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Expectations and Level of Satisfaction of the Patient with Parkinson’s Disease Undergoing Deep Brain Stimulation Surgery at the National Institute of Neurology and Neurosurgery

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Advances in Parkinson's Disease 2024年第1期13卷 1-7页

作者： paola Bazán-Rodríguez Eduardo Ichikawa-Escamilla Etienne Reséndiz-Henríquez Carlos E. Martínez-Cortés Amin Cervantes-Arriaga Mayela Rodríguez-Violante Lisette Bazán-Rodríguez Laboratorio de Enfermedades Neurodegenerativas en el Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez Ciudad de México México Laboratorio de Enfermedades Neurodegenerativas en el Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez Ciudad de México México. Unidad Periférica para el Estudio de la Neuroinflamación en Patologías Neurológicas del Instituto de Investigaciones Biomédicas en el Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez Ciudad de México México

Background: Deep brain stimulation (DBS) is an established treatment for patients with advanced Parkinson’s disease (PD). Reports show continued patient satisfaction after surgery despite not maintaining clinical improvement as measured by evolution scales. Objectives: The present study sought to explore expectations and level of satisfaction in patients after DBS surgery with a semi-structured questionnaire and subsequent correlation with functional scales, Quality of Life (QoL), and motor and non-motor symptoms. Methods: We performed descriptive statistics to represent demographic data, Wilcoxon rank tests to determine significant differences, and Spearman correlation between the applied scales. Results: We evaluated 20 patients with a history of DBS surgery. 45% were female, with a mean age of 55.7 ± 14.15 years, a mean disease duration of 13.42 ± 8.3 years, and a mean time after surgery of 3.18 ± 1.86 years. Patients reported surgery meeting expectations in 85.5% and continued satisfaction in 92%. These two variables showed a significant correlation. Conclusions: This sample of patients remained satisfied after DBS surgery, although we found no differences in motor and non-motor clinimetric scales. Further studies are needed to confirm the importance of assessing quality of life in patients with DBS.

关键词： Parkinson’s Disease Quality of Life Deep Brain Stimulation Patient Satisfaction

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Plant virus-derived siRNAs“turn on”broad-spectrum plant immunity in wheat

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Molecular Plant 2021年第7期14卷 1038-1040页

作者： paola Leonetti Vitantonio Pantaleo Department of Biology Agricultural and Food SciencesInstitute for Sustainable Plant ProtectionBari UnitCNRBari 70126Italy

Viruses are the most abundant biological entities on Earth and the major carriers of disease and mortality as well as the drivers of global *** plant viruses potentially influence global processes is an emergent issue,particularly for their putative implications in *** infection and spread,plant viruses are capable of reprogramming host gene expression via RNA silencing by releasing viral suppressors of RNA silencing,viral small interfering RNAs(vsiRNAs),and by inducing the production of viral-associated small interfering RNAs(va-siRNAs).Recently,studies on various crop-virus pathosystems suggest that RNA silencing suppressors(RSSs)。

关键词： immunity mortality releasing

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Minimal Free Resolutions of Zero-dimensional Schemes in P1 ×P1

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Algebra Colloquium 2015年第1期22卷 97-108页

作者： paola Bonacini Lucia Marino Universita degli Studi di Catania ViMe A. Doria 6 95125 Catania Italy

Let X be a zero-dimensional scheme in p1 × p1. Then X has a minimal free resolution of length 2 if and only if X is ACM. In this paper we determine a class of reduced schemes whose resolutions, similarly to the ACM case, can be obtained by their Hilbert functions and depend only on their distributions of points in a grid of lines. Moreover, a minimal set of generators of the ideal of these schemes is given by curves split into the union of lines.

