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Applications of integrative OMICs approaches to gene regulation studies

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Frontiers of Electrical and Electronic Engineering in China 2016年第4期4卷 283-301页

作者： Jing Qin Bin Yan Yaohua Hu panwen wang Junwen wang School of Life Sciences The Chinese University of Hong Kong Hong Kong SAR 999077 China Laboratory for Food Safety and Environmental Technology Institutes of Biomedicine and Biotechnology Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China School of Biomedical Sciences The University of Hong Kong Hong Kong SAR 999077 China College of Mathematics and Statistics Shenzhen University Shenzhen 518060 China Department of Health Sciences Research and Center for Individualized Medicine Mayo Clinic Scottsdale AZ 85259 USA Department of Biomedical Informatics Arizona State University Scottsdale AZ 85259 USA

Functional genomics employs dozens of OMICs technologies to explore the functions of DNA, RNA and protein regulators in gene regulation processes. Despite each of these technologies being powerful tools on their own, fike the parable of blind men and an elephant, any one single technology has a limited ability to depict the complex regulatory system. Integrative OMICS approaches have emerged and become an important area in biology and medicine. It provides a precise and effective way to study gene regulations. Results： This article reviews current popular OMICs technologies, OMICs data integration strategies, and bioinformatics tools used for multi-dimensional data integration. We highlight the advantages of these methods, particularly in elucidating molecular basis of biological regulatory mechanisms. Conclusions： To better understand the complexity of biological processes, we need powerful bioinformatics tools to integrate these OMICs data. Integrating multi-dimensional OMICs data will generate novel insights into system-level gene regulations and serves as a foundation for further hypothesis-driven research.

关键词： gene regulatory networks integrative analysis OMICs ChlP-seq RNA-seq

lmpact of non-canonical ALK fusion on the efficacy of targeted therapy in non-small cell lung cancer

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Chinese Medical Journal 2024年第12期137卷 1468-1470页

作者： Hao Zeng Qi Wei Yuan Tang Yuanyuan Zhang Sihan Tan Qin Huang Xin Pu Yalun Li panwen Tian Department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Department of Pathology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Pulmonary and Critical Care Medicine Lung Cancer CenterWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Pulmonary and Critical Care Medicine State Key Laboratory of Respiratory Health and MultimorbidityPrecision Medicine Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengduSichuan 610041China

To the Editor:With the wide application of next-generation sequencing(NGS),a number of EML4-ALK fusion partners or coexisting(non)-EML4-ALK and non-EML4-ALK have been detected in non-small cell lung cancer(NSCLC).Although targeted therapies for patients with metastatic NSCLC and actionable mutations dramatically change how these patients are treated,studies have demonstrated differences in progression-free survival(PFS)among patients based on different ALK fusion partners.

关键词： targeted lung NSCLC

Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer

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World Journal of Gastroenterology 2018年第8期24卷 905-916页

作者： Mohamad A Mouchli Lidia Ouk Marianne R Scheitel Alisha P Chaudhry Donna Felmlee-Devine Diane E Grill Shahrooz Rashtak panwen wang Junwen wang Rajeev Chaudhry Thomas C Smyrk Ann L Oberg Brooke R Druliner Lisa A Boardman Division of Gastroenterology and Hepatology Mayo Clinic Knowledge and Delivery Center Mayo Clinic Biostatistics and Bioinformatics Health Sciences Research Mayo Clinic Division of Biomedical Statistics and Informatics Health Sciences Research Mayo Clinic Biostatistics and Bioinformatics Health Science Research Center for Individualized Medicine Mayo Clinic Department of Biomedical Informatics Arizona State University Primary Care Internal Medicine Mayo Clinic Center for Innovation Mayo Clinic Department of Laboratory Medicine and Pathology Mayo Clinic

