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Cryoablation of osteoid osteomas:Is it a valid treatment option?

World Journal of Radiology 2024年第9期16卷 389-397页

作者： Antonios Michailidis Athanasios Panos Efthimios Samoladas Georgios Dimou Georgia Mingou panagiotis kosmoliaptsis Maria Arvaniti Christos Giankoulof Evangelos Petsatodis Department of Interventional Radiology Georgios Papanikolaou General Hospital of ThessalonikiThessaloniki 57010Greece Department of 1st Orthopaedic Clinic Georgios Papanikolaou General Hospital of ThessalonikiAristotle University of ThessalonikiThessaloniki 57010Greece Dental School EKPAAthens 15773Greece

BACKGROUND Osteoid osteoma is a benign bone tumor with characteristic clinical *** selected method for its treatment is percutaneous radiofrequency ***,percutaneous cryoablation is an alternative method with certain *** To evaluate percutaneous computed tomography(CT)-guided cryoablation for the treatment of osteoid osteoma in young patients and *** A total of 25 patients were treated with percutaneous CT-guided cryoablation for osteoid osteomas between October 2020 and March 2023 at a single *** patients were above 14-years-old(mean age,24-years-old),and all procedures were performed under local *** the 25 patients,8 were female and 17 were *** sites included the femur(n=9),medial malleolus(n=4),sacral ala(n=4),facets(n=4),humerus(n=3),and tibia(n=1).One cryoprobe was used in each procedure and,when possible,the lesion was covered by the ice-ball using an extraosseous position without penetrating the *** necessary thermal protective techniques were used depending on the anatomical structure at *** All patients treated had complete response(100%clinical success rate)starting on the day of the *** success was achieved in all *** analog scale(VAS)scores at 1 year were 0,compared to a mean VAS score of 8.5±1(SD)before the *** recurrences were reported at the 1-year follow-up and no complications were *** 11/25 cases,an extraosseous position of the cryoprobe was used with less procedural time achieving technical and clinical success and no complications with less patient *** patients were discharged from the hospital on the same day as the *** Cryoablation of osteoid osteomas is an efficacious and safe procedure with durable clinical *** greatest advantage is that the procedure can be performed under local anesthesia using an extraosseous position of the cryoprobe when possible.

关键词： Cryoablation Osteoid osteoma Computed tomography guidance Interventional radiology Orthopedics Bone tumors

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Colorectal liver metastases: Current management and future perspectives

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World Journal of Clinical Oncology 2020年第10期11卷 761-808页

作者： Jack Martin Angelica Petrillo Elizabeth C Smyth Nadeem Shaida Samir Khwaja HK Cheow Adam Duckworth Paula Heister Raaj Praseedom Asif Jah Anita Balakrishnan Simon Harper Siong Liau Vasilis kosmoliaptsis Emmanuel Huguet Department of Surgery Addenbrookes HospitalNIHR Comprehensive Biomedical Research and Academic Health Sciences CentreCambridge University Hospitals NHS Foundation TrustCambridge CB20QQUnited Kingdom Department of Precision Medicine Division of Medical OncologyUniversity of Campania"L.Vanvitelli"Napoli 80131Italy&Medical Oncology UnitOspedale del Mare80147 Napoli Italy Department of Oncology Addenbrookes HospitalNIHR Comprehensive Biomedical Research and Academic Health Sciences CentreCambridge University Hospitals NHS Foundation TrustCambridge CB20QQUnited Kingdom Department of Radiology Addenbrookes HospitalNIHR Comprehensive Biomedical Research and Academic Health Sciences CentreCambridge University Hospitals NHS Foundation TrustCambridge CB220QQUnited Kingdom Department of Nuclear Medicine Addenbrookes HospitalNIHR Comprehensive Biomedical Research and Academic Health Sciences CentreCambridge University Hospitals NHS Foundation TrustCambridge CB20QQUnited Kingdom Department of Pathology Addenbrookes HospitalNIHR Comprehensive Biomedical Research and Academic Health Sciences CentreCambridge University Hospitals NHS Foundation TrustCambridge CB20QQUnited Kingdom

The liver is the commonest site of metastatic disease for patients with colorectal cancer,with at least 25%developing colorectal liver metastases(CRLM)during the course of their *** management of CRLM has evolved into a complex field requiring input from experienced members of a multi-disciplinary team involving radiology(cross sectional,nuclear medicine and interventional),Oncology,Liver surgery,Colorectal surgery,and *** management is based on assessment of sophisticated clinical,radiological and biomarker *** incomplete evidence in this very heterogeneous patient group,maximising resection of CRLM using all available techniques remains a key objective and provides the best chance of long-term survival and *** this end,liver resection is maximised by the use of downsizing chemotherapy,optimisation of liver remnant by portal vein embolization,associating liver partition and portal vein ligation for staged hepatectomy,and combining resection with ablation,in the context of improvements in the functional assessment of the future remnant *** resection may safely be carried out laparoscopically or open,and synchronously with,or before,colorectal surgery in selected *** unresectable patients,treatment options including systemic chemotherapy,targeted biological agents,intraarterial infusion or bead delivered chemotherapy,tumour ablation,stereotactic radiotherapy,and selective internal radiotherapy contribute to improve survival and may convert initially unresectable patients to *** evolving areas include biomarker characterisation of tumours,the development of novel systemic agents targeting specific oncogenic pathways,and the potential reemergence of radical surgical options such as liver transplantation.

关键词： Colorectal Cancer Liver Metastases Management Review

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