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Nanoengineered hydrogels as 3D biomimetic extracellular matrix with injectable and sustained delivery capability for cartilage regeneration

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Bioactive Materials 2023年第1期19卷 487-498页

作者： Penglei Cui panpan pan Ling Qin Xinluan Wang Xiaodong Chen Yonghui Deng Xiaoling Zhang Department of Orthopedic Surgery Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200092People’s Republic of China Department of Chemistry Fudan UniversityShanghai200433People’s Republic of China Translational Medicine R&D Center Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518057People’s Republic of China Department of Spine Surgery Beijing Jishuitan HospitalPeking University Fourth School of Clinical MedicineBeijing100035People’s Republic of China

The regeneration of articular cartilage remains a great challenge due to the difficulty in effectively enhancing spontaneous healing.Recently,the combination of implanted stem cells,suitable biomaterials and bioactive molecules has attracted attention for tissue regeneration.In this study,a novel injectable nanocomposite was rationally designed as a sustained release platform for enhanced cartilage regeneration through integration of a chitosan-based hydrogel,articular cartilage stem cells(ACSCs)and mesoporous SiO_(2)nanoparticles loaded with anhydroicaritin(AHI).The biocompatible engineered nanocomposite acting as a novel 3D biomimetic extracellular matrix exhibited a remarkable sustained release effect due to the synergistic regulation of the organic hydrogel framework and mesopore channels of inorganic mSiO_(2)nanoparticles(mSiO_(2)NPs).Histological assessment and biomechanical tests showed that the nanocomposites exhibited superior performance in inducing ACSCs proliferation and differentiation in vitro and promoting extracellular matrix(ECM)production and cartilage regeneration in vivo.Such a novel multifunctional biocompatible platform was demonstrated to significantly enhance cartilage regeneration based on the sustained release of AHI,an efficient bioactive natural small molecule for ACSCs chondrogenesis,within the hybrid matrix of hydrogel and mSiO_(2)NPs.Hence,the injectable nanocomposite holds great promise for use as a 3D biomimetic extracellular matrix for tissue regeneration in clinical diagnostics.

关键词： Injectable nanocomposite Mesoporous silica 3D biomimetic extracellular matrix Sustained release of anhydroicaritin Cartilage regeneration

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Versatile core-shell magnetic fluorescent mesoporous microspheres for multilevel latent fingerprints magneto-optic information recognition

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InfoMat 2022年第5期4卷 152-163页

作者： Bingjie Yu Shude Liu Wenhe Xie panpan pan Peng Zhou Yidong Zou Qin Yue Yonghui Deng Department of Chemistry Department of Gastroenterology and HepatologyZhongshan HospitalState Key Laboratory of Molecular Engineering of PolymersShanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghaiChina State Key Laboratory of ASIC and System School of MicroelectronicsFudan UniversityShanghaiChina Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengduChina

Latent fingerprints are extremely vital for personal identification and criminalinvestigation,and potential information recognition techniques have been widelyused in the fields of information and communication electronics.Although physicalpowder dusting methods have been frequently employed to develop latent fingerprintsand most of them are carried out by using single component powders ofmicron-sized fluorescent particles,magnetic powders,or metal particles,there isstill an enormous challenge in producing high-resolution image of latent fingerprintsat different backgrounds or substrates.Herein,a novel and effectivenanoimpregnation method is developed to synthesize bifunctional magnetic fluorescentmesoporous microspheres for latent fingerprints visualization by growthof mesoporous silica(mesoSiO_(2))on magical Fe_(3)O_(4) core and then deposition offluorescent YVO4:Eu^(3+)nanoparticles in the mesopores.The obtainedFe_(3)O_(4)@mesoSiO_(2)@YVO4:Eu^(3+)microspheres possess spatially isolated magneticcore and fluorescent shell which were insulated by mesoporous silica layer.Dueto their small particle size of submicrometer scale,high magnetization and lowmagnetic remanence as well as the combined magnetic and fluorescent properties,the microspheres show superior performance in visual latent fingerprint recognitionwith high contrast,high anti-interference,and sensitivity as well as goodretention on multifarious substrates regardless of surface permeability,roughness,refraction,colorfulness,and background fluorescence interference,and it makesthem ideal candidates for practical application in fingerprint visualization andeven magneto-optic information storage.

