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Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto paola pramaggiore.laura cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

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Goncrete block pavements in urban and local roads:Analysis of stress-strain condition and proposal for a catalogue

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第6期6卷 557-566页

作者： paola Di Mascio laura Moretti Americo Capannolo Department of Civil Building and Environmental EngineeringSapienza University of RomeRome 00184Italy

Although the construction of block pavements has grown fast in the last decades,there is still a need for simple tools that could be applied to design *** paper analyzed and verified concrete block pavements for urban and local roads composed of rectangular concrete pavers with plane side surfaces(no interlocking effect).The examined blocks were laid on a bedding sand layer,a cement treated base layer and a granular unbound foundation *** commercial finite element(FE)software ANSYS?was used to calculate the response of the pavement when subjected to different loading,construction *** wheel positions,five blocks patterns,three bedding sand thicknesses and joints gaps have been considered to evaluate stress-strain condition on pavement *** and rutting verification was performed respectively for bound and unbound pavement materials using analytical curves available in the *** the end of this study,a proposal for a catalogue is *** has nine pavement sets,because it takes into account three values of subgrade capacity(30,90,and 150 MPa of resilient modulus)and three levels of traffic(400,000,1,500,000,and 4,000,000 passages of commercial vehicles during the service life).The obtained results provide an inexpensive procedure for the preliminary design of concrete block pavements.

关键词： Block pavement Finite element model Concrete pavers Local roads Urban roads

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On predicting and improving the quality of Volunteer Geographic Information projects

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International Journal of Digital Earth 2016年第2期9卷 134-155页

作者： Gloria Bordogna paola Carrara laura Criscuolo Monica Pepe Anna Rampini CNR IREANational Research Council of ItalyInstitute for Environmental Remote SensingMilanoItaly

Initiatives that rely upon the contributions of volunteers to reach a specific goal are growing more and more with the success of Web 2.0–interactive *** scientific projects are testing and exploiting volunteers’collaboration,but the quality of information obtained with this approach is often *** paper offers a rich overview of many scientific projects where geographic contributions are committed to volunteers,to the aim of defining strategies to improve information *** describing real examples of Volunteer Geographic Information(VGI),the contribution establishes a categorization based on the characteristics of the information,tasks,and scopes of the *** a discussion on the relationships of categories and VGI quality,the paper analyses techniques to improve the quality of volunteered information according to the moment of its assessment(i.e.,ex ante,ex post,or both with respect to information creation).The paper outlines the main limitations of the different approaches and indicates some guidelines for future developments.

关键词： Volunteered Geographic Information Citizen Science information quality quality improvement

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Methodology and evidence from a case study in Rome to increase pedestrian safety along home-to-school routes

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第5期7卷 715-727页

作者： Maria Vittoria Corazza Daniela D'Alessandro paola Di Mascio laura Moretti Department of Civil Building and Environmental EngineeringSapienza University of RomeRome 00185Italy

Home-to-school routes are very sensitive areas: they represent, for children, a learning tool for their everyday activities, but if poorly designed, maintained and equipped they can expose them to traffic risks. Sidewalks' inappropriate level of service and poor maintenance, especially, are main factors contributing to walking unsuitability, thus to poor comfort and safety levels for young pedestrians, and more in general for all the vulnerable non-motorized road users. This paper deals with a methodology specifically developed to highlight the quality of the urban environment where the home-to-school routes are located, according to four main criteria: wellbeing, usage, appearance, and safety and security. Each criterion is associated with a checklist including the most relevant features to assess, with a focus on maintenance as a key parameter to create safe and comfortable routes to school. An application, a case study in Rome, where the lack of regular maintenance results into a network of unsafe sidewalks, is also presented, analyzing three different areas where a number of schools are located. Detours when approaching school premises were surveyed, due to the levels of distresses and linked to the poor comfort and safety levels. As the mutual influence of built environment over road safety and maintenance requirements for home-to-school paths is not largely investigated thus far, the paper's goal is to provide advanced knowledge for studies and applications further afield.

关键词： Traffic engineering Road safety Pedestrians Home-to-school routes Sidewalks

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Immortalized hippocampal astrocytes from 3xTg-AD mice,a new model to study disease-related astrocytic dysfunction:a comparative review

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Neural Regeneration Research 2023年第8期18卷 1672-1678页

作者： laura Tapella Giulia Dematteis Armando A Genazzani Massimiliano De paola Dmitry Lim Department of Pharmaceutical Sciences Universitàdel Piemonte Orientale“Amedeo Avogadro”NovaraItaly Department of Neuroscience Mario Negri Institute for Pharmacological Research IRCCSMilanoItaly

