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On predicting and improving the quality of Volunteer Geographic Information projects

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International Journal of Digital Earth 2016年第2期9卷 134-155页

作者： Gloria Bordogna paola Carrara Laura Criscuolo Monica Pepe Anna Rampini CNR IREANational Research Council of ItalyInstitute for Environmental Remote SensingMilanoItaly

Initiatives that rely upon the contributions of volunteers to reach a specific goal are growing more and more with the success of Web 2.0–interactive *** scientific projects are testing and exploiting volunteers’collaboration,but the quality of information obtained with this approach is often *** paper offers a rich overview of many scientific projects where geographic contributions are committed to volunteers,to the aim of defining strategies to improve information *** describing real examples of Volunteer Geographic Information(VGI),the contribution establishes a categorization based on the characteristics of the information,tasks,and scopes of the *** a discussion on the relationships of categories and VGI quality,the paper analyses techniques to improve the quality of volunteered information according to the moment of its assessment(i.e.,ex ante,ex post,or both with respect to information creation).The paper outlines the main limitations of the different approaches and indicates some guidelines for future developments.

关键词： Volunteered Geographic Information Citizen Science information quality quality improvement

L-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes

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Protein & Cell 2018年第4期9卷 322-332页

作者： Cecile Apert paola Romagnoli Joost P, M. van Meerwijk CPTP Universite de Toulouse CNRS Inserm UPS Toulouse France

Immunosuppressive regulatory T lymphocytes （Treg） expressing the transcription factor Foxp3 play a vital role in the maintenance of tolerance of the immune-system to self and innocuous non-self. Most Treg that are critical for the maintenance of tolerance to self, develop as an independent T-cell lineage from common T cell precursors in the thymus. In this organ, their differentiation requires signals from the T cell receptor for antigen, from co-stimulatory molecules, as well as from cytokine-receptors. Here we focus on the cytokines implicated in thymic development of Treg, with a particular emphasis on the roles of interleukin-2 （IL-2） and IL-15. The more recently appreciated involvement of TGF-β in thymic Treg development is also briefly discussed. Finally, we discuss how cytokine-dependence of Treg development allows for temporal, quantitative, and potentially qualitative modulation of this process.

关键词： regulatory T cells thymus differentiation,IL-2 IL-15

Tumor-associated myeloid cells:diversity and therapeutic targeting

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Cellular & Molecular Immunology 2021年第3期18卷 566-578页

作者： Alberto Mantovani Federica Marchesi Sebastien Jaillon Cecilia Garlanda paola Allavena Department of Immunology and Inflammation Humanitas Clinical and Research Center-IRCCSRozzanoItaly Department of Biomedical Science Humanitas UniversityRozzanoItaly The William Harvey Research Institute Queen Mary University of LondonLondonUK Department of Biotechnology and Translational Medicine University of MilanMilanItaly

Myeloid cells in tumor tissues constitute a dynamic immune population characterized by a non-uniform phenotype and diverse functional *** tumor-associated macrophages(TAMs),which are more abundantly represented,and tumor-associated neutrophils(TANs)are known to sustain tumor cell growth and invasion,support neoangiogenesis and suppress anticancer adaptive immune *** recent decades,several therapeutic approaches have been implemented in preclinical cancer models to neutralize the tumor-promoting roles of both TAMs and *** of the most successful strategies have now reached the clinic and are being investigated in clinical *** this review,we provide an overview of the recent literature on the evergrowing complexity of the biology of TAMs and TANs and the development of the most promising approaches to target these populations therapeutically in cancer patients.

