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Anticoagulant use before COVID-19 diagnosis prevent COVID-19 associated acute venous thromboembolism or not:A systematic review and meta-analysis

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World Journal of Methodology 2024年第3期14卷 141-162页

作者： Kinza Iqbal Akshat Banga Taha Bin Arif Sawai Singh Rathore Abhishek Bhurwal Syeda Kisa Batool Naqvi Muhammad Mehdi pankaj Kumar Mitali Madhu Salklan Ayman Iqbal Jawad Ahmed Nikhil sharma Amos Lal Rahul Kashyap Vikas Bansal Juan Pablo Domecq Department of Internal Medicine Dow Medical CollegeKarachi 74200Pakistan Department of Internal Medicine Sawai Man Singh Medical CollegeJaipur 302004India Department of Internal Medicine Dr.Sampurnanand Medical CollegeJodhpur 342003RajasthanIndia Department of Gastroenterology and Hepatology Rutgers Robert Wood Johnson School of MedicineNew BrunswickNJ 08901United States Department of Internal Medicine Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia Department of Nephrology and Hypertension Mayo ClinicRochesterMN 55905United States Department of Medicine Division of Pulmonary and Critical Care MedicineMayo ClinicRochesterMN 55905United States Department of Research Wellspan HealthYorkPA 17403United States

BACKGROUND Coagulopathy and thromboembolic events are associated with poor outcomes in coronavirus disease 2019(COVID-19)*** is conflicting evidence on the effects of chronic anticoagulation on mortality and severity of COVID-19 *** To summarize the body of evidence on the effects of pre-hospital anticoagulation on outcomes in COVID-19 *** A Literature search was performed on LitCovid PubMed,WHO,and Scopus databases from inception(December 2019)till June 2023 for original studies reporting an association between prior use of anticoagulants and patient outcomes in adults with *** primary outcome was the risk of thromboembolic events in COVID-19 patients taking *** outcomes included COVID-19 disease severity,in terms of intensive care unit admission or invasive mechanical ventilation/intubation requirement in patients hospitalized with COVID-19 infection,and *** random effects models were used to calculate crude and adjusted odds ratios(aORs)with 95%confidence intervals(95%CIs).RESULTS Forty-six observational studies met our inclusion *** unadjusted analysis found no association between prior anticoagulation and thromboembolic event risk[n=43851,9 studies,odds ratio(OR)=0.67(0.22,2.07);P=0.49;I2=95%].The association between prior anticoagulation and disease severity was non-significant[n=186782;22 studies,OR=1.08(0.78,1.49);P=0.64;I2=89%].However,pre-hospital anticoagulation significantly increased all-cause mortality risk[n=207292;35 studies,OR=1.72(1.37,2.17);P<0.00001;I2=93%].Pooling adjusted estimates revealed a statistically non-significant association between pre-hospital anticoagulation and thromboembolic event risk[aOR=0.87(0.42,1.80);P=0.71],mortality[aOR=0.94(0.84,1.05);P=0.31],and disease severity[aOR=0.96(0.72,1.26);P=0.76].CONCLUSION Prehospital anticoagulation was not significantly associated with reduced risk of thromboembolic events,improved survival,and lower disease seve

关键词： Prior anticoagulation COVID-19 Prehospital anticoagulation Chronic anticoagulation Mortality Severity Thromboembolic events

Should we redefi ne large common bile duct stone?

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World Journal of Gastroenterology 2008年第4期14卷 651-652页

作者： Shyam Sunder sharma pankaj Jain Department of Gastroenterology SMS Medical College and Hospital JaipurJaipur-302021India

The definition of large stones is not clear ranging from 10 mm to 15 mm and does not include the lower common bile duct (CBD) diameter. Three hundred and four patients who underwent endoscopic retrograde cholangiopancreatography and stone extraction were retrospectively analyzed over a 1-year period. Sixteen patients were different from others in that 10 patients with large stones had stone extraction with a wire basket or a balloon catheter and 6 patients with small stones had stone extraction with mechanical lithotripsy. The defi nition of large stones should include diameter of the lower CBD and any stone in lower CBD with its diameter greater than 2 mm.

