检索结果-南通市图书馆

Some pathogenic characters of paratyphoid Salmonella enterica strains isolated from poultry

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2017年第12期10卷 1161-1166页

作者： Fabrizio Bertelloni Giovanni Tosi paola Massi laura Fiorentini Maria Parigi Domenico Cerri Valentina Virginia Ebani Department of Veterinary Science University of PisaViale Delle Piagge 256124 Pisa Italy Istituto Zooprofilattico Sperimentale Della Lombardia e Dell'Emilia Romagna Sezione Diagnostica di Forl(i)Via Don E. Servadei 3E/3F47122 Forl(i)(FC) Italy

Objective: To investigate some pathogenic characters of Salmonella enterica strains isolated from ***: Twenty-three genetically distinct Salmonella enterica strains, of different serovars and pulsotype, were examined for virulence traits. Resistance to gastric acid environment was estimated by measuring the percentage of survived bacterial cells after exposure for 2 h to a synthetic gastric juice. Strains were analyzed with PCR for the presence of the following virulence genes: mgtC and rhu M located on SPI-3, sopB and pipB located on SPI-5, Salmonella virulence plasmid(spv)R(spvR), spvB and spvC located on Salmonella plasmid virulence and sodCI, sopE, and gipA located on ***, resistance to 21 antibiotics was tested with Kirby–Bauer ***: A percentage of 82.60% of strains were resistant to gastric environment after induction and 60.87% of the strains exhibited constitutive resistance too. Nineteen different virulence profiles were detected. The phage related genes sodCI and sopE and the plasmid mediated operon spvR, spvB and spvC(spvRBC) were detected in 82.60%,47.82% and 52.17% of strains, respectively. Typhimurium and Enteritidis strains showed the highest number of virulence genes. Twenty-one different antibiotic resistance profiles were obtained and two isolates(Typhimurium and Enteritidis) resulted sensible to all the tested molecules. The ampicillin, streptomycin, sulfonamide and tetracycline resistance profile was detected in seven isolates(30.43%).Conclusion: Our results show that paratyphoid Salmonella strains with several characters of pathogenicity, that may be cause of severe pathology in animals and humans, are circulating among poultry.

关键词： Paratyphoid salmonellae Poultry Gastric acid resistance Virulence genes Antimicrobial resistance

Quality of life in chronic pancreatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第39期12卷 6249-6251页

作者： Raffaele Pezzilli laura Bini Lorenzo Fantini Elena Baroni Davide Campana paola Tomassetti Roberto Corinaldesi Department of Internal Medicine University of Bologna Sant'Orsola-Malpighi Hospital. Bologna Italy

In an era such as the present one in which there is a high demand for health services with the associated pressure of controlling spending, health care organizations are concerned about the cost-effectiveness of quality improvement interventions. On the other hand, the impact of the disease and the treatment on the patient’s overall well-being and functioning has become a topic of growing interest not only in clinical research but also in practice. The clinical evaluation of the benefits of specific treatments for chronic, debilitating and incurable diseases should increasingly include formal assessment of patient activity and well-being. Thus, health-related quality of life as subjectively perceived by the patient, is becoming a major issue in the evaluation of any therapeutic intervention, mainly in patients with chronic or difficult diseases where the aim of the intervention is to keep patients either symptom-free and capable of living in the community for a long time or to reduce the discomfort caused by the disease. In this paper, we review the current knowledge on the quality of life assessment in chronic pancreatitis patients.

关键词： Pancreatitis Pancreatitis Alcoholic Quality of Life Questionnaires

Circulating tumor DNAs and non-coding RNAs as potential biomarkers for hepatocellular carcinoma diagnosis, prognosis and response to therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatoma Research 2019年第2期5卷 12-33页

作者： paola Guerriero Farzaneh Moshiri laura Lupini Silvia Sabbioni Massimo Negrini Elisa Callegari Department of Morphology Surgery and Experimental MedicineUniversity of FerraraFerrara 44121Italy Department of Molecular Medicine School of Advanced Technologies in MedicineTehran University of Medical SciencesTehran 11369Iran Department of Life Sciences and Biotechnologies University of FerraraFerrara 44121Italy