关键词： tumor-associated macrophages tumor microenvironment macrophage targeting

Methodology and evidence from a case study in Rome to increase pedestrian safety along home-to-school routes

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第5期7卷 715-727页

作者： Maria Vittoria Corazza Daniela D'Alessandro paola Di Mascio Laura Moretti Department of Civil Building and Environmental EngineeringSapienza University of RomeRome 00185Italy

Home-to-school routes are very sensitive areas: they represent, for children, a learning tool for their everyday activities, but if poorly designed, maintained and equipped they can expose them to traffic risks. Sidewalks' inappropriate level of service and poor maintenance, especially, are main factors contributing to walking unsuitability, thus to poor comfort and safety levels for young pedestrians, and more in general for all the vulnerable non-motorized road users. This paper deals with a methodology specifically developed to highlight the quality of the urban environment where the home-to-school routes are located, according to four main criteria: wellbeing, usage, appearance, and safety and security. Each criterion is associated with a checklist including the most relevant features to assess, with a focus on maintenance as a key parameter to create safe and comfortable routes to school. An application, a case study in Rome, where the lack of regular maintenance results into a network of unsafe sidewalks, is also presented, analyzing three different areas where a number of schools are located. Detours when approaching school premises were surveyed, due to the levels of distresses and linked to the poor comfort and safety levels. As the mutual influence of built environment over road safety and maintenance requirements for home-to-school paths is not largely investigated thus far, the paper's goal is to provide advanced knowledge for studies and applications further afield.

关键词： Traffic engineering Road safety Pedestrians Home-to-school routes Sidewalks

Cardiovascular dysfunction and vitamin D status in childhood acute lymphoblastic leukemia survivors

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World Journal of Pediatrics 2019年第5期15卷 465-470页

作者： paola Muggeo Vito Michele Rosario Muggeo paola Giordano Maurizio Delvecchio Maria Altomare Chiara Novielli Marco Matteo Ciccone Gabriele D'Amato Maria Felicia Faienza Nicola Santoro Department of Pediatric Oncology and Hematology University Hospital of PoliclinicoPiazza G.Cesare 1170124 BariItaly Department of Economical Business and Statistical SciencesUniversity of PalermoPalermoItaly Department of Biomedicine and Human Oncology Pediatric SectionUniversity"A.Moro"BariItaly Pediatric and Neonatology Unit Mother and Children Health Care Department"Madonna delle Grazie"HospitalASL MateraMateraItaly Cardiovascular Diseases Section Department of Emergency and Organ TransplantationUniversity"A.Moro"BariItaly Neonatal Intensive Care Unit Di Venere HospitalBariItaly

Background Vitamin D(25-OHD)has a role in bone health after treatment for cancer.25-OHD deficiency has been associated with risk factors for cardiovascular disease,but no data focusing on this topic in childhood cancer survivors have been *** investigated the 25-OHD status in children treated for acute lymphoblastic leukemia(ALL),and evaluated its influence on vascular *** 25-OHD levels were evaluated in 52 ALL survivors and 40 matched healthy *** were grouped according to 25-OHD level(<20 ng/m or≥20 ng/ml).Auxological parameters,biochemical and hemostatic markers of endothelial function(AD,HMW-AD,ET-1,vWFAg,TAT,D-dimers,Fbg,and hs-CRP),ultrasound markers of vascular endothelial function(flow-mediated dilatation,FMD,common carotid intima-media thickness,C-IMT,and antero-posterior diameter of infra-renal abdominal aorta,APAO)were evaluated in the *** Cases showed higher prevalence of 25-OHD deficiency than controls(p=0.002).In univariate analysis via mean comparisons,25-OHD deficient(<20 ng/ml)patients showed higher C-IMT values compared to the 25-OHD non-deficient(≥20 ng/ml)group(P=0.023).Significant differences were also found for ET-1(P=0.035)and AD-HMW(P=0.015).In the multiple regression models controlling for some confounders,25-OHD still was associated with C-IMT(P=0.0163),ET-1(P=0.0077),and AD-HMW(P=0.0008).Conclusions Childhood ALL survivors show higher prevalence of 25-OHD deficiency as compared to *** 25-OHD levels appear to be linked to indicators of endothelial and vascular *** monitoring of 25-OHD balance may help to prevent cardiovascular diseases in childhood ALL survivors,characterized by high cardiovascular risk.

