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和谐话语分析理论视角下的语篇分析

外国语文 2023年第6期39卷 84-90页

作者：庞亚飞佛山科学技术学院人文与教育学院广东佛山528000

本文在和谐话语分析视角下对一个与动物有关的语篇进行生态话语分析,聚焦的是和谐话语分析中“以人为本”假定以及“良知原则”“亲近原则”和“制约原则”,所要回答的研究问题是“如何通过和谐话语分析揭示人与动物之间的关系”。本文... 详细信息

本文在和谐话语分析视角下对一个与动物有关的语篇进行生态话语分析,聚焦的是和谐话语分析中“以人为本”假定以及“良知原则”“亲近原则”和“制约原则”,所要回答的研究问题是“如何通过和谐话语分析揭示人与动物之间的关系”。本文的语料是刊登在《中国日报》的英文语篇,所得出的结论是:语言构建和塑造了人与动物之间的关系,和谐话语分析可以揭示人与自然和谐共生中的各种关系。

关键词：和谐话语分析以人为本良知原则亲近原则制约原则

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心脏建模研究现状及发展趋势

中国医疗器械杂志 2011年第1期35卷 58-63页

作者：庞亚飞杨明上海交通大学仪器系上海200240

心脏建模对于心脏疾病的诊断和治疗具有重要意义。随着生物医学技术、材料及计算机科学的发展,心脏建模仿真在心脏数据的获取、建模方法的研究以及临床应用方面提出了新的要求。该文从几何/解剖学、电生理学和机械动力学角度对心脏模型... 详细信息

心脏建模对于心脏疾病的诊断和治疗具有重要意义。随着生物医学技术、材料及计算机科学的发展,心脏建模仿真在心脏数据的获取、建模方法的研究以及临床应用方面提出了新的要求。该文从几何/解剖学、电生理学和机械动力学角度对心脏模型进行了介绍,并综合分析了心脏建模中存在的问题及今后的发展趋势。

关键词：心脏建模心脏几何/解剖学模型心脏电生理模型心脏机械动力学模型

Genetic insights into adaptation of alfalfa

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Molecular Plant 2024年第8期17卷 1170-1171页

作者： yafei Guo Lipeng Kang Fei Lu State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijingChina Key Laboratory of Seed Innovation Institute of Genetics and Developmental BiologyChineseAcademyof SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina CAS-JIC Centre of Excellence for Plant and Microbial Science(CEPAMS) Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijingChina

Climate change is increasingly affecting agricultural outputs,as evidenced by the changing global temperature and extreme weather events that significantly impact crop yields(Lesk et al.,2016).To address this challenge,there is a growing interest in developing crops that can endure these adverse conditions to ensure food *** examples in nature show how crops have adapted to diverse environments(Gutaker and Purugganan,2023),leaving behind a rich genomic *** genomics has started to provide insights into these adaptive processes from evolutionary and genetic perspectives(Savolainen et al.,2013;Aguirre-Liguori et al.,2021;Sang et al.,2022).Recently,Zhang et al.(Zhang et al.,2024)investigated alfalfa(Medicago sativa ***),known as the"queen of forages,"for its broad *** analyzing whole-genome sequencing data of 702 accessions from 24 Medicago species,this study enriches our understanding of how to develop crops and meet the challenges of climate change.

关键词： sativa) crops environments

C_(60) as a metal-free catalyst for lithium-oxygen batteries

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Nano Research 2024年第5期17卷 3982-3987页

作者： Xinxin Zhang Jiaming Tian Yu Wang Shaohua Guo yafei Li Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials School of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China College of Engineering and Applied Sciences Jiangsu Key Laboratory of Artificial Functional MaterialsNational Laboratory of Solid State MicrostructuresCollaborative Innovation Center of Advanced MicrostructuresFrontiers Science Center for Critical Earth Material CyclingNanjing UniversityNanjing 210023China

Carbon materials have shown significant potential as catalysts for lithium-oxygen batteries(LOBs).However,the intrinsic carbon sites are typically inert,necessitating extensive modifications and resulting in a limited density of active *** we present C_(60) as a metal-free cathode catalyst for LOBs,using density functional theory calculations and experimental *** lithiation reactions on the pristine carbon sites of C_(60) are energetically favorable due to its curvedπ-conjugation over the pentagon-hexagon *** kinetic analysis specifically reveals low energy barriers for Li_(2)O_(2) decomposition and Li diffusion on C_(60).Consequently,C_(60) exhibits significantly higher catalytic activity than typical carbon materials such as graphene and carbon *** electrochemical measurements validate the predictions,notably demonstrating that the intrinsic activity of C_(60) is comparable to that of noble metals.