Alzheimer's disease(AD)is characterized by complex etiology,long-lasting pathogenesis,and celltype-specific ***,there is no cure for AD,emphasizing the urgent need for a comprehensive understanding of cell-specific ***,principal homeostatic cells of the central nervous system,are key players in the pathogenesis of neurodegenerative diseases,including *** models greatly facilitate the investigation of cell-specific pathological alterations and the dissection of molecular mechanisms and ***-derived and immortalized astrocytic cell lines,alongside the emerging technology of adult induced pluripotent stem cells,are widely used to study cellular dysfunction in ***,no stable cell lines were available from genetic mouse AD ***,we established immortalized hippocampal astroglial cell lines from amyloid-βprecursor protein/presenilin-1/Tau triple-transgenic(3xTg)-AD mice(denominated as wild type(WT)-and 3Tg-iAstro cells)using retrovirus-mediated transduction of simian virus 40 large T-antigen and propagation without clonal selection,thereby maintaining natural heterogeneity of primary *** groups have successfully used 3Tg-iAstro cells for single-cell and omics approaches to study astrocytic AD-related alterations of calcium signaling,mitochondrial dysfunctions,disproteostasis,altered homeostatic and signaling support to neurons,and blood-brain barrier *** we provide a comparative overview of the most used models to study astrocytes in vitro,such as primary culture,tumor-derived cell lines,immortalized astroglial cell lines,and induced pluripotent stem cell-derived *** conclude that immortalized WT-and 3Tg-iAstro cells provide a noncompetitive but complementary,low-cost,easy-to-handle,and versatile cellular model for dissection of astrocyte-specific AD-related alterations and preclinical drug discovery.

关键词： Alzheimer's disease astrocytes immortalization astroglial Alzheimers's disease model blood-brain barrier calcium signaling central nervous system homeostasis disproteostasis endoplasmic reticulum-mitochondria contacts induced pluripotent stem cell-derived astrocytes protein synthesis

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Topographic effects observed at Amatrice hill during the 2016-2017 Central Italy seismic sequence

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Earthquake Engineering and Engineering Vibration 2021年第1期20卷 63-78页

作者： Gerardo Grelle laura Bonito Maresca Rosalba Silvia Iacurto Claudia Madiai paola Revellino Giuseppe Sappa Department of Civil Building and Environmental EngineeringSapienza University of RomeItaly Department of Sciences and Technologies University of SannioItaly Department of Civil and Environmental Engineering University of FlorenceItaly

The estimate of seismic site effects by experimental approaches is based on different assumptions aimed at simplifying the complex actual site conditions and related ***,the reliability of the results can increase if the experimental data is focused on quite strong seismic sequences and the on-site acquisition of a large number of signals is deemed strategic for the assessment of the expected *** on these considerations,the ground motion at the Red Zone sector of Amatrice hill,violently struck by the 2016-2017 Central Italy seismic sequence,was analyzed via an observational approach.A large set of weak motions(moment magnitude Mw 2.5-3.9)was analyzed in this study by means of standard(SSR)and horizontal to vertical(HVSR)spectral ratio *** results from the experimental analysis of the site effects by using weak motion and noise signals show a significant amplification at the top of Amatrice hill with a remarkable polarization of the motion and changes in spectral shapes according to the topographic setting of the relief.

关键词： topographic effects standard spectra ratio(SSR) horizontal and vertical spectral ratio(HVSR) directional effects

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Sperm quality improvement after natural anti-oxidant treatment of asthenoteratospermic men with leukocytospermia

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Asian Journal of Andrology 2008年第2期10卷 201-206页

作者： paola Piomboni laura Gambera Francesca Serafini Giovanna Campanella Giuseppe Morgante Vincenzo De Leo Department of Surgery Biology SectionObstetrics and Reproductive Medicine Gynecology and Obstetrics Section University of Siena Siena 53100 Italy Center for Diagnosis and Treatment of Couple Sterility Siena Hospital Siena 53100 Italy Department of Pediatrics Obstetrics and Reproductive Medicine Gynecology and Obstetrics Section University of Siena Siena 53100 Italy

Aim： To study the immune-modulating and anti-oxidant effects of beta-glucan, papaya, lactoferrin, and vitamins C and E on sperm characteristics of patients with asthenoteratozoospermia associated with leucocytosis. Methods： Fifty-one patients referred to our Sterility Center for semen analysis were selected. Sperm parameters were assessed before and after patient＇s treatment with beta-glucan, lactoferrin, papaya, and vitamins C and E. DNA damage was assessed by the acridine orange test and sperm structural characteristics were evaluated by transmission electron microscopy. Results： After 90 days of treatment, an increase in the percentage of morphologically normal sperm （17.0 ± 5.2 vs. 29.8 ± 6.5） and total progressive motility （19.0± 7.8 vs. 34.8 ± 6.8） were detected. Structural sperm characteristics as well as chromatin integrity were also improved after treatment. In terms of leukocyte concentration in seminal fluid, a significant reduction was recorded （2.2 ± 0.9 vs. 0.9± 0.2）. Conclusion： The treatment of an inflammatory process by the synergic action of immune modulators and anti-oxidants could protect sperm during maturation and migration, leading to improved sperm function. （Asian JAndrol 2008 Mar;. 10： 201-206）

