检索结果-南通市图书馆

Can glial cells save neurons in epilepsy?

Neural Regeneration Research 2023年第7期18卷 1417-1422页

作者： Weida Shen Jelena BogdanovićPristov paola nobili Ljiljana Nikolić Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of MedicineZhejiang University City CollegeHangzhouZhejiang ProvinceChina Department of Life Sciences University of BelgradeInstitute for Multidisciplinary ResearchBelgradeSerbia Institute of Functional Genomics(IGF) University of MontpellierCNRSINSERMMontpellierFrance Department of Neurophysiology Institute for Biological Research Siniša StankovićNational Institute of Republic of SerbiaUniversity of BelgradeBelgradeSerbia

Epilepsy is a neurological disorder caused by the pathological hyper-synchronization of neuronal *** fundamental research of epilepsy mechanisms and the targets of drug design options for its treatment have focused on ***,approximately 30%of patients suffering from epilepsy show resistance to standard anti-epileptic chemotherapeutic agents while the symptoms of the remaining 70%of patients can be alleviated but not completely removed by the current ***,new strategies for the treatment of epilepsy are in urgent *** the past decades,with the increase in knowledge on the role of glia in the genesis and development of epilepsy,glial cells are receiving renewed *** a normal brain,glial cells maintain neuronal health and in partnership with neurons regulate virtually every aspect of brain *** epilepsy,however,the supportive roles of glial cells are compromised,and their interaction with neurons is altered,which disrupts brain *** this review,we will focus on the role of glia-related processes in epileptogenesis and their contribution to abnormal neuronal activity,with the major focus on the dysfunction of astroglial potassium channels,water channels,gap junctions,glutamate transporters,purinergic signaling,synaptogenesis,on the roles of microglial inflammatory cytokines,microglia-astrocyte interactions in epilepsy,and on the oligodendroglial potassium channels and myelin abnormalities in the epileptic *** recent findings suggest that glia should be considered as the promising next-generation targets for designing anti-epileptic drugs that may improve epilepsy and drug-resistant epilepsy.

关键词： astrocyte cytokines glutamate ion channel microglia myelin neuron oligodendrocyte purinergic signaling seizures

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

星形胶质细胞嘌呤能信号在癫痫中的作用

引用

神经损伤与功能重建 2020年第8期15卷 F0003-F0003页

作者： Ljiljana Nikolic paola nobili Weida Shen Etienne Audinat Institute for Biological Research Siniša Stanković University of BelgradeSerbia Neuroscience Institute CNR MilanItaly Zhejiang University City College ZhejiangHangzhouChina Institute for Functional Genomics(IGF) University of MontpellierCNRSINSERMMontpellierFrance

癫痫是由神经元的超同步放电引起的不可预知的反复发作。越来越多的研究表明,星形胶质细胞向神经元传递信号的异常在神经网络的过度兴奋中起着重要作用。对多种中枢神经系统疾病(如阿尔茨海默病、卒中、重度抑郁、精神分裂症和癫痫)的... 详细信息

癫痫是由神经元的超同步放电引起的不可预知的反复发作。越来越多的研究表明,星形胶质细胞向神经元传递信号的异常在神经网络的过度兴奋中起着重要作用。对多种中枢神经系统疾病(如阿尔茨海默病、卒中、重度抑郁、精神分裂症和癫痫)的病理学研究结果显示,嘌呤信号传导在神经元-胶质细胞和胶质细胞-胶质细胞相互作用中有重要的作用,嘌呤受体障碍可影响细胞间的信号传导。本综述将首先对星形胶质细胞影响神经元活动的机制进行分析总结。近期研究显示,星形胶质细胞嘌呤信号转导的异常促进了癫痫中神经元异常活动的出现,本综述也将对相关研究报道进行描述和总结。

关键词：钙信号细胞因子胶质传输炎症小胶质细胞

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pediatric nonalcoholic fatty liver disease,metabolic syndrome and cardiovascular risk

引用

世界胃肠病学杂志：英文版 2011年第26期17卷 3082-3091页

作者： Lucia Pacifico Valerio nobili Caterina Anania paola Verdecchia Claudio Chiesa Department of Pediatrics Sapienza University of Rome Department of Hepato-gastroenterology and Nutrition Pediatric Hospital "Bambino Gesù" Institute of Translational Pharmacology National Research Council

Nonalcoholic fatty liver disease(NAFLD) encompasses a range of liver histology severity and outcomes in the absence of chronic alcohol *** mildest form is simple steatosis in which triglycerides accumulate within hepatocytes.A more advanced form of NAFLD,nonalcoholic steatohepatitis,includes inflammation and liver cell injury,progressive to cryptogenic *** has become the most common cause of chronic liver disease in children and *** recent rise in the prevalence rates of overweight and obesity likely explains the NAFLD epidemic *** is strongly associated with abdominal obesity,type 2 diabetes,and dyslipidemia,and most patients have evidence of insulin ***,NAFLD shares many features of the metabolic syndrome(MetS),a highly atherogenic condition,and this has stimulated interest in the possible role of NAFLD in the development of *** evidence suggests thatNAFLD is associated with a significantly greater overall mortality than in the general population,as well as with increased prevalence of cardiovascular disease(CVD),independently of classical atherosclerotic risk ***,several studies including the pediatric population have reported independent associations between NAFLD and impaired flow-mediated vasodilatation and increased carotid artery intimal medial thickness-two reliable markers of subclinical atherosclerosis-after adjusting for cardiovascular risk factors and ***,the rising prevalence of obesity-related MetS and NAFLD in childhood may lead to a parallel increase in adverse cardiovascular *** children,the cardiovascular system remains plastic and damage-reversible if early and appropriate interventions are established *** goals for NAFLD should address nutrition,physical activity,and avoidance of smoking to prevent not only end-stage liver disease but also CVD.

关键词：心血管疾病脂肪肝病代谢综合征酒精性肝疾病动脉粥样硬化小儿风险

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：