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Effect of nocturia in patients with different severity of obstructive sleep apnea on polysomnography: A retrospective observational study

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Asian Journal of Urology 2024年第3期11卷 486-496页

作者： Chin-Heng Lu Hung-Min Chang Kuang-Hsi Chang Yen-Chuan Ou Chao-Yu Hsu Min-Che Tung Frank Cheau-Feng Lin Stella Chin-shaw Tsai Division of Urology Department of SurgeryTungs’Taichung Metroharbor HospitalTaichungTaiwanChina Rong Hsing Research Center for Translational Medicine Chung Hsing UniversityTaichungTaiwanChina College of Life Sciences Chung Hsing UniversityTaichungTaiwanChina Department of Otolaryngology Tungs’Taichung Metroharbor HospitalTaichungTaiwanChina Department of Medical Research Tungs’Taichung Metroharbor HospitalTaichungTaiwanChina General Education Center Jen-Teh Junior College of MedicineNursing and ManagementMiaoliTaiwanChina Graduate Institute of Biomedical Sciences China Medical UniversityTaichungTaiwanChina Department of Post-Baccalaureate Medicine College of MedicineChung Hsing UniversityTaichungTaiwanChina Department of Nursing Jen-Teh Junior College of MedicineNursing and ManagementMiaoliTaiwanChina Department of Surgery Chung Shan Medical UniversityTaichungTaiwanChina College of Medicine Chung Shan Medical UniversityTaichungTaiwanChina

Patients with suspected OSA were examined using *** were divided into two groups based on the presence of *** was defined as a patient who needed to void at least *** index(AHI)was employed to classify patients according to degrees of severity:AHI<5 events/h,5 events/hAHI<15 events/h,15 events/hAHI<30 events/h,and AHI30 events/h,defined as normal,mild OSA,moderate OSA,and severe OSA,*** variables,PSG parameters,International Prostate Symptom Scores(IPSSs),and quality of life scores due to urinary symptoms were ***:In total 140 patients,114 patients had OSA(48 had mild OSA;34 had moderate OSA;and 32 had severe OSA)and 107 patients had *** total IPSS was significantly higher in nocturia patients in all groups except the group of severe OSA *** the increasing severity of OSA,more correlated factors related to nocturia were *** mild OSA patients,nocturia related to increased age(p=0.025),minimum arterial blood oxygenation saturation(p=0.046),and decreased AHI of non-rapid eye movement(p=0.047),AHI of total sleep time(p=0.010),and desaturation index(p=0.012).In moderate OSA patients,nocturia related to increased age(p<0.001),awake time(p=0.025),stage 1 sleep(p=0.033),and sleep latency(p=0.033),and decreased height(p=0.044),weight(p=0.025),and sleep efficiency(p=0.003).In severe OSA patients,nocturia related to increased weight(p=0.011),body mass index(p=0.009),awake time(p=0.008),stage 1 sleep(p=0.040),arousal number(p=0.030),arousal index(p=0.013),periodic limb movement number(p=0.013),and periodic limb movement index(p=0.004),and decreased baseline arterial blood oxygenation saturation(p=0.046).Conclusion:Our study revealed that there were more correlated factors related to nocturia with increasing severity of *** study helps in clinical education and treatment for OSA patients with different severity.

关键词： Nocturia Obstructive sleep apnea Polysomnography Apneaehypopnea index International Prostate Symptom Score

Female Infertility and Obesity across the United States—A Geographic Cross-Sectional Analysis

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Advances in Reproductive Sciences 2024年第3期12卷 179-189页

作者： Raegan Abadie Emily M. Dantes Jennifer H. shaw Dani Zoorob Health Sciences Center in Shreveport Louisiana State University Shreveport LA USA Department of Biomedical Sciences Philadelphia College of Osteopathic Medicine South Georgia Moultrie GA USA Health Sciences Center in Shreveport Department of Obstetrics and Gynecology Louisiana State University Shreveport LA USA

This cross-sectional study investigates a connection between female infertility and obesity across various regions of the United States, utilizing data from the NIH’s “All of Us” Researcher Workbench. Analysis suggested that the Southern region exhibited the highest percentage of concurrently infertile and obese females at 32.3%, in contrast to the lowest in the Western region at 28.7%. The findings underscore the significant regional disparities in obesity-related infertility, particularly in medically underserved areas where healthcare access is limited. The study highlights the urgent need for targeted public health interventions, particularly in the Southern United States, to address the rising prevalence of obesity and its impact on infertility. Further, these results advocate for enhanced public health education and policies aimed at improving healthcare accessibility, with the goal of mitigating the adverse effects of obesity on reproductive health.