关键词： lithium-oxygen batteries C_(60) density functional theory(DFT)calculations metal-free cathode

Constructing porous ZnFC-PA/PSF composite spheres for highly efficient Cs^(+) removal

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Journal of Environmental Sciences 2024年第9期143卷 126-137页

作者： Senjian Han Chao Gao Wenfeng Yan yafei Guo Shiqiang Wang Tianlong Deng College of Marine and Environmental Sciences Tianjin University of Science and TechnologyTianjin 300457China Key Laboratory of Marine Resource Chemistry and Food Technology Ministry of EducationTianjin 300457China

Radioisotope leaking from nuclear waste has become an intractable problem due to its gamma radiation and strong water *** this work,a novel porous ZnFC-PA/PSF composite sphere was fabricated by immobilization of ferrocyanides modified zinc phytate into polysulfone(PSF)substrate for the treatment of Cs-contaminated *** maximum adsorption capacity of ZnFC-PA/PSF was 305.38 mg/g,and the removal efficiency of Cs+was reached 94.27%within 2 *** ZnFC-PA/PSF presented favorable stability with negligible dissolution loss of Zn^(2+)and Fe^(2+)(<2%).The ZnFC-PA/PSF achieved high-selectivity towards Cs+(K_(d)=2.24×10^(4)mL/g)even in actual geothermal *** adsorption mechanism was inferred to be the ion-exchange between Cs^(+)and K^(+).What’s more,ZnFC-PA/PSF worked well in the fixed-bed adsorption(E=91.92%),indicating the application potential for the hazardous Cs^(+)removal from wastewater.

关键词： Adsorption Cesium Metal ferrocyanide Composite adsorbent

Engineered plant extracellular vesicles for autoimmune diseases therapy

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Nano Research 2024年第4期17卷 2857-2873页

作者： Ruina Han Yan Wu yafei Han Xiangfei Liu Han Liu Jiacan Su Institute of Translational Medicine Shanghai UniversityShanghai 200444China Organoid Research Center Shanghai UniversityShanghai 200444China National Center for Translational Medicine(Shanghai)SHU Branch Shanghai UniversityShanghai 200444China Department of Orthopedics Shanghai Zhongye HospitalShanghai 200941China Department of Orthopedics Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China

Autoimmune diseases(AID)encompass a diverse array of conditions characterized by immune system dysregulation,resulting in aberrant responses of B cells and T cells against the body’s own healthy *** extracellular vesicles(PEVs)are nanoscale particles enclosed by phospholipid bilayers,secreted by plant cells,which facilitate intercellular communication by transporting various bioactive *** to their nanoscale structure,safety,abundant sources,low immunogenicity,high yield,biocompatibility,and effective targeting of the colon and liver,PEVs are regarded as a promising platform for the treatment of *** review provides a comprehensive summary of PEV biogenesis,physicochemical and biological properties,internalization mechanisms,isolation methods,and their applications in various diseases,with a specific focus on their potential roles in ***,we propose engineering approaches and administration methods for ***,we present an overview of the advantages and challenges associated with utilizing PEVs for the treatment of *** gaining a comprehensive understanding of PEVs,we anticipate the development of innovative therapeutic strategies for *** and engineered PEVs hold substantial promise as a valuable resource for innovative technologies in AID treatment.

关键词： autoimmune diseases plant extracellular vesicles extracellular vesicles engineering modification

FaSnRK1a mediates salicylic acid pathways to enhance strawberry resistance to Botrytis cinerea

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Horticultural Plant Journal 2024年第1期10卷 131-144页

作者： Jingjing Luo Wenying Yu Yuansong Xiao yafei Zhang Futian Peng State Key Laboratory of Crop Biology College of Horticulture Science and EngineeringShandong Agricultural UniversityTaianShandong 271018China

Strawberry is a major fruit crop worldwide because its nutritional and health benefits to human health,but its productivity is limited by Botrytis *** nonfermentation 1-related protein kinase 1(SnRK1)has a defense function against pathogens,but the function of SnRK1 in the defense response to *** in plants is still *** this study,FaSnRK1a-OE and RNAi fruits were constructed and then inoculated with *** result reveals a positive role of Fa SnRK1a in the regulation of resistance to gray ***1a affects SA content by regulating FaPAL1 and FaPAL2 *** genes related to the SA signaling pathway(FaTGA1 and FaTGA2.1)were significantly increased/decreased in FaSnRK1a-OE or FaSnRK1a-RNAi fruit,***1a interacted with the FaWRKY33.2 protein and negatively regulated FaWRKY33.2 expression,and FaWRKY33.2 acts as a repressor of disease resistance to ***,FaSnRK1a regulates the expression of six PR genes and the activities of antioxidant enzymes to boost defense response after *** *** findings showed that FaSnRK1a increases the resistance of strawberry fruit to *** via SA signaling pathway and interaction with the FaWRKY33.2 transcription factor.

