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Pomegranate extract inhibits EMT in clear cell renal cell carcinoma in a NF-κB and JNK dependent manner

Asian Journal of Urology 2015年第1期2卷 38-45页

作者： Jiabin An Yanchuan Guo Ting Wang Allan J.pantuck Matthew B.Rettig Department of Medicine Division of Hematology-OncologyVA Greater Los Angeles Healthcare SystemLos AngelesCA90073USA Technical Institute of Physics and Chemistry Chinese Academy of ScienceBeijing100190China Department of Urology David Geffen School of Medicine at UCLALos AngelesCA90095USA Department of Medicine Division of Hematology-OncologyDavid Geffen School of Medicine at UCLALos AngelesCA90095USA

Objective:Clear cell renal cell carcinoma(ccRCC)is the most common subtype of renal cell carcinoma(RCC)and is characterized by biallelic inactivation of the von Hippel-Lindau(VHL)tumor suppressor *** effect of VHL inactivation is hypoxia inducible factor alpha(HIFa)-independent constitutive activation of nuclear factor kappa B(NF-κB)and c-jun N-terminal kinase(JNK).Both NF-κB and JNK drive ccRCC growth and epithelial to mesenchymal transition(EMT).The purpose of this study was to determine the biochemical effects of pomegranate juice extracts(PE)on RCC cell ***:The pre-clinical effects of PE on NF-κB,JNK,and the EMT phenotype were assayed,including its effect on proliferation,anchorage-independent growth,and invasion of pVHLdeficient ***:PE inhibits the NF-κB and JNK pathways and consequently inhibits the EMT phenotype of pVHL-deficient *** effects of PE are concentration-dependent and affect not only biochemical markers of EMT(i.e.,cadherin expression)but also functional manifestations of EMT,such as *** effects are manifested within days of exposure to PE when diluted *** dilute concentrations of PE(106 dilution),which do not impact these pathways in the short term,were found to have NF-κB and JNK inhibitory effects and ability to reverse the EMT phenotype following prolonged ***:These findings suggest that PE may mediate inhibition growth of pVHL-deficient ccRCCs and raises the possibility of its use as a dietary adjunct to managing patients with active surveillance for small,localized,incidentally identified renal tumors so as to avoid more invasive procedures such as nephrectomy.

关键词： Pomegranate extract von Hippel-Lindau(VHL)tumor suppressor Clear cell renal cell carcinoma c-Jun N-terminal kinase Epithelial to mesenchymal transition Nuclear factor kappa B

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人参对大鼠血浆中乙醇浓度的影响

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人参研究 1996年第1期8卷 45-47页

作者： Young Joo Lee Carol B pantuck Eugene J pantuck 宿延英王利群通化市中心医院通化师范学院

用被乙醇处置过的雄性费歇尔344大鼠来研究红参提取物对乙醇代谢的影响。给大鼠口服水溶性人参(200mg/kg),对照组给予同等剂量的水,随即用50％的乙醇给大鼠口服(3.2g/kg)或腹腔注射(1.5g/kg)。在给药前和给药后0.5、1、2、3、4和5小时... 详细信息

用被乙醇处置过的雄性费歇尔344大鼠来研究红参提取物对乙醇代谢的影响。给大鼠口服水溶性人参(200mg/kg),对照组给予同等剂量的水,随即用50％的乙醇给大鼠口服(3.2g/kg)或腹腔注射(1.5g/kg)。在给药前和给药后0.5、1、2、3、4和5小时分别从大鼠尾部动脉抽取一定量血液,测得一定的数值,绘制成血浆浓度—时间曲线(0-5小时)。发现,对于经口给予乙醇的大鼠来说,口服人参组血浆中乙醇的浓度——时间曲线下的平均面积比水对照组减少21.0％,而对于腹腔注射乙醇的大鼠来说,人参组与水对照组的乙醇浓度——时间曲线下的面积无显著区别。说明,大鼠血浆中乙醇浓度在口服乙醇的同时加用人参将比单独口服乙醇要低。而口服人参对经腹腔注射乙醇的大鼠来说,其血浆中乙醇的浓度不受影响。

关键词：人参乙醇传统的朝鲜药物生物处置

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Saw Palmetto-Based Nutritional Supplement Prostataplex Relieves Symptoms of Benign Prostatic Hyperplasia (BPH) in Patients with Mild to Moderate BPH

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Open Journal of Urology 2012年第3期2卷 104-108页

