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Immune checkpoint inhibition mediated with liposomal nanomedicine for cancer therapy

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Military Medical Research 2024年第1期11卷 98-114页

作者： Guang-Long Ma wei-feng Lin Faculty of Medicine Centre for Cancer ImmunologyUniversity of SouthamptonSouthampton SO166YDUK Department of Molecular Chemistry and Materials Science Weizmann Institute of Science76100 RehovotIsrael Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191China

Immune checkpoint blockade(ICB)therapy for cancer has achieved great success both in clinical results and on the market.At the same time,success drives more attention from scientists to improve it.However,only a small portion of patients are responsive to this therapy,and it comes with a unique spectrum of side effects termed immunerelated adverse events(irAEs).The use of nanotechnology could improve ICBs’delivery to the tumor,assist them in penetrating deeper into tumor tissues and alleviate their irAEs.Liposomal nanomedicine has been investigated and used for decades,and is well-recognized as the most successful nano-drug delivery system.The successful combination of ICB with liposomal nanomedicine could help improve the efficacy of ICB therapy.In this review,we highlighted recent studies using liposomal nanomedicine(including new emerging exosomes and their inspired nanovesicles)in associating ICB therapy.

关键词： Liposome Exosome Immune checkpoint blockade(ICB)

Flow Field Simulation and Parameter Analysis of Hydraulic Unbalanced Bionic Self-recovery Actuator for Rotary Equipment

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Journal of Bionic Engineering 2024年第1期21卷 325-343页

作者： wei Li Xin pan Dehong Ge Jinji Gao Key Laboratory of Engine Health Monitoring-Control and Networking of Ministry of Education Beijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of High-End Mechanical Equipment Health Monitoring and Self-Recovery Beijing University of Chemical TechnologyBeijing 100029China

The rotor is the most important component of rotating machinery,and the vibration produced by its mass unbalance has a serious influence on the secure and steady operation of the machine,so an effective online suppression technology is urgently needed.A new hydraulic unbalanced bionic self-recovery system is introduced,imitating the way of manually repairing faulty equipment.To accomplish the effect of actuator mass redistribution,the technology employs pressurized air to drive the quantitative transfer of liquid in the reservoir cavity at opposite positions.It can complete the online adjustment of the equipment's balancing state and suppress the unbalanced vibration of equipment in real time,which gives the equipment the ability to maintain an autonomous health state and improve equipment performance.The composition and working principle of the system are introduced in detail,and the key performance parameters,such as the minimum running speed and the balancing liquid transfer speed,are analyzed theoretically.The fluid-solid coupling model of the actuator was established,and the two-phase flow from inside the hydraulic unbalanced bionic self-recovery actuator was simulated under multiple working conditions and the performance parameters were quantitatively analyzed.A balancing simulation test bed was built,and its effectiveness was verified by performance parameter tests and unbalanced bionic self-recovery experiments.The experimental results show that the mass distribution adjustment of the balancing disk can be achieved using different viscosity balancing liquid,and the response of liquid viscosity 10 cSt is faster than that of liquid viscosity 100 cSt in the process of balancing liquid transfer,and the time is reduced by more than 75%;the system can reduce the simulated rotor amplitude from 18.3μm to 10.6μm online in real time,which provides technical support for the subsequent development of a new generation of bionic intelligent equipment.

关键词： Engineering self-recovery-Bionics Simulation analysis Self-recovery regulation

Carbon-based materials with combined functions of thermal management and electromagnetic protection: Preparation, mechanisms, properties, and applications

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Nano Research 2024年第3期17卷 883-903页

作者： Junwei Yue Yiyu feng Mengmeng Qin wei feng School of Materials Science and Engineering and Tianjin Key Laboratory of Composite and Functional Materials Tianjin UniversityTianjin 300350China

The proliferation of high-power,highly informationized,and highly integrated electronic devices and weapons equipment has given rise to increasingly conspicuous issues about electromagnetic(EM)pollution and thermal accumulation.These issues,in turn,impose constraints on the performance of such equipment and jeopardize personnel safety.Carbon materials,owing to their diverse and modifiable structures,offer adjustable thermal and electric conductivity,rendering them highly promising for applications in fields such as thermal management and EM protection which have garnered extensive research and review.The pursuit of integrated device and equipment development has elevated the demand for multifunctional materials,prompting significant research into carbon-based composite materials that include both thermal management and EM protection functionalities.Notably,there are no relevant reviews on this topic at present.Consequently,this work consolidates research findings from recent years on carbon matrix composites exhibiting dual attributes of thermal management and EM protection.These attributes include thermally conductive electromagnetic interference(EMI)shielding materials,thermally insulating EMI shielding materials,thermally conductive EM wave(EMW)absorbing materials,and thermally insulating EMW absorbing materials.The paper elucidates the fundamental principles underpinning thermal conduction,thermal insulation,EMW absorbing,and EMI shielding.Additionally,it engages in discussions surrounding areas of contention,design strategies,and the functional properties of various material designs.Ultimately,the paper concludes by presenting the challenges encountered and potential research strategies about composites endowed with both thermal management and EM protection functionalities,while also envisaging the development of novel multifunctional EM protection materials.

