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mpact of antioxidants on seminal vesicles function ind fertilizing potential in diabetic rats

Asian Journal of Andrology 2017年第6期19卷 639-646页

作者： panagiota tsounapi Masashi Honda Fotios Dimitriadis Bunya Kawamoto Katsuya Hikita Kuniyasu Muraoka Motoaki Saito Nikolaos Sofikitis Atsushi Takenaka Division of Urology Department of Surgery Tottori University School of Medicine 36-1 Nishimachi Yonago 683-8503 Japan Department of Urology University of Ioannina School of Medicine P.O. Box 1186 45110 Ioannina Greece Department of Pharmacology Kochi University Kochi Medical School Nankoku 783-8505 Japan.

Diabetes mellitus significantly affects the male reproduction and sexual function. In the present study, we investigated the diabetes-induced dysfunction of seminal vesicles （SVs） in the diabetes-rat model and the role of antioxidants. Streptozotocin-induced diabetes after 4 weeks caused smaller size of the organs, hypercontractility, histological abnormalities, increased concentrations of malondialdehyde in the serum and tissue, overexpression of oxidative stress markers, and cleaved caspase-3 as identified by immunohistochemistry in the SVs. In addition, diabetes resulted in deceased levels of serum testosterone and no newborns after the mating studies. Antioxidants significantly normalized all the above parameters, except for the severely decreased serum testosterone levels and the negative outcome of the mating studies. The present study gives evidence for the important role of diabetes-induced oxidative stress in the function and structure of these androgen-dependent organs. Antioxidants may be a promising supplementary therapy for diabetic male patients to alleviate ejaculatory disorders but alone is not efficient treatment for the mitigation of infertility.

关键词： diabetes mellitus male infertility oxidative stress seminal vesicles seminiferous epithelium smooth muscle cellcontractions

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An experience of hyperbaric oxygen and transurethral coagulation combination therapy for abnormal vessels and intractable macrohematuria due to pelvic arteriovenous malformations

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Case Reports in Clinical Medicine 2013年第7期2卷 399-401页

作者： Seiya Inoue Masashi Honda Shinji Hirano Noriya Yamaguchi Bunya Kawamoto tsounapi panagiota Katsuya Hikita Kuniyasu Muraoka Takehiro Sejima Chihiro Takahashi Atsushi Takenaka Department of Urology National Hospital Organization Yonago Medical Center Yonago Japan Department of Urology National Hospital Organization Yonago Medical Center Yonago Japan of Urology Tottori University School of Medicine Yonago Japan Department of Urology Tottori University School of Medicine Yonago Japan Department of Urology Tottori University School of Medicine Yonago Japan

A 78-year-old man was admitted to our hospital with a chief complaint of gross hematuria. The patient was diagnosed with pelvic arteriovenous malformations and repeated arterial embolization. A cystoscopy demonstrated that bladder trigone was covered by many clots. At the same time, bleeding mucosa at the right side of the bladder dome was confirmed. We administered hyperbaric oxygen therapy 7 days after admission. Macrohematuria recovered gradually and we then performed transurethral coagulation at the dome with failed mucosa 14 days after admission. Macrohematuria recovered completely and there was no recurrence during hospitalization. Thirty days after admission, we performed cystoscopy and found clear mucosa in the trigone. The patient was discharged 32 days after admission.

关键词： Hyperbaric Oxygen Therapy Macrohematuria Pelvic Arteriovenous Malformations Transurethral Coagulation

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Effects of phosphodiesterase 5 inhibitors on sperm parameters and fertilizing capacity

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Asian Journal of Andrology 2008年第1期10卷 115-133页

作者： F. Dimitriadis D. Giannakis N. Pardalidis K. Zikopoulos E. Paraskevaidis N. Giotitsas V. Kalaboki P.tsounapi D. Baltogiannis Georgiou M.Saito T.Watanabe I. Miyagawa N.Sofildtis Laboratory of Molecular Urology and Genetics of Human Reproduction Department of Urology Ioannina University School of Medicine Ioannina 45110 Greece Department of Urology Tottori University School of Medicine Yonago 683 Japan

The aim of this review study is to elucidate the effects that phosphodiesterase 5 （PDE5） inhibitors exert on spermatozoa motility, capacitation process and on their ability to fertilize the oocyte. Second messenger systems such as the cAMP/adenylate cyclase （AC） system and the cGMP/guanylate cyclase （GC） system appear to regulate sperm functions. Increased levels of intracytosolic cAMP result in an enhancement of sperm motility and viability. The stimulation of GC by low doses of nitric oxide （NO） leads to an improvement or maintenance of sperm motility, whereas higher concentrations have an adverse effect on sperm parameters. Several in vivo and in vitro studies have been carried out in order to examine whether PDE5 inhibitors affect positively or negatively sperm parameters and sperm fertilizing capacity. The results of these studies are controversial. Some of these studies demonstrate no significant effects of PDE5 inhibitors on the motility, viability, and morphology of spermatozoa collected from men that have been treated with PDE5 inhibitors. On the other hand, several studies demonstrate a positive effect of PDE5 inhibitors on sperm motility both in vivo and in vitro. In vitro studies of sildenafil citrate demonstrate a stimulatory effect on sperm motility with an increase in intracellular cAMP suggesting an inhibitory action of sildenafil citrate on a PDE isoform other than the PDE5. On the other hand, tadalafil＇s actions appear to be associated with the inhibitory effect of this compound on PDE11. In vivo studies in men treated with vardenafil in a daily basis demonstrated a significantly larger total number of spermatozoa per ejaculate, quantitative sperm motility, and qualitative sperm motility; it has been suggested that vardenafil administration enhances the secretory function of the prostate and subsequently increases the qualitative and quantitative motility of spermatozoa. The effect that PDE5 inhibitors exert on sperm parameters may lead to the impr

关键词： sperm fertilizing capacity phosphodiesterase 5 inhibitors spermatozoa testis male infertility

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