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Pyogenic liver abscess:An audit of 10 years’experience

World Journal of Gastroenterology 2011年第12期17卷 1622-1630页

作者： Tony cy pang Thomas Fung Jaswinder Samra Thomas J Hugh Ross C Smith Upper Gastrointestinal Surgical Unit Royal North Shore HospitalUniversity of SydneySt Leonards NSW 2065Australia

AIM:To describe our own experience with pyogenic liver abscesses over the past 10 years and investigate the risk factors associated with failure of initial percutaneous ***:A retrospective study of records of 63 PLA patients presenting between 1998 and 2008 to Australian tertiary referral centre,were *** and hydatid abscesses were ***,clinical,radiological,and microbiological characteristics,as well as surgical/radiological interventions,were ***:Sixty-three patients(42 males,21 females) aged 65(±14) years[mean±(SD) ]had prodromal symptoms for a median(interquartile range;IQR) of 7(5-14) *** 59%of patients were febrile at presentation;however,the serum C-reactive protein was elevated in all 47 in whom it was *** function tests were non-specifically abnormal.67%of patients had a solitary abscess,while 32%had>3 abscesses with a median(IQR) diameter of 6.3(4-9) *** organisms were:Streptococcus milleri 25%,Klebsiella pneumoniae 21%,and Escherichia coli 16%.A presumptive cryptogenic cause was most common (34%).Four patients died in this series:one from sepsis,two from advanced cancer,and one from acute myocardial *** initial procedure was radiological aspiration±drainage in 54 and surgery in two patients.17%underwent surgical management during their *** hypoalbuminaemia[mean (95%CI) :32(29-35) g/L vs 28(25-31) g/L,P=0.045] on presentation was found to be the only factor related to failure of initial percutaneous therapy on univariate ***:PLA is a diagnostic challenge,because the presentation of this condition is *** antibiotics and radiological drainage in the first instance allows resolution of most PLAs;However,a small proportion of patients still require surgical drainage.

关键词： Pyogenic liver abscess Image guided drainage Surgical drainage C-reactive protein Hypoalbuminaemia

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Data-driven Surrogate-assisted Method for High-dimensional Multi-area Combined Economic/Emission Dispatch

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 52-64页

作者： Chenhao Lin Huijun Liang Aokang pang Jianwei Zhong Yongchao Yang the College of Intelligent Systems Science and Engineering Hubei Minzu UniversityEnshiChina

Multi-area combined economic/emission dispatch(MACEED)problems are generally studied using analytical ***,as the scale of power systems increases,ex isting solutions become time-consuming and may not meet oper ational *** overcome excessive computational ex pense in high-dimensional MACEED problems,a novel data-driven surrogate-assisted method is ***,a cosine-similarity-based deep belief network combined with a back-propagation(DBN+BP)neural network is utilized to replace cost and emission ***,transfer learning is applied with a pretraining and fine-tuning method to improve DBN+BP regression surrogate models,thus realizing fast con struction of surrogate models between different regional power ***,a multi-objective antlion optimizer with a novel general single-dimension retention bi-objective optimization poli cy is proposed to execute MACEED optimization to obtain scheduling *** proposed method not only ensures the convergence,uniformity,and extensibility of the Pareto front,but also greatly reduces the computational ***,a 4-ar ea 40-unit test system with different constraints is employed to demonstrate the effectiveness of the proposed method.

关键词： Multi-area combined economic/emission dispatch high-dimensional power system deep belief network data driven transfer learning

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猪臀部游离与岛状皮瓣继发性缺血耐受时间的比较

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中华烧伤杂志 1998年第1期 9-12页

作者：赫伟章建荣 pang cy 加拿大多伦多大学儿童医院研究所北京100041 中国医学科学院中国协和医科大学整形外科医院

目的观测猪臀部游离与岛状皮瓣继发性缺血耐受时间。方法臀部岛状皮瓣与游离皮瓣2小时原发性热缺血,12小时再灌注,0、2、4、6、10小时继发性热缺血,7天后测定皮瓣存活率。结果岛状皮瓣可耐受10小时继发性缺血,无皮瓣坏死。游离皮瓣坏死... 详细信息