关键词： Female Infertility Medical Deserts Obesity South

Vonoprazan 10 mg or 20 mg *** 15 mg as maintenance therapy in Asian patients with healed erosive esophagitis:A randomized controlled trial

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Chinese Medical Journal 2024年第8期137卷 962-971页

作者： Yinglian Xiao Jiaming Qian Shutian Zhang Ning Dai Hoon Jai Chun Chengtang Chiu chui Fung Chong Nobuo Funao Yuuichi Sakurai Jessica D.Eisner Li Xie Minhu Chen Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510062China Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100006China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Gastroenterology Sir Run Run Shaw HospitalSchool of Medicine Zhejiang UniversityHangzhouZhejiang 310020China Department of Internal Medicine Korea University Anam HospitalKorea University College of Medicine73 Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea Department of Gastroenterology&Hepatology Linkou Medical CenterChang Gung Memorial HospitalTaoyuanTaiwan 33353China College of Medicine Chang Gung UniversityTaoyuanTaiwan 33353China Takeda Development Center Asia Singapore 018981Singapore Takeda Pharmaceutical Company Chuo-kuOsaka 540-8645Japan Takeda Pharmaceuticals International Company CambridgeMA02142 USA China Medical Team Takeda ChinaBeijing 100027China Hoffmann-La Roche Basel4070 Switzerland Abbott Laboratories Lake ForestIL 60045USA

Background:Erosive esophagitis(EE)is a gastroesophageal reflux disease characterized by mucosal breaks in the *** pump inhibitors are widely used as maintenance therapy for EE,but many patients still *** this trial,we evaluated the noninferiority of vonoprazan *** as maintenance therapy in patients with healed ***:We performed a double-blind,double-dummy,multicenter,phase 3 clinical trial among non-Japanese Asian adults with endoscopically confirmed healed EE from April 2015 to February *** from China,South Korea,and Malaysia were randomized to vonoprazan 10 mg or 20 mg once daily or lansoprazole 15 mg once daily for 24 *** primary endpoint was endoscopically confirmed EE recurrence rate over 24 weeks with a noninferiority margin of 10%using a two-sided 95%confidence interval(CI).Treatment-emergent adverse events(TEAEs)were ***:Among 703 patients,EE recurrence was observed in 24/181(13.3%)and 21/171(12.3%)patients receiving vonoprazan 10 mg or 20 mg,respectively,and 47/184(25.5%)patients receiving lansoprazole(differences:-12.3%[95%CI,-20.3%to-4.3%]and-13.3%[95%CI,-21.3%to-5.3%],respectively),meeting the primary endpoint of noninferiority to lansoprazole in preventing EE recurrence at 24 *** of superiority(upper bound of 95%CI<0%)was also *** 12 weeks,endoscopically confirmed EE recurrence was observed in 5/18,2/20,and 7/20 of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** were experienced by 66.8%(157/235),69.0%(156/226),and 65.3%(158/242)of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** most common TEAE was upper respiratory tract infection in 12.8%(30/235)and 12.8%(29/226)patients in vonoprazan 10 mg and 20 mg groups,respectively and 8.7%(21/242)patients in lansoprazole ***:Vonoprazan maintenance therapy was well-tolerated and noninferior to lansoprazole for preventing EE recurrence i

关键词： Erosive esophagitis Lansoprazole Maintenance therapy Potassium-competitive acid blockers Vonoprazan

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工党胜选

财新周刊 2024年第27期 12-13页

作者： David shaw(图) 无不详 IC PHOTO

当地时间2024年7月4日,英国伦敦,英国广播公司屏幕上显示的大选出口民调。当日夜间,英国议会大选的投票全部结束。出口民调显示,在英国议会下院的650个席位中,工党最终斩获的席位或将多达410席,从而使其以约170席的优势取得压倒性的多... 详细信息

当地时间2024年7月4日,英国伦敦,英国广播公司屏幕上显示的大选出口民调。当日夜间,英国议会大选的投票全部结束。出口民调显示,在英国议会下院的650个席位中,工党最终斩获的席位或将多达410席,从而使其以约170席的优势取得压倒性的多数地位。保守党获131席。这是时隔14年后,工党再次成为英国执政党。按照规定,英国首相苏纳克5日将向国王查尔斯三世递交辞呈,获得批准后卸任首相一职。从四年前开始担任工党党魁、现年61岁的吉尔斯塔默将获国王任命成为新一任英国首相并负责组阁。

关键词：英国议会英国广播公司工党英国首相保守党大选胜选压倒性

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好莱坞难以开启增长和繁荣新时代

商业周刊（中文版） 2024年第2期 8-9页

作者： Lucas shaw 竹西(译) 不详

2023年的罢工使好莱坞电影公司关闭了大部分时间,但这并没有让娱乐业重新调整。它们暴露了该行业最大的弱点:这桩生意已经不行了。有线电视正在流失数以百万计的观众和数以十亿计的广告销售额。电影业仍未从疫情打击中恢复过来。

