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Diagnostic and therapeutic implications of the association between ferritin level and severity of nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2012年第29期18卷 3782-3786页

作者： Luca Valenti paola Dongiovanni Silvia Fargion Università degli Studi di Milano Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico20122 MilanoItaly

Nonalcoholic fatty liver disease(NAFLD),defined by excessive liver fat deposition related to the metabolic syndrome,is a leading cause of progressive liver disease,for which accurate non-invasive staging systems and effective treatments are still *** has shown that increased ferritin levels are associated with the metabolic insulin resistance syndrome,and higher hepatic iron and fat *** and iron stores have been associated with the severity of liver damage in NAFLD,and iron depletion reduced insulin resistance and liver ***,Kowdley et al demonstrated in a multicenter study in 628 adult patients with NAFLD from the NAFLD-clinical research network database with central re-evaluation of liver histology and iron staining that the increased serum ferritin level is an independent predictor of liver damage in patients with NAFLD,and is useful to identify NAFLD patients at risk of non-alcoholic steatohepatitis and advanced *** data indicate that incorporation of serum ferritin level may improve the performance of noninvasive scoring of liver damage in patients with NAFLD,and that iron depletion still represents an attractive therapeutic target to prevent the progression of liver damage in these patients.

关键词：脂肪含量蛋白水平严重程度酒精性血清铁肝病治疗肝功能损害

Long-term spatial memory in Vespula germanica social wasps： the influence of past experience on foraging behavior

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Insect Science 2017年第5期24卷 853-858页

作者： Sabrina Moreyra paola D'Adamo Mariana Lozada Laboratory Ecotono INIBIOMA CONICET Universidad Nacional de/Comahue Quintral 1250 (8400) Bariloche Argentina

Social insects exhibit complex learning and memory mechanisms while for- aging. Vespula germanica （Fab.）（Hymenoptera： Vespidae） is an invasive social wasp that frequently forages on undepleted food sources, making several flights between the resource and the nest. Previous studies have shown that during this relocating behavior, wasps learn to associate food with a certain site, and can recall this association 1 h later. In this work, we evaluated whether this wasp species is capable of retrieving an established association after 24 h. For this purpose, we trained free flying individuals to collect proteinaceous food from an experimental plate （feeder） located in an experimental array. A total of 150 individuals were allowed 2, 4, or 8 visits. After the training phase, the array was re- moved and set up again 24 h later, but this time a second baited plate was placed opposite to the first. After 24 h we recorded the rate of wasps that returned to the experimental area and those which collected food from the previously learned feeding station or the nonlearned one. During the testing phase, we observed that a low rate of wasps trained with 2 collecting visits returned to the experimental area （22%）, whereas the rate of returning wasps trained with 4 or 8 collecting visits was higher （51% and 41%, respectively）. Moreover, wasps trained with 8 feeding visits collected food from the previously learned feeding station at a higher rate than those that did from the nonlearned one. In contrast, wasps trained 2 or 4 times chose both feeding stations at a similar rate. Thus, significantly more wasps returned to the previously learned feeding station after 8 repeated foraging flights but not after only 2 or 4 visits. This is the first report that demonstrates the existence of long-term spatial memory in V. germanica wasps.

关键词： foraging behavior learning long-term memory relocating behavior social wasps

The influence of past experience on wasp choice related to foraging behavior

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Insect Science 2014年第6期21卷 759-764页

作者： Moreyra Sabrina paola D'Adamo Mariana Lozada Laboratory Ecotono INIBIOMA Quintral 1250 (8400) Bariloche Argentina

Memory has been little studied in social wasps. Vespula germanica （Fab.）（Hymenoptera： Vespidae） frequently revisits nondepleted food sources, making several trips between the resource and the nest. In this study, we analyzed this relocating behavior in order to evaluate whether this species is capable of remembering an established association after 1 h. To this end, we trained wasps to feed from a certain array. Then it was removed, setting it up again 1 h later, but this time 2 baited feeders were put in place, one at the original feeding site and the other opposite the first. We recorded the proportion of returning foragers, and their choice of feeder, after either 1 or 4 feeding trials. After 1 h, 78% of wasps trained with 4 feeding trials and 65% trained with 1, returned to the experimental area. Furthermore, during the testing phase, wasps trained with 4 feeding trials collected food from the previously learned feeder significantly more frequently than from the nonlearned one （P 〈 0.05）. In contrast, wasps that had been trained only once chose both feeders equally. Thus, memory retrieval could be observed 1 h after wasps had collected food on 4 consecutive occasions, but not after only 1. To our knowledge, this is the first study showing that V. germanica is capable of remembering an association 1 h after the last associative event, demonstrating that 1 h does not impair memory retention if4 feeding experiences have occurred.