AIM To determine the frequency and risk factors for colorectal cancer(CRC) development among individuals with resected advanced adenoma(AA)/traditional serrated adenoma(TSA)/advanced sessile serrated adenoma(ASSA). METHODS Data was collected from medical records of 14663 subjects found to have AA, TSA, or ASSA at screening or surveillance colonoscopy. Patients with inflammatory bowel disease or known genetic predisposition for CRC were excluded from the study. Factors associated with CRC developing after endoscopic management of high risk polyps were calculated in 4610 such patients who had at least one surveillance colonoscopy within 10 years following the original polypectomy of the incident advanced polyp. RESULTS84/4610(1.8%) patients developed CRC at the polypectomy site within a median of 4.2 years(mean 4.89 years), and 1.2%(54/4610) developed CRC in a region distinct from the AA/TSA/ASSA resection site within a median of 5.1 years(mean 6.67 years). Approximately, 30%(25/84) of patients who developed CRC at the AA/TSA/ASSA site and 27.8%(15/54) of patients who developed CRC at another site had colonoscopy at recommended surveillance intervals. Increasing age; polyp size; male sex; right-sided location; high degree of dysplasia; higher number of polyps resected; and piecemeal removal were associated with an increased risk for CRC developmentat the same site as the index polyp. Increasing age; right-sided location; higher number of polyps resected and sessile endoscopic appearance of the index AA/TSA/ASSA were significantly associated with an increased risk for CRC development at a different site. CONCLUSION Recognition that CRC may develop following AA/TSA/ASSA removal is one step toward improving our practice efficiency and preventing a portion of CRC related morbidity and mortality.

关键词： Colon cancer Rectal Cancer Advanced adenoma Sessile serrated adenoma High risk polyps Post-polypectomy colorectal cancer

Calorimetric Study on LaNi4M（M=Ni,Cu,Fe）-H Systems

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Chemical Journal of Chinese Universities 1985年第1期 25-31页

作者： Shen panwen,wang Genshi,Song Deying and Lu Shuqin (Department of Chemistry,Nankai University,Tianjin)

The relative partial molar enthalpies and the partial molar free energiesof hydrogen dissolved in LaNi5,LaNi4Cu,and LaNi4Fe were measured respectively by acalorimetric system at 298.3K,and the partial molar entropies were also calculated By X-ray diffraction analysis the unit cell volumes V were *** was found that both and vary with V according to the following linear relations

关键词： M M=Ni,Cu,Fe La Calorimetric Study on LaNi4M H Systems Cu Ni

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可切除非小细胞肺癌新辅助免疫治疗研究进展

中国肺癌杂志 2024年第2期27卷 138-146页

作者：齐畅田攀文李为民四川大学华西医院呼吸与危重症医学科呼吸和共病全国重点实验室精准医学四川省重点实验室成都610041 四川大学华西医院呼吸健康研究所疾病分子网络前沿科学中心呼吸和共病研究院四川大学华西医院中国医学科学院创新单元四川大学华西医院肺癌中心

近年来,免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)对晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者预后的改善已成为共识,越来越多的临床研究也逐渐证明了免疫治疗对于可切除NSCLC患者的重要价值。然而,目前关... 详细信息

近年来,免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)对晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者预后的改善已成为共识,越来越多的临床研究也逐渐证明了免疫治疗对于可切除NSCLC患者的重要价值。然而,目前关于新辅助治疗背景下免疫联合策略的探索、治疗相关副作用、预后生物标志物等问题仍存在争议。本文综述了可切除NSCLC患者新辅助免疫治疗的最新进展,引发了新的思考,并讨论了其在临床应用中的优势及挑战。

关键词：肺肿瘤新辅助治疗免疫检查点抑制剂围手术期可切除非小细胞肺癌

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恶性胸腔积液的肿瘤微环境特征与治疗进展

中华结核和呼吸杂志 2024年第7期47卷 668-675页

作者：谈思含李为民田攀文四川大学华西医院呼吸与危重症医学科/肺癌中心呼吸和共病全国重点实验室精准医学四川省重点实验室成都610041

恶性胸腔积液(malignant pleural effusion, MPE)可继发于多种晚期恶性肿瘤。尽管全身抗肿瘤治疗对原发肿瘤治疗有效, 但仍有部分患者MPE控制不佳。肿瘤细胞、免疫细胞、间质细胞相互作用以及肿瘤相关血管异常增殖构建了MPE免疫抑制微环... 详细信息

恶性胸腔积液(malignant pleural effusion, MPE)可继发于多种晚期恶性肿瘤。尽管全身抗肿瘤治疗对原发肿瘤治疗有效, 但仍有部分患者MPE控制不佳。肿瘤细胞、免疫细胞、间质细胞相互作用以及肿瘤相关血管异常增殖构建了MPE免疫抑制微环境, 促进肿瘤细胞异常增殖和MPE的形成。随着对肿瘤微环境的深入研究, 胸腔内局部应用免疫检查点抑制剂、免疫细胞及细胞因子和基因介导的细胞毒等免疫疗法可有效改善免疫抑制的肿瘤微环境, 抑制MPE的形成。本文将阐述MPE的肿瘤微环境特征及相应的治疗新进展。

