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False Color Method for Retinal Oximetry

Journal of Biomedical Science and Engineering 2019年第12期12卷 533-544页

作者： Erwin Michel Davila-Iniesta Santiago Guerrero-Gonzalez Jorge Santiago-Amaya paola castillo-juarez Luis Nino-de-Rivera-Oyarzabal SEPI ESIME Culhuacan Instituto Politecnico NacionalMexico CityMexico ENCB Santo Tomas Instituto Politecnico NacionalMexico CityMexico

Oximetry is a method for measuring the oxygen saturation of haemoglobin in blood. Particularly, retinal oximetry based in the measurement of oxygen saturation in retinal vessels has acquired great interest to gather information on blood oxygenation from said vessels within inner and outer retina. Non-invasive spectrophotometric retinal oximetry has been studied for over five decades based on imaging spectroscopy. However, Optical Coherence Tomography (OCT) is an alternative to analyze the absorption difference between oxyhaemoglobin (HbO2) and deoxyhaemoglobin (Hb) in the retinal vessels and the choroidal structure. We propose in this paper an alternative process to manipulate conventional OCT images to evaluate changes in the relative haemoglobin oxygen saturation. Conventional OCT images from 570 nm and 600 nm in gray scale are converted to a corresponding color scale to be compared to the oxygenation information involved in the original gray scale OCT images.

关键词： Choroidal Structure False Color Method Filters Fundus OCT Image Oxygen Saturation Oximetry Retinal Vessels

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Association between Helicobacter pylori infection,mismatch repair,HER2 and tumor-infiltrating lymphocytes in gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2487-2503页

作者： Carlos A Castaneda Miluska castillo Luis A Bernabe Joselyn Sanchez Matteo Fassan Katherine Tello Ignacio Ivan Wistuba Ivan Chavez Passiuri Eloy Ruiz Juvenal Sanchez Fernando Barreda Daniel Valdivia Yaqueline Bazan Milagros Abad-Licham Claudio Mengoa Hugo Fuentes paola Montenegro Ebert Poquioma Raul Alatrista Claudio J Flores Luis Taxa Faculty of Health Sciences Universidad Cientifica del SurLima 15038Peru GECO PERU Grupo de Estudios Clinicos Oncologicos del PeruLima 15038Peru Department of Research Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Faculty of Human Medicine Universidad Ricardo PalmaLima 15039Peru Department of Medicine Surgical Pathology&Cytopathology UnitUniversity of PaduaPadua 35121Italy Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Abdominal Surgery Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Medical Specialties Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Regional de Enfermedades Neoplasicas del NorteTrujillo 13001Peru Faculty of Human Medicine Universidad Privada Antenor OrregoTrujillo 13008Peru Department of Surgery Instituto Regional de Enfermedades Neoplasicas del SurArequipa 04002Peru Department of Medical Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Epidemiology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Unidad de Investigación Básica y Traslacional Oncosalud-AUNALima 15038Peru Faculty of Medicine Universidad San Martin de PorresLima 15008Peru

BACKGROUND The influence of Helicobacter-pylori(***)infection and the characteristics of gastric cancer(GC)on tumor-infiltrating lymphocyte(TIL)levels has not been extensively *** of infiltrating-immune-cell subtypes as well as survival is necessary to obtain comprehensive *** To determine the rates of deficient mismatch-repair(dMMR),HER2-status and *** infection and their association with TIL levels in *** Samples from 503 resected GC tumors were included and TIL levels were evaluated following the international-TILs-working-group recommendations with assessment of the intratumoral(IT),stromal(ST)and invasive-border(IB)*** density of CD3,CD8 and CD163 immune cells,and dMMR and HER2-status were determined by immunohistochemistry(IHC).*** infection was evaluated by routine histology and quantitative PCR(qPCR)in a subset of *** dMMR was found in 34.4%,HER2+in 5%and ***-positive in 55.7%of *** IT-TIL was associated with grade-3(P=0.038),while ST-TIL with grade-1(P<0.001),intestinal-histology(P<0.001)and no-recurrence(P=0.003).dMMR was associated with high TIL levels in the ST(P=0.019)and IB(P=0.01)compartments,and STCD3(P=0.049)and ST-CD8(P=0.05)***2-was associated with high IT-CD8(P=0.009).*** was associated with high IT-TIL levels(P=0.009)when assessed by routine-histology,and with high TIL levels in the 3 compartments(P=0.002-0.047)and CD8 density in the IT and ST compartments(P=0.001)when assessed by qPCR.A longer overall survival was associated with low IT-CD163(P=0.003)and CD8/CD3(P=0.001 in IT and P=0.002 in ST)and high IT-CD3(P=0.021),ST-CD3(P=0.003)and CD3/CD163(P=0.002).CONCLUSION TIL levels were related to dMMR and *** CD8/CD3 and high CD163/CD3 were associated with lower recurrence and longer survival.