关键词： Large common bile duct stone Definition

Recent development in asymmetric organocatalytic domino reactions involving 1,6-addition as a key step

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Organic Chemistry Frontiers 2022年第2期9卷 572-592页

作者： Yaseen Hussain Tamanna Manisha sharma Akshay Kumar pankaj Chauhan Department of Chemistry Indian Institute of Technology JammuJagtiNH-44Nagrota BypassJammu181221 J&KIndia Department of Chemistry DAV UniversityPathankot-Jalandhar RoadJalandhar 144001PunjabIndia

Due to their unique activation modes,small organic molecule catalysts(organocatalysts)have proved their potential in facilitating the remote functionalizations of unsaturated acceptors with extended *** organocatalytic 1,6-addition reaction involving the attack of nucleophiles on the δ-carbon of the α,β,γ,δ-unsaturated acceptors has emerged as an excellent strategy to create a stereocenter at the δ-site with high regio-and *** has also opened the window for developing complex domino reactions involving the 1,6-addition *** advancement has been accomplished in the organocatalytic asymmetric 1,6-addition and related domino reactions for the stereocontrolled synthesis of complex molecular structures bearing multiple *** review article summarizes the significant advancement in stereoselective domino reactions involving 1,6-addition as a critical step.

关键词： domino asymmetric stereo

Spatial distribution of fossil fuel derived CO_(2) over India using radiocarbon measurements in crop plants

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Journal of Environmental Sciences 2023年第2期124卷 19-30页

作者： Rajveer sharma Ravi Kumar Kunchala Sunil Ojha pankaj Kumar Satinath Gargari Sundeep Chopra Inter University Accelerator Centre New Delhi 110067India Centre for Atmospheric Sciences Indian Institute of Technology DelhiNew Delhi 110016India

Examining the contribution of fossil fuel CO_(2) to the total CO_(2) changes in the atmosphere is of primary concern due to its alarming levels of fossil fuel emissions over the globe,specifically developing *** radiocarbon represents an important observational constraint and utilized to trace fossil fuel derived CO_(2)(CO_(2ff))in the *** the first time,we have presented a detailed analysis on the spatial distribution of fossil fuel derived CO_(2)(CO_(2ff))over India using radiocarbon(Δ14C)measurements during three-year *** shows that theΔ14C values are varying between 29.33‰ to-34.06‰ across India in the year 2017,where highest value belongs to a location from Gujarat while lowest value belongs to a location from *** on the14C patterns,spatial distributions of CO_(2ff) mole fractions have been determined over India and the calculated values of CO_(2ff) mole fractions are varying between 4.85 ppm to 26.59 ppm across *** is also noticed that the highest CO_(2ff) mole fraction is observed as 26.59 ppm from a site in ***_(2ff) mole fraction values from four high altitude sites are found to be varied between 4.85 ppm to 14.87 *** of sampling different crop plants from the same growing season and different crop plant organs(grains,leaves,stems)on theΔ14C and CO_(2ff) have been *** and intra seasonal variations in theΔ14C and CO_(2ff) mole fractions have also been analyzed from a rural location(Dholpur,Rajasthan).

关键词： Carbon dioxide Crop plants Fossil fuel CO_(2) Radiocarbon measurements

Extent of mismatch between the period of circadian clocks and light/dark cycles determines time-to-emergence in fruit flies

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Insect Science 2015年第4期22卷 569-577页

作者： pankaj Yadav Deepak Choudhury Madhumala K. Sadanandappa Vijay Kumar sharma Chronobiology Laboratory Evolutionary and Organismal Biology Unit Jawaharlal Nehru Centre for Advanced Scientific Research Bangalore 560064 Kamataka India

Circadian clocks time developmental stages of fruit flies Drosophila melanogaster, while light/dark （LD） cycles delimit emergence of adults, conceding only during the ＂allowed gate.＂ Previous studies have revealed that time-to-emergence can be altered by mutations in the core clock gene period （per）, or by altering the length of LD cycles. Since this evidence came from studies on genetically manipulated flies, or on flies maintained under LD cycles with limited range of periods, inferences that can be drawn are limited. Moreover, the extent of shortening or lengthening of time-to-emergence re- mains yet unknown. In order to pursue this further, we assayed time-to-emergence of D. rnelanogaster under 12 different LD cycles as well as in constant light （LL） and constant dark conditions （DD）. Time-to-emergence in flies occurred earlier under LL than in LD cycles and DD. Among the LD cycles, time-to-emergence occurred earlier under T4-T8, followed by T36-T48, and then T12-T32, suggesting that egg-to-emergence duration in flies becomes shorter when the length of LD cycles deviates from 24 h, bearing a strong positive and a marginally negative correlation with day length, for values shorter and longer than 24 h, respectively. These results suggest that the extent of mismatch between the period of circadian clocks and environmental cycles determines the time-to-emergence in Drosophila.