关键词： resolution Hilbert function separators

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Thermal survival limits of young and mature larvae of a cold stenothermal chironomid from the Alps （Diamesinae： Pseudodiamesa branickii [Nowicki, 1873]）

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Insect Science 2017年第2期24卷 314-324页

作者： Valeria Lencioni paola Bernabo Section of Invertebrate Zoology and Hydrobiology MUSE-Museo delle Scienze Corso del Lavoro e della Scienza 3 38123 Trento Italy

The threats posed by climate change make it important to expand knowl- edge concerning cold and heat tolerance in stenothermal species from habitats potentially threatened by temperature changes. Thermal limits and basal metabolism variations were investigated in Pseudodiamesa branickii （Diptera： Chironomidae） under thermal stress between -20 and 37 ℃. Supercooling point （SCP）, lower （LLTs） and upper lethal temper- atures （ULTs）, and oxygen consumption rate were measured in overwintering young （lst and 2nd instar） and mature （3rd and 4th instar） larvae from an Alpine glacier-fed stream. Both young and mature larvae were freezing tolerant （SCPs = -7.1 ℃ and -6.4 ℃, re- spectively; LLT100 〈SCP and 〉 -20 ℃） and thermotolerant （ULTso = 31.7 ± 0.4, 32.5± 0.3, respectively）. However, ontogenetic differences in acute tolerance were observed. The LLT50 calculated for the young larvae （=-7.4 ℃） was almost equal to their SCP （= -7.1 ℃） and the overlapping of the proportion of mortality curve with the CPIF curve highlighted that the young larvae are borderline between freezing tolerance and freezing avoidance. Furthermore, a lower ULT100 in the young larvae （of ca. 1 ℃）, suggests that they are less thermotolerant than mature larvae. Finally, young larvae exhibit a higher oxygen consumption rate （mgO2/gAFDM/h） at any temperature tested and are overall less resistant to oxygen depletion compared to mature larvae at ≥ 10 ℃. These findings sug- gest that mature larvae enter into a dormant state by lowering their basal metabolism until environmental conditions improve in order to save energy for life cycle completion during stressful conditions.

关键词： basal metabolism glacier-fed streams larval development supercooling point thermotolerance

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Binary Operations for the Lattice Structure in a Many-to-Many MatchingModel

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Journal of the Operations Research Society of China 2021年第1期9卷 207-228页

作者： paola Belén Manasero Instituto de Matemática Aplicada San Luis Universidad Nacional de San Luis and CONICETAv.Ejército de los andes 950D5700HHW San LuisArgentina

The lattice structure of the set of stable matchings in many-to-many matching model is well known in *** preferences of the agents are substitutable,this result can be obtained by fixed-point methods,for that purpose an algorithm for finding a fixed-point matching is *** the fixed-point set equals the set of stable matchings,the latter has a lattice structure *** this paper,we consider a many-to-many matching market where the preferences of firms satisfy substitutability and the law of aggregate demand,and workers have responsive *** this many-to-many matching market,we explicitly compute for any pair of stable matchings the least upper bound and the greatest lower bound,without using fixed-point methods.

关键词： Many-to-many matching model Binary operations Lattice structure

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Cannabis and male reproduction:Impact on offspring via sperm epigenome

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BIOCELL 2022年第2期46卷 301-304页

作者： paola GRIMALDI Department of Biomedicine and Prevention University of Rome Tor VergataRome00133Italy

Cannabis is the most widely used drug in theWestern societies particularly among adolescent and young *** studies demonstrate that men use cannabis more frequently than women with higher risk in developing cannabis-related *** the direct adverse effects of cannabis on male reproductive functions have been studied both in humans and animal models,the possible long-term risks for the health of the users and their offspring are still an area of active research.

关键词： Cannabis Endocannabinoid system Sperm Paternal inheritance

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Effect of acoustic field on C02 desorption in a fluidized bed of fine activated carbon

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Particuology 2015年第6期13卷 8-15页

作者： Federica Raganati paola Ammendola Riccardo Chirone Department of Chemical Engineering Materials and Industrial Production University of Naples Federico II P. le V. Tecchio 80 80125 Napoli Italy Istituto di Ricerche sulla Combustione CNR P. le K Tecchio 80 80125 Napoli Italy