关键词： core-shell structure fluorescent materials latent fingerprint magnetic microspheres magneto-optic information recognition

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Real-time monitoring flexible hydrogels based on dual physically cross-linked network for promoting wound healing

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中国化学快报:英文版 2023年第10期34卷 229-235页

作者： Le Hu Yuxin Wang Qing Liu Man Liu Faming Yang Chunxiao Wang panpan pan Lin Wang Li Chen Jingdi Chen Marine College Shandong UniversityWeihai 264209China Shandong Laboratory of Advanced Materials and Green Manufacturing Yantai 265599China College of Biological Science and Technology Fuzhou UniversityFuzhou 350108China

To achieve smart and personalized medicine, the development of hydrogel dressings with sensing properties and biotherapeutic properties that can act as a sensor to monitor of human health in real-time while speeding up wound healing face great challenge. In the present study, a biocompatible dual-network composite hydrogel(DNCGel) sensor was obtained via a simple process. The dual network hydrogel is constructed by the interpenetration of a flexible network formed of poly(vinyl alcohol)(PVA) physical cross-linked by repeated freeze-thawing and a rigid network of iron-chelated xanthan gum(XG) impregnated with Fe^(3+) interpenetration. The pure PVA/XG hydrogels were chelated with ferric ions by immersion to improve the gel strength(compressive modulus and tensile modulus can reach up to 0.62 MPa and0.079 MPa, respectively), conductivity(conductivity values ranging from 9 × 10^(-4) S/cm to 1 × 10^(-3)S/cm)and bacterial inhibition properties(up to 98.56%). Subsequently, the effects of the ratio of PVA and XG and the immersion time of Fe^(3+) on the hydrogels were investigated, and DNGel3 was given the most priority on a comprehensive consideration. It was demonstrated that the DNCGel exhibit good biocompatibility in vitro, effectively facilitate wound healing in vivo(up to 97.8% healing rate) under electrical stimulation, and monitors human movement in real time. This work provides a novel avenue to explore multifunctional intelligent hydrogels that hold great promise in biomedical fields such as smart wound dressings and flexible wearable sensors.

关键词： Conductive hydrogel Dual cross-linked network Antimicrobial activity Real-time monitorin Wound healing

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One-dimensional nanochains consisting of magnetic core and mesoporous aluminosilicate for use as efficient nanocatalysts

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Nano Research 2021年第11期14卷 4197-4203页

作者： Tong Zhang Qin Yue panpan pan Yuan Ren Xuanyu Yang Xiaowei Cheng Fahad A.Alharthi Abdulaziz A.Alghamdi Yonghui Deng Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu610051China Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersFudan UniversityShanghai200433China State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai200050China Department of Chemistry College of ScienceKing Saud UniversityP.O.Box 2455Riyadh11451Saudi Arabia

Magnetic assembly at the nanoscale level brings potential possibilities in obtaining novel delicate nanostructures with unique physical, photonic or electronic properties. Interface surfactant micelle-directed assembly strategy holds great promising in fabricating ordered mesoporous materials with multifunctionality and pore parameter tunability. Combing these, herein, one-dimensional (1D) nanochains with well-aligned silica-coated magnetic particles as core and mesoporous aluminosilicate as shell are rational fabricated for the first time through magnetic field induced interface coassembly in biliquid system followed by the incorporation of Al species via in-situ chemical modification and transformation strategy. The obtained magnetic mesoporous aluminosilicate nanochains (MMAS-NCs) possess well-defined core-shell-shell sandwich nanostructure, tunable perpendicular mesopore channels in the shell (2.7–7.6 nm), high surface area (359 m^(2)·g^(-1)), abundant acidic sites, and superparamagnetism with a magnetization saturation of 13.8 emu·g^(-1). Thanks to the unique properties, the MMAS-NCs exhibit excellent performance in acting as magnetically recyclable superior solid acid catalysts and nanostirrers with high conversion of over 96.8%, selectivity of 95.0% in the deprotection reaction of benzaldehyde dimethylacetal to benzaldehyde. Moreover, MMAS-NCs exhibit an interesting pore size effect on the catalytic activity, namely, in the pore size range of 2–8 nm, the catalysts with larger pores show significantly enhanced catalytic activity due to the balanced mass transport and density of surface active sites.