关键词： Lymphocytes Macrophages Gastric cancer Helicobacter pylori HER2 Mismatch repair

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Use of a combination strategy to improve neuroprotection and neuroregeneration in a rat model of acute spinal cord injury

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Neural Regeneration Research 2019年第6期14卷 1060-1068页

作者： Elisa García Roxana Rodríguez-Barrera Vinnitsa Buzoianu-Anguiano Adrian Flores-Romero Emanuel Malagón-Axotla Marco Guerrero-Godinez Estefanía De la Cruz-castillo Laura castillo-Carvajal Monserrat Rivas-Gonzalez paola Santiago-Tovar Ivis Morales Cesar Borlongan Antonio Ibarra Centro de Investigación en Ciencias de la Salud (CICSA) Facultad de Ciencias de la SaludUniversidad Anáhuac México Campus Norte Centro de Investigación del Proyecto CAMINA A.C. Unidad de Investigación Médica en Enfermedades Neurologicas Hospital Especialidades CMN Siglo XXI Unidad de Rehabilitación Osteoarticular.Instituto Nacional de Rehabilitación. Luis Guillermo Ibarra Ibarra Center of Excellence for Aging and Brain Repair Department of Neurosurgery and Brain RepairUniversity of South Florida Morsani College of Medicine

Spinal cord injury is a very common pathological event that has devastating functional consequences in patients. In recent years, several research groups are trying to find an effective therapy that could be applied in clinical practice. In this study, we analyzed the combination of different strategies as a potential therapy for spinal cord injury. Immunization with neural derived peptides(INDP), inhibition of glial scar formation(dipyridyl: DPY), as well as the use of biocompatible matrix(fibrin glue: FG) impregnated with bone marrow mesenchymal stem cells(MSCs) were combined and then its beneficial effects were evaluated in the induction of neuroprotection and neuroregeneration after acute SCI. Sprague-Dawley female rats were subjected to a moderate spinal cord injury and then randomly allocated into five groups: 1) phosphate buffered saline; 2) DPY; 3) INDP + DPY; 4) DPY+ FG; 5) INDP + DPY + FG + MSCs. In all rats, intervention was performed 72 hours after spinal cord injury. Locomotor and sensibility recovery was assessed in all rats. At 60 days after treatment, histological examinations of the spinal cord(hematoxylin-eosin and Bielschowsky staining) were performed. Our results showed that the combination therapy(DPY+ INDP + FG+ MSCs) was the best strategy to promote motor and sensibility recovery. In addition, significant increases in tissue preservation and axonal density were observed in the combination therapy group. Findings from this study suggest that the combination theapy(DPY+ INDP + FG + MSCs) exhibits potential effects on the protection and regeneration of neural tissue after acute spinal cord injury. All procedures were approved by the Animal Bioethics and Welfare Committee(approval No. 178544; CSNBTBIBAJ 090812960)on August 15, 2016.

