Relating structure to affinity has long been a challenge for molecular modelers and structural *** to now,the modeling studies concerned with the binding affinity of protein-protein complexes have been based mostly on...
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Relating structure to affinity has long been a challenge for molecular modelers and structural *** to now,the modeling studies concerned with the binding affinity of protein-protein complexes have been based mostly on the structure of the final product,ignoring the reactants and the role of conformation *** help developing and testing methods,we have assembled a benchmark set of 144 protein-protein complexes for which equilibrium dissociation constants have been
Photosystem I(PSI)is one of two photosystems involved in oxygenic *** of cyanobacteria exists in monomeric,trimeric,and tetrameric forms,in contrast to the strictly monomeric form of PSI in plants and *** tetrameric o...
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Photosystem I(PSI)is one of two photosystems involved in oxygenic *** of cyanobacteria exists in monomeric,trimeric,and tetrameric forms,in contrast to the strictly monomeric form of PSI in plants and *** tetrameric organization raises questions about its structural,physiological,and evolutionary *** we report the3.72 A˚resolution cryo-electron microscopy structure of tetrameric PSI from the thermophilic,unicellular cyanobacterium Chroococcidiopsis *** structure resolves 44 subunits and 448 cofactor *** conclude that the tetramer is arranged via two different interfaces resulting from a dimer-of-dimers *** localization of chlorophyll molecules permits an excitation energy pathway within and between adjacent *** analysis reveals conserved regions in the Psal subunit that correlate with the oligomeric *** PSI may function as a key evolutionary step between the trimeric and monomeric forms of PSI organization in photosynthetic organisms.
Background.: Neoplastic meningitis in patients with carcinoma of the uterine cervix is unusual in the course of their diseases. Even more unusual are intramedullary spinal metastases. Case.: We report the case of a 64...
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Background.: Neoplastic meningitis in patients with carcinoma of the uterine cervix is unusual in the course of their diseases. Even more unusual are intramedullary spinal metastases. Case.: We report the case of a 64-year-old woman who presented with leptomeningeal and intramedullary spinal cord metastases from a grade 2 squamous cell cancer of the uterine cervix. This is just the second case of intramedullary metastases from cervical carcinoma. Conclusion.: Neoplastic meningitis or intramedullary metastases are extremely rare in the course of uterine cervix carcinoma. Nevertheless, when indicated by symptoms, patients should undergo MRI of the brain and/or spine and have a lumbar puncture performed, for the diagnosis of this devastating complication. Treatment is mainly palliative but may offer symptom relief.
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