关键词： Acute lymphoblastic leukemia Cardiovascular disease C-IMT Vascular ultrasound studies Vitamin D

Instagram广告如何影响千禧一代的购买意愿

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Instagram广告如何影响千禧一代的购买意愿

作者： paola Fernanda Herring Juárez 浙江工商大学

学位级别：硕士

Purpose-The study has the purpose of understanding how Instagram advertising influences purchases intentions in millennials in *** research work is based on analyzing the set of strategies and elements that advertising on Instagram have to contain in order to generate advertising strategies that has an impact on the ***-This study proposes a research model of purchase intention in Instagram,based on the advertising value factors,which are involvement,creativity and credibility;which leads to consumer ***,the model was measured by surveying millennials regarding to the popular Instagram platform,the data was collected via online questionnaires using the Google forms ***-Results explain 22% of variance of Purchase Intention and reveal that consumer engagement is a significant predictor effect and influences purchase intention,also it can be seen that the three independent variables,are significant,being credibility the most valuable factor,followed by involvement and then creativity being the least impactful,but still being a significant *** evidence from the study shows that the five factors studied play a very significant role in Instagram ***-This research improves theoretical literature about several authors who talk about the subject in question and examine the purchase intentions of millennials according to the advertising value factors.

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Predictive value of preoperative albumin-bilirubin score and other risk factors for short-term outcomes after open pancreatoduodenectomy

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世界临床病例杂志 2023年第26期11卷 6051-6065页

作者： Hana Zavrtanik Davide Cosola David Badovinac Benjamin Hadžialjević Gašper Horvat Danaja Plevel Selene Bogoni paola Tarchi Nicolòde Manzini AlešTomažič Department of Abdominal Surgery University Medical Centre LjubljanaLjubljana 1000Slovenia Clinica Chirurgica Azienda Sanitaria Universitaria Giuliano IsontinaCattinara HospitalTrieste 34149Italy Department of Medical Surgical and Health SciencesUniversity of TriesteTrieste 34149Italy Faculty of Medicine University of LjubljanaLjubljana 1000Slovenia

BACKGROUND Pancreatoduodenectomy represents a complex procedure involving extensive organ resection and multiple alimentary *** is still associated with high morbidity,even in high-volume *** tools including preoperative patient-related factors to preoperatively identify patients at high risk for postoperative complications could enable tailored perioperative management and improve patient *** To evaluate the clinical significance of preoperative albumin-bilirubin score and other risk factors in relation to short-term postoperative outcomes in patients after open *** This retrospective study included all patients who underwent open pancreatic head resection(pylorus-preserving pancreatoduodenectomy or Whipple resection)for various pathologies during a five-year period(2017-2021)in a tertiary care setting at University Medical Centre Ljubljana,Slovenia and Cattinara Hospital,Trieste,***-term postoperative outcomes,namely,postoperative complications,postoperative pancreatic fistula,reoperation,and mortality,were evaluated in association with albumin-bilirubin score and other risk *** logistic regression models were built to identify risk factors associated with these short-term postoperative *** Data from 347 patients were *** complications,major postoperative complications,postoperative pancreatic fistula,reoperation,and mortality were observed in 52.7%,22.2%,23.9%,21.3%,and 5.2%of patients,*** was no statistically significant association between the albumin-bilirubin score and any of these short-term postoperative complications based on univariate *** controlling for other predictor variables in a logistic regression model,soft pancreatic texture was statistically significantly associated with postoperative complications[odds ratio(OR):2.09;95%confidence interval(95%CI):1.19-3.67];male gender(OR:2.12;95%CI:1.15-3.93),soft pan

关键词： Pancreatoduodenectomy Albumin Bilirubin Postoperative complications Pancreatic fistula Perioperative care

Effect of grassland mosaic structure and dynamism on the reproductive habitat suitability for Alectoris graeca in central Apennines

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Journal of Mountain Science 2019年第12期16卷 2783-2792页

