6卷 253-256页

作者： Ariana Marie Martin Andrea paola sanchez-Cantul Andrea Cantu-Rodriguez Raul Martinez-Salinas Jesus Damian Valdez-Bocanegra Department of School of Medicine and Health Sciences TecSalud Tecnológico de MonterreyMonterreyNuevo Leon 64849Mexico Department of Radiology Hospital Christus Muguerza Alta EspecialidadMonterreyNuevo Leon 64040Mexico Department of Obstetrics and Gynecology Tecnológico de MonterreyMonterreyNuevo Leon 64849Mexico.

Approximately 75%of lymphangiomas manifest in the head and neck region,with limb and bone involvement observed in only 2%of *** case report presents a rare instance of fetal lymphangioma associated with hydrops fetalis,affecting the left lower extremity and abdomen.A 22-year-old secundigravida woman was referred to the gynecology department at 31.2 weeks of *** fetal ultrasound revealed a live fetus with a large lymphangioma involving the left lower extremity,gluteal region,and *** ultrasound findings included subcutaneous edema,pericardial effusion,ascites,placentomegaly,and tricuspid *** clinical examination confirmed the diagnosis of lymphatic ***,only one other similar case has been reported in the English-language PubMed *** report adds to the medical literature as a rare instance of prenatally diagnosed lymphangioma-associated hydrops fetalis.

关键词： Lymphatic abnormalities Lower extremity lymphangioma Hydrops fetalis Ultrasonography Case report

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Liver Transplantation in a Monolung Patient: A Strategy of Sequential Treatments of Multiple Lung Tuberculosis Ca-vitations and Hepatocellular Carcinoma on Hepatitis B Related Virus Cirrhosis

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Surgical Science 2011年第5期2卷 257-261页

作者： Dino Donataccio paola Del bravo Alberto Masotto Marcello Ceola Francesco Calabrò Matteo Donataccio 不详

The presence of extrahepatic infection is a contraindication for liver transplantation, even more if supported by an advanced pulmonary tuberculosis with persistent cavitation not curable with medical treatment. We report a case of a young patient with hepatocellular carcinoma on hepatitis B virus related liver cirrhosis and multiple lung tuberculosis cavitations. The patient was referred to our centre for liver transplantation. We adopted a strategy with sequential treatments. First a left extra-pericardial pneumonectomy was performed without opening the infected cavern, followed by a therapy with rifampicin, isoniazid and ethambutol for a period of nine months. After the cure of tuberculosis, the monolung patient eventually was listed for liver transplantation. An accurate planning of a multistep therapeutical strategy, an appropriate anesthetic management and a meticulous surgical technique allowed to successfully transplant a young patient suffering from three life-threatening diseases: cavitary tuberculosis, hepatitis B virus cirrhosis and hepatocellular carcinoma. Thirty months after liver transplantation the patient is in good health, with normal liver function, forced expiratory volume in one second of 42% (1.53 liters) and without any tuberculosis disease reactivation.

关键词： Mycobacterium Tuberculosis Infection Pneumonectomy Liver Disease Liver Surgery

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Densities and viscosities of binary mixtures of n-decane + 1-pentanol,+1-hexanol,+1-heptanol at temperatures from 293.15 to 363.15 K and atmospheric pressure

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Chinese Journal of Chemical Engineering 2015年第3期23卷 559-571页

作者： Alejandro Estrada-Baltazar Micael Gerardo bravo-sanchez Gustavo Arturo Iglesias-Silva Juan Francisco Javier Alvarado Edgar Omar Castrejon-Gonzalez Mariana Ramos-Estrada Department of Chemical Engineering Instituto Tecnologico de Celaya Faculty of Chemical Engineering Universidad Michoacana de San Nicolas de Hidalgo

Densities(ρ) and dynamic viscosities(η) for three binary mixtures of n-decane with 1-pentanol,1-hexanol and1-heptanol are presented at temperatures from 293.15 to 363.15 K and atmospheric pressure over the entire composition *** density and viscosity are measured using a vibrating tube densimeter and a cylindrical Couette type rotating viscometer,*** molar volumes(V^E),viscosity deviations(△η) and excess Gibbs energy of activation of viscous flow(△G^(*E)) are calculated from the experimental *** and structural interactions are indicated by the sign and magnitude of these *** molar volumes and infinity dilution molar partial volumes are also calculated for each binary *** results are correlated using Redlich-Kister type equations.