Hepatocellular carcinoma(HCC)is the second leading cause of cancer-related deaths worldwide and despite improvement in therapeutic approaches,prognosis remains *** can be partly attributed to the fact that the majority of HCCs are diagnosed at intermediate or advanced *** of circulating biomarkers able to detect HCC at early stages could improve patients'*** present,however,alpha fetoprotein or des-g-carboxyprothrombin are unable to reliably detect HCC at early stages and better circulating biomarkers are *** tumor DNA(ctDNA)and non-coding RNAs(ncRNAs)are emerging as promising biomarkers to achieve the *** and epigenetic alterations in ctDNA allow to pinpoint tumor-specific biomarkers,reveal tumor heterogeneity,help monitor tumor evolution over time and assess therapy *** remains to be fully evaluated the possibility of detecting these biomarkers at early tumor *** ncRNAs are quantitative biomarkers with potential use in diagnostic,prognostic and predictive clinical *** may help to reveal HCC at early ***,because of heterogeneous and sometimes conflicting reported results,they still require validation and standardization of pre-analytical and analytical approaches before clinical applications could be envisaged.

关键词： Liquid biopsy hepatocellular carcinoma circulating tumor DNA non-coding RNA diagnosis prognosis therapy response

Neurodegenerative diseases as proteinopathies-driven immune disorders

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第5期15卷 850-856页

作者： Fausta Ciccocioppo Giuseppina Bologna Eva Ercolino laura Pierdomenico Pasquale Simeone paola Lanuti Damiana Pieragostino Piero Del Boccio Marco Marchisio Sebastiano Miscia Department of Medicine and Aging Science University “G. d’Annunzio” of Chieti-PescaraChietiItaly Centre on Aging Sciences and Translational Medicine (Ce.S.I-MeT) University “G. d’Annunzio” of Chieti-PescaraChietiItaly Department of Medical Oral and Biotechnological SciencesUniversity “G. d’Annunzio” of Chieti-PescaraChietiItaly

In the pathophysiology of neurodegenerative disorders,the role of misfolded protein deposition leading to neurodegeneration has been primarily *** the last decade,however,it has been proposed a parallel involvement of innate immune activation,chronic inflammation and adaptive immunity in the neurodegeneration mechanisms triggered by *** insights in the neurodegenerative field strongly suggest a role for the immune system in the pathophysiology of neurodegenerative ***,the hypothesis underlining the modulation of the innate and the adaptive immune system in the events linked to brain deposition of misfolded proteins could open new perspectives in the setting of specific immunotherapeutic strategies for the treatment of neurodegenerative ***,we have reviewed the pathogenic hypothesis in neurodegenerative pathologies,underling the links between the deposition of misfolded protein mechanisms and the immune activation.

关键词： adaptive immunity choroid plexus immunotherapy innate immunity neurodegenerative diseases neuroinflammation proteinopathies

Acute abdomen: Rare and unusual presentation of right colic xanthogranulomatosis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第26期20卷 8717-8721页

作者： paola Addario Chieco laura Antolino Valentina Giaccaglia Francesca Centanini Gaetano Vincenzo Cunsolo Alessandra Sparagna Stefania Uccini Vincenzo Ziparo Department of General Surgery General Surgery 1 UnitS. Andrea University Hospital Department of Pathology S. Andrea University Hospital

Xanthogranulomatous inflammation (XGI) is a disease of unknown origin, most frequently described in the kidney and gallbladder; its localization in the colorectal tract is extremely rare. The extension of the typical inflammatory process to the surrounding tissues may lead to misdiagnosis as cancer. We report the case of a 56-year-old woman presenting to the Emergency Department with pain, increased levels of α1 and α2 proteins and C-reactive protein (17.5 mg/dL; normal value 0-0.5), and a palpable mass, localized in the right lower quadrant of the abdomen. A computed tomography scan showed a large right cecal mass with necrotic areas, local inflammation of retroperitoneal fat, and enlargement of local lymph nodes. Because of the high suspicion of colic abscess as well as malignancy and worsening of the clinical condition, the patient underwent right colectomy after 4 d of antibiotic treatment. Pathology revealed xanthogranulomatous inflammation involving the ileocecal valve. We review the reports of large bowel tract XGI in the international literature.