关键词： asthenoteratozoospermia leukocytospermia anti-oxidant beta-glucan papaya lactoferrin vitamin C vitamin E chromatinintegrity transmission electron microscopy

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Diagnosis of pervasive developmental disorders:when and how?An area-based study about health care providers

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World Journal of Pediatrics 2015年第1期11卷 48-53页

作者： Silvia Manea laura VisonàDalla Pozza Monica Mazzucato Oliviana Gelasio paola Facchin Veneto Region Child&Mother Health Observatory Epidemiology and Community Medicine UnitDepartment of PediatricsPadua University

Background:Pervasive developmental disorders(PDDs)can be very difficult to diagnose in children and to communicate such a diagnosis to their *** of children with PDD learn of their child's diagnosis long after the first symptoms are noted in the child's ***:An area-based survey was conducted to assess all social and health care providers taking care of patients with PDDs in the Veneto Region(North-East Italy).Results:Only 28%of health care providers arrived at a definite diagnosis when the child was in his/her first year of age,51%when the child was 2-3 years old and 21%from age of 4 years and *** average,the latency between the time of the diagnosis and its communication to the family was 6.9 ***,a number of families did not ever have a diagnosis communicated to ***,68%of the providers did not communicate a PDDs diagnosis to patient's families,and 4%of them quite ***:The well-known delay in making a diagnosis of PDDs has two distinct components:one relating to the difficulty of confirming a diagnosis of PDDs,the other,hitherto unrecognized,relating to the family being notified.

关键词： autism,pervasive development disorders classification system communication diagnosis

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Managing sidewalk pavement maintenance:A case study to increase pedestrian safety

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Journal of Traffic and Transportation Engineering(English Edition) 2016年第3期3卷 203-214页

作者： Maria Vittoria Corazza paola Di Mascio laura Moretti Department of Civil Building and Environmental EngineeringSapienza University of Rome

Comfort is a major requirement in planning pedestrian facilities. Pedestrians walk where they feel comfortable and when they do not feel at ease, they walk elsewhere. A typical example is that filthy, distressed, or too narrow sidewalks induce pedestrians to walk on carriageways. This behaviour jeopardizes road safety and highly dangerous to most users, leave them vulnerable. Unsuitable pavements can be the result of irregular maintenance operations to restore evenness after shock damage, weather phenomena, installation of equipment （e.g., posts, fences, urban furniture） with a reduction of walkable surface, or substandard repair work on pavements and patches due to emergency operations. These problems can be solved with an appropriate maintenance management system, which optimizes financial resources to make smart decisions about how to intervene with an adequate and lasting maintenance operation. This paper defines an evaluation index for sidewalk conditions as a part of an efficient set-up of a Sidewalk Management System, which is similar to the better known Road Management System. The study relies on sur- veys, as well as the classification and analysis of sidewalk distresses. The authors adapted an index already standardized by ASTM for roads and airports： the Pavement Condition Index （PCI）. PCI has been modified to consider the specific types on the sidewalks studied within this paper. To validate the method, a case study of a residential district in Rome, Italy, was carried out. The chosen area lacks regular maintenance and has therefore resulted in a network of unsafe sidewalks. Frequent detour routes were surveyed and related to the level of distresses within a general assessment of safety. This study con- centrates on sidewalks with flexible pavements because this type of pavement is the only one adopted in the survey areas and, in general, throughout Italy.

关键词： Sidewalks Maintenance Condition index Pedestrians Safety Asphalt pavements

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Mucosal Schwann cell “Hamartoma”:A new entity?

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World Journal of Gastroenterology 2009年第18期15卷 2287-2289页

作者： paola Pasquini Andrea Baiocchini laura Falasca Dante Annibali Guido Gimbo Francesco Pace Franca Del Nonno Department of Pathology Policlinico Militare CelioRome 00184Italy Department of Pathology INMI-IRCCS "L.Spallanzani"Rome 00149Italy Lab of Electron Microscopy INMI-IRCCS "L. Spallanzani"Rome 00149Italy Digestive Endoscopy Policlinico Militare CelioRome 00184Italy

Schwannoma is a well-described,benign nerve sheath tumor of the soft tissue,but is rare in the gastrointestinal *** schwannomas are often incidentally discovered as small polypoid intraluminal *** this report,we describe the clinicopathologic and immunohistochemical features of a distinctive neural mucosal polyp composed of a diffuse cellular proliferation of uniform bland spindled cells in the lamina propria that entraps the colonic *** analysis revealed strong and diffuse positivity for the S-100 *** avoid confusion of these solitary colorectal polyps containing pure spindled Schwann cell proliferation in the lamina propria with neural lesions that have significant association with inherited syndromes,it is better to use the designation "mucosal Schwann hamartoma".

关键词： Nerve sheath tumors Gastrointestinal Schwannoma Hamartoma

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