目的观测猪臀部游离与岛状皮瓣继发性缺血耐受时间。方法臀部岛状皮瓣与游离皮瓣2小时原发性热缺血,12小时再灌注,0、2、4、6、10小时继发性热缺血,7天后测定皮瓣存活率。结果岛状皮瓣可耐受10小时继发性缺血,无皮瓣坏死。游离皮瓣坏死发生率依继发性缺血时间0、2、4、6、10小时为0、10％、50％、80％、100％。另一组实验中,用15μm 微球测量两种皮瓣4小时继发性缺血后皮瓣血流,8个血运障碍的游离皮瓣为对侧岛状皮瓣的8％,其余12个血运正常的游离皮瓣是岛状皮瓣的76％。结论猪臀部游离皮瓣的继发性缺血耐受时暗短于岛状皮瓣,与皮瓣低血流相关。

关键词：显微外科缺血耐受时间微球测量皮瓣

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腺苷促进猪横行腹直肌肌皮瓣成活的实验研究

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中华整形烧伤外科杂志 1999年第6期15卷 444-446页

作者：赫伟章建荣钟安国 pang cy 中国医学科学院中国协和医科大学整形外科医院北京100041 中国医学科学院中国协和医科大学整形外科医院北京100041 加拿大多伦多大学儿童医院研究所

目的研究腺苷对猪横行腹直肌肌皮瓣成活率的影响。方法横行腹直肌肌皮瓣以左侧腹壁下动脉为供血血管,肌蒂宽6cm,皮瓣面积8cm×30cm。20头猪分为生理盐水对照组和1mg、2mg、5mg 腺苷注射实验组,掀起皮瓣前从腹壁上动脉注射不同剂量的腺... 详细信息

目的研究腺苷对猪横行腹直肌肌皮瓣成活率的影响。方法横行腹直肌肌皮瓣以左侧腹壁下动脉为供血血管,肌蒂宽6cm,皮瓣面积8cm×30cm。20头猪分为生理盐水对照组和1mg、2mg、5mg 腺苷注射实验组,掀起皮瓣前从腹壁上动脉注射不同剂量的腺苷和生理盐水。术后7天注射荧光素,以模片法记录腹直肌同侧皮瓣、对侧皮瓣和整个皮瓣的成活率。结果 2mg 和5mg 腺苷注射组,肌皮瓣成活率明显高于生理盐水对照组(P<0.05)。结论小剂量术中局部使用腺苷可增加猪横行腹直肌肌皮瓣成活率。

关键词：腺苷横行腹直肌骨皮瓣成活率实验

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术中预缺血对猪骨骼肌保护作用的实验研究

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中华整形烧伤外科杂志 1999年第5期15卷 348-350页

作者：赫伟章建荣钟安国 pang cy 北京中国医学科学院中国协和医科大学整形外科医院 100041 加拿大多伦多大学儿童医院研究所

目的研究术中预缺血对骨骼肌缺血坏死的保护作用及相关的肌肉代谢变化。方法 10只猪背阔肌瓣在4h 缺血前先进行3个循环10min 的术中预缺血,48h 后用染色法记录肌肉成活率,于肌肉缺血前、缺血后2,4h 和再灌流1.5h 分别作肌肉活检。结果 ... 详细信息

目的研究术中预缺血对骨骼肌缺血坏死的保护作用及相关的肌肉代谢变化。方法 10只猪背阔肌瓣在4h 缺血前先进行3个循环10min 的术中预缺血,48h 后用染色法记录肌肉成活率,于肌肉缺血前、缺血后2,4h 和再灌流1.5h 分别作肌肉活检。结果 4h 缺血后的肌瓣,术中预缺血组成活率高出对照组44％,肌肉活检三磷酸腺苷(ATP)增加和乳酸降低(P<0.05)。结论术中预缺血可增加骨骼肌对缺血坏死的保护作用,这与肌肉中能量代谢的减低相关。

关键词：骨骼肌术中预缺血缺血坏死保护实验

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术中预缺血对猪骨骼肌保护作用的实验研究

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中华烧伤杂志 1999年第5期 348-350页

作者：赫伟章建荣钟安国 pang cy 加拿大多伦多大学儿童医院研究所 100041 北京中国医学科学院中国协和医科大学整形外科医院

关键词：骨骼肌术中预缺血缺血坏死

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腺苷促进猪横行腹直肌肌皮瓣成活的实验研究

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中华烧伤杂志 1999年第6期 444-446页

作者：赫伟章建荣钟安国 pang cy 中国医学科学院中国协和医科大学整形外科医院加拿大多伦多大学儿童医院研究所 100041北京

关键词：腺苷横行腹直肌肌皮瓣成活率

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猪臀部游离与岛状皮瓣继发性缺血耐受时间的比较

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中华整形烧伤外科杂志 1998年第1期14卷 9-12页