关键词： nanochain mesoporous materials magnetic particle acid catalysis aluminosilicate

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A fast on-demand preparation of injectable self-healing nanocomposite hydrogels for efficient osteoinduction

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Chinese Chemical Letters 2021年第7期32卷 2159-2163页

作者： panpan pan Xiao Chen Huaran Xing Yonghui Deng Jingdi Chen Fahad AAlharthi Abdulaziz AAlghamdi Jiacan Su Department of Chemistry Department of GastroenterologyZhongshan Hospital of Fudan UniversityState Key Laboratory of Molecular Engineering of PolymersFudan UniversityShanghai 200433China Department of Orthopaedics Trauma Changhai HospitalSecond Military Medical UniversityShanghai 200433China Institute of Biomedical and Pharmaceutical Technology Fuzhou UniversityFuzhou 350002China Marine College Shandong UniversityWeihai 264209China Department of Chemistry College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China

Injectable hydrogels have been considered as promising materials for bone regeneration,but their osteoinduction and mechanical performance are yet to be improved.In this study,a novel biocompatible injectable and self-healing nano hybrid hydrogel was on-demand prepared via a fast(within 30 s)and easy gelation approach by reversible Schiff base formed between-CH=O of oxidized sodium alginate(OSA)and-NH2 of glycol chitosan(GCS)mixed with calcium phosphate nanoparticles(CaP NPs).Its raw materials can be ready in large quantities by a simple synthesis process.The mechanical strength,degradation and swelling behavior of the hydrogel can be readily controlled by simply controlling the molar ratio of-CH=O and-NH2.This hydrogel exhibits pH responsiveness,good degradability and biocompatibility.The hydrogel used as the matrix for mesenchymal stem cells can significantly induce the proliferation,differentiation and osteoinduction in vitro.These results showed this novel hydrogel is an ideal candidate for applications in bone tissue regeneration and drug delivery.

关键词： Dynamic coordination Nanocomposite hydrogels Fast and easy on-demand preparation Injectable and self-healing abilities Stem cell osteoinduction

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Effects of a periodic intermittent theta burst stimulation in Alzheimer's disease

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General Psychiatry 2024年第1期37卷 53-63页

作者： Xingqi Wu Yibing Yan panpan Hu Lu Wang Yue Wu pan Wu Zhi Geng Guixian Xiao Shanshan Zhou Gongjun Ji Bensheng Qiu Ling Wei Yanghua Tian Hesheng Liu Kai Wang Department of Neurology First ffiliated Hospital of Anhui Medical UniversityHefeiAnhuiChina School of Mental Health and Psychological Sciences Anhui Medical UniversityHefeiAnhuiChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhuiChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhuiChina Department of Psychology and Sleep Medicine The Second Affliated Hospital of Anhui Medical UniversityHefeiAnhuiChina Center for Biomedical Imaging University of Science and Technology of ChinaHefeiAnhuiChina institute of Artificial Intlligence Hefei Comprehensive National Science CenterHefeiAnhuiChina Department of Neuroscience Medical University of South CarolinaCharlestonSouth CarolinaUSA

