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On predicting and improving the quality of Volunteer Geographic Information projects

International Journal of Digital Earth 2016年第2期9卷 134-155页

作者： Gloria Bordogna paola carrara Laura Criscuolo Monica Pepe Anna Rampini CNR IREANational Research Council of ItalyInstitute for Environmental Remote SensingMilanoItaly

Initiatives that rely upon the contributions of volunteers to reach a specific goal are growing more and more with the success of Web 2.0–interactive *** scientific projects are testing and exploiting volunteers’collaboration,but the quality of information obtained with this approach is often *** paper offers a rich overview of many scientific projects where geographic contributions are committed to volunteers,to the aim of defining strategies to improve information *** describing real examples of Volunteer Geographic Information(VGI),the contribution establishes a categorization based on the characteristics of the information,tasks,and scopes of the *** a discussion on the relationships of categories and VGI quality,the paper analyses techniques to improve the quality of volunteered information according to the moment of its assessment(i.e.,ex ante,ex post,or both with respect to information creation).The paper outlines the main limitations of the different approaches and indicates some guidelines for future developments.

关键词： Volunteered Geographic Information Citizen Science information quality quality improvement

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Hyperthermia combined with chemotherapy vs chemotherapy in patients with advanced pancreatic cancer:A multicenter retrospective observational comparative study

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World Journal of Clinical Oncology 2023年第6期14卷 215-226页

作者： Giammaria Fiorentini Donatella Sarti Andrea Mambrini Ivano Hammarberg Ferri Massimo Bonucci paola Giordano Sciacca Marco Ballerini Salvatore Bonanno Carlo Milandri Roberto Nani Stefano Guadagni Patrizia Dentico Caterina Fiorentini Integrative Oncology Integrative Oncology Outpatient ClinicBologna 40121Italy Department of Oncology Santa Maria della Misericordia HospitalUrbino 60129Italy Department of Oncology Azienda Sanitaria Locale Toscana Nord OvestMassa Carrara HospitalMassa 54100Italy Integrative Oncology Association Research Center for Integrative Oncology TreatmentsRoma 00166Italy Complementary Medicine Service District Hospital of MeranoMerano 39012Italy Hyperthermia Unit Bellessere Medical CenterTerni 05100Italy Radiotherapy Unit A.Rizza HospitalSiracusa 96100Italy Medical Oncology San Donato HospitalArezzo 52100Italy Interventional Radiology Unit Humanitas GavazzeniBergamo 24121Italy Applied Clinical Sciences and Biotechnology Section of General SurgeryUniversity of L'AquilaL'Aquila 67100Italy Hyperthermia Service Medical Oncology UnitSan Giuseppe HospitalEmpoli 50053Italy Prevention and Sports Medicine University Hospital Klinikum rechts der IsarTechnical University of MunichMunich 80331Germany

BACKGROUND Several studies report the useful therapeutic results of regional hyperthermia in association with chemotherapy(CHT) and radiotherapy for the treatment of pancreatic cancer. Modulated electrohyperthermia(mEHT) is a new hyperthermia technique that induces immunogenic death or apoptosis of pancreatic cancer cells in laboratory experiments and increases tumor response rate and survival in pancreatic cancer patients, offering beneficial therapeutic effects against this severe type of *** To assess survival, tumor response and toxicity of mEHT alone or combined with CHT compared with CHT for the treatment of locally advanced or metastatic pancreatic *** This was a retrospective data collection on patients affected by locally advanced or metastatic pancreatic cancer(stage Ⅲ and IV) performed in 9 Italian centers, members of International Clinical Hyperthermia Society-Italian Network. This study included 217 patients, 128(59%) of them were treated with CHT(no-mEHT) and 89(41%) patients received mEHT alone or in association with CHT. mEHT treatments were performed applying a power of 60-150 watts for 40-90 min, simultaneously or within 72 h of administration of *** Median patients’ age was 67 years(range 31-92 years). mEHT group had a median overall survival greater than non-mEHT group(20 mo, range 1.6-24, vs 9 mo, range 0.4-56.25, P < 0.001). mEHT group showed a higher number of partial responses(45% vs 24%, P = 0.0018) and a lower number of progressions(4% vs 31%, P < 0.001) than the no-mEHT group, at the three months follow-up. Adverse events were observed as mild skin burns in 2.6% of mEHT *** mEHT seems safe and has beneficial effects on survival and tumor response of stage Ⅲ-IV pancreatic tumor treatment. Further randomized studies are warranted to confirm or not these results.

关键词： Modulated electro hyperthermia Locally advanced pancreatic tumor Overall survival Tumor response Gemcitabine Apoptosis Immunogenic cell death

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