关键词： fibrin glue mesenchymal stem cells glial scar protective autoimmunity neural derived peptides neural regeneration

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Immunization with Cop-1 promotes neuroprotection and neurogenesis after ischemic stroke

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Neural Regeneration Research 2015年第11期10卷 1733-1734页

作者： Yolanda Cruz paola Suárez-Meade Antonio Ibarra Facultad de Ciencias de la Salud Universidad Anáhuac México Norte Av.Universidad Anáhuac No.46 Col.Lomas Anáhuac C.P.52786 Huixquilucan Edo.de México Proyecto CAMINA A.C. Tlalpan No.4430 Col.Toriello Guerra C.P.14050México City México

Cerebrovascular diseases are considered to be amongst the most serious public health issues,since they are the third leading cause of death（WHO,2014）and the most common cause of disability *** monetary significance is evidenced by the economic burden imposed on health care systems,given that the cost of medical care for a patient that has suffered a stroke is around$25,741US dollars every 5 years（Luengo-Fernandez et al.,2012）.A stroke occurs as a result of a disturbance or interruption of cerebral blood flow that significantly reduces the supply of oxygen and glucose to the neural tissue. Consequently, several cell death mechanisms （secondary lesion mechanisms） such as necrosis, excitotoxicity, free radical production and inflammation are triggered （castillo, 2000）.

关键词： Immunization with Cop-1 promotes neuroprotection and neurogenesis after ischemic stroke BDNF Figure

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瑞吉欧学校

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现代装饰 2023年第2期 86-91页

作者： Andrés Jaque Roberto Gonzalez Garcia Luis Gonzalez Cabrera Alberto Heras Ismael Medina Manzano Jesus Meseguer Cortés paola Pardo-castillo Rajvi Anandpara Juan David Barreto Ines Barros Ludovica Battista Shubhankar Bhajekar Elise Durand Drishti Gandhi Maria Karagianni Bansi Mehta Alessandro Peja Meeerati Rana Mishti Shah Saumil Shanghavi JoséHevia(摄影) 范嘉苑(编译) 不详

瑞吉欧学校(Reggio School)的设计理念是通过建筑环境来激发孩子们的探索和求知欲。因此,该建筑被视作一个复杂的生态系统,让孩子们在通过自我驱动的集体实验过程中引导自身教育,这也遵循了罗里斯·马拉古奇(Loris Malaguzzi)和意大利... 详细信息

瑞吉欧学校(Reggio School)的设计理念是通过建筑环境来激发孩子们的探索和求知欲。因此,该建筑被视作一个复杂的生态系统,让孩子们在通过自我驱动的集体实验过程中引导自身教育,这也遵循了罗里斯·马拉古奇(Loris Malaguzzi)和意大利吉欧·艾米利亚市当地家长共同提出的教育理念,旨在增强孩子们应对不可预测挑战和潜在风险的能力。从该建筑的设计、建造到使用,都旨在超越可持续的范式,并将生态作为一种路径,继而将环境影响、多种群类别、物质动态化、集体治理以及教学方法通过建筑相交汇。

关键词：瑞吉欧艾米利亚环境影响教学方法生态系统不可预测教育理念自我驱动

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Current role of capsule endoscopy in Crohn's disease

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World Journal of Gastrointestinal Endoscopy 2016年第17期8卷 572-583页

作者： Marisol Luján-Sanchis Laura Sanchis-Artero Laura Larrey-Ruiz Laura Peno-Munoz paola Nunez-Martinez Génesis castillo-López Lara González-González Carlos Boix Clemente Cecilia Albert Antequera Ana Durá-Ayet Javier Sempere-Garcia-Argüelles Digestive Diseases Unit General University Hospital of Valencia 46014 Valencia Spain

Capsule endoscopy(CE) currently plays an important role in Crohn's disease(CD). It is a noninvasive technique that has led to a breakthrough in the endoscopic diagnosis of diseases of the small intestine. Its superior diagnostic performance and excellent safety profile lead to its considerable acceptance on the part of the patient. This paper reviews current indications of CE in three stages of clinical practice: Suspected CD, unclassified colitis and its extensive role in diagnosed CD. The diagnostic and therapeutic impact of the results of CE on the monitoring of this disease is also reviewed. Knowledge of its applications, the interpretation of its results in an appropriate context and the existence of a validated endoscopic activity index could change the way in which these patients are managed. The definition of mucosal healing and postoperative recurrence by means of endoscopic scoring systems will endow CE with new applications in the management of CD in the near future.

关键词： Capsule endoscopy Inflammatory bowel disease Crohn’s disease

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