Adsorption using solid sorbents has the potential to complement or replace current absorption technol- ogy, because of its low energy requirements. Among the commercially available adsorbent materials, attention is focused on activated carbons because they are easily regenerable by reason of their low heat of adsorption. These sorbents are generally available in the form of fine powders. Sound-assisted fluidization can process large amounts of fine powders, promoting and enhancing CO2 capture on fine sorbents, because it maximizes gas-solid contact. Temperature swing adsorption （TSA）, consisting of inducing sor- bent regeneration and CO2 recovery by appropriate temperature increase and gas purge, is one of the most promising techniques. This study investigates the CO2 desorption process by TSA in a sound-assisted flu- idized bed of fine activated carbon. Desorption tests were performed under ordinary and sound-assisted fluidization conditions to assess the capability of sound to promote and enhance the desorption efficiency in terms of CO2 recovery, CO2 purity, and desorption time. The results show that the application of sound results in higher desorption rates, CO2 recovery and purity. Regular and stable desorption profiles can be obtained under sound-assisted fluidization conditions. This stability makes it possible to successfully realize a cyclic adsorption/desorption process.

关键词： Temperature swing adsorption Sound-assisted fluidization CO2 capture Activated carbons Fine powders

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Photoluminescence monitoring of oxide formation and surface state passivation on InAs quantum dots exposed to water vapor

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Nano Research 2016年第10期9卷 3018-3026页

作者： Giovanna Trevisi Luca Seravalli paola Frigeri CNR-IMEM Institute Parco Area delle Scienze 37a 43124 Parma Italy

The room-temperature light emission of uncapped III-V semiconductor quantum dots is used to investigate the properties and evolution of the surface under exposure to a humid environment. Enhanced photoluminescence intensity resulting from exposure to polar molecules has already been reported; here we demonstrate that the external environment also has a relevant effect on the emission energy of quantum dots. Experimental results are interpreted on the basis of a model of the quantum system that takes into account the formation of oxide on pristine III-V surfaces and the presence of surface states. As a result of our study, we can clearly distinguish the effect of surface oxidation from that of surface state passivation on the emission of InAs surface quantum dots. This work sheds new light on the properties of semiconductor surface quantum dots as building blocks of novel and highly efficient sensing devices based on optical transduction.

关键词： epitaxial quantum dots surface states oxide photoluminescence quantum modeling optical nanosensor

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A review of the current state of biofuels production from lignocellulosic biomass using thermochemical conversion routes

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Chinese Journal of Chemical Engineering 2019年第7期27卷 1523-1535页

作者： paola Ibarra-Gonzalez Ben-Guang Rong Department of Chemical Engineering Biotechnology and Environmental Technology University of Southern Denmark

The rapid increase in energy demand,the extensive use of fossil fuels and the urgent need to reduce the carbon dioxide emissions have raised concerns in the transportation *** renewable and sustainable sources have become the ultimate solution to overcome the expected depletion of fossil *** conversion of lignocellulosic biomass to liquid(BtL)transportation fuels seems to be a promising path and presents advantages over first generation biofuels and fossil ***,development of BtL systems is critical to increase the potential of this resource in a sustainable and economic *** of lignocellulosic BtL transportation fuels,such as,gasoline,diesel and jet fuel can be accomplished through various thermochemical processes and processing *** major steps for the production of BtL fuels involve feedstock selection,physical pretreatment,production of bio-oil,upgrading of bio-oil to transportation fuels and recovery of value-added *** present work is aiming to give a comprehensive review of the current process technologies following these major steps and the current scenarios of biomass to liquid facilities for the production of biofuels.

关键词： Biofuels Lignocellulosic biomass Process route Thermochemical conversion Upgrading Separation

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Defective autophagy and Alzheimer’s disease: is calcium the key?

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Neural Regeneration Research 2019年第12期14卷 2081-2082页

作者： Riccardo Filadi paola Pizzo Department of Biomedical Sciences University of Padua and Neuroscience Institute-Italian National Research Council (CNR)

Presenilins and autophagy: Presenilin 1 (PS1) and presenilin 2 (PS2) are homologous, multi-pass transmembrane proteins endowed with pleiotropic functions, ranging from the regulation of membrane trafficking to cell differentiation. Their catalytic activity within the γ-secretase complex, an aspartyl-protease responsible for the intramembrane cleavage of several different type I transmembrane proteins, has been intensively studied in the context of Alzheimer’s disease (AD). Indeed, tens of autosomal dominant mutations in the PSEN1 and PSEN2 genes (encoding PS1 and PS2, respectively) have been associated with the rare familial forms of AD (FAD).

关键词： Alzheimer is cell tens has PS1 PS2

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