关键词： cognition foraging behavior learning memory social wasps Vespula germanica

Anti-BCMA novel therapies for multiple myeloma

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Cancer Drug Resistance 2023年第1期6卷 169-181页

作者： Vincenzo Sammartano Marta Franceschini Sara Fredducci Federico Caroni Sara Ciofini paola Pacelli Monica Bocchia Alessandro Gozzetti Department of Medicine Surgery and NeuroscienceUniversity of SienaAzienda Ospedaliero Universitaria SeneseSiena 53100Italy.

Recent advances in multiple myeloma therapy have increased the depth of response and ultimately survivals;however,the prognosis remains *** BCMA antigen is highly expressed in myeloma cells,thus representing a target for novel *** agents that target BCMA through different mechanisms,including bispecific T cell engagers drug conjugated to antibody and CAR-T cells,are now available or under *** targeting BCMA have shown good results in efficacy and safety in multiple myeloma patients previously treated with several lines of *** review will discuss the recent development of anti-BCMA targeted treatments in myeloma,with a special focus on currently available agents.

关键词： Multiple myeloma BCMA belantamab teclistamab CART

Goncrete block pavements in urban and local roads:Analysis of stress-strain condition and proposal for a catalogue

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第6期6卷 557-566页

作者： paola Di Mascio Laura Moretti Americo Capannolo Department of Civil Building and Environmental EngineeringSapienza University of RomeRome 00184Italy

Although the construction of block pavements has grown fast in the last decades,there is still a need for simple tools that could be applied to design *** paper analyzed and verified concrete block pavements for urban and local roads composed of rectangular concrete pavers with plane side surfaces(no interlocking effect).The examined blocks were laid on a bedding sand layer,a cement treated base layer and a granular unbound foundation *** commercial finite element(FE)software ANSYS?was used to calculate the response of the pavement when subjected to different loading,construction *** wheel positions,five blocks patterns,three bedding sand thicknesses and joints gaps have been considered to evaluate stress-strain condition on pavement *** and rutting verification was performed respectively for bound and unbound pavement materials using analytical curves available in the *** the end of this study,a proposal for a catalogue is *** has nine pavement sets,because it takes into account three values of subgrade capacity(30,90,and 150 MPa of resilient modulus)and three levels of traffic(400,000,1,500,000,and 4,000,000 passages of commercial vehicles during the service life).The obtained results provide an inexpensive procedure for the preliminary design of concrete block pavements.

关键词： Block pavement Finite element model Concrete pavers Local roads Urban roads

In vitro cultures of circulating tumor cells:a potential tool to unravel drug sensitivity

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Cancer Drug Resistance 2022年第1期5卷 245-260页

作者： Gianluigi De Renzi Giulia De Marco Michela De Meo Eleonora Del Rosso paola Gazzaniga Chiara Nicolazzo Cancer Liquid Biopsy Unit Department of Molecular MedicineSapienza University of RomeRome 00161Italy

Since taking part as leading actors in driving the metastatic process,circulating tumor cells(CTCs)have displayed a wide range of potential applications in the cancer-related research *** their well-proved prognostic value,the role of CTCs in both predictive and diagnostics terms might be extremely informative about cancer properties and therefore highly helpful in the clinical decision-making ***,CTCs are scarcely released in the blood circulation and their counts vary a lot among different types of cancer,therefore CTC detection and consequent characterization are still highly *** this context,in vitro CTC cultures could potentially offer a great opportunity to expand the number of tumor cells isolated at different stages of the disease and thus simplify the analysis of their biological and molecular features,allowing a deeper comprehension of the nature of neoplastic *** aim of this review is to highlight the main attempts to establish in vitro CTC cultures from patients harboring different tumor types in order to highlight how powerful this practice could be,especially in optimizing the therapeutic strategies available in clinical practice and potentially preventing or contrasting the development of treatment resistance.

