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The 3rd Asia Pacific Protein Association Conference in Conjunction with the 3rd Symposium of the Chinese Protein Society

作者： Joёl Janin panagiotis l.kastritis lain H.Moal Howook Hwang Zhiping Weng Paul A.Bates Alexandre M.J.J.Bonvin Yeast Structural Genomics IBBMC Bat.430Universit Paris-Sud 91405-OrsayFrance Bijvoet Center for Biomolecular Research Utrecht University Biomolecular Modelling laboratory Cancer Research UK London Research Institute Program in Bioinformatics and Integrative Biology University of Massachusetts Medical School

Relating structure to affinity has long been a challenge for molecular modelers and structural *** to now,the modeling studies concerned with the binding affinity of protein-protein complexes have been based mostly on the structure of the final product,ignoring the reactants and the role of conformation *** help developing and testing methods,we have assembled a benchmark set of 144 protein-protein complexes for which equilibrium dissociation constants have been

关键词： Protein-protein binding affinity and conformation changes:a structure/affinity benchmark

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Cryo-EM structure of a tetrameric photosystem I from Chroococcidiopsis TS-821, a thermophilic, unicellular, non-heterocyst-forming cyanobacterium

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Plant Communications 2022年第1期3卷 53-70页

作者： Dmitry A.Semchonok Jyotirmoy Mondal Connor J.Cooper Katrina Schlum Meng li Muhamed Amin Carlos O.S.Sorzano Erney Ramirez-Aportela panagiotis l.kastritis Egbert J.Boekema Albert Guskov Barry D.Bruce Groningen Biomolecular Sciences&Biotechnology Institute University of GroningenGroningenthe Netherlands Biochemistry&Cellular and Molecular Biology Department University of TennesseeKnoxvilleTNUSA Program in Genome Science and Technology University of TennesseeKnoxvilleTNUSA Bredesen Center for Interdisciplinary Research&Education University of TennesseeKnoxvilleTNUSA Department of Sciences University College GroningenGroningenthe Netherlands Biocomputing Unit National Center for Biotechnology(CSIC)Darwin 3Campus Universidad Auto´noma de MadridCantoblanco28049 MadridSpain Universidad CEU San Pablo Campus Urb.Monteprı´ncipeBoadilla del Monte28668 MadridSpain Institute of Biochemistry and Biotechnology Martin Luther University Halle-WittenbergHalle/SaaleGermany Microbiology Department University of TennesseeKnoxvilleTNUSA Present address:Institute of Biochemistry and Biotechnology Martin Luther University Halle-WittenbergHalle/SaaleGermany School of Oceanography University of WashingtonSeattleWAUSA

Photosystem I(PSI)is one of two photosystems involved in oxygenic *** of cyanobacteria exists in monomeric,trimeric,and tetrameric forms,in contrast to the strictly monomeric form of PSI in plants and *** tetrameric organization raises questions about its structural,physiological,and evolutionary *** we report the3.72 A˚resolution cryo-electron microscopy structure of tetrameric PSI from the thermophilic,unicellular cyanobacterium Chroococcidiopsis *** structure resolves 44 subunits and 448 cofactor *** conclude that the tetramer is arranged via two different interfaces resulting from a dimer-of-dimers *** localization of chlorophyll molecules permits an excitation energy pathway within and between adjacent *** analysis reveals conserved regions in the Psal subunit that correlate with the oligomeric *** PSI may function as a key evolutionary step between the trimeric and monomeric forms of PSI organization in photosynthetic organisms.

关键词： cryo-EM photosystem I non-heterocyst-forming cyanobacteria Chroococcidiopsis evolution of chloroplast high light adaptation

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宫颈癌患者脊髓髓内和软脑膜转移1例

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世界核心医学期刊文摘（妇产科学分册） 2006年第10期2卷 48-48页

作者： kastritis E. Moulopoulos l.A. Politi Ek. A. Bamias 朱磊 Department of Clinical Therapeutics Alexandra Hospital Athens University School of Medicine 31 Komninon St Haidari 124 62 Athens Greece

Background.: Neoplastic meningitis in patients with carcinoma of the uterine cervix is unusual in the course of their diseases. Even more unusual are intramedullary spinal metastases. Case.: We report the case of a 64-year-old woman who presented with leptomeningeal and intramedullary spinal cord metastases from a grade 2 squamous cell cancer of the uterine cervix. This is just the second case of intramedullary metastases from cervical carcinoma. Conclusion.: Neoplastic meningitis or intramedullary metastases are extremely rare in the course of uterine cervix carcinoma. Nevertheless, when indicated by symptoms, patients should undergo MRI of the brain and/or spine and have a lumbar puncture performed, for the diagnosis of this devastating complication. Treatment is mainly palliative but may offer symptom relief.

关键词：软脑膜脑脊膜转移姑息性腰椎穿刺

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