关键词： circadian Drosophila light/dark regimes period time-to-emergence

Preoperative therapy in locally advanced esophageal cancer

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World Journal of Gastroenterology 2016年第39期22卷 8750-8759页

作者： pankaj Kumar Garg Jyoti sharma Ashish Jakhetiya Aakanksha Goel Manish Kumar Gaur Department of Surgery University College of Medical Sciences and Guru Teg Bahadur Hospital University of Delhi Department of Surgical Oncology Sawai Man Singh Medical College Department of Surgical Oncology Dr BRA Institute Rotary Cancer Hospital All India Institute of Medical Sciences

Esophageal cancer is an aggressive malignancy associated with dismal treatment outcomes. Presence of two distinct histopathological types distinguishes it from other gastrointestinal tract malignancies. Surgery is the cornerstone of treatment in locally advanced esophageal cancer(T2 or greater or node positive); however, a high rate of disease recurrence(systemic and loco-regional) and poor survival justifies a continued search for optimal therapy. Various combinations of multimodality treatment(preoperative/perioperative, or postoperative; radiotherapy, chemotherapy, or chemoradiotherapy) are being explored to lower disease recurrence and improve survival. Preoperative therapy followed by surgery is presently considered the standard of care in resectable locally advanced esophageal cancer as postoperative treatment may not be feasible for all the patients due to the morbidity of esophagectomy and prolonged recovery time limiting the tolerance of patient. There are wide variations in the preoperative therapy practiced across the centres depending upon the institutional practices, availability of facilities and personal experiences. There is paucity of literature to standardize the preoperative therapy. Broadly, chemoradiotherapy is the preferred neo-adjuvant modality in western countries whereas chemotherapy alone is considered optimal in the far East. The present review highlights the significant studies to assist in opting for the best evidence based preoperative therapy(radiotherapy, chemotherapy or chemoradiotherapy) for locally advanced esophageal cancer.

关键词： Esophageal cancer Preoperative therapy Multimodality treatment Chemotherapy Radiotherapy Chemoradiotherapy

Petrology and Sr-Nd isotope systematics of the Ahobil kimberlite(Pipe-16)from the Wajrakarur field, Eastern Dharwar craton, southern India

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Geoscience Frontiers 2019年第3期10卷 1167-1186页

作者： Abhinay sharma Alok Kumar Praveer pankaj Dinesh Pandit Ramananda Chakrabarti N.V.Chalapathi Rao EPMA and SEM Laboratories Department of Geology Banaras Hindu University Centre for Earth Sciences Indian Institute of Science

Detailed mineralogical, bulk-rock geochemical and Sr-Nd isotopic data for the recently discovered Ahobil kimberlite(Pipe-16) from the Wajrakarur kimberlite field(WKF), Eastern Dharwar craton(EDC),southern India, are presented. Two generations of compositionally distinct olivine, Ti-poor phlogopite showing orangeitic evolutionary trends, spinel displaying magmatic trend-1, abundant perovskite, Tirich hydrogarnet, calcite and serpentine are the various mineral constituents. On the basis of(i) liquidus mineral composition,(ii) bulk-rock chemistry, and(iii) Sr-Nd isotopic composition, we show that Ahobil kimberlite shares several characteristic features of archetypal kimberlites than orangeites and lamproites. Geochemical modelling indicate Ahobil kimberlite magma derivation from small-degree melting of a carbonated peridotite source having higher Gd/Yb and lower La/Sm in contrast to those of orangeites from the Eastern Dharwar and Bastar cratons of Indian shield. The T_(Dm) Nd model age(～2.0 Ga) of the Ahobil kimberlite is(i) significantly older than those(1.5～1.3 Ga) reported for Wajrakarur and Narayanpet kimberlites of EDC,(ii) indistinguishable from those of the Mesoproterozoic EDC lamproites,and(iii) strikingly coincides with the timing of the amalgamation of the Columbia supercontinent. High bulk-rock Fe-Ti contents and wide variation in oxygen fugacity fO_2, as inferred from perovskite oxybarometry, suggest non-prospective nature of the Ahobil kimberlite for diamond.