关键词： Xanthogranulomatosis Large bowel xanthogranulomatosis Abdominal mass Abdominal abscess

Scaffold proteins of cancer signaling networks: The paradigm of FK506 binding protein 51 (FKBP51) supporting tumor intrinsic properties and immune escape

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2023年第4期31卷 423-436页

作者： laura MARRONE MASSIMO D’AGOSTINO CAROLINA GIORDANO VALERIA DI GIACOMO SIMONA URZINI CHIARA MALASOMMA MARIA paola GAMMELLA MARTINA TUFANO SIMONA ROMANO MARIA FIAMMETTA ROMANO Department of Molecular Medicine and Medical Biotechnology University of Naples Federico IINaples80131Italy Dipartimento di Diagnostica per Immagini e Neuroradiologia Fondazione Policlinico Universitario“A.Gemelli”IRCCSUniversitàCattolica S.CuoreRomeItaly

Scaffold proteins are crucial regulators of signaling networks,and their abnormal expression may favor the development of *** the scaffold proteins,immunophilin covers a unique role as‘protein-philin’(Greek‘philin’=friend)that interacts with proteins to guide their proper *** growing list of human syndromes associated with the immunophilin defect underscores the biological relevance of these proteins that are largely opportunistically exploited by cancer cells to support and enable the tumor’s intrinsic *** the members of the immunophilin family,the FKBP5 gene was the only one identified to have a splicing *** cells impose unique demands on the splicing machinery,thus acquiring a particular susceptibility to splicing *** review article aims to overview the current knowledge of the FKBP5 gene functions in human cancer,illustrating how cancer cells exploit the scaffolding function of canonical FKBP51 to foster signaling networks that support their intrinsic tumor properties and the spliced FKBP51s to gain the capacity to evade the immune system.

关键词： Immunophilin Alternative splicing Signal transduction

Beneficial effects of coffee in non-alcoholic fatty liver disease:a narrative review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatoma Research 2020年第10期6卷 36-44页

作者： Alessio Calabrò Anna Caterina Procopio Francesco Primerano Tiziana Larussa Francesco Luzza laura Di Renzo Antonino De Lorenzo paola Gualtieri Ludovico Abenavoli Indipendent Nutritionist Viale dei Bizantini 25Catanzaro 88100Italy Department of Health Sciences University“Magna Graecia”of CatanzaroViale EuropaCatanzaro 88100Italy Indipendent Biomedical Engineer Viale degli Aurunci 988060 MontepaoneCatanzaro 88100Italy Department of Biomedicine and Prevention University of Rome“Tor Vergata”Rome 00133Italy

Non-alcoholic fatty liver disease(NAFLD)is one of the most common liver diseases and is related to unhealthy lifestyle habits,characterized by a diet rich in sugars and fats leading to excessive calorie intake,and lack of *** recent years,there is a growing incidence of this pathology,raising the attention of hepatologists,endocrinologists,diabetologists,and *** this context,the alimentary regimen adopted by patients with NAFLD has become an increasingly scrutinised *** is now considered a crucial factor in the treatment of NAFLD since it has been observed that some functional foods play a beneficial *** include coffeewhose health effects have already been amply *** we describe the beneficial effects of coffee consumption reported in the NAFLD literature.

关键词： Caffeine steatosis functional food liver disease antioxidant chlorogenic-acid

Boceprevir is highly effective in treatment-experienced hepatitis C virus-positive genotype-1 menopausal women

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第44期20卷 16726-16733页

作者： Veronica Bernabucci Alessia Ciancio Salvatore Petta Aimilia Karampatou laura Turco Silvia Strona Rosina Critelli paola Todesca Caterina Cerami Caterina Sagnelli Mario Rizzetto Calogero Cammà Erica Villa Division of Gastroenterology Azienda Ospedaliero-Universitaria Policlinico di Modena Italy Università degli Studi di Modena e Reggio Emilia Division of Gastroenterology University of Turin Division of Gastroenterology Di Bi MIS University of Palermo Dipartimento Medico-Chirurgico di Internistica Clinica e Sperimentale "F. Magrassi-A. Lanzara" Second University of Naples