关键词： Strawberry B.cinerea SnRK1 Salicylic acid WRKY transcription factor

Inhalable nanoparticles with enhanced cuproptosis and cGAS-STING activation for synergistic lung metastasis immunotherapy

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3697-3710页

作者： Chongzheng Yan Huaiyou Lv yafei Feng Yuhan Li Zhongxi Zhao Department of Pharmaceutics Key Laboratory of Chemical Biology of Ministry of EducationSchool of Pharmaceutical SciencesCheelloo College of MedicineShandong UniversityJinan 250012China Key University Laboratory of Pharmaceutics&Drug Delivery Systems of Shandong Province School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Department of Pharmacy Yantai Yuhuangding Hospital Affiliated to Qingdao UniversityYantai 264001China

Due to the insufficient Cu^(+)accumulation,Cu^(+)efflux mechanism,and highly immunosuppressive tumor microenvironment(TME)in lung metastasis,the cuproptosis efficacy is ***,an inhalable nanodevice(CLDCu)is constructed to successfully overcome the drawbacks of *** consists of a Cu^(2+)-chitosan shell and low molecular weight heparin-tocopherol succinate(LMWH-TOS,LT)core with disulfiram(DSF)*** prepared CLDCu can be inhaled and accumulate in large amounts in lung lesions(63.6%)with 56.5 times higher than intravenous *** tumor cells,the mild acidity triggers the co-release of DSF and Cu2+,thus generating bis(diethyldithiocarbamate)-copper(CuET)to block Cu^(+)efflux protein ATP7B and forming toxic Cu^(+),leading to enhanced ***,the released chitosan cooperates with CLDCu-induced cuproptosis to activate stimulator of interferon genes(STING)pathway,which significantly potentiates dendritic cells(DCs)maturation,as wells as evokes innate and adaptive *** lung metastatic mice model,CLDCu is found to induce cuproptosis and reverse the immunosuppressive TME by inhalation ***,CLDCu combined with anti-programmed cell death protein ligand-1 antibody(aPD-L1)provokes stronger antitumor ***,nanomedicine that combines cuproptosis with STING activation is a novel strategy for tumor immunotherapy.

关键词： Cuproptosis cGAS-STING activation Disulfiram Inhalation administration Tumor microenvironment PD-L1 checkpoint blockade Lung metastasis Immunotherapy

Copy number variants of ABCF1, IL17REL, and FCGR3A are associated with the risk of gout

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Protein & Cell 2017年第6期8卷 467-470页

作者： Dong, Zheng Li, Yuan Zhou, Jingru Jiang, Shuai Wang, Yi Chen, Yulin Zhao, Dongbao Yang, Chengde Qian, Qiaoxia Ma, Yanyun He, Hongjun Ji, Hengdong Yang, Yajun Wang, Xiaofeng Xu, Xia pang, yafei Zou, Hejian Jin, Li Zhang, Feng Wang, Jiucun Fudan Univ Sch Life Sci Collaborat Innovat Ctr Genet & Dev State Key Lab Genet Engn Shanghai 200433 Peoples R China Changhai Hosp Div Rheumatol & Immunol Shanghai 200433 Peoples R China Shanghai Jiao Tong Univ Sch Med Ruijin Hosp Div Rheumatol Shanghai 200025 Peoples R China Taixing Peoples Hosp Div Rheumatol Taixing 225499 Peoples R China Taizhou Peoples Hosp Div Rheumatol Taizhou 225300 Peoples R China Fudan Taizhou Inst Hlth Sci Taizhou 225316 Peoples R China Fudan Univ Huashan Hosp Div Rheumatol Shanghai 200040 Peoples R China Fudan Univ Inst Rheumatol Immunol & Allergy Shanghai 200040 Peoples R China

Dear Editor Gout is usually characterized by recurrent flares of acute inflammatory arthritis and the crystallization of urate in tissues and joints （Dong et al., 2017）. The formation of monosodium urate crystals （MSU） is due to the elevated uric acid levels in the blood （Yang et al., 2016）. But only 10% of individuals with hyperuricemia develop gout, suggesting that certain people are at a higher risk of developing MSU crystals （Mer- riman and Dalbeth, 2011） or initiating of the acute inflamma- tory response than others.

关键词： Systemic Lupus Erythematosus Gout Copy Number Variant Comparative Genomic Hybridization High Copy Number