关键词：肿瘤微环境免疫抑制恶性胸腔积液 MPE 治疗进展

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文化传播视域下讲好中国故事刍议

中国矿业大学学报（社会科学版） 2024年第4期26卷 27-36页

作者：邹霞何攀文重庆理工大学马克思主义学院西南大学马克思主义学院

故事是人类文化的基本元素和重要标识,具有独特的影响力和感染力。讲好中国故事不仅是新时代国际传播能力建设的重要使命,还是加强国际传播能力建设的重要手段,更是展示中国形象、传播中国文化的重要方式。讲好中国故事关乎中华民族伟... 详细信息

故事是人类文化的基本元素和重要标识,具有独特的影响力和感染力。讲好中国故事不仅是新时代国际传播能力建设的重要使命,还是加强国际传播能力建设的重要手段,更是展示中国形象、传播中国文化的重要方式。讲好中国故事关乎中华民族伟大复兴战略全局,对于提升国际话语权、建设文化强国、弘扬中国共产党人精神谱系具有重要意义。文化传播视域下讲好中国故事要突出讲好文化传承、发展与交流的故事,重点在于讲好“两个结合”、文化“两创”、文明交流互鉴的故事,凸显中华文化的时代魅力与精神力量。当前,面对百年未有之大变局,讲好中国故事迎来了难得的历史机遇,也面临着国际舆论格局、中外文化差异、宏观叙事体系所构筑的文化壁垒。为此,要从挖掘中华文化资源、培育主体文化素养、打造文化平台、营造文化氛围四个方向进行实践创新,构建讲好中国故事的文化路径,进而全面提升国际传播效能,不断增强中华文明的传播力和影响力。

关键词：文化传播话语权中国特色社会主义文化中华文明中国故事

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热处理对锆合金管在纯水环境下腐蚀性能的影响

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钢管 2024年第3期53卷 13-18页

作者：谢麒麟郑建聪孙盼文宝山钢铁股份有限公司钢管条钢事业部上海201900

为评价反应堆燃料包壳用锆合金管在纯水环境下的腐蚀性能,研究不同热处理工艺对低锡低铌锆合金管的显微组织和腐蚀性能的影响。采用扫描电子显微镜和透射电子显微镜表征了合金的基体组织,并在高压釜中进行了360℃/18.6 MPa纯水环境下长... 详细信息

为评价反应堆燃料包壳用锆合金管在纯水环境下的腐蚀性能,研究不同热处理工艺对低锡低铌锆合金管的显微组织和腐蚀性能的影响。采用扫描电子显微镜和透射电子显微镜表征了合金的基体组织,并在高压釜中进行了360℃/18.6 MPa纯水环境下长达300 d的腐蚀试验。结果表明:低锡低铌锆合金管在550℃退火、保温5 h后的显微组织为完全再结晶状态,组织形貌为均匀的等轴晶组织,其第二相均匀地分布在晶粒中;而β相水淬+500℃退火、保温5 h后的合金是非完全再结晶的,其组织主要呈板条状。两种热处理温度下制备的低锡低铌锆合金在360℃/18.6 MPa高温高压水中的耐腐蚀性能均优于商用ZIRLO合金。

关键词：锆合金管热处理腐蚀性能显微组织氧化膜

Changes in hospitalizations for respiratory diseases following the COVID-19 epidemic

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Chinese Medical Journal 2022年第19期135卷 2386-2388页

作者： Kaige wang Li Guo Qianfeng Xiao panwen Tian Dan Liu Weimin Li Department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Department of Cardiology West China HospitalSichuan UniversityChengduSichuan 610041China.

Tothe Editor:During the ongoing,coronavirus disease 2019(COVID-19)pandemic,hundreds of millions of people have been *** prevention and control measures guided by the Chinese government,including the wearing of,facemasks,maintaininghand hygiene,reducing gatherings,and physical distancing,have become commonplace across *** protective measures have been confirmed to reduce the risk of severe acute respiratorysyndromecoronavirus 2(SARS-CoV-2)*** addition to COVID-19,other respiratory infectious diseases,such as viral pneumonia and bacterial pneumonia,remain a threat to *** the pandemic,and associated protective measures have impacted thespectrum of respiratorydiseases in inpatients in pulmonary and critical care medicine(PCCM)departments remains unclear.

关键词： respiratory protective diseases