关键词： carbon-based composites electromagnetic interference shielding microwave absorption thermal conduction thermal insulation

Properties of collective flow and pion production in intermediate-energy heavy-ion collisions with a relativistic quantum molecular dynamics model

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Nuclear Science and Techniques 2024年第1期35卷 155-169页

作者： Si-Na wei Zhao-Qing feng School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China

The relativistic mean-field approach was implemented in the Lanzhou quantum molecular dynamics transport model(LQMD.RMF). Using the LQMD.RMF, the properties of collective flow and pion production were investigated systematically for nuclear reactions with various isospin asymmetries. The directed and elliptic flows of the LQMD.RMF are able to describe the experimental data of STAR Collaboration. The directed flow difference between free neutrons and protons was associated with the stiffness of the symmetry energy, that is, a softer symmetry energy led to a larger flow difference. For various collision energies, the ratio between the π^(-) and π^(+) yields increased with a decrease in the slope parameter of the symmetry energy. When the collision energy was 270 MeV/nucleon, the single ratio of the pion transverse momentum spectra also increased with decreasing slope parameter of the symmetry energy in both nearly symmetric and neutron-rich systems.However, it is difficult to constrain the stiffness of the symmetry energy with the double ratio because of the lack of threshold energy correction on the pion production.

关键词： Heavy-ion collision Collective flow Pion production Symmetry energy Relativistic mean field

Clinical application of COVID-19 vaccine in liver transplant recipients

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Hepatobiliary & pancreatic Diseases International 2024年第4期23卷 339-343页

作者： feng-Chao Liu Man Xie wei Rao Division of Hepatology Liver Disease CenterThe Affiliated Hospital of Qingdao UniversityQingdao 266000China Organ Transplantation Center The Affiliated Hospital of Qingdao UniversityQingdao 266000China Institute of Organ Donation and Transplantation of Qingdao University Qingdao 266000China Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdao 266000China

Background:Solid organ transplant(SOT)activities,such as liver transplant,have been greatly influenced by the pandemic of coronavirus disease 2019(COVID-19),a disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Immunosuppressed individuals of liver transplant recipients(LTRs)tend to have a high risk of COVID-19 infection and related complications.Therefore,COVID-19 vaccination has been recommended to be administered as early as possible in LTRs.Data sources:The keywords“liver transplant”,“SARS-CoV-2”,and“vaccine”were used to retrieve articles published in PubMed.Results:The antibody response following the 1st and 2nd doses of vaccination was disappointingly low,and the immune responses among LTRs remarkably improved after the 3rd or 4th dose of vaccination.Although the 3rd or 4th dose of COVID-19 vaccine increased the antibody titer,a proportion of patients remained unresponsive.Furthermore,recent studies showed that SARS-CoV-2 vaccine could trigger adverse events in LTRs,including allograft rejection and liver injury.Conclusions:This review provides the recently reported data on the antibody response of LTRs following various doses of vaccine,risk factors for poor serological response and adverse events after vaccination.

关键词： Liver transplant COVID-19 SARS-CoV-2 Vaccine Antibody response

Mobile Crowdsourcing Task Allocation Based on Dynamic Self-Attention GANs

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Computers, Materials & Continua 2024年第4期79卷 607-622页

作者： Kai wei Song Yu Qingxian pan School of Computer and Control Engineering Yantai UniversityYantai264005China School of Computer and Information Science Southwest UniversityChongqing400715China

Crowdsourcing technology is widely recognized for its effectiveness in task scheduling and resource allocation.While traditional methods for task allocation can help reduce costs and improve efficiency,they may encounter challenges when dealing with abnormal data flow nodes,leading to decreased allocation accuracy and efficiency.To address these issues,this study proposes a novel two-part invalid detection task allocation framework.In the first step,an anomaly detection model is developed using a dynamic self-attentive GAN to identify anomalous data.Compared to the baseline method,the model achieves an approximately 4%increase in the F1 value on the public dataset.In the second step of the framework,task allocation modeling is performed using a twopart graph matching method.This phase introduces a P-queue KM algorithm that implements a more efficient optimization strategy.The allocation efficiency is improved by approximately 23.83%compared to the baseline method.Empirical results confirm the effectiveness of the proposed framework in detecting abnormal data nodes,enhancing allocation precision,and achieving efficient allocation.