AIM: To investigate the safety/efficacy of Boceprevirbased triple therapy in hepatitis C virus(HCV)-G1 menopausal women who were historic relapsers, partial-responders and null-responders. METHODS: In this single-assignment, unblinded study, we treated fifty-six menopausal women with HCV-G1, 46% F3-F4, and previous PEG-α/RBV failure(7% null, 41% non-responder, and 52% relapser) with 4 wk lead-in with PEG-IFNα2b/RBV followed by PEGIFNα2b/RBV+Boceprevir for 32 wk, with an additional 12 wk of PEG-IFN-α-2b/RBV if patients were HCV-RNApositive by week 8. In previous null-responders, 44 wk of triple therapy was used. The primary objective of retreatment was to verify whether a sustained virological response(SVR)(HCV RNA undetectable at 24 wk of follow-up) rate of at least 20% could be obtained. The secondary objective was the evaluation of the percent of patients with negative HCV RNA at week 4(RVR), 8(RVR BOC), 12(EVR), or at the end-of-treatment(ETR) that reached SVR. To assess the relationship between SVR and clinical and biochemical parameters, multiple logistic regression analysis was ***: After lead-in, only two patients had RVR; HCV-RNA was unchanged in all but 62% who had ≤1 log10 decrease. After Boceprevir, HCV RNA became undetectable at week 8 in 32/56(57.1%) and at week 12 in 41/56(73.2%). Of these, 53.8% and 52.0%, respectively, achieved SVR. Overall, SVR was obtained in 25/56(44.6%). SVR was achieved in 55% previous relapsers vs. 41% non-responders(P = 0.250), in 44% F0-F2 vs 54% F3-F4(P = 0.488), and in 11/19(57.9%) of patients with cirrhosis. At univariate analysis for baseline predictors of SVR, only previous response to antiviral therapy(OR = 2.662, 95%CI: 0.957-6.881, P = 0.043), was related with SVR. When considering "on treatment" factors, 1 log10 HCV RNA decline at week 4(3.733, 95%CI: 1.676-12.658, P = 0.034) and achievement of RVR BOC(7.347, 95%CI: 2.156-25.035, P = 0.001) were significantly related with the SVR, although RVR BOC only(6.794

关键词： Hepatitis C virus treatment Pegylated In-terferon Viral Hepatitis Menopause Genotype 1

Varicocele repair in severe oligozoospermia: A case report of post-operative azoospermia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2014年第4期2卷 94-96页

作者： Marco Milone Mario Musella Miguel Emilio Sosa Fernandez paola Maietta Annarita Sasso Loredana Maria Sosa Fernandez laura Virginia Sosa Fernandez Francesco Milone Department of Advanced Biomedical Science University of Naples "Federico Ⅱ"80131 Naples Italy Embryos IVF Center in Battipaglia84100 Salerno Italy

Varicocele has been implicated as a cause in 35%-50% of patients with primary infertility and up to 81% of men with secondary infertility. Although a large number of reports have shown improvement in the semen parameters after correction of varicocele, other studies have suggested no benefit. We report the first case of azoospermia after surgery in a young infertile male patient with left-sided varicocele and severe oligozoospermia undergoing laparoscopic varicocelectomy. A pregnancy was only achieved with assisted reproductive technology because semen cryopreservation was performed before surgery. In the light of the above, the deterioration of sperm count after varicocele repair in patients with severe oligozoospermia could be due to irreversible impairment of spermatogenesis of such patients, together with the possible temporary damage of the surgical repair. This possible complication could therefore turn the severe oligozoospermia into an indication to perform cryopreservation before surgery, on both clinical and medico-legal grounds. Further research is needed before drawing definitive conclusions regarding the management of varicocele-related severe oligozoospermia.

关键词： Varicocele Fertility Semen Cryopreservation Oligozoospermia