关键词： Liquid biopsy circulating tumor cells liquid tumor biomarkers cell cultures circulating tumor cell cultures biomarker evaluation precision medicine drug sensitivity

Instrumental and bio-monitoring of heavy metal and nanoparticle emissions from diesel engine exhaust in controlled environment

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Journal of Environmental Sciences 2010年第9期22卷 1357-1363页

作者： Simonetta Giordano paola Adamo Valeria Spagnuolo Bianca Maria Vaglieco Department of Structural and Functional Biology University of Naples Federico II Department of Soil Plant Environment and Animal Production Sciences University of Naples Federico II Istituto Motori CNR Via Marconi 8 I-80125 Napoli Italy

In the present article we characterized the emissions at the exhaust of a Common Rail （CR） diesel engine, representative of lightduty class, equipped with a catalyzed diesel particulate filter （CDPF） in controlled environment. The downstream exhausts were directly analyzed （for PM, CO, CO/, Oz, HCs, NOx） by infrared and electrochemical sensors, and SEM-EDS microscope; heavy metals were chemically analyzed using mosses and lichens in bags, and glass-fibre filters all exposed at the engine exhausts. The highest particle emission value was in the 7-54 nm size range; the peak concentration rose until one order of magnitude for the highest load and speed. Particle composition was mainly carbonaceous, associated to noticeable amounts of Fe and silica fibres. Moreover, the content of Cu, Fe, Na, Ni and Zn in both moss and lichen, and of A1 and Cr in moss, was significantly increased. Glass-fibre filters were significantly enriched in A1, B, Ba, Cu, Fe, Na, and Zn. The role of diesel engines as source of carbonaceous nanoparticles has been confirmed, while further investigations in controlled environment are needed to test the catalytic muffler as a possible source of silica fibres considered very hazardous for human health.

关键词： common rail diesel engine exhaust and non-exhaust emissions moss and lichen bags particulate matter

Bidirectional Electron Transfer in the Reaction Centre of Photosystem I

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Journal of Integrative Plant Biology 2010年第8期52卷 735-749页

作者： Stefano Santabarbara Luca Galuppini Anna paola Casazza Istituto di Biofisica Consiglio Nazionale delle Ricerche Department of Physics University of Strathclyde Centre for Fundamental Research in Photosynthesis The Burroughs Consiglio Nazionale delle Ricerche Istituto di Biologia e Biotecnologia Agraria

In the past decade light-induced electron transfer reactions in photosystem I have been the subject of intensive investigations that have led to the elucidation of some unique characteristics, the most striking of which is the existence of two parallel, functional, redox active cofactors chains. This process is generally referred to as bidirectional electron transfer. Here we present a review of the principal evidences that have led to the uncovering of bidirectionality in the reaction centre of photosystem I. A special focus is dedicated to the results obtained combining time-resolved spectroscopic techniques, either difference absorption or electron paramagnetic resonance, with molecular genetics, which allows, through modification of the binding of redox active cofactors with the reaction centre subunits, an effect on their physical-chemical properties.

关键词： Bidirectional Electron Transfer in the Reaction Centre of Photosystem I PsaA

Drug resistance and minimal residual disease in multiple myeloma

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Cancer Drug Resistance 2022年第1期5卷 171-183页

作者： Alessandro Gozzetti Sara Ciofini Anna Sicuranza paola Pacelli Donatella Raspadori Emanuele Cencini Dania Tocci Monica Bocchia Hematology University of SienaAzienda Ospedaliera Universitaria SeneseSiena 53100Italy

Great progress has been made in improving survival in multiple myeloma(MM)patients over the last 30 *** drugs have been introduced and complete responses are frequently ***,the majority of MM patients do experience a relapse at a variable time after treatment,and ultimately the disease becomes drug-resistant following ***,minimal residual disease(MRD)detection has been introduced in clinical trials utilizing novel therapeutic agents to measure the depth of *** can be considered as a surrogate for both progression-free and overall *** this perspective,the persistence of a residual therapy-resistant myeloma plasma cell clone can be associated with inferior *** present review gives an overview of drug resistance in MM,i.e.,mutation ofβ5 subunit of the proteasome;upregulation of pumps of efflux;heat shock protein induction for proteasome inhibitors;downregulation of CRBN expression;deregulation of IRF4 expression;mutation of CRBN,IKZF1,and IKZF3 for immunomodulatory drugs and decreased target expression;complement protein increase;sBCMA increase;and BCMA down expression for monoclonal *** flow cytometry,or next-generation flow,and next-generation sequencing are currently the techniques available to measure MRD with sensitivity at *** MRD negativity is related to prolonged survival,and it is evaluated in all recent clinical trials as a surrogate of drug efficacy.

关键词： Multiple myeloma minimal residual disease drug resistance therapy next-generation flow cytometry