关键词：好莱坞电影娱乐业电影业有线电视销售额

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用天花粉蛋白基因转化小麦获得转基因植株

遗传 2001年第2期23卷 135-137页

作者：徐琼芳李连城马有志叶兴国李晓兵杜丽璞辛志勇张增艳邵鹏柱中国农业科学院作物育种栽培研究所中国科学院遗传研究所北京100101 香港中文大学生物系

取普通小麦品种京411未成熟胚诱导愈伤组织，10天左右，对820个胚性愈伤组织用含有35S启动子的天花粉蛋白（trichosanthin, TCS）基因轰击。2周后，将这些被轰击的愈伤组织转到含潮霉素50mg/L的筛选培养基上，经分化和生根，获得了33棵... 详细信息

取普通小麦品种京411未成熟胚诱导愈伤组织，10天左右，对820个胚性愈伤组织用含有35S启动子的天花粉蛋白（trichosanthin, TCS）基因轰击。2周后，将这些被轰击的愈伤组织转到含潮霉素50mg/L的筛选培养基上，经分化和生根，获得了33棵再生植株，经接饲毒蚜虫抗病性鉴定和PCR、Southern杂交分析，从中筛选出4株含有编码TCS的转基因小麦植株。转化频率为0.49%。

关键词：转基因小麦 TCS基因转化基因枪天花粉蛋白基因

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防范地缘风险华尔街引入情报人员

商业周刊（中文版） 2024年第3期 20-22页

作者： William shaw Silla Brush Sonali Basak 王非(译) 不详

2023年10月7日破晓时分,杰米·米西克(Jami Miscik)在加利福尼亚州的家中醒过来,打开iPad,看到了令人震惊的消息:哈马斯袭击以色列。这位美国中央情报局(Central Intelligence Agency,简称:CIA)前资深雇员马上打电话叫醒了两位同僚——... 详细信息

2023年10月7日破晓时分,杰米·米西克(Jami Miscik)在加利福尼亚州的家中醒过来,打开iPad,看到了令人震惊的消息:哈马斯袭击以色列。这位美国中央情报局(Central Intelligence Agency,简称:CIA)前资深雇员马上打电话叫醒了两位同僚——一位是美国中央司令部前司令,另一位是前美国海军上将,并迅速就不断升级的危机做出反应,围绕以色列的潜在反应及其可能产生的广泛影响进行了多种情境推演。

关键词：美国中央情报局哈马斯情报人员海军上将加利福尼亚州破晓时分华尔街

CONCISE REPRESENTATIONS FOR ASSOCIATION RULES IN MULTI-LEVEL DATASETS

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Journal of Systems Science and Systems Engineering 2009年第1期18卷 53-70页

作者： Gavin shaw School of Inforrnation Technology Queensland University of TechnologyBrisbane4001Australia

Association rule mining plays an important role in knowledge and information discovery. Often for a dataset, a huge number of rules can be extracted, but many of them are redundant, especially in the case of multi-level datasets. Mining non-redundant rules is a promising approach to solve this problem. However, existing work （Pasquier et al. 2005, Xu ＆ Li 2007） is only focused on single level datasets. In this paper, we firstly present a definition for redundancy and a concise representation called Reliable basis for representing non-redundant association rules, then we propose an extension to the previous work that can remove hierarchically redundant rules from multi-level datasets. We also show that the resulting concise representation of non-redundant association rules is lossless since all association rules can be derived from the representation. Experiments show that our extension can effectively generate multilevel non-redundant rules.

关键词： Association rule mining redundant association rules closed itemsets multi-level datasets

Thirty Years of Science,Technology,and Academia in Disaster Risk Reduction and Emerging Responsibilities

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International Journal of Disaster Risk Science 2020年第4期11卷 414-425页

作者： Rajib shaw Graduate School of Media and Governance Keio UniversityFujisawa 252-0882Japan

The 1990 initiation of the International Decade for Natural Disaster Reduction marked its 30th year in *** three decades since then have seen significant developments in science and technology and their incorporation into the decision making in the field of disaster risk *** disasters that have occurred during that time have enhanced the importance of the field,and new research and innovations have *** article summarizes this evolution through the review of specific *** the Sendai Framework for Disaster Risk Reduction 2015–2030 provides opportunities for synergies with the sustainable development agenda,the science and technology communities have also changed their roles from advisory to co-designing and co-delivering *** education plays an important role in developing new generations of professionals,and the role of thematic incubation in higher education institutions is highlighted along with the development of the professional society in disaster risk *** evolution from Society 4.0(information age)to Society 5.0 will see an enhanced role of the technology-driven approach in disaster risk reduction,while traditional knowledge and indigenous technologies still remain valid for *** and science communities need to be more sensitive to changing the“last mile”concept to“first mile”thinking with respect to the users’needs and perspectives.

关键词： Co-design solutions in disaster risk reduction Professional society Science and technology in disaster risk reduction Society 5.0