作者：赫伟章建荣 pang cy 中国医学科学院中国协和医科大学整形外科医院北京100041 加拿大多伦多大学儿童医院研究所

关键词：显微外科缺血耐受时间微球皮瓣

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Genomic characterization of peritoneal lavage cytology-positive gastric cancer

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Chinese Journal of Cancer Research 2024年第1期36卷 66-77页

作者： Zhouqiao Wu Tingfei Gu Changxian Xiong Jinyao Shi Jingpu Wang Ting Guo Xiaofang Xing Fei pang Ning He Rulin Miao Fei Shan Yuan Zhou Ziyu Li Jiafu Ji Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Gastrointestinal Cancer CenterPeking University Cancer Hospital&InstituteBeijing 100142China Department of Biomedical Informatics Department of Physiology and PathophysiologyCenter for Noncoding RNA MedicineMOE Key Lab of Cardiovascular SciencesSchool of Basic Medical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchGastrointestinal Cancer CenterPeking University Cancer Hospital&InstituteBeijing 100142China

Objective: Positive peritoneal lavege cytology(cy1) gastric cancer is featured by dismal prognosis, with high risks of peritoneal metastasis. However, there is a lack of evidence on pathogenic mechanism and signature of cy1and there is a continuous debate on cy1 therapy. Therefore, exploring the mechanism of cy1 is crucial for treatment strategies and targets for cy1 gastric ***: In order to figure out specific driver genes and marker genes of cy1 gastric cancer, and ultimately offer clues for potential marker and risk assessment of cy1, 17 cytology-positive gastric cancer patients and 31matched cytology-negative gastric cancer patients were enrolled in this study. The enrollment criteria were based on the results of diagnostic laparoscopy staging and cytology inspection of exfoliated cells. Whole exome sequencing was then performed on tumor samples to evaluate genomic characterization of cytology-positive gastric ***: Least absolute shrinkage and selection operator(LASSO) algorithm identified 43 cytology-positive marker genes, while Mut Sig CV identified 42 cytology-positive specific driver genes. CD3G and CDKL2 were both driver and marker genes of cy1. Regarding mutational signatures, driver gene mutation and tumor subclone architecture, no significant differences were observed between cy1 and negative peritoneal lavege cytology(cy0).Conclusions: There might not be distinct differences between cy1 and cy0, and cy1 might represent the progression of cy0 gastric cancer rather than constituting an independent subtype. This genomic analysis will thus provide key molecular insights into cy1, which may have a direct effect on treatment recommendations for cy1and cy0 patients, and provides opportunities for genome-guided clinical trials and drug development.

关键词： cytology gastric carcinoma peritoneal metastasis whole exome sequencing

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Surgical management of hepatocellular carcinoma

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World Journal of Hepatology 2015年第2期7卷 245-252页

作者： Tony cy pang Vincent WT Lam Department of Surgery Westmead Hospital Western Clinical School Sydney Medical School University of Sydney

Hepatocellular carcinoma(HCC) is the second most common cause of death from cancer worldwide. Standard potentially curative treatments are either resection or transplantation. The aim of this paper is to provide an overview of the surgical management of HCC, as well as highlight current issues in hepatic resection and transplantation. In summary, due to the relationship between HCC and chronic liver disease, the management of HCC depends both on tumourrelated and hepatic function-related considerations. As such, HCC is currently managed largely through nonsurgical means as the criteria, in relation to the above considerations, for surgical management is still largelyrestrictive. For early stage tumours, both resection and transplantation offer fairly good survival outcomes(5 years overall survival of around 50%). Selection therefore would depend on the level of hepatic function derangement, organ availability and local expertise. Patients with intermediate stage cancers have limited options, with resection being the only potential for cure. Otherwise, locoregional therapy with transarterial chemoembolization or radiofrequency ablation are viable options. Current issues in resection and transplantation are also briefly discussed such as laparoscopic resection, ablation vs resection, anatomical vs non-anatomical resection, transplantation vs resection, living donor liver transplantation and salvage liver transplantation.

关键词： Hepatocellular carcinoma Liver surgery Liver resection Liver transplantation Laparoscopic liversurgery

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