关键词： Petrology Isotopes Kimberlite Wajrakarur Dharwar craton India

Giant exophytic renal angiomyolipoma masquerading as a retroperitoneal liposarcoma: A case report and review of literature

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World Journal of Clinical Oncology 2018年第7期9卷 162-166页

作者： Gopal sharma Ayush Jain Prerit sharma Sonal sharma Vinita Rathi pankaj Kumar Garg Department of Surgery University College of Medical Sciences and Guru Teg Bahadur Hospital University of Delhi Department of Pathology University College of Medical Sciences and Guru Teg Bahadur Hospital University of Delhi Department of Radiology University College of Medical Sciences and Guru Teg Bahadur Hospital University of Delhi

A 42-years-old lady, presented with a large retroperitoneal mass which was preoperatively diagnosed as a retroperitoneal liposarcoma following an image guided core biopsy. She underwent a margin-negative resection of the retroperitoneal mass(multi visceral resection-enbloc excision of the retroperitoneal mass with a left nephrectomy and a segmental descending colectomy). The final histopathological examination of the resected specimen confirmed an exophytic renal angiomyolipoma(AML) which was extending into the retroperitoneum. AML is a rare benign tumor arising most commonly from the kidney. It can sometimes present as a diagnostic challenge as it mimics a retroperitoneal liposarcoma or a fat-containing renal cell carcinomas closely. We present this case to share our experience of managing a case of giant exophytic AML which resembled retroperitoneal liposarcoma closely and resulted into an aggressive surgery.

关键词： Angiomyolipoma Retroperitoneum Liposarcoma Diagnosis Biopsy

Assessment of reproductive health service utilization in urban slums: Evidence from Western Rajasthan

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Asian pacific Journal of Reproduction 2023年第2期12卷 52-57页

作者： Jyoti sharma Nitin Kumar Joshi Yogesh Kumar Jain Kuldeep Singh pankaj Bhardwaj School of Public Health All India Institute of Medical SciencesJodhpurIndia Department of Community Medicine and Family Medicine and School of Public Health All India Institute of Medical SciencesJodhpurIndia

Objective:To assess the utilization of reproductive health services in urban slum of Jodhpur city,***:A community based cross-sectional study was conducted in an urban slums of Jodhpur city amongst 300 married women of reproductive age between March and June ***-structured questionnaire was used to gather demographic data and information about utilization of antenatal care(ANC)services,delivery and post-partum ***:The majority of females were aged less than 25 years(n=195;65.0%),married after 18 years(n=240;80%),living in extended families(n=265;88.3%)and with monthly family income less than 10000 rupees(n=182;60.7%).Statistically significant associations were found between≥4 ANC visits and educational level of secondary and above(OR 2.47,95%CI 1.03–6.28;P=0.04),older age(OR 15.70,95%CI 14.87–16.54 for women aged 26-35 years,OR 16.14,95%CI 12.12–20.01 for women aged≥36 years;P<0.01),and backward and general castes(OR 15.91,95%CI 13.57–17.85 for backward caste and OR 8.11,95%CI 8.07–8.26 for general category of caste;P<0.01).Seven percent of females had undergone *** age was associated with higher risks of postpartum complications(OR 1.06,95%CI 1.01–1.57 for women aged 26-35 years,OR 3.56,95%CI 1.29–4.69 for women aged≥36 years;P<0.01).In addition,risks of postpartum complications were associated with backward and general castes(OR 1.69,95%CI 1.34–2.13 for backward classes and OR 5.01,95%CI 4.29–5.31 for general category castes;P<0.01),and more than 4 ANC visits(OR 0.20,95%CI 0.09–0.34;P<0.01).Conclusions:More frequent ANC visits are associated with a lower risk of postpartum ***,a high utilization of reproductive health services represents good implementation of reproductive and child health programme at the peripheral level resulting in a stark rise in maternal health indicators in the state of Rajasthan.

关键词： Female Pregnancy Maternal health Maternal health services Prenatal care Postpartum period Facilities and services utilization Health services accessibility