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Management of potentially resectable colorectal cancer liver metastases

World Journal of Gastrointestinal Surgery 2013年第5期5卷 138-145页

作者： Fausto Meriggi paola bertocchi Alberto Zaniboni Oncology Department Istituto Ospedaliero Fondazione Poliambulanza

Colorectal cancer is a very common malignancy worldwide and development of liver metastases,both synchronous or metachronous,is a common *** all patients with metastatic colorectal cancer,up to 77% have a liver-only disease and approximately 10%-20% of patients with colorectal liver metastases are considered resectable at the time of *** resection of liver metastases remains the best treatment option and it is associated with a survival plateau and a 20%-25% of long-term *** chemotherapy for resectable liver metastases may improve resecability of liver metastases and disease free survival,but its impact on overall survival is still unclear and more studies are ***,preoperative chemotherapy can increase postoperative *** studies are needed to define the role of adjuvant chemotherapy after a R0 resection of liver metastases and to define the criteria for a better selection of patients candidate to *** strategies such as targeted therapies are emerging with promising *** management requires a multidisciplinary approach,local and systemic,but it is a still pending *** liver metastases represent a major challenge for oncologists and *** this review will be analyzed available data about assessment and management of the patients with potentially resectable colorectal liver metastases.

关键词： Colorectal cancer Liver metastases Perioperative chemotherapy Surgical resection Targeted therapies

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Pancreatic cancer:New hopes after first line treatment

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World Journal of Gastrointestinal Oncology 2016年第9期8卷 682-687页

作者： Francesca Aroldi paola bertocchi Giordano Savelli Edoardo Rosso Alberto Zaniboni Department of Medical Oncology Poliambulanza Foundation Department of Nuclear Medicine Poliambulanza Foundation Department of General Surgery Poliambulanza Foundation

Pancreatic cancer is the fourth leading cause of cancerrelated death *** research has yielded advances in first-line treatment strategies,but there is no standardized second-line *** this review,we examine the literat... 详细信息

关键词： Nab-paclitaxel Nal-iri Pancreatic cancer Second line Algorithm

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Thyroid carcinoma showing thymus-like differentiation: Case presentation of a young man

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World Journal of Clinical Oncology 2014年第5期5卷 1117-1120页

作者： Chiara Abeni Chiara Ogliosi Luigina Rota paola bertocchi Alessandra Huscher Giordano Savelli Mariano Lombardi Alberto Zaniboni Department of Medical Oncology Fondazione Poliambulanza 25124 Brescia Italy Department of Radiotherapy Fondazione Poliambulanza 25124 Brescia Italy Department of Nuclear Medicine Fondazione Poliambulanza 25124 Brescia Italy Department of Pathology Fondazione Poliambulanza 25124 Brescia Italy

Ectopic thymic tissue can be present in the thyroid gland and a carcinoma showing thymus-like differentiation(CASTLE) may arise from such tissue. We are reported the case of a 26-year-old man with CASTLE, with cervical subcutaneous nodules relapse, who showed a good response to treatment with surgery, chemotherapy and radiotherapy. The problematic aspect of this case was the diagnosis; only on review were we able to make a final diagnosis. CASTLE is a very rare neoplasm. It is important to differentiate this cancer from others tumors such as primary or metastatic squamous cell carcinoma of the head and neck or squamous cell thyroid carcinoma, because the therapy and prognosis are *** is complicated and requires careful histological analysis(CD5- and P63-positive with presence of Hassall's corpuscles); unfortunately there is no gold standard treatment so, in this case, we administered a sandwich of chemotherapy and radiotherapy.

关键词： Carcinoma showing thymus-like differentiation thymic CD5 Hassall’s corpuscles Thyroidectomy Chemotherapy Radiotherapy

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