作者： Andrea BRUSAFERRO Valentina IESARI Federico Maria TARDELLA paola SCOCCO Andrea CATORCI School of Biosciences and Veterinary Medicine University of Camerino

Over the last several decades,the Mediterranean region has been subjected to mountain abandonment and farming cessation,leading to changes in vegetation and coenological features of grasslands,contextually to the strong decline of the rock partridge(Alectoris graeca).Our hypothesis was that the ongoing dynamic processes leading to the compositional changes of grasslands in central Apennines affect the habitat suitability for the singing male(territorial male defending its reproductive site).In 2015,we defined the presence/absence of spring territorial singing males in seven sites(1,250-2,400 m a.s.l.),by the census in 74 playback stations,distributed along 15 *** characterized the topography and the vegetation mosaic of such sites according to the collected topographic and vegetation cover data in 59 randomly selected plots(100 m×100 m)along the *** understand the relations among the environmental variables and the effect of the composition and dynamism of the vegetation mosaics on the presence/absence of the singing male,we used principal components analysis and generalized linear mixed-effect *** results emphasized the marked overlap between the general environmental conditions,which proved to define the habitat suitability for ***,and the characteristics of the site chosen by the singing male for starting the reproductive ***,we found that the site suitability for the singing male decreases when the vegetation recovery processes are ongoing,because of the spread of coarse tall grassesdominated communities and/or grassland types with dense *** grass-dominated communities and thick-turf grasslands exert their negative effect decreasing the habitat suitability for the singing male starting from low cover ***,it is conceivable that singing male’s suitable habitat will be dramatically restricted to the steepest south-facing slopes,where topographic and soil conditions do not allow the spread of grassl

关键词： Brachypodium genuense Grazing cessation Reproductive habitat suitability Rock partridge Singing male Vegetation recovery processes

Auditory function in symptomatic patients recovered from SARS-CoV-2 and unexposed patients:An analytical cross-sectional study

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Journal of Otology 2023年第3期18卷 118-124页

作者： Katherin Andrea Borda Pedraza Sergio Mauricio Moreno Lopez Javier Amaya-Nieto Liliana Akli Serpa Ginna paola Saavedra Martínez Mauricio Ernesto Quinche Pardo Alberto Pena Valenzuela Otorhinolaryngology Department Universidad Nacional ColombiaColombia Epidemiology Department Universidad de Los AndesColombia Health Systems and Services Research Group Universidad Nacional de ColombiaBogotaColombia Audiology Department Universidad Nacional de ColombiaColombia Health and Social Protection Ministry Colombia Universidad Nacional Colombia Colombia Otorhinolaryngology Department Universidad Nacional de ColombiaColombia

Objective:To describe audiological symptoms,audiometric profile,and distortion product otoacoustic emission in symptomatic patients recovering from SARS-CoV-2 infection(positive RT-PCR test)and asymptomatic patients(negative RT-PCR test).Methods:An analytical cross-sectional study was conducted using data obtained from clinical charts,physical examination,audiometry,and distortion product otoacoustic emission on 40 patients[case patients(CP)]recovering from SARS-CoV-2 infection diagnosed by a positive RT-PCR test and 22asymptomatic participants with a negative RT-PCR test[non-case(NC)].Results:Sixty-two patients(mean age:31.1 and 28.2 years in the CP and NC groups,respectively)were *** participants were young without significant comorbidities,risk factors for hearing loss or otological ***(5%),tinnitus(17.5%)and aural fullness/hearing loss(35%)were found in the CP group.A statistically significant difference was found in specific frequencies(1000,4000,and 8000 Hz)and pure tone average(low and high conversational frequencies with increased threshold in the PC group compared with the NC group),which was not found in distortion product otoacoustic ***:Audiovestibular symptoms are frequent in symptomatic patients recovering from SARS-CoV-2 ***-CoV-2 infection was consistently associated with an increased audiometric hearing threshold at specific frequencies and low tone average.

关键词： SARS-CoV-2 Cochlear diseases Pure tone audiometry Otoacoustic emissions Hearing loss Otological symptoms