关键词： Mobile crowdsourcing task allocation anomaly detection GAN attention mechanisms

Simultaneous purification of minor components in natural products using twin-column recycling chromatography with a step solvent gradient

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Chinese Journal of Chemical Engineering 2024年第5期69卷 212-219页

作者： Guangxia Jin Yuxue Wu feng wei School of Biological and Chemical Engineering NingboTech UniversityNingbo 315100China

The isolation of minor components from complex natural product matrices presents a significant challenge in the field of purification science due to their low concentrations and the presence of structurally similar compounds.This study introduces an optimized twin-column recycling chromatography method for the efficient and simultaneous purification of these elusive constituents.By introducing water at a small flowing rate between the twin columns,a step solvent gradient is created,by which the leading edge of concentration band would migrate at a slower rate than the trailing edge as it flowing from the upstream to downstream column.Hence,the band broadening is counterbalanced,resulting in an enrichment effect for those minor components in separation process.Herein,two target substances,which showed similar peak position in high performance liquid chromatography(HPLC)and did not exceed 1.8%in crude paclitaxel were selected as target compounds for separation.By using the twin-column recycling chromatography with a step solvent gradient,a successful purification was achieved in getting the two with the purity almost 100%.We suggest this method is suitable for the separation of most components in natural produces,which shows higher precision and recovery rate compared with the common lab-operated separation ways for natural products(thin-layer chromatography and prep-HPLC).

关键词： Solvent gradient Twin-column recycling chromatography Purification Minor component Natural products

Robot-Oriented 6G Satellite-UAV Networks: Requirements, Paradigm Shifts, and Case Studies

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China Communications 2024年第2期21卷 74-84页

作者： Peng wei wei feng Yunfei Chen Ning Ge wei Xiang Department of Electronic Engineering Tsinghua UniversityBeijing 100084China Department of Engineering University of DurhamDH13LEDurhamUK School of Computing Engineering and Mathematical SciencesLa Trobe UniversityMelbourneVIC 3086Australia

Networked robots can perceive their surroundings, interact with each other or humans,and make decisions to accomplish specified tasks in remote/hazardous/complex environments. Satelliteunmanned aerial vehicle(UAV) networks can support such robots by providing on-demand communication services. However, under traditional open-loop communication paradigm, the network resources are usually divided into user-wise mostly-independent links,via ignoring the task-level dependency of robot collaboration. Thus, it is imperative to develop a new communication paradigm, taking into account the highlevel content and values behind, to facilitate multirobot operation. Inspired by Wiener’s Cybernetics theory, this article explores a closed-loop communication paradigm for the robot-oriented satellite-UAV network. This paradigm turns to handle group-wise structured links, so as to allocate resources in a taskoriented manner. It could also exploit the mobility of robots to liberate the network from full coverage,enabling new orchestration between network serving and positive mobility control of robots. Moreover,the integration of sensing, communications, computing and control would enlarge the benefit of this new paradigm. We present a case study for joint mobile edge computing(MEC) offloading and mobility control of robots, and finally outline potential challenges and open issues.

关键词： closed-loop communication mobility control satellite-UAV network structured resource allocation

Limits of Uneven Battery Power in Modular Multilevel Converter-based Battery Energy Storage Systems

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 686-695页

作者： Yao pan Xiaofeng Sun wei Zhao Xin Li Yao Cai Institute of Electrical Engineering Yanshan UniversityQinhuangdao 066004China

For modular multilevel converter-based battery energy storage systems (MMC-BESS), uneven power among batteries of SMs will be deduced by battery aging, battery fault, etc., which will degrade performance and even lead to system failure. For maintaining the balance of capacitor voltage, this paper analyzes the limits of the uneven power of batteries, which are presented as the current limits in this paper. According to analysis, an analytical method is proposed that only the dc and fundamental frequency components of the arm current are used to calculate current limits. With the current limits it is able to evaluate the reasonability of power distribution among batteries. Meanwhile, increase of fundamental frequency component will enhance the current limits, and the dc component determines the size relationship between the absolute values of the upper and lower current limits. Finally, simulation model and experiment prototype are built for verifying the theoretical analysis and current limits calculation method, and satisfactory results are provided.

关键词： Arm current balance of capacitor voltage current limits MMC-BESS uneven power