Background Previous studies havedemonstrated that excitatory repetitive transcranial magnetic stimulation(rTMS)can improve the cognitive function of patients with Alzheimer's disease(AD).Intermittent theta burst stimulation(iTBS)is a novel excitatory rTMS protocol for brain activity stimulation with the ability to induce long-term potentiation-like plasticity and represents a promising treatment for AD.However,the long-term effects of iTBS on cognitive decline and brain structure in patients with AD areunknown.Aims We aimed to explore whether repeating accelerated iTBS every three months could slow down the cognitive decline in patients with AD.Methods In this randomised,assessor-blinded,controlled trial,iTBS was administered to the left dorsolateral prefrontal cortex(DLPFC)of 42 patients with AD for 14days every 13weeks.Measurements included the Montreal Cognitive Assessment(MoCA),a comprehensive neuropsychological battery,and the grey matter volume(GMV)of the hippocampus.Patients were evaluated at baseline and after follow-up.The longitudinal pipeline of the Computational Anatomy Toolbox for SPM was used to detect significant treatment-related changes over time.Results The iTBS group maintained MoCA scores relative to the control group(t=3.26,p=0.013)and reduced hippocampal atrophy,which was significantly correlated with global degeneration scale changes.The baseline Mini-Mental State Examination(MMSE)score,apolipoprotein E genotype and Clinical Dementia Rating were indicative of MoCA scores at follow-up.Moreover,the GMV of the left(t=0.08,p=0.996)and right(t=0.19,p=0.977)hippocampus were maintained in the active group but significantly declined in the control group(left:t=4.13,p<0.001;right:t=5.31,p<0.001).GMV change in the left(r=0.35,p=0.023)and right(r=0.36,p=0.021)hippocampus across the intervention positively correlated with MoCA changes;left hippocampal GMV change was negatively correlated with global degeneration scale(r=-0.32,p=0.041)changes.Conclusions DLPFC-iTBS maybe a feasible and easy-to-implement

关键词： stimulation Alzheimer maintained

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“专创融合”视域下软件测试技术课程的教学改革与实践

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创新创业理论研究与实践 2024年第1期7卷 55-57页

作者：王胜浮盼盼董全德潘正高宿州学院安徽宿州234000

该文以“专创融合”为视角,针对计算机软件工程专业课程的教学改革,以软件测试技术课程为切入点,重点阐述了“专创融合”课程的建设内容与应用实践,提出了软件测试技术课程专业知识与创新教育教学有效结合的新型课堂教学方式。实践中,... 详细信息

该文以“专创融合”为视角,针对计算机软件工程专业课程的教学改革,以软件测试技术课程为切入点,重点阐述了“专创融合”课程的建设内容与应用实践,提出了软件测试技术课程专业知识与创新教育教学有效结合的新型课堂教学方式。实践中,“专创融合”课程基于OBE(成果导向教育)理念,采用线上线下并分阶段的混合式教学,通过项目驱动课堂教学,融入企业实践项目与学科科研项目等,改进课程内容与教学方法。结果表明:“融合创新型”课堂教学能够使学生学习的主观能动性得以提高,学生的问题剖析、解决能力与沟通协作能力得到增强,学生的创新精神与创业技能得以培养。

关键词：软件测试技术 “专创融合” 课程建设课程建设方案创新教学方法实施与成效

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Hydraulic path dependence of shear strength for compacted loess

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第7期15卷 1872-1882页

作者： pan Chen Shengao Jia Xiaoqi Wei Pingping Sun panpan Yi Changfu Wei State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Xuzhou Highway Engineering Corporation Xuzhou221000China School of Human Settlements and Civil Engineering Xi’an Jiaotong UniversityXi’an710061China

Shear strength is an essential geotechnical parameter for assessing the landslide potential of loess slopes under rainfall infiltration and farm irrigation conditions on the loess plateau.However,the hydraulic path dependence of shear strength for compacted loess under varying rainfall infiltration conditions has not been thoroughly investigated yet.To this end,a series of direct shear tests and nuclear magnetic resonance(NMR)measurements are carried out on compacted loess.The shear strength tests were continuously implemented on loess specimens under scanning wetting paths besides initial drying paths.The experimental data quantitatively verify the significant effect of hydraulic paths applied to specimens on shear strength of compacted loess.The unique failure envelope of shear strength of loess is identified under the effective stress framework based on intergranular stress,which verifies that the effective stress framework can consider the effect of hydraulic paths on shear strength.Based on the effective stress,a shear strength formula is proposed to characterize shear strengths under varying hydraulic paths,in which the parameters from the soil-water retention curve and shear strength at saturated state are simply required.The proposed shear strength formula can properly predict the measured shear strength data of compacted loess experiencing three hydraulic paths.Furthermore,the distribution curves of transverse relaxation time for pore water in soil under varying hydraulic paths are simultaneously measured using the NMR method.The physical mechanism for the difference in shear strength of loess subjected to different hydraulic paths can be uncovered based on soil-water evolutions in pores in microscale.