作者： Qingwen Xie Jing Leng Jianwei Lv Allan pantuck Lawrence Yen Mina Shariff Kenneth Kami Jianyu Rao Rong Shi Department of Pathology and Laboratory Medicine David Geffen School of Medicine University of California Los Angeles USA Department of Preventive Medicine School of Public Health Shanghai Jiao Tong University School of Medicine Shanghai China Department of Research DRM Resources Costa Mesa USA Department of Urology David Geffen School of Medicine University of California Los Angeles USA Department of Urology Shanghai Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China

The goal of this study was to assess the efficacy of the saw palmetto-based nutritional supplement, Prostataplex, for relieving the symptoms associated with benign prostatic hyperplasia (BPH) in men with mild to moderate degrees of BPH. A randomized, double-blind, placebo-controlled trial was performed in Shanghai, China. Eighty patients with BPH were randomly assigned to either the intervention group (39 cases) or control group (41 cases). Patients in the intervention group were administered Prostataplex orally and placebos were given to patients in the control group. The duration of treatment was 12 weeks in both groups. Following the intervention of Prostataplex, the maximum urinary flow rates (MFR), total scores of International Prostate Symptom Score (IPSS) and quality of life indicators were significantly better among the patients in the intervention group than those in the control group (P < 0.01 for all variables). Significant improvement of symptoms including dysuria, reducing nocturnal polyuria and increasing urinary flow rate was seen after two months of intervention, especially for the improvement of incomplete bladder emptying. Prostataplex has positive effects on improving symptoms as well as quality of life in men with mild to moderate BPH.

关键词： Saw Palmetto Prostataplex Benign Prostatic Hyperplasia Intervention

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透明细胞肾癌:应用多期相多层CT鉴别其他肾细胞癌亚型及嗜酸细胞瘤

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国际医学放射学杂志 2013年第4期 369-369页

作者： J.R. Young D. Margolis S. Sauk A.J. pantuck J. Sayre S.S. Raman 张晓丹 Department of Radiology David Geffen School of Medicine at UCLA Ronald Reagan UCLA Medical Center757 Westwood Plaza Suite 1638 Los Angeles CA 90095 -7437

目的确定多期相多层CT扫描中的强化表现是否有助于透明细胞癌(RCC)与嗜酸细胞瘤、乳头状肾细胞癌及嫌色细胞肾癌的鉴别。材料与方法本回顾性研究经机构审查委员会批准并符合HIPAA标准,从入组的298例术前行多层CT的4期增强(平扫、皮髓质... 详细信息

目的确定多期相多层CT扫描中的强化表现是否有助于透明细胞癌(RCC)与嗜酸细胞瘤、乳头状肾细胞癌及嫌色细胞肾癌的鉴别。材料与方法本回顾性研究经机构审查委员会批准并符合HIPAA标准,从入组的298例术前行多层CT的4期增强(平扫、皮髓质期、肾实质期和排泄期)扫描的RCC及嗜酸细胞瘤病人的病例中收集病理学数据。共170例透明细胞肾癌、57例乳头状肾细胞癌、49例嗜酸细胞瘤、22例嫌色细胞肾癌病人行多期相增强CT检查,并采用t检验进行比较。应用截止分析确定鉴别4组病变的最佳阈值水平。结果透明细胞肾癌和嗜酸细胞瘤的强化均值在皮髓质期达到顶点;乳头状和嫌色细胞肾癌的强化均值在实质期达到顶点。透明细胞肾癌在皮髓质期(125HU∶106HU,P=0.045)和排泄期(80HU∶67HU,P=0.034)的强化程度高于嗜酸细胞瘤;在皮髓质期(125HU∶54HU,P<0.001)、实质期(103HU∶64HU,P<0.001)、排泄期(80HU∶54HU,P<0.001)的强化程度高于乳头状肾细胞癌;在皮质期(125HU∶74HU,P<0.001)和排泄期(80HU∶60HU,P=0.008)的强化程度高于嫌色细胞肾癌。强化的阈值有助于区分透明细胞肾癌与嗜酸细胞瘤、乳头状肾细胞癌和嫌色细胞肾癌,精确度分别为77%(83/108)、85%(101/119)和84%(81/97)。结论若以前瞻性研究证实,透明细胞肾癌在多层CT多期相扫描中的强化特征有助于其与嗜酸细胞瘤、乳头状肾细胞癌及嫌色细胞肾癌的鉴别。

关键词：嗜酸细胞瘤透明细胞肾癌肾肿瘤 CT

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