关键词： n-Decane 1-Alcohol Density Viscosity Partial molar volumes

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Association between Helicobacter pylori infection,mismatch repair,HER2 and tumor-infiltrating lymphocytes in gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2487-2503页

作者： Carlos A Castaneda Miluska Castillo Luis A Bernabe Joselyn sanchez Matteo Fassan Katherine Tello Ignacio Ivan Wistuba Ivan Chavez Passiuri Eloy Ruiz Juvenal sanchez Fernando Barreda Daniel Valdivia Yaqueline Bazan Milagros Abad-Licham Claudio Mengoa Hugo Fuentes paola Montenegro Ebert Poquioma Raul Alatrista Claudio J Flores Luis Taxa Faculty of Health Sciences Universidad Cientifica del SurLima 15038Peru GECO PERU Grupo de Estudios Clinicos Oncologicos del PeruLima 15038Peru Department of Research Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Faculty of Human Medicine Universidad Ricardo PalmaLima 15039Peru Department of Medicine Surgical Pathology&Cytopathology UnitUniversity of PaduaPadua 35121Italy Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Abdominal Surgery Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Medical Specialties Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Regional de Enfermedades Neoplasicas del NorteTrujillo 13001Peru Faculty of Human Medicine Universidad Privada Antenor OrregoTrujillo 13008Peru Department of Surgery Instituto Regional de Enfermedades Neoplasicas del SurArequipa 04002Peru Department of Medical Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Epidemiology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Unidad de Investigación Básica y Traslacional Oncosalud-AUNALima 15038Peru Faculty of Medicine Universidad San Martin de PorresLima 15008Peru

BACKGROUND The influence of Helicobacter-pylori(***)infection and the characteristics of gastric cancer(GC)on tumor-infiltrating lymphocyte(TIL)levels has not been extensively *** of infiltrating-immune-cell subtypes as well as survival is necessary to obtain comprehensive *** To determine the rates of deficient mismatch-repair(dMMR),HER2-status and *** infection and their association with TIL levels in *** Samples from 503 resected GC tumors were included and TIL levels were evaluated following the international-TILs-working-group recommendations with assessment of the intratumoral(IT),stromal(ST)and invasive-border(IB)*** density of CD3,CD8 and CD163 immune cells,and dMMR and HER2-status were determined by immunohistochemistry(IHC).*** infection was evaluated by routine histology and quantitative PCR(qPCR)in a subset of *** dMMR was found in 34.4%,HER2+in 5%and ***-positive in 55.7%of *** IT-TIL was associated with grade-3(P=0.038),while ST-TIL with grade-1(P<0.001),intestinal-histology(P<0.001)and no-recurrence(P=0.003).dMMR was associated with high TIL levels in the ST(P=0.019)and IB(P=0.01)compartments,and STCD3(P=0.049)and ST-CD8(P=0.05)***2-was associated with high IT-CD8(P=0.009).*** was associated with high IT-TIL levels(P=0.009)when assessed by routine-histology,and with high TIL levels in the 3 compartments(P=0.002-0.047)and CD8 density in the IT and ST compartments(P=0.001)when assessed by qPCR.A longer overall survival was associated with low IT-CD163(P=0.003)and CD8/CD3(P=0.001 in IT and P=0.002 in ST)and high IT-CD3(P=0.021),ST-CD3(P=0.003)and CD3/CD163(P=0.002).CONCLUSION TIL levels were related to dMMR and *** CD8/CD3 and high CD163/CD3 were associated with lower recurrence and longer survival.

