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Goncrete block pavements in urban and local roads:Analysis of stress-strain condition and proposal for a catalogue

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第6期6卷 557-566页

作者： paola Di Mascio Laura Moretti Americo Capannolo Department of Civil Building and Environmental EngineeringSapienza University of RomeRome 00184Italy

Although the construction of block pavements has grown fast in the last decades,there is still a need for simple tools that could be applied to design *** paper analyzed and verified concrete block pavements for urban and local roads composed of rectangular concrete pavers with plane side surfaces(no interlocking effect).The examined blocks were laid on a bedding sand layer,a cement treated base layer and a granular unbound foundation *** commercial finite element(FE)software ANSYS?was used to calculate the response of the pavement when subjected to different loading,construction *** wheel positions,five blocks patterns,three bedding sand thicknesses and joints gaps have been considered to evaluate stress-strain condition on pavement *** and rutting verification was performed respectively for bound and unbound pavement materials using analytical curves available in the *** the end of this study,a proposal for a catalogue is *** has nine pavement sets,because it takes into account three values of subgrade capacity(30,90,and 150 MPa of resilient modulus)and three levels of traffic(400,000,1,500,000,and 4,000,000 passages of commercial vehicles during the service life).The obtained results provide an inexpensive procedure for the preliminary design of concrete block pavements.

关键词： Block pavement Finite element model Concrete pavers Local roads Urban roads

In vitro cultures of circulating tumor cells:a potential tool to unravel drug sensitivity

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Cancer Drug Resistance 2022年第1期5卷 245-260页

作者： Gianluigi De Renzi Giulia De Marco Michela De Meo Eleonora Del Rosso paola Gazzaniga Chiara Nicolazzo Cancer Liquid Biopsy Unit Department of Molecular MedicineSapienza University of RomeRome 00161Italy

Since taking part as leading actors in driving the metastatic process,circulating tumor cells(CTCs)have displayed a wide range of potential applications in the cancer-related research *** their well-proved prognostic value,the role of CTCs in both predictive and diagnostics terms might be extremely informative about cancer properties and therefore highly helpful in the clinical decision-making ***,CTCs are scarcely released in the blood circulation and their counts vary a lot among different types of cancer,therefore CTC detection and consequent characterization are still highly *** this context,in vitro CTC cultures could potentially offer a great opportunity to expand the number of tumor cells isolated at different stages of the disease and thus simplify the analysis of their biological and molecular features,allowing a deeper comprehension of the nature of neoplastic *** aim of this review is to highlight the main attempts to establish in vitro CTC cultures from patients harboring different tumor types in order to highlight how powerful this practice could be,especially in optimizing the therapeutic strategies available in clinical practice and potentially preventing or contrasting the development of treatment resistance.

关键词： Liquid biopsy circulating tumor cells liquid tumor biomarkers cell cultures circulating tumor cell cultures biomarker evaluation precision medicine drug sensitivity

Bidirectional Electron Transfer in the Reaction Centre of Photosystem I

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Journal of Integrative Plant Biology 2010年第8期52卷 735-749页

作者： Stefano Santabarbara Luca Galuppini Anna paola Casazza Istituto di Biofisica Consiglio Nazionale delle Ricerche Department of Physics University of Strathclyde Centre for Fundamental Research in Photosynthesis The Burroughs Consiglio Nazionale delle Ricerche Istituto di Biologia e Biotecnologia Agraria

In the past decade light-induced electron transfer reactions in photosystem I have been the subject of intensive investigations that have led to the elucidation of some unique characteristics, the most striking of which is the existence of two parallel, functional, redox active cofactors chains. This process is generally referred to as bidirectional electron transfer. Here we present a review of the principal evidences that have led to the uncovering of bidirectionality in the reaction centre of photosystem I. A special focus is dedicated to the results obtained combining time-resolved spectroscopic techniques, either difference absorption or electron paramagnetic resonance, with molecular genetics, which allows, through modification of the binding of redox active cofactors with the reaction centre subunits, an effect on their physical-chemical properties.