关键词： Shear strength Loess Hydraulic hysteresis Effective stress Nuclear magnetic resonance(NMR)

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活性炭负载ZnS/TiO_2光催化剂的制备及其性能研究

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非金属矿 2019年第2期42卷 76-79页

作者：李健闫龙潘盼盼亢玉红王玉飞任国瑜榆林学院化学与化工学院陕西榆林719000 陕西省低变质煤洁净利用重点实验室陕西榆林719000

采用溶胶浸渍法制备了活性炭负载TiO_2掺杂ZnS的光催化剂,并以TiO_2光催化剂、TiO_2掺杂ZnS的光催化剂和用硫脲法制取的Zn S光催化剂等作为对照试样,通过XRD、SEM对各催化剂进行表征分析,利用光化学反应仪光降解孔雀石绿模拟废水,探究... 详细信息

采用溶胶浸渍法制备了活性炭负载TiO_2掺杂ZnS的光催化剂,并以TiO_2光催化剂、TiO_2掺杂ZnS的光催化剂和用硫脲法制取的Zn S光催化剂等作为对照试样,通过XRD、SEM对各催化剂进行表征分析,利用光化学反应仪光降解孔雀石绿模拟废水,探究了不同类型光催化剂、不同焙烧温度、不同光照功率等因素对光催化剂的催化活性及性能的影响。结果表明:在光化学反应仪中进行降解孔雀石绿模拟废水试验,焙烧温度为500℃、光照功率为960 W时,活性炭负载TiO_2/ZnS的降解率高达82.1%。

关键词：有机废水二氧化钛孔雀石绿硫化锌

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水滑石超级电容器电极材料层间距调控研究进展

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硅酸盐学报 2024年第6期52卷 2162-2174页

作者：王晓亮高靖淞宋晓琦张一波潘奎王宏伟郭力歌李盼盼刘忆黄传辉杨绍斌辽宁工程技术大学材料科学与工程学院辽宁省地矿工程特种材料专业技术创新中心辽宁省矿物高值化与储能材料重点实验室辽宁阜新123000 徐州工程学院机电工程学院江苏徐州221111

水滑石具有二维层状结构和高理论比电容,在超级电容器电极材料领域崭露头角。通过调控层间距,提高水滑石层间电化学活性位点利用率,降低离子传输阻力,成为水滑石等二维电极材料常用而有效的结构调控方法。近年来,水滑石层间距调控和电... 详细信息

水滑石具有二维层状结构和高理论比电容,在超级电容器电极材料领域崭露头角。通过调控层间距,提高水滑石层间电化学活性位点利用率,降低离子传输阻力,成为水滑石等二维电极材料常用而有效的结构调控方法。近年来,水滑石层间距调控和电容性能研究报道迅速增加,但至今关于水滑石层间距调控提升电容性能的综述文章依然很少。因此,本文对水滑石的结构和储能机理进行了介绍,系统对比评述了离子交换法和一步合成方法调控层间距的优缺点,深入对比并总结了客体插层、金属阳离子配比调控、插层及水滑石载量调控等方法对水滑石层间距、成分、结构和电容性能的影响研究的进展情况,梳理出了调控层间距提升电容性能的常用方法和电容性能提升的内在机制,为推进水滑石电极材料的深入研究和应用发挥重要作用。

关键词：水滑石超级电容器电极材料层间距调控电容性能

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