关键词： Lymphocytes Macrophages Gastric cancer Helicobacter pylori HER2 Mismatch repair

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Cytogenetic and Molecular Characterization of Hematological Neoplasm in an Ecuadorian Population

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Open Journal of Blood Diseases 2013年第4期3卷 108-115页

作者： Cesar Paz-y-Mino Maria Eugenia sanchez Santiago Araujo Ligia Ocampo Victor Hugo Espin paola ELeone Instituto de Investigaciones Biomedicas Universidad de las AmericasQuitoEcuador Laboratorio de Genetica Sociedad de Lucha contra el Cancer(SOLCA)QuitoEcuador Laboratorio de Genetica Hospital Carlos Andrade MarinQuitoEcuador.

Cancer is one of the major causes of mortality in Ecuador and annually, hematological malignancies are within the top ten most common cancers. In this multicentric study, we analyzed a series of patients diagnosed with different hematological disorders between the years 1984 and 2012. Chromosome abnormalities were detected in 1886 (45.9%) patients. FISH and RT-PCR techniques were used in order to determine the presence of genetic rearrangements and complement conventional cytogenetics results. Using FISH and RT-PCR, positive cases were increased by 1.8% and 6.9% respec- tively. We analyzed fusion genes resulting from t(8;21), t(15;17), inv(16), t(9;22), 11q23 rearrangements, t(4;11) and t(1;19). The frequency of transcripts of some of these fusion genes was of particular interest as our results differ from studies on other populations. Specifically, the fusion gene BCR-ABL was present in the form of the b2/a2 transcript in 95% of CML patients and in the form of b3/a2 transcript in the remaining 5%. The PML-RARA fusion gene also showed a distinct pattern of transcript expression. This fusion gene exhibited the bcr2 (36%) and bcr3 (64%) transcripts, how- ever the bcr1 transcript was absent from our sample population. All cases carrying the CBFB-MYH11 fusion gene ex- hibited the F transcript. This was also of interest due to the rarity of this particular transcript worldwide. Finally all cases carrying the MLL-AF4 fusion gene displayed the e7-e8 transcript. The frequency of the subtypes of some fusion genes differ from those reported in other populations, possibly due to the particular genetic make-up of the Ecuadorian population, mostly mestizo, as well as environmental factors.

关键词： Hematological Diseases Chromosomal Aberration BCR-ABL PML-RARA CBFB-MYH11 MLL-AF4 Geographical Heterogeneity

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Survival after curative pancreaticoduodenectomy for ampullary adenocarcinoma in a South American population:A retrospective cohort study

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World Journal of Gastrointestinal Surgery 2022年第1期14卷 24-35页

作者： Ramiro Manuel Fernandez-Placencia paola Montenegro Melvy Guerrero Mariana Serrano Emperatriz Ortega Mercedes bravo Lourdes Huanca Stéphane Bertani Juan Manuel Trejo Patricia Webb Jenny Malca-Vasquez Luis Taxa Alberto Lachos-Davila Juan Celis-Zapata Carlos Luque-Vasquez Eduardo Payet Eloy Ruiz Francisco Berrospi Hepato-Pancreato-Biliary Section Department of Abdominal SurgeryInstituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Medical Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru International Joint Laboratory of Molecular Anthopological Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Unite Pharmacochim&Pharmacol Dev UMR152F-31062 ToulouseFrance Department of Radiation Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Abdominal Surgery Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru

BACKGROUND Ampullary adenocarcinoma(AAC)is a rare neoplasm that accounts for only 0.2%of all gastrointestinal *** incidence rate is lower than 6 cases per million *** prognostic factors have been described for AAC and are associated with a wide range of survival ***,these studies have been exclusively conducted in patients originating from Asian,European,and North American *** To evaluate the histopathologic predictors of overall survival(OS)in South American patients with AAC treated with curative pancreaticoduodenectomy(PD).METHODS We analyzed retrospective data from 83 AAC patients who underwent curative(R0)PD at the National Cancer Institute of Peru between January 2010 and October 2020 to identify histopathologic predictors of *** Sixty-nine percent of patients had developed intestinal-type AAC(69%),23%had pancreatobiliary-type AAC,and 8%had other ***-one percent of patients were classified as Stage I,according to the AJCC 8 th *** occurred primarily in the liver(n=8),peritoneum(n=4),and lung(n=4).Statistical analyses indicated that T3 tumour stage[hazard ratio(HR)of 6.4,95%confidence interval(CI)of 2.5-16.3,P<0.001],lymph node metastasis(HR:4.5,95%CI:1.8-11.3,P=0.001),and pancreatobiliary type(HR:2.7,95%CI:1.2-6.2,P=0.025)were independent predictors of *** Extended tumour stage(T3),pancreatobiliary type,and positive lymph node metastasis represent independent predictors of a lower OS rate in South American AAC patients who underwent curative PD.

关键词： Gastrointestinal neoplasms Adenocarcinoma Ampulla Pancreaticoduodenectomy Survival South America

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Osteomodulin downregulation is associated with osteoarthritis development

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Bone Research 2023年第4期11卷 721-736页

作者： Jérémie Zappia Qiao Tong Renée Van der Cruyssen Frederique MFCornelis Cécile Lambert Tiago Pinto Coelho Juliane Grisart Erika Kague Rik JLories Marc Muller Dirk Elewaut Chrissy LHammond Christelle sanchez Yves Henrotin MusculoSKeletal Innovative Research Lab Center for Interdisciplinary Research on MedicinesUniversitéde LiègeLiègeBelgium School of Physiology Pharmacologyand NeuroscienceUniversity of BristolBristolUK Department of Biomedical Molecular Biology Ghent UniversityGhentBelgium Laboratory for Molecular Immunology and Inflammation Department of RheumatologyGhent University HospitalGhentBelgium Laboratory of Tissue Homeostasis and Disease Skeletal Biology and Engineering Research CenterDepartment of Development and RegenerationKU LeuvenLeuvenBelgium Cardiovascular Sciences Groupe Interdisciplinaire de Génoprotéomique AppliquéeUniversitéde LiègeLiègeBelgium Division of Nephrology CHU of LiègeUniversitéde LiègeLiègeBelgium Artialis SA Tour GIGACHU Sart-TilmanLiègeBelgium Division of Rheumatology University Hospitals LeuvenLeuvenBelgium Laboratoire d’Organogenèse et Régénération Groupe Interdisciplinaire de Génoprotéomique AppliquéeUniversitéde LiègeLiègeBelgium Physical Therapy and Rehabilitation Department Princess Paola HospitalVivaliaMarche-en-FamenneBelgium

Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis(OA), and osteomodulin(OMD), a proteoglycan involved in extracellular matrix mineralization, is associated with the sclerotic phenotype. However, the functions of OMD remain poorly understood, specifically in vivo. We used Omd knockout and overexpressing male mice and mutant zebrafish to study its roles in bone and cartilage metabolism and in the development of OA. The expression of Omd is deeply correlated with bone and cartilage microarchitectures affecting the bone volume and the onset of subchondral bone sclerosis and spontaneous cartilage lesions. Mechanistically, OMD binds to RANKL and inhibits osteoclastogenesis, thus controlling the balance of bone remodeling. In conclusion, OMD is a key factor in subchondral bone sclerosis associated with OA. It participates in bone and cartilage homeostasis by acting on the regulation of osteoclastogenesis. Targeting OMD may be a promising new and personalized approach for OA.

关键词： metabolism conclusion homeostasis

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