关键词： Bidirectional Electron Transfer in the Reaction Centre of Photosystem I PsaA

Instrumental and bio-monitoring of heavy metal and nanoparticle emissions from diesel engine exhaust in controlled environment

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Journal of Environmental Sciences 2010年第9期22卷 1357-1363页

作者： Simonetta Giordano paola Adamo Valeria Spagnuolo Bianca Maria Vaglieco Department of Structural and Functional Biology University of Naples Federico II Department of Soil Plant Environment and Animal Production Sciences University of Naples Federico II Istituto Motori CNR Via Marconi 8 I-80125 Napoli Italy

In the present article we characterized the emissions at the exhaust of a Common Rail （CR） diesel engine, representative of lightduty class, equipped with a catalyzed diesel particulate filter （CDPF） in controlled environment. The downstream exhausts were directly analyzed （for PM, CO, CO/, Oz, HCs, NOx） by infrared and electrochemical sensors, and SEM-EDS microscope; heavy metals were chemically analyzed using mosses and lichens in bags, and glass-fibre filters all exposed at the engine exhausts. The highest particle emission value was in the 7-54 nm size range; the peak concentration rose until one order of magnitude for the highest load and speed. Particle composition was mainly carbonaceous, associated to noticeable amounts of Fe and silica fibres. Moreover, the content of Cu, Fe, Na, Ni and Zn in both moss and lichen, and of A1 and Cr in moss, was significantly increased. Glass-fibre filters were significantly enriched in A1, B, Ba, Cu, Fe, Na, and Zn. The role of diesel engines as source of carbonaceous nanoparticles has been confirmed, while further investigations in controlled environment are needed to test the catalytic muffler as a possible source of silica fibres considered very hazardous for human health.

关键词： common rail diesel engine exhaust and non-exhaust emissions moss and lichen bags particulate matter

Drug resistance and minimal residual disease in multiple myeloma

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Cancer Drug Resistance 2022年第1期5卷 171-183页

作者： Alessandro Gozzetti Sara Ciofini Anna Sicuranza paola Pacelli Donatella Raspadori Emanuele Cencini Dania Tocci Monica Bocchia Hematology University of SienaAzienda Ospedaliera Universitaria SeneseSiena 53100Italy

Great progress has been made in improving survival in multiple myeloma(MM)patients over the last 30 *** drugs have been introduced and complete responses are frequently ***,the majority of MM patients do experience a relapse at a variable time after treatment,and ultimately the disease becomes drug-resistant following ***,minimal residual disease(MRD)detection has been introduced in clinical trials utilizing novel therapeutic agents to measure the depth of *** can be considered as a surrogate for both progression-free and overall *** this perspective,the persistence of a residual therapy-resistant myeloma plasma cell clone can be associated with inferior *** present review gives an overview of drug resistance in MM,i.e.,mutation ofβ5 subunit of the proteasome;upregulation of pumps of efflux;heat shock protein induction for proteasome inhibitors;downregulation of CRBN expression;deregulation of IRF4 expression;mutation of CRBN,IKZF1,and IKZF3 for immunomodulatory drugs and decreased target expression;complement protein increase;sBCMA increase;and BCMA down expression for monoclonal *** flow cytometry,or next-generation flow,and next-generation sequencing are currently the techniques available to measure MRD with sensitivity at *** MRD negativity is related to prolonged survival,and it is evaluated in all recent clinical trials as a surrogate of drug efficacy.

关键词： Multiple myeloma minimal residual disease drug resistance therapy next-generation flow cytometry

Etherification of HMF to biodiesel additives: The role of NH4+ confinement in Beta zeolites

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Journal of Energy Chemistry 2019年第9期28卷 114-121页

作者： paola Lanzafame Georgia Papanikolaou Katia Barbera Gabriele Centi Siglinda Perathoner Departments of ChiBioFarAm and MIFT-Section of Industrial Chemistry University of Messina ERIC aisbl and CASPE-INSTM

The role of NH4^+ ion confinement in the catalytic etherification of HMF(5-hydroxymethylfurfural) with ethanol to biodiesel additives was evidenced by studying the catalytic behavior of NH4^+-Beta zeolites with SiO2/Al2O3 ratios of 25 and *** order to affect the strength and distribution of the acidic sites, as well as the mobility of NH4^+ ions in the zeolites cages, a secondary level of porosity was introduced in the NH4^+-Beta, presenting a different stability versus alkaline treatment, by using a thermal or an ultrasound assisted *** analyzing the catalytic behavior in these two series of samples with respect to the changes in porosity by nonlocal density functional theory, structure by XRD, amount of acid sites by FT-IR and mobility of NH4^+ cations by measurements of reversible NH4^+ exchange capacity, was evidenced a decrease in catalytic performances both in terms of rate of HMF depletion and productivity to the main products, when confinement of the ammonium ions is lost due to the introduction of *** high capability of ammonium ions release, associated to the mono-dentate configuration,and the minor confinement effect inside the zeolite pore system, due to the more opened pores structure of mesoporous zeolites, hinders both the direct etherification of HMF to EMF [5-(ethoxymethyl)furan-2-carbaldehyde] and the parallel reaction pathway via acetalization, favoring the rapid desorption of the HMFDEA [5-(hydroxymethyl)furfural diethyl acetal] product out of the crystal and the consequent inhibition of the consecutive reactions to EMFDEA [5-(ethoxymethyl)furfural diethyl acetal] and EMF.

关键词： Ammonium ion Beta zeolite HMF etherification Confinement effect 5-(ethoxymethyl)furan-2-carbaldehyde

Palazzo Valentini： Archaeological discoveries and redevelopment projects

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Frontiers of Architectural Research 2015年第2期4卷 91-99页

作者： Luisa Napoli paola Baldassarri Provincia di Rome - Dipartimento II Servizio 2 via IV Novembre 119/A 00187 Roma Italy

Palazzo Valentini, a historical site of Rome＇s Provincial Administration, is located at the heart of the city. The building was purchased in 1827 by Vincenzo Valentini, a banker and consul general of the Prussian Crown. In 1939, with the outbreak of World War II, a fully self-contained, air-raid shelter was built under the courtyard, with an exit tunnel heading onto the Trajan＇s Forum. Archaeological investigations started in 2005 in view of a simple rehabilitation work of the underground level. As work progressed, the sample-plots brought to light new archaeological findings： relics of a huge temple and what remained of two residential houses with thermal baths. We therefore designed an exhibition space with glass surfaces to allow visitors to appreciate the findings while following a path through historical ages： from the 16th-century courtyard to the underground Roman domus （the sumptuous houses of senators and dignitaries of the Roman Empire）, with private baths, to the remains of a Roman temple, and all the way to the Trajan＇s Column pedesta（ by way of the air-raid shelter. Virtual reconstructions, graphic effects, and movies are the means used to revive the hypothetical origina（ appearance of the environments and the daily life of that epoch in order to help us build a prototype of an on-site museum of the third millennium.

关键词： Museum Domus Thermal baths Archaeological inves-tigations Historical path Barrier-free accessi-bility Multimedia exhibition

Implementation outcomes of a sensory integration therapy program with computerized dynamic posturography in patients with balance and sensory dysfunction

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Journal of Otology 2023年第1期18卷 26-32页

作者： Francisco Javier Gonzalez Eslait paola Andrea Escudero Trivino Yaidy Viviana Giraldo Vergara Monica Andrea Morales Garcia Vanessa Fernanda Lucero Gutierrez Universidad del Valle Audiological and Otological Balance CenterImbanaco Clinic-Grupo Quiron SaludCaliColombia Research Institute.Imbanaco Clinic-Grupo Quiron Salud CaliColombia

Objective:We describe the first-year implementation experience of an Instrumented Sensory Integration Therapy Program in Audiological&Balance Center ***:This is a retrospective descriptive *** included Seventy-three adults with diagnoses of acute,episodic,or chronic vestibular *** were classified into the following two groups:group 1 included 46 individuals treated with ISIT plus VRT,and group 2 included 27 individuals treated only with ***:The Sensory Organization Test(SOT)for both groups showed a statistical significance for all three sensory inputs;visual systems(G1:p=0.0003;G2:p=0.0337),vestibular system(G1:p<0.0001;G2:p=0.0003),and balance as demonstrated by compound balance score(G1:p<0.0001;G2:p=0.0035),and balance percentage deficit(G1:p<0.0001;G2:p=0.0078).Conclusions:The severity and complexity of functional neurological disorders in the context of vestibular syndromes seem to require between 10 and 20 therapy sessions,and combined ISIT plus VRT appears to be more effective than ISIT as a monotherapy.

关键词： Posturography Vestibular rehabilitation therapy Dizziness handicap inventory

In search for novel strategies towards neuroprotection and neuroregeneration: is PPARα a promising therapeutic target?

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Neural Regeneration Research 2015年第9期10卷 1409-1412页

作者： Sandra Moreno Maria paola Cerù Department of Science-LIME University Roma Tre Department of Life Health and Environmental Sciences University of L’AquilaCoppito (AQ) Italy

Peroxisome proliferator activated receptors： In the early 1990s, seminal work on rodent liver demonstrated that the hypolipidemic effect of xenobiotics, referred to as peroxisome proliferators, was mediated by a member of steroid hormone receptor superfamily, thus designated peroxisome proliferator-activated receptors （PPARs）（Issemann and Green, 1990; Dreyer et al., 1992）. The research field opened by this discovery led to the identification of three isotypes, namely PPARa （NR1C1）, PPAR[3/6 （NRIC2）, PPARy （NRIC3）, in a wide range of tissues. All these receptors act as ligand-activated transcription factors, binding lipid molecules with different, though overlapping, specificity.

关键词： PPAR a promising therapeutic target is PPAR